{"id":10334,"date":"2020-04-23T04:03:20","date_gmt":"2020-04-23T01:03:20","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/anticorpi-anti-srp\/"},"modified":"2025-02-06T11:41:27","modified_gmt":"2025-02-06T09:41:27","slug":"anticorpi-anti-srp","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/anticorpi-anti-srp\/","title":{"rendered":"\u0410\u043d\u0442\u0438-SRP \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430"},"content":{"rendered":"<p><strong><em>Informa\u021bii generale Anticorpi anti-SRP<\/em><\/strong><\/p>\n<p>SRP este considerat un anticorp specific patologiei numit\u0103 miozit\u0103. Anti-SRP a fost descris pentru prima dat\u0103 la un pacient cu polimiozit\u0103 \u00een 1986.<\/p>\n<p>Miopatiile inflamatorii idiopatice sunt un grup mic de miopatii dob\u00e2ndite care sunt asociate cu sl\u0103biciune muscular\u0103, cre\u0219terea creatinkinazei serice \u0219i tulburari miopatice la electromiografie<sup>1,2<\/sup>. Miopatia necrozant\u0103 mediat\u0103 imun sau miopatia autoimun\u0103 necrozant\u0103 reprezint\u0103 un grup eterogen de boli care se caracterizeaz\u0103 prin prezen\u021ba fibrelor necrotice la biopsia muscular\u0103 \u00eempreun\u0103 cu niveluri serice crescute de creatinkinaz\u0103 \u0219i un rezultat anormal la electromiogram\u0103<sup>3<\/sup>.<\/p>\n<p>Anticorpii anti-SRP sunt cei mai frecventi anticorpi asocia\u021bi cu miopatia autoimun\u0103 necrozant\u0103. Ace\u0219ti anticorpi specifici miozitei g\u0103si\u021bi la 4-6% dintre pacien\u021bii cu miopatii inflamatorii idiopatice<sup>4<\/sup>. Ei sunt direc\u021biona\u021bi \u00eempotriva SRP, o structur\u0103 ribonuclear\u0103 care regleaz\u0103 translocarea proteinelor prin membrana reticulului endoplasmatic, \u00een timpul sintezei proteinelor. Studiile au demonstrat c\u0103 miopatia anti-SRP se prezint\u0103 distinct fa\u021b\u0103 de polimiozit\u0103 \u0219i alte miopatii inflamatorii idiopatice prin caracteristicile sale clinice \u0219i histopatologie<sup>5<\/sup>.<\/p>\n<p>Pacien\u021bii cu anticorpi anti-SRP prezint\u0103 adesea clinic o miopatie sever\u0103, caracterizat\u0103 prin niveluri serice crescute de\u00a0<a href=\"https:\/\/www.synevo.ro\/shop\/creatinkinaza-ck\/\" target=\"_blank\" rel=\"noopener nofollow\" data-wpel-link=\"internal\">creatinkinaz\u0103<\/a>\u00a0\u0219i sl\u0103biciune muscular\u0103 proximal\u0103 rapid progresiv\u0103, care duce la dizabilitate semnificativ\u0103. Din punct de vedere histopatologic, pacien\u021bii ce prezint\u0103 anticorpi anti-SRP demonstreaz\u0103 o miopatie necrozant\u0103 f\u0103r\u0103 inflama\u021bie primar\u0103.<\/p>\n<p>Miopatia anti-SRP difer\u0103, de asemenea, de alte miopatii mediate imun, prin r\u0103spunsul s\u0103u caracteristic slab la monoterapia cu steroizi \u0219i terapiile imunosupresoare conven\u021bionale. Anticorpii anti-SRP sunt adesea \u00eent\u00e2lni\u021bi la femeile afro-americane, ce au un debut acut, sever al polimiozitei, cu r\u0103spuns slab la terapie<sup>6<\/sup>.<\/p>\n<p><strong><em>Recomand\u0103ri pentru determinarea anticorpilor anti-SRP<\/em><\/strong><\/p>\n<ul>\n<li>Diagnosticul \u0219i evaluarea pacien\u021bilor cu miopatii<sup>5,6<\/sup><\/li>\n<\/ul>\n<p><strong><em>Specimen recoltat \u2013\u00a0<\/em><\/strong>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c<sup>7<\/sup><\/p>\n<p><strong><em>Prelucrare necesar\u0103 dup\u0103 recoltare \u2013\u00a0<\/em><\/strong>Proba se centrifugheaz\u0103 \u0219i se alicoteaz\u0103 serul<sup>7<\/sup>.<\/p>\n<p><strong><em>Volum prob\u0103 \u2013\u00a0<\/em><\/strong>1mL<sup>7<\/sup><\/p>\n<p><strong><em>Cauze de respingere a probei<\/em><\/strong><sup>7<\/sup><\/p>\n<ul>\n<li>Specimen hemolizat<\/li>\n<li>Specimen lipemic<\/li>\n<li>Specimen icteric<\/li>\n<li>Specimen contaminat bacterian<\/li>\n<\/ul>\n<p><strong><em>Stabilitate prob\u0103 \u2013\u00a0<\/em><\/strong>timp de 14 zile la temperaturi cuprinse \u00eentre 2-8<sup>o<\/sup>\u0412<sup>7<\/sup><\/p>\n<p><strong><em>Metod\u0103 \u2013\u00a0<\/em><\/strong>ARN imunoprecipitare\/ELISA<sup>8<\/sup><\/p>\n<p><strong><em>Valori de referin\u021b\u0103 \u2013\u00a0<\/em><\/strong>\u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0439\/\u043e\u0442\u0440\u0438\u0446\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0439<sup>7<\/sup><\/p>\n<p><strong><em>\u00a0<\/em><\/strong><\/p>\n<p><strong><em>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/em><\/strong><\/p>\n<ol>\n<li>Watanabe, Y., Uruha, A., Suzuki, S., Nakahara, J., Hamanaka, K., Takayama, K., Suzuki, N., &amp; Nishino, I. (2016). Clinical features and prognosis in anti-SRP and anti-HMGCR necrotising myopathy. Journal of neurology, neurosurgery, and psychiatry, 87(10), 1038\u20131044.\u00a0<a href=\"https:\/\/doi.org\/10.1136\/jnnp-2016-313166\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1136\/jnnp-2016-313166<\/a><\/li>\n<li>Carvalho, A., Silva, V., Vieira, T. F., Delgado, P. O., Corazini, R., Feder, D., &amp; Fonseca, F. (2018). Proposed cut-off for reactivity of anti-HMGCR and anti-SRP antibodies in patients statin-exposed and statin-unexposed. Medicine, 97(35), e11858.\u00a0<a href=\"https:\/\/doi.org\/10.1097\/MD.0000000000011858\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1097\/MD.0000000000011858<\/a><\/li>\n<li>Ousmane, C., Makhtar, B. E., Fatoumata, B., Massi, G. D., L\u00e9mine, D. S., Soda, D. M., Dieynaba, S. A., Anna, B., Bouna, S. L., Moustapha, N., Gallo, D. A., &amp; Mansour, N. M. (2016). Polymyositis anti-SRP antibodies and pregnancy about 2 cases. The Pan African medical journal, 24, 192.\u00a0<a href=\"https:\/\/doi.org\/10.11604\/pamj.2016.24.192.9690\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.11604\/pamj.2016.24.192.9690<\/a><\/li>\n<li>Zhao, Y., Zhang, W., Liu, Y., Wang, Z., &amp; Yuan, Y. (2020). Factors associated with refractory autoimmune necrotizing myopathy with anti-signal recognition particle antibodies.\u00a0<em>Orphanet journal of rare diseases<\/em>,\u00a0<em>15<\/em>(1), 181.\u00a0<a href=\"https:\/\/doi.org\/10.1186\/s13023-020-01431-7\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1186\/s13023-020-01431-7<\/a><\/li>\n<li>Miller, T., Al-Lozi, M.T., Lopate, G., and Pestronk, A. (2002). Myopathy with antibodies to the signal recognition particle: clinical and pathological featuresJournal of Neurology, Neurosurgery &amp; Psychiatry;73:420-428.<\/li>\n<li>Takada, T., Hirakata, M., Suwa, A., Kaneko, Y., Kuwana, M., Ishihara, T., &amp; Ikeda, Y. (2009). Clinical and histopathological features of myopathies in Japanese patients with anti-SRP autoantibodies. Modern rheumatology, 19(2), 156\u2013164.\u00a0<a href=\"https:\/\/doi.org\/10.1007\/s10165-008-0139-8\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1007\/s10165-008-0139-8<\/a><\/li>\n<li>Labcorp Tests. Digoxin [on-line]: https:\/\/www.labcorp.com\/tests\/520014\/anti-srp-ab-rdl [Accesat la data de 18.01.2022]<\/li>\n<li>Suzuki, S., Nishikawa, A., Kuwana, M., Nishimura, H., Watanabe, Y., Nakahara, J., Hayashi, Y. K., Suzuki, N., &amp; Nishino, I. (2015). Inflammatory myopathy with anti-signal recognition particle antibodies: case series of 100 patients. Orphanet journal of rare diseases, 10, 61.\u00a0<a href=\"https:\/\/doi.org\/10.1186\/s13023-015-0277-y\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1186\/s13023-015-0277-y<\/a><\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"<p>\u041c\u0438\u0448\u0435\u043d\u044c \u044d\u0442\u0438\u0445 \u0410\u0422 &#8212; \u0441\u0438\u0433\u043d\u0430\u043b-\u0443\u0437\u043d\u0430\u044e\u0449\u0430\u044f \u0447\u0430\u0441\u0442\u0438\u0446\u0430 (SRP), \u0446\u0438\u0442\u043e\u043f\u043b\u0430\u0437\u043c\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0440\u0438\u0431\u043e\u043d\u0443\u043a\u043b\u0435\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u043e\u0432\u044b\u0439 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441, \u043e\u0442\u0432\u0435\u0442\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u0437\u0430 \u0442\u0440\u0430\u043d\u0441\u043b\u043e\u043a\u0430\u0446\u0438\u044e \u0432\u043d\u043e\u0432\u044c \u0441\u0438\u043d\u0442\u0435\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u043e\u0432 \u0438\u0437 \u0440\u0438\u0431\u043e\u0441\u043e\u043c \u0432 \u044d\u043d\u0434\u043e\u043f\u043b\u0430\u0437\u043c\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0440\u0435\u0442\u0438\u043a\u0443\u043b\u0443\u043c. \u0410\u043d\u0442\u0438-SRP \u0410\u0422 \u043c\u043e\u0433\u0443\u0442 \u0432\u044b\u044f\u0432\u043b\u044f\u0442\u044c\u0441\u044f \u0432 \u0441\u043b\u0443\u0447\u0430\u044f\u0445 \u0442\u044f\u0436\u0435\u043b\u043e\u0433\u043e \u043c\u0438\u043e\u0437\u0438\u0442\u0430. \u0418\u0445 \u0432\u0441\u0442\u0440\u0435\u0447\u0430\u0435\u043c\u043e\u0441\u0442\u044c \u043f\u0440\u0438 \u043c\u0438\u043e\u0437\u0438\u0442\u0430\u0445 \u0441\u043e\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 \u043e\u043a\u043e\u043b\u043e 4%; \u043f\u0440\u0438\u043c\u0435\u0440\u043d\u043e \u0443 \u0447\u0435\u0442\u0432\u0435\u0440\u0442\u0438 SRP-\u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u0432\u0430\u044e\u0442 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043f\u0440\u0438\u0437\u043d\u0430\u043a\u0438 \u0434\u0435\u0440\u043c\u0430\u0442\u043e\u043c\u0438\u043e\u0437\u0438\u0442\u0430.<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"262\"><b>\u041f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c<\/b><\/td>\n<td width=\"361\"><b>\u0425\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0430<\/b><\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><b>\u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b<\/b><\/td>\n<td width=\"361\">\u0412\u0435\u043d\u043e\u0437\u043d\u0430\u044f\u00a0\u043a\u0440\u043e\u0432\u044c<\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><b>\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438\u00a0\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430<\/b><\/td>\n<td width=\"361\">\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><b>\u0422\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u0430\u044f\u00a0\u0441\u0440\u0435\u0434\u0430,\u00a0\u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0430<\/b><\/td>\n<td width=\"361\">\u0412\u0430\u043a\u0443\u0442\u0430\u0439\u043d\u0435\u0440\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0433\u0435\u043b\u0435\u0432\u043e\u0439\u00a0\u0444\u0430\u0437\u044b<\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><b>\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u0438\u00a0\u0443\u0441\u043b\u043e\u0432\u0438\u044f\u00a0\u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0438\u0440\u043e\u0432\u043a\u0438,\u00a0\u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c\u00a0\u043f\u0440\u043e\u0431\u044b<\/b><\/td>\n<td width=\"361\">\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><\/td>\n<td width=\"361\"><\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><\/td>\n<td width=\"361\"><\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><\/td>\n<td width=\"361\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table>\n<tbody>\n<tr>\n<td width=\"624\"><b>\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u00a0\u043a\u00a0\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044e<\/b><\/td>\n<\/tr>\n<tr>\n<td width=\"624\"><b>\u041c\u0430\u0440\u043a\u0435\u0440\u00a0\u043c\u0438\u043e\u0437\u0438\u0442\u0430<\/b><\/p>\n<p>\u00b7\u00a0\u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430\u00a0\u0438\u00a0\u0434\u0438\u0444\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u0430\u044f\u00a0\u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430\u00a0\u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0433\u043e\u00a0\u043c\u0438\u043e\u0437\u0438\u0442\u0430<\/td>\n<\/tr>\n<tr>\n<td width=\"624\"><b>\u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f\u00a0\u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/b><\/td>\n<\/tr>\n<tr>\n<td width=\"624\"><b>\u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435\u00a0\u0443\u0440\u043e\u0432\u043d\u044f<\/b><\/td>\n<\/tr>\n<tr>\n<td width=\"624\">\u041c\u0438\u043e\u0437\u0438\u0442\u00a0\u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0439<\/td>\n<\/tr>\n<\/tbody>\n<\/table>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[929],"product_tag":[],"class_list":{"0":"post-10334","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-pentru-afectiuni-reumatismale-si-vasculite","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10334","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10334"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10334"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10334"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10334"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10334"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}