{"id":10326,"date":"2020-04-23T04:03:06","date_gmt":"2020-04-23T02:03:06","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/ag-hbs-cantitativ\/"},"modified":"2025-07-01T07:57:44","modified_gmt":"2025-07-01T04:57:44","slug":"ag-hbs-cantitativ","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/ag-hbs-cantitativ\/","title":{"rendered":"\u041a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 HBsAg"},"content":{"rendered":"<p><strong><em>\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n<p>Infec\u0163ia cu virusul hepatitei B (VHB) continu\u0103 s\u0103 reprezinte o problem\u0103 de s\u0103n\u0103tate public\u0103 cu toate c\u0103 sunt disponibile vaccinuri eficiente \u00eenc\u0103 din 1982.<\/p>\n<p>Antigenul de suprafa\u0163\u0103 al virusului hepatitei B (AgHBs) reprezint\u0103 marker-ul serologic cel mai important al infec\u0163iei VHB. De la descoperirea (1965) \u015fi raportarea sa (1968) de c\u0103tre Blumberg \u015fi colaboratorii, AgHBs a fost utilizat \u00een practica medical\u0103 curent\u0103 exclusiv \u00een scop diagnostic; detec\u0163ia sa fiind calitativ\u0103 nu a prezentat relevan\u0163\u0103 pentru monitorizarea terapiei antivirale \u00een infec\u0163ia cronic\u0103<sup>1<\/sup>.<\/p>\n<p>\u00cen 2007 a fost introdus\u0103 \u00een testarea curent\u0103 determinarea viremiei B (cantitatea de ADN al virusului hepatitei B \u00een s\u00e2nge, ADN-VHB) aceasta devenind factorul prognostic esen\u0163ial pentru pacien\u0163ii cu infec\u0163ie VHB cronic\u0103, stabilind at\u00e2t gradul de activitate a bolii c\u00e2t \u015fi riscul de carcinom hepatocelular<sup>1;2<\/sup>. De asemenea, \u00een func\u0163ie de ADN-VHB se decide momentul ini\u0163ierii terapiei antivirale \u015fi se evalueaz\u0103 r\u0103spunsul la tratament<sup>2<\/sup>.<\/p>\n<p>Recent a devenit disponibil\u0103 \u015fi cuantificarea AgHBs, iar studiile efectuate au subliniat importan\u0163a acestui test \u00een stabilirea riscului de progresie a bolii \u015fi valoarea sa predictiv\u0103 \u00een ceea ce prive\u015fte r\u0103spunsul la tratament al pacien\u0163ilor cu infec\u0163ie cronic\u0103 VHB. Astfel, concentra\u0163ia \u00een s\u00e2nge a antigenului de suprafa\u0163\u0103 al virusului hepatitei B (AgHBs cantitativ) se coreleaz\u0103 cu cantitatea \u015fi activitatea transcrip\u0163ional\u0103 a ADN-ului dublu catenar, circular, \u00eenchis prin leg\u0103turi covalente (engl. <em>covalently closed, circular, double-stranded DNA<\/em>, cccDNA), un epizom care nu se replic\u0103, localizat \u00een nucleul hepatocitelor infectate \u015fi care constituie exclusiv matri\u0163a transcrip\u0163iilor virale ulterioare.<\/p>\n<p>Din acest motiv, AgHBs cantitativ furnizeaz\u0103 informa\u0163ii despre activitatea bolii care nu se limiteaz\u0103 numai la estimarea replic\u0103rii virale<sup>2;3<\/sup>. Astfel, nivelul de AgHBs reflect\u0103 capacitatea sistemului imun al gazdei de a controla infec\u0163ia VHB<sup>1<\/sup>.<\/p>\n<p>Genomul VHB con\u0163ine 4 cadre de citire deschise, ORF-uri (<em>engl. open reading frames<\/em>) denumite \u00een func\u0163ie de proteinele pe care le codific\u0103:<\/p>\n<p>S \u2013 proteina de suprafa\u0163\u0103, AgHBs;<\/p>\n<p>C \u2013 proteina \u201ecore\u201d, a nucleocapsidei (AgHBc);<\/p>\n<p>P \u2013 ADN polimeraza viral\u0103, \u201c<em>pol<\/em>\u201d, cu func\u0163ie \u015fi de revers-transcriptaz\u0103, denumit\u0103 \u015fi polimeraza\/revers-transcriptaza;<\/p>\n<p>X \u2013 proteina HBx, cu func\u0163ie neelucidat\u0103 (posibil implicat\u0103 in dezvoltarea carcinomului hepato-celular, prin legarea de p53)<sup>4;5;6<\/sup>.<\/p>\n<p>Gena S prezint\u0103 \u00een amonte regiunile denumite pre-S1 \u015fi pre-S2. Prin transcrip\u0163ia genei S a cccDNA sunt genera\u0163i preS1-ARNm \u015fi pre-S2\/S-ARNm ai c\u0103ror mesaje vor fi traduse \u00een 3 proteine AgHBs: \u201esmall\u201d (S), \u201emedium\u201d (M) \u015fi \u201elarge\u201d (L), dintre care proteina S este exprimat\u0103 \u00een cantitatea cea mai mare \u00een cursul infec\u0163iei VHB. Replicarea ADN-ului VHB se realizeaz\u0103 printr-un produs de transcrip\u0163ie separat (generat tot de cccDNA), ARN-ul pregenomic, care codific\u0103 de asemenea proteinele precore\/core. Astfel, producerea proteinelor VHB \u015fi replicarea se desf\u0103\u015foar\u0103 pe c\u0103i moleculare diferite, \u00een paralel sau disociat, a\u015fa cum se poate \u00eent\u00e2mpla \u00een cursul tratamentului cu analogi nucleoz(t)idici. \u00cen plus, AgHBs poate fi generat \u015fi din secven\u0163ele genei S virale care s-au integrat \u00een genomul hepatocitelor. Se pare c\u0103 ADN-VHB integrat reprezint\u0103 matri\u0163a principal\u0103 de sintez\u0103 a AgHBs \u00een hepatita cronic\u0103 AgHBe negativ\u0103 precum \u015fi \u00een carcinomul hepatocelular asociat infec\u0163iei HBV. Faptul c\u0103 AgHBs circulant provine at\u00e2t din transcrip\u0163ia cccDNA c\u00e2t \u015fi din cea a secven\u0163elor virale integrate explic\u0103 de ce nivelul AgHBs furnizeaz\u0103 informa\u0163ii diferite, dar complementare cu cele generate de valoarea viremiei VHB.<\/p>\n<p>AgHBs circul\u0103 \u00een serul pacien\u0163ilor infecta\u0163i at\u00e2t sub forma unui num\u0103r mare de particule sferice \u015fi structuri filamentoase neinfec\u0163ioase (denumite \u015fi particule subvirale \u201egoale\u201d) c\u00e2t \u015fi ca protein\u0103 glicozilat\u0103 de \u00eenveli\u015f a virionilor maturi (particule Dane). Particulele subvirale nu con\u0163in genomul VHB \u015fi sunt \u00een exces fa\u0163\u0103 de particulele virale mature. AgHBs circulant con\u0163ine toate cele 3 tipuri de proteine S, M \u015fi L, ce nu pot fi diferen\u0163iate de testele calitative \u015fi cantitative de determinare a antigenului de suprafa\u0163\u0103<sup>3;7<\/sup>.<\/p>\n<p>Dintre formele clinice ale infec\u0163iei VHB starea de purt\u0103tor inactiv de AgHBs nu necesit\u0103 monitorizare frecvent\u0103 \u015fi terapie antiviral\u0103. De aceea identificarea acestui status prezint\u0103 o importan\u0163\u0103 deosebit\u0103. Pe baza studiilor de cohort\u0103 pe termen lung, starea de purt\u0103tor inactiv este definit\u0103 prin persisten\u0163a unui nivel normal de alanin aminotransferaz\u0103 (ALT) \u015fi o valoare a viremiei VHB &lt; 2000 UI\/mL la un pacient AgHBe negativ \u015fi cu leziuni hepatice absente sau minime. Date recente au ar\u0103tat \u00eens\u0103 c\u0103 pacien\u0163ii cu AgHBe negativ, cu niveluri ALT persistent normale \u015fi cu viremii cuprinse \u00eentre 2000 UI\/mL \u015fi 20000 UI\/mL pot avea de asemenea un prognostic foarte bun, f\u0103r\u0103 a fi necesar\u0103 administrarea terapiei antivirale. Mai mult, ADN-VHB poate prezenta fluctua\u0163ii mari \u00een timp, fiind posibile reactiv\u0103ri ale infec\u0163iei la <a href=\"\/ru\/pacienti\/\">pacien\u0163i<\/a> care au avut la un moment dat viremii joase. Pe de alt\u0103 parte, nivelul AgHBs se modific\u0103 foarte pu\u0163in \u015fi prezint\u0103 valori sc\u0103zute la purt\u0103torii inactivi veritabili, constituind astfel un marker adjuvant viremiei VHB \u00een identificarea acestui status al infec\u0163iei. Numeroase studii au ar\u0103tat c\u0103 purt\u0103torii inactivi prezint\u0103 niveluri AgHBs &lt; 1000 UI\/mL<sup>8<\/sup>.<\/p>\n<p>\u00cen studiul efectuat de Brunetto \u015fi colaboratorii, ce a inclus pacien\u0163i asimptomatici netrata\u0163i, infecta\u0163i cu genotipul D VHB, s-a ar\u0103tat c\u0103 o singur\u0103 combina\u0163ie de <a href=\"\/ru\/spitale\/rezultate\/\">rezultate<\/a> AgHBs &lt; 1000 UI\/mL \u015fi ADN-VHB &lt; 2000 UI\/mL poate identifica o stare de purt\u0103tor inactiv timp de 3 ani cu o acurate\u0163e diagnostic\u0103 de 94.3%, sensibilitate 91.1%, specificitate 95.4%, valoare predictiv\u0103 pozitiv\u0103 87.9% \u015fi valoare predictiv\u0103 negativ\u0103 96.7%<sup>9<\/sup>. \u00cen plus, pacien\u0163ii cu AgHBs &lt; 1000 UI\/mL au un risc de carcinom hepatocelular semnificativ sc\u0103zut \u00een compara\u0163ie cu cei av\u00e2nd AgHBs &gt; 1000 UI\/mL<sup>8<\/sup>.<\/p>\n<p>Recent, European Association for the Study of Liver (EASL) a modificat denumirea fazelor infec\u021biei VHB starea de purt\u0103tor inactiv de AgHBs fiind redenumit\u0103 ca infec\u021bie VHB cronic\u0103 AgHBe negativ\u0103<sup>10<\/sup>.<\/p>\n<p>Determinarea AgHBs cantitativ este util\u0103 \u015fi \u00een monitorizarea pacien\u0163ilor care primesc tratament cu interferon pegylat. Studiile de faz\u0103 III ale peginterferonului alfa-2a (cu sau f\u0103r\u0103 lamivudin\u0103) administrat la pacien\u0163i AgHBe pozitivi au ar\u0103tat c\u0103 o valoare AgHBs &gt; 20000 UI\/mL \u00een s\u0103pt\u0103m\u00e2nile 12 sau 24 reprezint\u0103 un factor predictiv de e\u015fec al tratamentului. La pacien\u0163ii cu monoterapie PEG-INF, nivelurile AgHBs &gt; 20000 UI\/mL \u00eempreun\u0103 cu ADN-VHB &gt; 20000 UI\/mL pot cre\u015fte valoarea predictiv\u0103 negativ\u0103 pentru seroconversia AgHBe la 91%. Pe de alt\u0103 parte, o sc\u0103dere precoce marcat\u0103 a AgHBs \u00eencep\u00e2nd cu s\u0103ptam\u00e2na 4 de tratament cu peg-interferon alfa2b a fost observat\u0103 la pacien\u0163ii cu r\u0103spuns virusologic sus\u0163inut (seroconversie AgHBe \u015fi ADN-VHB &lt; 2000 UI\/mL la 6 luni de la \u00eencheierea terapiei), \u00een timp ce absen\u0163a unei astfel de sc\u0103deri \u00een s\u0103pt\u0103m\u00e2nile 12 \u015fi 24 a fost asociat\u0103 cu valori predictive negative de 97% \u015fi respectiv 92%. Atunci c\u00e2nd peginterferonul este administrat pacien\u0163ilor AgHBe negativi, regula de oprire a tratamentului cea mai bine validat\u0103 a fost descris\u0103 \u00een cazul persoanelor infectate cu genotipul D la care nu s-a ob\u0163inut un declin al AgHBs \u015fi o reducere &gt; 2 log a ADN-VHB, dar sunt necesare studii suplimentare pentru a generaliza aceast\u0103 regul\u0103 \u015fi \u00een cazul pacien\u0163ilor infecta\u0163i cu alte genotipuri VHB. \u00cen general, s-a constatat c\u0103 un declin al AgHBs cu &gt;10% sau &gt;1 log \u00een s\u0103pt\u0103m\u00e2nile 12, 24 sau la sf\u00e2r\u015fitul tratamentului cu peginterferon indic\u0103 o mare probabilitate de ob\u0163inere a unui r\u0103spuns virusologic sus\u0163inut la pacien\u0163ii AgHBe negativi (ADN-VHB &lt; 2000 UI\/mL sau dispari\u0163ia AgHBs). O valoare AgHBs &lt; 10 UI\/mL \u00een s\u0103pt\u0103m\u00e2na 48 se asociaz\u0103 cu un clearance al AgHBs \u00een decurs de 3 ani de la \u00eencheierea tratamentului \u00een 52% din cazuri<sup>8<\/sup>.<\/p>\n<p>La pacien\u0163ii care primesc tratament cu analogi nucleoz(t)idici rolul AgHBs cantitativ nu este bine caracterizat. \u00centr-un studiu recent ce a inclus pacien\u0163i AgHBe pozitivi s-a ar\u0103tat c\u0103 \u00een decursul a 48 s\u0103pt\u0103m\u00e2ni de tratament cu entecavir AgHBs a sc\u0103zut predominant la pacien\u0163ii care au avut un clearance al AgHBe sau AgHBs. Cu toate acestea, spre deosebire de tratamentul cu inteferon pegylat, declinul precoce al AgHBs nu a constituit un factor predictiv pentru r\u0103spunsul serologic la un an de tratament cu entecavir<sup>11<\/sup>.<\/p>\n<p><strong><em>Recomand\u0103ri pentru determinarea AgHBs cantittaiv<\/em><\/strong><\/p>\n<ul>\n<li>identificarea pacien\u021bilor cu infec\u021bie VHB cronic\u0103 AgHBe negativ\u0103 (denumire veche: statusul de purt\u0103tor inactiv de AgHBs), \u00eempreun\u0103 cu ADN-VHB;<\/li>\n<li>monitorizarea r\u0103spunsului la tratamentul cu peginterferon<sup>8;10<\/sup>.<\/li>\n<\/ul>\n<p><strong><em>Preg\u0103tire pacient <\/em><\/strong>\u2013 nu este necesar\u0103 o preg\u0103tire special\u0103<sup>12<\/sup>.<\/p>\n<p><strong><em>Specimen recoltat <\/em><\/strong>\u2013 s\u00e2nge venos<sup>12<\/sup>.<\/p>\n<p><strong><em>Recipient de recoltare <\/em><\/strong>\u2013 vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator<sup>12<\/sup>.<\/p>\n<p><strong><em>Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>\u2013 se separ\u0103 serul prin centrifugare; se lucreaz\u0103 imediat; dac\u0103 acest lucru nu este posibil, serul se p\u0103streaz\u0103 la 2-8\u00b0C sau la -20\u00b0C<sup>12<\/sup>.<\/p>\n<p><strong><em>Volum prob\u0103 <\/em><\/strong>\u2013 minim 1 mL ser<sup>12<\/sup>.<\/p>\n<p><strong><em>Cauze de respingere a probei <\/em><\/strong>\u2013 specimen hemolizat; specimen expus la temperaturi ridicate; specimen contaminat bacterian<sup>12<\/sup>.<\/p>\n<p><strong><em>Stabilitate prob\u0103 <\/em><\/strong>\u2013 serul separat este stabil <em>14 zile<\/em> la 2-8\u00b0C; <em>timp \u00eendelungat<\/em> la -20\u00b0C<sup>12<\/sup>.<\/p>\n<p><strong><em>Metod\u0103 <\/em><\/strong>\u2013 chemiluminiscen\u0163\u0103 pe baz\u0103 de microparticule (CMIA)<sup> 12<\/sup>.<\/p>\n<p><strong><em>Valori de referin\u0163\u0103 <\/em><\/strong>\u2013 AgHBs cantitativ &lt;0.05 UI\/mL<sup>12<\/sup>.<\/p>\n<p><strong><em>Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n<ul>\n<li>Interferen\u0163e analitice<\/li>\n<\/ul>\n<p>Pot produce interferen\u0163e cu unele componente ale kit-ului \u015fi conduce la rezultate neconcludente anticorpii monoclonali proveni\u0163i de la \u015foarece administra\u0163i la unii pacien\u0163i \u00een scop diagnostic sau terapeutic<sup>12<\/sup>.<\/p>\n<p><strong>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/strong><\/p>\n<ol>\n<li>Tseng TC, Kao JH. Clinical utility of quantitative HBsAg in natural history and nucleos(t)ide analogue treatment of chronic hepatitis B: new trick of old dog. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23090000##\" rel=\"nofollow noopener\" target=\"_blank\">J Gastroenterol.<\/a> 2013 Jan;48(1):13-21.<\/li>\n<li>Chan HL, Thompson A, Martinot-Peignoux M, Piratvisuth T, Cornberg M, Brunetto MR, et al. Hepatitis B surface antigen quantification: why and how to use itin 2011\u2014a core group report. J Hepatol 2011;55:1121-31.<\/li>\n<li>Hadziyannis E. Quantification of HBsAg in serum: characteristics of the assays. OA Hepatology 2013 Apr 01;1(1):1.<\/li>\n<li>Kao JH, Chen DS. Global control of hepatitis B virus infection. Lancet Infect Dis. 2002;2:395\u2013403.<\/li>\n<li>Bouchard M.J. and Schneider R.J.The Enigmatic X Gene of Hepatitis B Virus. Journal of Virology. 2004; Volume 78, Issue 23: 12725\u201312734.<\/li>\n<li>Chotiyaputta, Watcharasak and Lok, Anna S. F. \u201eHepatitis B virus variants\u201d, Nature Reviews-Gastroenterology &amp; Hepatology. August 2009; Volume 6:453-462.<\/li>\n<li>Dandri M, Locarnini S. New insight in the pathobiology of hepatitis B virus infection. Gut. 2012;61(Suppl 1):i6\u201317.<\/li>\n<li>Wong GL, Chan HL. Use of Quantitative Hepatitis B Surface Antigen with Hepatitis B Virus DNA in Clinical Practice. <em>Clinical Liver Disease<\/em>, Vol. 2, No. 1, February 2013.<\/li>\n<li>Brunetto MR, Oliveri F, Colombatto P, Moriconi F, Ciccorossi P, Coco B, et al. Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers. <em>Gastroenterology<\/em>. 2010;139:483\u2013490.<\/li>\n<li>European Association for the Study of the Liver. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection. J Hepatol. 2017 Apr 18. pii: S0168-8278(17)30185-X. doi: 10.1016\/j.jhep.2017.03.021. [Epub ahead of print].<\/li>\n<li>Gish RG, Chang TT, Lai CL, de Man RA, Gadano A, Llamoso C, Tang H. Quantitative hepatitis B surface antigen analysis in hepatitis B e antigen- positive nucleoside-naive patients treated with entecavir. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23510982##\" rel=\"nofollow noopener\" target=\"_blank\">Antivir Ther. <\/a>2013;18(5):691-8.<\/li>\n<li>Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2017. Ref Type: Catalog.<\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"<p>\u0412\u0438\u0440\u0443\u0441 HBV \u2013 \u044d\u0442\u043e \u0448\u0438\u0440\u043e\u043a\u043e \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u043d\u0430\u044f \u043f\u0440\u0438\u0447\u0438\u043d\u0430 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412. \u0421\u0447\u0438\u0442\u0430\u0435\u0442\u0441\u044f, \u0447\u0442\u043e \u043d\u0430\u0441\u0442\u043e\u044f\u0449\u0435\u0435 \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u043e \u0438\u043d\u0444\u0438\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u043f\u0440\u0435\u0432\u044b\u0448\u0430\u0435\u0442 \u043e\u0444\u0438\u0446\u0438\u0430\u043b\u044c\u043d\u0443\u044e \u0441\u0442\u0430\u0442\u0438\u0441\u0442\u0438\u043a\u0443, \u0442\u0430\u043a \u043a\u0430\u043a \u043c\u043d\u043e\u0433\u0438\u0435 \u0437\u0430\u0440\u0430\u0437\u0438\u0432\u0448\u0438\u0435\u0441\u044f \u0438\u0441\u043f\u044b\u0442\u044b\u0432\u0430\u044e\u0442 \u043b\u0438\u0448\u044c \u043b\u0435\u0433\u043a\u0438\u0435 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u044b \u0438 \u043d\u0435 \u043f\u043e\u0434\u043e\u0437\u0440\u0435\u0432\u0430\u044e\u0442, \u0447\u0442\u043e \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u044b \u0432\u0438\u0440\u0443\u0441\u043e\u043c. \u0412 \u043c\u0438\u0440\u0435 \u043f\u043e\u0440\u044f\u0434\u043a\u0430 350 \u043c\u043b\u043d \u043b\u044e\u0434\u0435\u0439 \u0438\u043d\u0444\u0438\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u044b \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u043c \u0438 \u043e\u043a\u043e\u043b\u043e 620 \u0442\u044b\u0441. \u0435\u0436\u0435\u0433\u043e\u0434\u043d\u043e \u0443\u043c\u0438\u0440\u0430\u044e\u0442 \u043e\u0442 \u043d\u0435\u0433\u043e.<\/p>\n<p>\u0412\u0438\u0440\u0443\u0441 HBV \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u044f\u0435\u0442\u0441\u044f \u0447\u0435\u0440\u0435\u0437 \u043a\u043e\u043d\u0442\u0430\u043a\u0442 \u0441 \u043a\u0440\u043e\u0432\u044c\u044e \u0438\u043b\u0438 \u0441 \u0434\u0440\u0443\u0433\u0438\u043c\u0438 \u0444\u0438\u0437\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438 \u0436\u0438\u0434\u043a\u043e\u0441\u0442\u044f\u043c\u0438 \u0438\u043d\u0444\u0438\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0433\u043e. \u0417\u0430\u0440\u0430\u0437\u0438\u0442\u044c\u0441\u044f \u043c\u043e\u0436\u043d\u043e, \u043d\u0430\u043f\u0440\u0438\u043c\u0435\u0440, \u0447\u0435\u0440\u0435\u0437 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u0435 \u043e\u0434\u043d\u043e\u0439 \u0438 \u0442\u043e\u0439 \u0436\u0435 \u0438\u0433\u043b\u044b \u043e\u0442 \u0448\u043f\u0440\u0438\u0446\u0430 \u0438\u043b\u0438 \u0447\u0435\u0440\u0435\u0437 \u043d\u0435\u0437\u0430\u0449\u0438\u0449\u0435\u043d\u043d\u044b\u0439 \u0441\u0435\u043a\u0441\u0443\u0430\u043b\u044c\u043d\u044b\u0439 \u043a\u043e\u043d\u0442\u0430\u043a\u0442. \u041f\u0443\u0442\u0435\u0448\u0435\u0441\u0442\u0432\u0438\u044f \u0432 \u043c\u0435\u0441\u0442\u0430, \u0433\u0434\u0435 \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d \u0433\u0435\u043f\u0430\u0442\u0438\u0442 \u0412, \u0442\u043e\u0436\u0435 \u043e\u043f\u0430\u0441\u043d\u043e. \u041c\u0430\u0442\u044c \u043c\u043e\u0436\u0435\u0442 \u0438\u043d\u0444\u0438\u0446\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u0441\u0432\u043e\u0435\u0433\u043e \u0440\u0435\u0431\u0435\u043d\u043a\u0430 \u0432\u043e \u0432\u0440\u0435\u043c\u044f \u0440\u043e\u0434\u043e\u0432 \u0438\u043b\u0438 \u043f\u043e\u0441\u043b\u0435. \u0412\u0438\u0440\u0443\u0441, \u043e\u0434\u043d\u0430\u043a\u043e, \u043d\u0435 \u043f\u0435\u0440\u0435\u0434\u0430\u0435\u0442\u0441\u044f \u0447\u0435\u0440\u0435\u0437 \u043f\u0438\u0449\u0443 \u0438 \u0432\u043e\u0434\u0443, \u0430 \u0442\u0430\u043a\u0436\u0435 \u0447\u0435\u0440\u0435\u0437 \u043f\u043e\u0432\u0441\u0435\u0434\u043d\u0435\u0432\u043d\u044b\u0435 \u043a\u043e\u043d\u0442\u0430\u043a\u0442\u044b: \u0440\u0443\u043a\u043e\u043f\u043e\u0436\u0430\u0442\u0438\u044f, \u043a\u0430\u0448\u0435\u043b\u044c \u0438\u043b\u0438 \u0447\u0438\u0445\u0430\u043d\u0438\u0435.<\/p>\n<p>\u0422\u0435\u0441\u0442\u044b \u043d\u0430 \u0431\u0438\u043b\u0438\u0440\u0443\u0431\u0438\u043d, \u043d\u0430 \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u043f\u0435\u0447\u0435\u043d\u0438 \u0444\u0438\u043a\u0441\u0438\u0440\u0443\u044e\u0442 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u043c, \u043d\u043e \u043d\u0435 \u0432\u044b\u044f\u0432\u043b\u044f\u044e\u0442 \u0435\u0433\u043e \u043f\u0440\u0438\u0447\u0438\u043d\u0443. \u0418\u043c\u0435\u043d\u043d\u043e \u0430\u043d\u0430\u043b\u0438\u0437 \u043d\u0430 HBsAg \u0432 \u043a\u0440\u043e\u0432\u0438 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u0435\u0442 \u0433\u0435\u043f\u0430\u0442\u0438\u0442 \u0412 \u0438 \u0432\u0438\u0440\u0443\u0441 HBV, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u0435\u0433\u043e \u0432\u044b\u0437\u044b\u0432\u0430\u0435\u0442.<\/p>\n<p>\u0412\u0438\u0440\u0443\u0441 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412 \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 \u0441\u043e\u0431\u043e\u0439 \u0414\u041d\u041a, \u043e\u043a\u0440\u0443\u0436\u0435\u043d\u043d\u0443\u044e \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u043e\u0432\u043e\u0439 \u043a\u0430\u043f\u0441\u0443\u043b\u043e\u0439\u00a0&#8211; \u043a\u0430\u043f\u0438\u0441\u0434\u043e\u043c, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u043e\u0442\u0432\u0435\u0447\u0430\u0435\u0442 \u0437\u0430 \u043f\u0440\u043e\u0446\u0435\u0441\u0441 \u0432\u043d\u0435\u0434\u0440\u0435\u043d\u0438\u044f \u0432\u0438\u0440\u0443\u0441\u0430 \u0432 \u043a\u043b\u0435\u0442\u043a\u0438 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430. \u0411\u0435\u043b\u043a\u0438 \u043a\u0430\u043f\u0441\u0438\u0434\u0430 \u043f\u043e\u043b\u0443\u0447\u0438\u043b\u0438 \u043d\u0430\u0437\u0432\u0430\u043d\u0438\u0435 HBsAg (\u043e\u0442 \u0430\u043d\u0433\u043b. &#8220;\u043f\u043e\u0432\u0435\u0440\u0445\u043d\u043e\u0441\u0442\u043d\u044b\u0439 \u0430\u043d\u0442\u0438\u0433\u0435\u043d \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412&#8221;), HBcAg (&#8220;\u0430\u043d\u0442\u0438\u0433\u0435\u043d \u044f\u0434\u0440\u0430 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412&#8221;) \u0438 HBeAg (&#8220;\u043a\u0430\u043f\u0441\u0443\u043b\u044c\u043d\u044b\u0439 \u0430\u043d\u0442\u0438\u0433\u0435\u043d \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412&#8221;). \u041f\u043e \u0438\u0445 \u043d\u0430\u043b\u0438\u0447\u0438\u044e \u0432 \u043a\u0440\u043e\u0432\u0438 \u043c\u043e\u0436\u043d\u043e \u043f\u0440\u0435\u0434\u043f\u043e\u043b\u043e\u0436\u0438\u0442\u044c, \u0447\u0442\u043e \u0447\u0435\u043b\u043e\u0432\u0435\u043a \u0437\u0430\u0440\u0430\u0436\u0435\u043d \u0432\u0438\u0440\u0443\u0441\u043e\u043c, \u043f\u043e\u044d\u0442\u043e\u043c\u0443 \u0430\u043d\u0430\u043b\u0438\u0437 \u043d\u0430 \u043d\u0430\u043b\u0438\u0447\u0438\u0435 \u044d\u0442\u0438\u0445 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u043e\u0432 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0441\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u043c \u043c\u0435\u0442\u043e\u0434\u043e\u043c \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412.<\/p>\n<p>HBsAg\u00a0&#8211; \u044d\u0442\u043e \u043f\u043e\u0432\u0435\u0440\u0445\u043d\u043e\u0441\u0442\u043d\u044b\u0439 \u0430\u043d\u0442\u0438\u0433\u0435\u043d \u0432\u0438\u0440\u0443\u0441\u0430 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412. \u041a\u043e\u0433\u0434\u0430 \u0432\u0438\u0440\u0443\u0441 \u043f\u043e\u043f\u0430\u0434\u0430\u0435\u0442 \u0432 \u043a\u043b\u0435\u0442\u043a\u0443, \u043e\u043d \u043d\u0430\u0447\u0438\u043d\u0430\u0435\u0442 \u043f\u0440\u043e\u0434\u0443\u0446\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u043d\u043e\u0432\u044b\u0435 \u0446\u0435\u043f\u043e\u0447\u043a\u0438 \u0414\u041d\u041a, \u0440\u0430\u0437\u043c\u043d\u043e\u0436\u0430\u0442\u044c\u0441\u044f\u00a0\u0438 \u0430\u043d\u0442\u0438\u0433\u0435\u043d HBsAg \u0432\u044b\u0434\u0435\u043b\u044f\u0435\u0442\u0441\u044f \u0432 \u043a\u0440\u043e\u0432\u044c. \u041f\u0440\u0438 \u043e\u0441\u0442\u0440\u043e\u043c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0435 \u0412 \u043e\u043d \u043f\u043e\u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0432 \u043a\u0440\u043e\u0432\u0438 \u0447\u0435\u0440\u0435\u0437 3-5 \u043d\u0435\u0434\u0435\u043b\u044c \u043f\u043e\u0441\u043b\u0435 \u0438\u043d\u0444\u0438\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f (\u0432 \u043f\u043e\u0441\u043b\u0435\u0434\u043d\u0438\u0435 1\u20132 \u043d\u0435\u0434\u0435\u043b\u0438 \u0438\u043d\u043a\u0443\u0431\u0430\u0446\u0438\u043e\u043d\u043d\u043e\u0433\u043e \u043f\u0435\u0440\u0438\u043e\u0434\u0430) \u0438 \u0441\u043e\u0445\u0440\u0430\u043d\u044f\u0435\u0442\u0441\u044f \u043e\u0431\u044b\u0447\u043d\u043e \u0434\u043e \u043a\u043e\u043d\u0446\u0430 \u043f\u0435\u0440\u0432\u044b\u0445 2-3 \u043d\u0435\u0434\u0435\u043b\u044c \u043f\u0435\u0440\u0438\u043e\u0434\u0430 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043f\u0440\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u0439. \u041f\u0440\u0438 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0435 \u0412 HBsAg \u0432\u044b\u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043d\u0430 \u0432\u0441\u0435\u0445 \u0444\u0430\u0437\u0430\u0445 \u0442\u0435\u0447\u0435\u043d\u0438\u044f \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f. \u041e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u0438\u0435 HBsAg \u043f\u0440\u0438 \u0441\u043a\u0440\u0438\u043d\u0438\u043d\u0433\u043e\u0432\u043e\u043c \u043e\u0431\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u0435\u043c \u0434\u043b\u044f \u043a\u043e\u043d\u0441\u0443\u043b\u044c\u0442\u0430\u0446\u0438\u0438 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u0438\u0441\u0442\u0430 \u0438 \u0434\u0430\u043b\u044c\u043d\u0435\u0439\u0448\u0435\u0433\u043e \u043e\u0431\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u043d\u0430 \u0434\u0440\u0443\u0433\u0438\u0435 \u043c\u0430\u0440\u043a\u0435\u0440\u044b \u0432\u0438\u0440\u0443\u0441\u0430 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412\u00a0\u0432 \u0446\u0435\u043b\u044f\u0445 \u0432\u0435\u0440\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u0438 \u0434\u0438\u0430\u0433\u043d\u043e\u0437\u0430 \u0438 \u0443\u0442\u043e\u0447\u043d\u0435\u043d\u0438\u044f \u0441\u0442\u0430\u0434\u0438\u0438 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f.<\/p>\n<p><strong id=\"subj7\" class=\"subj-header\">\u0414\u043b\u044f \u0447\u0435\u0433\u043e \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435?<\/strong><\/p>\n<ul>\n<li>\u0414\u043b\u044f \u0441\u043a\u0440\u0438\u043d\u0438\u043d\u0433\u0430 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438 \u043f\u0440\u0438 \u043e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0438 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043e\u0432 \u0431\u043e\u043b\u0435\u0437\u043d\u0438.<\/li>\n<li>\u0427\u0442\u043e\u0431\u044b \u0432\u044b\u044f\u0441\u043d\u0438\u0442\u044c, \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043b\u0438 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435 \u043e\u0441\u0442\u0440\u044b\u043c \u0438\u043b\u0438 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u043c.<\/li>\n<li>\u0414\u043b\u044f \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u044f \u0437\u0430 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u043c \u0412.<\/li>\n<li>\u0414\u043b\u044f \u043f\u0440\u043e\u0432\u0435\u0440\u043a\u0438 \u043d\u0430 \u0433\u0435\u043f\u0430\u0442\u0438\u0442 \u0412 \u0432 \u0433\u0440\u0443\u043f\u043f\u0430\u0445 \u0440\u0438\u0441\u043a\u0430 \u0438\u043b\u0438 \u0443 \u0434\u043e\u043d\u043e\u0440\u043e\u0432 \u043a\u0440\u043e\u0432\u0438.<\/li>\n<li>\u0414\u043b\u044f \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u043f\u0440\u0435\u0434\u044b\u0434\u0443\u0449\u0438\u0445 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0439 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\u043e\u0441\u0442\u0440\u043e\u0433\u043e \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430: \u0436\u0430\u0440, \u0443\u0441\u0442\u0430\u043b\u043e\u0441\u0442\u044c, \u043f\u043e\u0442\u0435\u0440\u044f \u0430\u043f\u043f\u0435\u0442\u0438\u0442\u0430, \u0442\u043e\u0448\u043d\u043e\u0442\u0430, \u0440\u0432\u043e\u0442\u0430, \u0431\u043e\u043b\u0438 \u0432 \u0436\u0438\u0432\u043e\u0442\u0435, \u043c\u043e\u0447\u0430 \u0442\u0435\u043c\u043d\u043e\u0433\u043e \u0446\u0432\u0435\u0442\u0430, \u0441\u0432\u0435\u0442\u043b\u043e\u043e\u043a\u0440\u0430\u0448\u0435\u043d\u043d\u044b\u0439 \u0441\u0442\u0443\u043b, \u0431\u043e\u043b\u044c \u0432 \u0441\u0443\u0441\u0442\u0430\u0432\u0430\u0445, \u0436\u0435\u043b\u0442\u0443\u0448\u043d\u0430\u044f \u043a\u043e\u0436\u0430.<\/li>\n<li>\u041f\u0440\u0438 \u0441\u043a\u0440\u0438\u043d\u0438\u043d\u0433\u0435 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0438\u0437 \u043a\u0430\u0442\u0435\u0433\u043e\u0440\u0438\u0439 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\u0433\u0434\u0435 \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u0438\u0435 H\u0412sAg \u043f\u043e\u043b\u0443\u0447\u0438\u043b\u043e \u0441\u0432\u044b\u0448\u0435 2 % (\u0431\u043e\u043b\u044c\u0448\u0438\u043d\u0441\u0442\u0432\u043e \u0441\u0442\u0440\u0430\u043d \u0410\u0437\u0438\u0438 \u0438 \u0410\u0444\u0440\u0438\u043a\u0438),<\/li>\n<li>\u0441\u0432\u043e\u0435\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e \u043d\u0435 \u043f\u0440\u043e\u0448\u0435\u0434\u0448\u0438\u0435 \u0432\u0430\u043a\u0446\u0438\u043d\u0430\u0446\u0438\u044e \u043f\u0440\u043e\u0442\u0438\u0432 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 (\u0432 \u0420\u043e\u0441\u0441\u0438\u0438 \u2013 \u0432 \u043f\u0435\u0440\u0432\u044b\u0435 12 \u0447\u0430\u0441\u043e\u0432 \u0438 \u0447\u0435\u0440\u0435\u0437 \u043c\u0435\u0441\u044f\u0446 \u043f\u043e\u0441\u043b\u0435 \u0440\u043e\u0436\u0434\u0435\u043d\u0438\u044f),<\/li>\n<li>\u0442\u0435, \u0447\u044c\u0438 \u0440\u043e\u0434\u0438\u0442\u0435\u043b\u0438 \u043f\u0440\u043e\u0438\u0441\u0445\u043e\u0434\u044f\u0442 \u0438\u0437 \u0440\u0435\u0433\u0438\u043e\u043d\u043e\u0432, \u0433\u0434\u0435 \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u043d\u043e\u0441\u0442\u044c H\u0412sAg \u043f\u0440\u0435\u0432\u044b\u0448\u0430\u0435\u0442 8 %,<\/li>\n<li>\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u044b, \u0443 \u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u043f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0438 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u0444\u0435\u0440\u043c\u0435\u043d\u0442\u043e\u0432 \u043f\u0435\u0447\u0435\u043d\u0438 (\u0410\u041b\u0422 \u0438 \u0410\u0421\u0422) \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u044b \u043f\u043e \u043d\u0435\u0438\u0437\u0432\u0435\u0441\u0442\u043d\u044b\u043c \u043f\u0440\u0438\u0447\u0438\u043d\u0430\u043c,<\/li>\n<li>\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u044b \u0441 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u043c\u0438, \u0442\u0440\u0435\u0431\u0443\u044e\u0449\u0438\u043c\u0438 \u043f\u043e\u0434\u0430\u0432\u043b\u0435\u043d\u0438\u044f \u0438\u0445 \u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b,<\/li>\n<li>\u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435,<\/li>\n<li>\u0441\u043e\u0441\u0442\u043e\u044f\u0449\u0438\u0435 \u0432 \u0442\u0435\u0441\u043d\u043e\u043c \u043a\u043e\u043d\u0442\u0430\u043a\u0442\u0435 \u0441 \u0438\u043d\u0444\u0438\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u043c\u0438\u0438 HBV,<\/li>\n<li>\u0431\u043e\u043b\u044c\u043d\u044b\u0435 \u0421\u041f\u0418\u0414\u043e\u043c.<\/li>\n<\/ul>\n<\/li>\n<li>\u0427\u0435\u0440\u0435\u0437 \u043a\u0430\u0436\u0434\u044b\u0435 6-12 \u043c\u0435\u0441\u044f\u0446\u0435\u0432 \u043f\u0440\u0438 \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u0435 \u0437\u0430 \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u0435\u043c \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432, \u0441\u0442\u0440\u0430\u0434\u0430\u044e\u0449\u0438\u0445 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u043c \u0412.<\/li>\n<li>\u041f\u0435\u0440\u0435\u0434 \u043b\u044e\u0431\u044b\u043c \u043f\u0435\u0440\u0435\u043b\u0438\u0432\u0430\u043d\u0438\u0435\u043c \u043a\u0440\u043e\u0432\u0438.<\/li>\n<\/ul>\n<p><strong id=\"subj5\" class=\"subj-header\">\u041a\u0430\u043a \u043f\u0440\u0430\u0432\u0438\u043b\u044c\u043d\u043e \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u0438\u0442\u044c\u0441\u044f \u043a \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044e?<\/strong><\/p>\n<ul>\n<li>\u041d\u0435 \u043a\u0443\u0440\u0438\u0442\u044c \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 30 \u043c\u0438\u043d\u0443\u0442 \u0434\u043e\u00a0\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/li>\n<\/ul>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[924],"product_tag":[],"class_list":{"0":"post-10326","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-virali","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10326","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10326"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10326"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10326"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10326"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10326"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}