{"id":10312,"date":"2020-04-23T05:02:42","date_gmt":"2020-04-23T02:02:42","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/hidroxiprolina-urinara-totala\/"},"modified":"2025-02-07T14:15:51","modified_gmt":"2025-02-07T12:15:51","slug":"hidroxiprolina-urinara-totala","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/hidroxiprolina-urinara-totala\/","title":{"rendered":"\u041e\u0431\u0449\u0438\u0439 \u0433\u0438\u0434\u0440\u043e\u043a\u0441\u0438\u043f\u0440\u043e\u043b\u0438\u043d \u0432 \u043c\u043e\u0447\u0435"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n

Hidroxiprolina este un aminoacid neesen\u0163ial, rezultat din hidroxilarea prolinei sub ac\u0163iunea prolil-hidroxilazei (\u00een prezen\u0163a vitaminei C), \u00een lumenul reticulului endoplasmic. Este componenta major\u0103 a colagenului reprezent\u00e2nd 13% din totalul aminoacizilor \u015fi av\u00e2nd rol important \u00een men\u0163inerea structurii de triplu helix a acestuia.<\/p>\n

Se g\u0103se\u015fte\u00a0\u00een cantit\u0103\u0163i semnificative \u00een \u0163esuturile bogate \u00een colagen cum ar fi: osul, tendoanele, cartilajele, pielea sau vasele sanguine.<\/p>\n

Hidroxiprolina se excret\u0103 urinar sub 2 forme: una liber\u0103, care reprezint\u0103 10%, \u015fi una conjugat\u0103, 90%, sub forma unor lan\u0163uri polipeptidice mici1;2<\/sup>.<\/p>\n

Deoarece 50% din colagenul uman rezid\u0103 \u00een os, excre\u0163ia hidroxiprolinei\u00a0\u00een urin\u0103 este considerat\u0103 un marker al resorb\u0163iei osoase<\/em> (componenta major\u0103 a matricei osoase este colagenul tip I care este bogat \u00een hidroxiprolin\u0103). De\u015fi colagenul de tip I este prezent \u015fi \u00een alte \u0163esuturi, osul are un turn-over mai mare \u015fi determin\u0103 aproximativ 50% din hidroxiprolinurie.<\/p>\n

Acest aminoacid poate fi, de asemenea, eliberat din degradarea frac\u0163iunii C1q a complementului, care are o regiune similar\u0103 structural cu molecula de colagen \u015fi, deci, con\u0163ine cantit\u0103\u0163i semnificative de hidroxiprolin\u0103, care ar putea reprezenta p\u00e2n\u0103 la 40% din hidroxiprolina urinar\u0103. Din acest motiv afec\u0163iunile inflamatorii pot determin\u0103 cre\u015fteri dramatice \u00een excre\u0163ia urinar\u0103 de hidroxiprolin\u0103.<\/p>\n

Nivele ridicate de hidroxiprolin\u0103 \u00een urin\u0103 pot fi \u00eent\u00e2lnite \u015fi\u00a0\u00een cazul consumului de produse alimentare care con\u0163in gelatin\u01031<\/sup>.<\/p>\n

Orice factori care modific\u0103 matricea osoas\u0103, tumori osoase primare sau secundare, procesul de vindecare\u00a0al fracturilor, afec\u0163iuni endocrine, diverse boli metabolice sau tubulopatii determin\u0103 cre\u015fteri ale concentra\u0163iei de hidroxiprolin\u0103 \u00een urin\u0103.<\/p>\n

Valori urinare modificate la pacien\u0163ii cu carcinom de s\u00e2n sau prostat\u0103 indic\u0103 prezen\u0163a unor metastaze osoase, chiar \u015fi \u00een lipsa unei dovezi radiologice6<\/sup>.<\/p>\n

\u00cen osteomalcie dozarea hidroxiprolinei urinare este util\u0103 atunci c\u00e2nd valoarea fosfatazei alcaline serice este normal\u0103 sau c\u00e2nd se asociaz\u0103 cu boli hepatice care determin\u0103 cre\u015fterea secundar\u0103 a fosfatazei alcaline2;5<\/sup>.<\/p>\n

Hidroxiprolina urinar\u0103, ca \u015fi fosfataza alcalin\u0103 seric\u0103, poate fi folosit\u0103 \u00een evaluarea \u015fi monitorizarea r\u0103spunsului la tratament\u00a0\u00een boala Paget3;5<\/sup>.<\/p>\n

Determinarea hidroxiprolinei urinare libere este important\u0103 \u00een\u00a0stabilirea diagnosticului de hidroxiprolinemie congenital\u0103,\u00a0afec\u0163iune caracterizat\u0103 prin retard mental \u015fi trombocitopenie3<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea hidroxiprolinei urinare <\/em><\/strong>\u2013 evaluarea metabolismului colagenului5<\/sup>.<\/p>\n

Preg\u0103tire pacient<\/em><\/strong> \u2013 cu 48 de ore \u00eenainte de testare se evita alimentele care con\u0163in colagen: carne, pe\u015fte, sosuri, budinc\u0103, iaurt, \u00eenghe\u0163at\u0103, deserturi pe baz\u0103 de gelatin\u0103 \u015fi bomboane; pacien\u0163ii trebuie s\u0103 evite, de asemenea, medicamentele care con\u0163in aspirin\u01034;5<\/sup>.<\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>variaz\u0103 \u00een func\u0163ie de v\u00e2rst\u0103:<\/p>\n

a) urina din 24 ore pentru pacien\u0163ii >16 ani<\/span>: la ora 7 diminea\u0163a pacientul urineaz\u0103 \u015fi nu re\u0163ine aceast\u0103 urin\u0103; apoi colecteaz\u0103 \u00eentr-un vas curat de 2-3 litri toate emisiunile de urin\u0103 p\u00e2n\u0103 la ora 7 diminea\u0163a \u00een ziua urm\u0103toare, inclusiv; omogenizeaz\u0103 (prin agitare) urina recoltat\u0103; m\u0103soar\u0103 \u00eentreaga cantitate; re\u0163ine aproximativ 10 ml, \u00een pahar de plastic de unic\u0103 folosin\u0163\u0103 pentru urin\u0103; proba se \u0163ine la 2-8\u00b0C \u00een timpul colect\u0103rii \u015fi ulterior, p\u00e2n\u0103 se lucreaz\u0103 efectiv.<\/p>\n

b) o prob\u0103 de urin\u0103 spontan\u0103 pentru pacien\u0163ii < 16 ani<\/span>4<\/sup>.<\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>a) vas de 2\u20133 litri \u015fi pahar de plastic de unic\u0103 folosin\u0163\u0103 pentru urin\u0103, pe care se noteaz\u0103 cantitatea total\u0103 de urin\u0103 din 24 ore; b) eprubeta pentru urin\u01034<\/sup>.<\/p>\n

Cantitate recoltat\u0103<\/em><\/strong> \u2013 a) toat\u0103 urina din 24 ore din care se re\u0163in 10 mL; b) 10 mL4<\/sup>.<\/p>\n

Cauze de respingere a probei<\/em><\/strong> \u2013 specimen care nu a fost p\u0103strat la 2-8\u00b0C; utilizarea de conservan\u0163i (produc interferen\u0163e)4<\/sup> .<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>-a) peste e\u015fantionul recoltat din urina de 24 ore se adaug\u0103 c\u00e2teva pic\u0103turi de acid acetic glacial; b) nu este necesar\u0103 ad\u0103ugarea de acid acetic glacial4<\/sup>.<\/p>\n

Stabilitate prob\u0103<\/em><\/strong> - 5 zile<\/em> la 2-8\u00b0C (pentru ambele tipuri de probe)4<\/sup>.<\/p>\n

Metoda<\/em><\/strong> - fotometric\u0103<\/span>; se determin\u0103 hidroxiprolina urinar\u0103 total\u01034<\/sup>.<\/p>\n

Valori de referin\u0163\u0103 <\/em><\/strong>-<\/em>variaz\u0103 \u00een func\u0163ie de v\u00e2rst\u0103 \u015fi sex:<\/p>\n

a) B\u0103rba\u0163i: <42 mg\/24h,<\/p>\n

b) Femei: <30 mg\/24h,<\/p>\n

c) Copii (<16 ani): <140 mg\/g creatinin\u01034<\/sup>.<\/p>\n

Interpretarea rezultatelor<\/em><\/strong>3;5<\/sup><\/p>\n\n\n\n\n
Cre\u015fteri ale hidroxiprolinei<\/strong><\/td>\nSc\u0103deri ale hidroxiprolinei<\/strong><\/td>\n<\/tr>\n
\u00a0-<\/strong> Hidroxiprolina liber\u0103:<\/strong><\/p>\n
    \n
  • Hidroxiprolinemia ereditar\u0103;<\/li>\n
  • Iminoglicinuria familial\u0103.<\/li>\n<\/ul>\n

    \u2013 Hidroxiprolina total\u0103:<\/strong><\/p>\n

      \n
    • Hipertiroidism;<\/li>\n
    • Hiperparatiroidism primar sau secundar;<\/li>\n
    • Boala Paget;<\/li>\n
    • Tumori osoase primare si secundare;<\/li>\n
    • Sindrom Marfan;<\/li>\n
    • Acromegalie;<\/li>\n
    • Osteoporoza;<\/li>\n
    • Osteomalacie;<\/li>\n
    • Rahitism;<\/li>\n
    • Arsuri severe;<\/li>\n
    • Mielom multiplu;<\/li>\n
    • Sarcina;<\/li>\n
    • Repaus la pat3;5<\/sup>.<\/li>\n<\/ul>\n<\/td>\n
\n
    \n
  • Hipopituitarism;<\/li>\n
  • Hipotiroidism;<\/li>\n
  • Hipoparatiroidism.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    \u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/strong><\/span><\/p>\n

    1. Baris Simsek, Ozg\u00fcl Karacaer , Inci Karaca. Urine products of bone breakdown as markers of bone resorption and clinical usefulness of urinary hydroxyproline: an overview. In Chinese Medical Journal 117(2):291- 295, 2004.<\/span><\/span><\/div>\n
    2. D. Erol, N. Adalar, S. Guvencli, F. Simsek, Urinary Hydroxyproline Levels in Patients with Prostatic Carcinoma, International Urology and Nephrology 15:267\u2014270, 1983.<\/span><\/div>\n
    3. Frances Fischbach. Urine Hydroxyproline. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams & Wilkins, USA, 8 ed. 2009, 278-279.<\/span><\/div>\n
    4. Laborator Synevo. Referin\u0163e specifice tehnologiei de lucru utilizate 2015. Ref Type: Catalog.<\/span><\/div>\n
    5. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Hydroxyproline, Total, Quantitative, 24-Hour Urine. www.labcorp.com 2010. Ref Type: Internet Communication.<\/span><\/div>\n
    6. Mercedes Hern\u00e1ndez Guerrero, Ligia Morales Cordero, Importancia De La Determinacion De Hidroxiprolina Urinaria En Diferentes Patologias Oseas. Reference Type: Internet Communication.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

    \u0413\u0438\u0434\u0440\u043e\u043a\u0441\u0438\u043f\u0440\u043e\u043b\u0438\u043d \u2014 \u044d\u0442\u043e \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u0430\u044f \u0430\u043c\u0438\u043d\u043e\u043a\u0438\u0441\u043b\u043e\u0442\u0430, \u043a\u043e\u0442\u043e\u0440\u0430\u044f \u0432 \u043e\u0441\u043d\u043e\u0432\u043d\u043e\u043c \u0441\u043e\u0434\u0435\u0440\u0436\u0438\u0442\u0441\u044f \u0432 \u043a\u043e\u043b\u043b\u0430\u0433\u0435\u043d\u0435. \u042d\u0442\u0430 \u0430\u043c\u0438\u043d\u043e\u043a\u0438\u0441\u043b\u043e\u0442\u0430 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0430 \u0434\u043b\u044f \u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u0438 \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u044b \u043a\u043e\u043b\u043b\u0430\u0433\u0435\u043d\u043e\u0432\u043e\u0439 \u0441\u043f\u0438\u0440\u0430\u043b\u0438. \u041a\u043e\u0433\u0434\u0430 \u043a\u043e\u043b\u043b\u0430\u0433\u0435\u043d \u0440\u0430\u0437\u0440\u0443\u0448\u0430\u0435\u0442\u0441\u044f, \u0433\u0438\u0434\u0440\u043e\u043a\u0441\u0438\u043f\u0440\u043e\u043b\u0438\u043d \u0432\u044b\u0441\u0432\u043e\u0431\u043e\u0436\u0434\u0430\u0435\u0442\u0441\u044f \u0438 \u0432\u044b\u0432\u043e\u0434\u0438\u0442\u0441\u044f \u0441 \u043c\u043e\u0447\u043e\u0439, \u0447\u0442\u043e \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0435\u0442 \u0438\u0437\u043c\u0435\u0440\u0438\u0442\u044c \u0441\u043a\u043e\u0440\u043e\u0441\u0442\u044c \u0440\u0430\u0437\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u043a\u043e\u043b\u043b\u0430\u0433\u0435\u043d\u0430.<\/p>\n

    \u0418\u0437\u043c\u0435\u0440\u0435\u043d\u0438\u0435 \u0443\u0440\u043e\u0432\u043d\u044f \u0433\u0438\u0434\u0440\u043e\u043a\u0441\u0438\u043f\u0440\u043e\u043b\u0438\u043d\u0430 \u0432 \u043c\u043e\u0447\u0435 \u043c\u043e\u0436\u0435\u0442 \u043f\u0440\u0435\u0434\u043e\u0441\u0442\u0430\u0432\u0438\u0442\u044c \u0432\u0430\u0436\u043d\u0443\u044e \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044e \u043e \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u0438 \u043a\u043e\u043b\u043b\u0430\u0433\u0435\u043d\u0430 \u0438 \u0441\u043e\u0435\u0434\u0438\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0442\u043a\u0430\u043d\u0438 \u0432 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0435.<\/p>\n

    \u041f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u0435 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 \u0433\u0438\u0434\u0440\u043e\u043a\u0441\u0438\u043f\u0440\u043e\u043b\u0438\u043d\u0430 \u043c\u043e\u0433\u0443\u0442 \u0443\u043a\u0430\u0437\u044b\u0432\u0430\u0442\u044c \u043d\u0430 \u0443\u0441\u0438\u043b\u0435\u043d\u043d\u043e\u0435 \u0440\u0430\u0437\u0440\u0443\u0448\u0435\u043d\u0438\u0435 \u043a\u043e\u043b\u043b\u0430\u0433\u0435\u043d\u0430, \u0447\u0442\u043e \u043c\u043e\u0436\u0435\u0442 \u043f\u0440\u043e\u0438\u0441\u0445\u043e\u0434\u0438\u0442\u044c \u043f\u0440\u0438 \u0442\u0430\u043a\u0438\u0445 \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u044f\u0445, \u043a\u0430\u043a:<\/p>\n

      \n
    • \u043e\u0441\u0442\u0435\u043e\u043f\u043e\u0440\u043e\u0437<\/li>\n
    • \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0432\u0438\u0434\u044b \u0440\u0430\u043a\u0430<\/li>\n
    • \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u041f\u0435\u0434\u0436\u0435\u0442\u0430<\/li>\n<\/ul>\n

      \u041a\u0440\u043e\u043c\u0435 \u0442\u043e\u0433\u043e, \u0432\u044b\u0441\u043e\u043a\u0438\u0435 \u0443\u0440\u043e\u0432\u043d\u0438 \u043c\u043e\u0433\u0443\u0442 \u0431\u044b\u0442\u044c \u0441\u0432\u044f\u0437\u0430\u043d\u044b \u0441 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f\u043c\u0438, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0443\u0432\u0435\u043b\u0438\u0447\u0438\u0432\u0430\u044e\u0442 \u0441\u0438\u043d\u0442\u0435\u0437 \u043a\u043e\u043b\u043b\u0430\u0433\u0435\u043d\u0430, \u0442\u0430\u043a\u0438\u043c\u0438 \u043a\u0430\u043a \u0441\u043a\u043b\u0435\u0440\u043e\u0434\u0435\u0440\u043c\u0438\u044f \u0438 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u0439 \u0430\u0440\u0442\u0440\u0438\u0442.<\/p>\n

      \u041a\u043e\u0433\u0434\u0430 \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u0441\u044f \u0430\u043d\u0430\u043b\u0438\u0437 \u043d\u0430 \u0433\u0438\u0434\u0440\u043e\u043a\u0441\u0438\u043f\u0440\u043e\u043b\u0438\u043d \u0432 \u043c\u043e\u0447\u0435?<\/p>\n

      \u042d\u0442\u043e\u0442 \u0430\u043d\u0430\u043b\u0438\u0437 \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e \u043f\u043e\u043b\u0435\u0437\u0435\u043d \u043f\u0440\u0438 \u043f\u043e\u0434\u043e\u0437\u0440\u0435\u043d\u0438\u0438 \u043d\u0430 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u0432\u043b\u0438\u044f\u044e\u0449\u0438\u0435 \u043d\u0430 \u0441\u043e\u0435\u0434\u0438\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u0443\u044e \u0442\u043a\u0430\u043d\u044c, \u043a\u043e\u0441\u0442\u0438 \u0438\u043b\u0438 \u0441\u0443\u0441\u0442\u0430\u0432\u044b. \u0412\u0440\u0430\u0447 \u043c\u043e\u0436\u0435\u0442 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u043e\u0432\u0430\u0442\u044c \u044d\u0442\u043e\u0442 \u0442\u0435\u0441\u0442, \u0435\u0441\u043b\u0438 \u0443 \u0432\u0430\u0441 \u0435\u0441\u0442\u044c \u0441\u043b\u0435\u0434\u0443\u044e\u0449\u0438\u0435 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u044b:<\/p>\n

        \n
      • \u0431\u043e\u043b\u044c \u0432 \u0441\u0443\u0441\u0442\u0430\u0432\u0430\u0445<\/li>\n
      • \u0441\u043a\u043e\u0432\u0430\u043d\u043d\u043e\u0441\u0442\u044c<\/li>\n
      • \u043f\u043e\u0442\u0435\u0440\u044f \u043f\u043e\u0434\u0432\u0438\u0436\u043d\u043e\u0441\u0442\u0438<\/li>\n
      • \u043b\u043e\u043c\u043a\u043e\u0441\u0442\u044c \u043a\u043e\u0441\u0442\u0435\u0439<\/li>\n<\/ul>\n

        \u041f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0430 \u043a \u0430\u043d\u0430\u043b\u0438\u0437\u0443 – \u0414\u043b\u044f \u044d\u0442\u043e\u0433\u043e \u0430\u043d\u0430\u043b\u0438\u0437\u0430 \u043d\u0435 \u0442\u0440\u0435\u0431\u0443\u0435\u0442\u0441\u044f \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u044c\u043d\u0430\u044f \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0430. \u041e\u0434\u043d\u0430\u043a\u043e \u0432\u0430\u0436\u043d\u043e \u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u044c \u0432\u0441\u0435\u043c \u0443\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u043c, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0434\u0430\u0435\u0442 \u043b\u0430\u0431\u043e\u0440\u0430\u043d\u0442, \u0432\u043a\u043b\u044e\u0447\u0430\u044f \u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0439 \u043f\u0435\u0440\u0438\u043e\u0434 \u0434\u043b\u044f \u0441\u0431\u043e\u0440\u0430 \u043c\u043e\u0447\u0438.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[927],"product_tag":[],"class_list":{"0":"post-10312","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-ososi","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10312","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10312"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10312"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10312"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10312"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}