{"id":10307,"date":"2020-04-23T04:02:33","date_gmt":"2020-04-23T02:02:33","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/proteina-s-libera-antigen\/"},"modified":"2025-02-05T10:47:11","modified_gmt":"2025-02-05T08:47:11","slug":"proteina-s-libera-antigen","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/proteina-s-libera-antigen\/","title":{"rendered":"\u0421\u0432\u043e\u0431\u043e\u0434\u043d\u044b\u0439 \u0431\u0435\u043b\u043e\u043a S (\u0430\u043d\u0442\u0438\u0433\u0435\u043d)"},"content":{"rendered":"<p><strong><em>\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">Proteina S este o glicoprotein\u0103 dependent\u0103 de vitamina K sintetizat\u0103 \u00een ficat, celule endoteliale \u015fi megakariocite. Aproximativ 60% din cantitatea circulant\u0103 de protein\u0103 S este legat\u0103 de proteina de legare a frac\u0163iunii C4b a complementului (C4b-binding protein). Restul cantit\u0103\u0163ii de protein\u0103 se g\u0103se\u015fte sub form\u0103 liber\u0103, capabil\u0103 s\u0103 ac\u0163ioneze ca un cofactor non-enzimatic al proteinei C activate. Proteina S intensific\u0103 inactivarea factorilor Va \u015fi VIIIa la nivelul suprafe\u0163elor fosfolipidice \u015fi de asemenea exercit\u0103 un rol \u00een efectul fibrinolitic al proteinei C activate. Studiile recente indic\u0103 o posibil\u0103 implicare a frac\u0163iunii legate a proteinei S \u00een activitatea anticoagulant\u0103 independent\u0103 de proteina C activat\u0103<sup>1;2<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Deficitul de protein\u0103 S se asociaz\u0103 cu tromboz\u0103 venoas\u0103 recurent\u0103, cu sau f\u0103r\u0103 embolism pulmonar, survenit\u0103 la pacien\u0163i tineri<sup>1;2;3<\/sup>. Inciden\u0163a deficitului de protein\u0103 S \u00een popula\u0163ia general\u0103 nu este bine precizat\u0103; \u00een popula\u0163ia caucazian\u0103 deficitul a fost detectat la 1-5% din pacien\u0163ii care au prezentat un episod trombotic<sup>3<\/sup>. \u00cen cazul deficitului heterozigot de protein\u0103 S riscul de tromboembolism venos este de ~ 10 ori mai mare dec\u00e2t \u00een popula\u0163ia general\u0103<sup>4<\/sup>, astfel c\u0103 60-80% dintre pacien\u0163i vor dezvolta tromboz\u0103 \u00een cursul vie\u0163ii<sup>5<\/sup>. Majoritatea evenimentelor trombotice apar la persoane cu v\u00e2rste &lt; 40-45 ani<sup>5<\/sup>. Alte expresii fenotipice ale deficitului de protein\u0103 S includ: pierderi recurente de sarcin\u0103, complica\u0163ii obstetricale (preeclampsie, abruptio placentae, restric\u0163ie de cre\u015ftere intrauterin\u0103, moartea f\u0103tului <em>in utero<\/em>) \u015fi posibil tromboz\u0103 arterial\u0103 (asocierea este controversat\u0103)<sup>4;5<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Deficitul homozigot de protein\u0103 S este rar \u015fi se manifest\u0103 ca purpur\u0103 fulminans neonatal\u0103, reflect\u00e2nd coagularea intravascular\u0103 sever\u0103 \u015fi fibrinoliza\/coagularea intravascular\u0103 diseminat\u0103 cauzate de valorile nedetectabile sau extrem de sc\u0103zute ale activit\u0103\u0163ii proteinei S<sup>4<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Exist\u0103 3 tipuri de deficit de protein\u0103 S \u00een func\u0163ie de nivelurile antigenului total al proteinei S, antigenului proteinei S libere \u015fi activitatea proteinei S \u00een plasm\u0103:<\/p>\n<p style=\"text-align: justify;\">\u2013 tipul I: proteina S este normal\u0103 func\u0163ional, dar se g\u0103se\u015fte \u00eentr-o cantitate insuficient\u0103 pentru a controla cascada coagul\u0103rii (sunt sc\u0103zute at\u00e2t antigenul total c\u00e2t \u015fi antigenul proteinei S libere, iar activitatea proteinei S este redus\u0103);<\/p>\n<p style=\"text-align: justify;\">\u2013 tipul II: cantitate normal\u0103 de protein\u0103 S (at\u00e2t antigenul total c\u00e2t \u015fi antigenul proteinei S libere \u00eenregistreaz\u0103 valori normale), care este \u00eens\u0103 incapabil\u0103 s\u0103-\u015fi exercite func\u0163ia (activitate redus\u0103 a proteinei S) ca urmare a unor defecte moleculare;<\/p>\n<p style=\"text-align: justify;\">\u2013 tipul III: cantitate redus\u0103 de protein\u0103 S liber\u0103 (antigenul proteinei S libere este sc\u0103zut) asociat\u0103 cu o activitate sc\u0103zut\u0103 a proteinei S, \u00een prezen\u0163a unei cantit\u0103\u0163i normale de protein\u0103 S total\u0103 (antigen total normal)<sup>3;4<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Deficitul dob\u00e2ndit de protein\u0103 S poate fi \u00eent\u00e2lnit \u00een sarcin\u0103, administrarea contraceptivelor orale, afec\u0163iuni hepatice, tratament cu anticoagulante orale, nefropatie diabetic\u0103, tromboza venelor cerebrale, purpura trombotic\u0103 trombocitopenic\u0103, siclemie precum \u015fi \u00een alte afec\u0163iuni autoimune \u015fi inflamatorii \u00een care se \u00eenregistreaz\u0103 o cre\u015ftere a proteinei de legare a frac\u0163iunii C4b \u015fi concomitent o sc\u0103dere a frac\u0163iunii libere<sup>1;4<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Conform recomand\u0103rilor actuale, determinarea \u00een plasm\u0103 a antigenului proteinei S libere constituie testul ini\u0163ial pentru evaluarea deficitului de protein\u0103 S<sup>4<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Recomand\u0103ri pentru determinarea proteinei S:<\/em><\/strong><\/p>\n<ul style=\"text-align: justify;\">\n<li>investigarea unor complica\u0163ii tromboembolice neexplicabile, \u00een special la pacien\u0163i &lt;50 ani \u015fi cu istoric familial pozitiv de evenimente trombotice;<\/li>\n<li>\u00eenaintea administr\u0103rii contraceptivelor orale la paciente cu episoade trombotice \u00een antecedente sau cu istoric familial pozitiv<sup>6<\/sup>.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong><em>Preg\u0103tire pacient<\/em><\/strong> <em>- <\/em>\u00e0 jeun; dac\u0103 pacientul se afl\u0103 sub terapie cu anticoagulante orale, acestea vor fi \u00eentrerupte cu 2 s\u0103pt\u0103m\u00e2ni \u00eenaintea recolt\u0103rii<sup> 6;7<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Specimen recoltat <\/em><\/strong><em>-<\/em> \u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c<sup>6<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Recipient de recoltare <\/em><\/strong><em>-<\/em> vacutainer cu citrat de Na 0.105 M (1\/9) (capac bleu\/verde)<sup>6<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Cantitatea recoltat\u0103 <\/em><\/strong>\u2013 c\u00e2t permite vacuumul<sup>6<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Cauze de respingere a probei:<\/em><\/strong><\/p>\n<ul>\n<li style=\"text-align: justify;\">specimen hemolizat<\/li>\n<li style=\"text-align: justify;\">specimen coagulat<\/li>\n<li style=\"text-align: justify;\">vacutainer care nu este plin<sup>6<\/sup><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong><em>Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>\u2013 se separ\u0103 plasma prin centrifugare \u015fi se lucreaz\u0103 imediat; dac\u0103 acest lucru nu este posibil, plasma se poate stoca la -20\u00b0C; probele de plasm\u0103 recoltate \u00een afara sediului laboratorului vor fi transportate \u00een recipientul destinat probelor congelate<sup>6<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Stabilitate prob\u0103<\/em><\/strong> \u2013 plasma separat\u0103 este stabil\u0103 <em>4 ore <\/em>la 18-25\u00b0C; <em>1 lun\u0103<\/em> la -20C<sup>4<\/sup>; se va evita decongelarea\/recongelarea<sup>6<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Metod\u0103 <\/em><\/strong><em>-<\/em> <u>latex-aglutinare<\/u>. Se utilizeaz\u0103 2 reactivi pe baz\u0103 de latex: particule de latex c\u0103ptu\u015fite cu proteina de legare a frac\u0163iunii C4b \u2013 C4bP \u2013 uman\u0103 purificat\u0103 \u015fi particule de latex c\u0103ptu\u015fite cu un anticorp monoclonal direc\u0163ionat \u00eempotriva proteinei S umane; plasma pacietului este incubat\u0103 cu C4bP care prezint\u0103 o afinitate crescut\u0103 pentru proteina S liber\u0103; proteina S liber\u0103 adsorbit\u0103 pe suprafa\u0163a particulelor c\u0103ptu\u015fite cu C4bP va declan\u015fa reac\u0163ia de aglutinare cu cel de al doilea reactiv latex; diametrul agregatelor formate va fi mai mare dec\u00e2t lungimea de und\u0103 a luminii (405 nm) ceea ce va induce o absorb\u0163ie a luminii; aceasta modificare a absorb\u0163iei va fi m\u0103surat\u0103 \u00een timp \u015fi raportat\u0103 ca diferen\u0163\u0103 de densitate optic\u0103, fiind propor\u0163ional\u0103 cu concentra\u0163ia antigenului proteinei S libere din plasma pacientului<sup>6<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Valori de referin\u0163\u0103:<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">&lt; 1 an: 32 \u2013 114%<\/p>\n<p style=\"text-align: justify;\">B\u0103rba\u0163i: 74 \u2013 146%<\/p>\n<p style=\"text-align: justify;\">Femei: 55 \u2013 124%<sup>6<\/sup><\/p>\n<p style=\"text-align: justify;\"><strong><em>Interpretarea rezultatelor <\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">Testul detecteaz\u0103 tipurile I \u015fi III de deficit de protein\u0103 S, dar nu permite diferen\u0163ierea lor. De aceea, \u00een cazul ob\u0163inerii unui nivel sc\u0103zut al antigenului proteinei S libere se recomand\u0103 testarea antigenului proteinei S totale. Dac\u0103 \u00een prezen\u0163a unor valori normale ale antigenului proteinei S libere se suspecteaz\u0103 totu\u015fi un deficit de protein\u0103 S (tipul II) se va testa suplimentar activitatea proteinei S<sup>6<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">\u00cen cursul sarcinii se produce o reducere progresiv\u0103 a proteinei S libere, astfel c\u0103 limitele inferioare ale normalului \u00een trimestrele II \u015fi III pot ajunge la 29% \u015fi respectiv 23%; din acest motiv nu se recomand\u0103 aceast\u0103 testare \u00een sarcin\u0103<sup>8<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Nu se recomand\u0103 testarea \u00een cursul unui proces trombotic acut deoarece nivelul proteinei S libere poate fi sc\u0103zut<sup>5<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><u>Influen<\/u><u>\u0163a tratamentului anticoagulant asupra determin\u0103rii proteinei S<\/u><\/p>\n<ul>\n<li style=\"text-align: justify;\"><strong>heparina nefrac\u0163ionat\u0103<\/strong> nu influen\u0163eaz\u0103 determinarea antigenului proteinei S libere, cu toate acestea, dat fiind faptul c\u0103 este administrat\u0103 \u00een cursul procesului trombotic acut nu se recomand\u0103 testarea sub aceast\u0103 terapie<sup>5;6<\/sup>;<\/li>\n<li style=\"text-align: justify;\"><strong>heparinele cu greutate molecular\u0103 mic\u0103<\/strong> nu influen\u0163eaz\u0103 testarea, totu\u015fi se recomand\u0103 ca recoltarea probei s\u0103 se efectueze la 12 ore de la ultima administrare sau imediat \u00eenaintea administr\u0103rii urm\u0103toarei doze<sup>6;9<\/sup>;<\/li>\n<li style=\"text-align: justify;\">tratamentul cu <strong>fondaparinux<\/strong> nu influen\u0163eaz\u0103 testarea<sup>9<\/sup>;<\/li>\n<li style=\"text-align: justify;\"><strong>anticoagulantele orale<\/strong> reduc proteina S (inclusiv nivelul antigenului proteinei S libere), de aceea se recomand\u0103 ca testarea s\u0103 se efectueze dup\u0103 minimum 2 s\u0103pt\u0103m\u00e2ni de la \u00eentreruperea tratamentului; dac\u0103 nu este posibil\u0103 stoparea anticoagul\u0103rii pacientul poate fi trecut temporar pe o heparin\u0103 cu greutate molecular\u0103 mic\u0103<sup>6;9<\/sup>;<\/li>\n<li style=\"text-align: justify;\"><strong>dabigatranul <\/strong>(inhibitor de trombin\u0103) precum \u015fi inhibitorii direc\u0163i de factor Xa (<strong>rivaroxaban<\/strong> \u0438\u043b\u0438 <strong>apixaban<\/strong>) nu influen\u0163eaz\u0103 determinarea antigeneului proteinei S libere<sup>9<\/sup>.<\/li>\n<\/ul>\n<p><span style=\"font-size: 10pt;\"><strong>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/strong><\/span><\/p>\n<ol>\n<li>\n<div><span style=\"font-size: 10pt;\">Fischbach F. Blood Studies; Hematology and Coagulation. In <em>A Manual of Laboratory and Diagnostic Tests.<\/em> Lippincott Williams &amp; Wilkins, USA, 8 ed. 2009, 179-181<\/span><\/div>\n<\/li>\n<li>\n<div><span style=\"font-size: 10pt;\">Jennings I, Cooper P. Screening for Thrombophilia: A Laboratory Perspective. \u00cen <em>British Journal of Biomedical Science<\/em>, 2003. 60(1):39-51<\/span><\/div>\n<\/li>\n<li>\n<div><span style=\"font-size: 10pt;\">Protein S Deficiency. <a href=\"http:\/\/www.med.uiuc.edu\/hematology.com\" rel=\"nofollow noopener\" target=\"_blank\">www.med.uiuc.edu\/hematology<\/a>\u00a0<\/span><\/div>\n<\/li>\n<li>\n<div><span style=\"font-size: 10pt;\">Mayo Clinic, Mayo Medical Laboratories. Protein S Activity, Plasma. http:\/\/www.mayomedicallaboratories.com\/test-catalog. 2015. Ref Type: Internet Communication<\/span><\/div>\n<\/li>\n<li>\n<div><span style=\"font-size: 10pt;\">Chisti MM. Protein S Deficiency. Medscape. http\/\/emedicine.medscape.com. 2015. Ref Type: Internet Communication<\/span><\/div>\n<\/li>\n<li>\n<div><span style=\"font-size: 10pt;\">Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2015. Ref Type: Catalog<\/span><\/div>\n<\/li>\n<li>\n<div><span style=\"font-size: 10pt;\">Laboratory Corporation of America. Directory of Services and Interpretive Guide. Protein S Antigen <a href=\"http:\/\/www.labcorp.com\/\" rel=\"nofollow noopener\" target=\"_blank\">www.labcorp.com<\/a> 2015. Ref Type: Internet Communication<\/span><\/div>\n<\/li>\n<li>\n<div><span style=\"font-size: 10pt;\">Reference values for Protein S, free in pregnancy. <a href=\"http:\/\/perinatology.com\/\" rel=\"nofollow noopener\" target=\"_blank\">http:\/\/perinatology.com<\/a>\u00a0<\/span><\/div>\n<\/li>\n<li>\n<div><span style=\"font-size: 10pt;\">\u0415<\/span><span style=\"font-size: 10pt;\">unk DM. Coagulation assays and anticoagulant monitoring. American Society of Hematology. 2012<\/span><\/div>\n<\/li>\n<\/ol>\n<div><\/div>","protected":false},"excerpt":{"rendered":"<p>\u041f\u0440\u043e\u0442\u0435\u0438\u043d S \u2013 \u044d\u0442\u043e \u0431\u0435\u043b\u043e\u043a, \u043e\u0431\u0440\u0430\u0437\u0443\u0435\u0442\u0441\u044f \u0432 \u043f\u0435\u0447\u0435\u043d\u0438 \u0438\u0437 \u0432\u0438\u0442\u0430\u043c\u0438\u043d\u0430 \u041a, \u043a\u043e\u0444\u0430\u043a\u0442\u043e\u0440 \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430 \u0421 \u0438 \u0434\u0435\u0439\u0441\u0442\u0432\u0443\u0435\u0442 \u0442\u043e\u043b\u044c\u043a\u043e \u0432 \u0435\u0433\u043e \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0438. \u041f\u0440\u043e\u0442\u0435\u0438\u043d \u0421 \u0438 \u043f\u0440\u043e\u0442\u0435\u0438\u043d S \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0443\u044e\u0442 \u0432 \u043a\u0440\u043e\u0432\u0438 \u0432 \u0441\u0432\u043e\u0431\u043e\u0434\u043d\u043e\u0439 \u0438 \u0441\u0432\u044f\u0437\u0430\u043d\u043d\u043e\u0439 \u0441 \u0431\u0435\u043b\u043a\u043e\u043c \u0444\u043e\u0440\u043c\u0435 (\u043e\u043d\u0430 \u043d\u0435\u0430\u043a\u0442\u0438\u0432\u043d\u0430). \u0422\u043e\u043b\u044c\u043a\u043e \u0441\u0432\u043e\u0431\u043e\u0434\u043d\u0430\u044f \u0444\u043e\u0440\u043c\u0430 \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u0430 \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u0442\u044c\u0441\u044f \u0441 \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u043e\u043c \u0421 \u0438 \u043e\u0433\u0440\u0430\u043d\u0438\u0447\u0438\u0432\u0430\u0442\u044c \u043f\u0440\u043e\u0446\u0435\u0441\u0441 \u0441\u0432\u043e\u0440\u0430\u0447\u0438\u0432\u0430\u043d\u0438\u044f \u043a\u0440\u043e\u0432\u0438.<\/p>\n<p>\u041f\u0440\u0438 \u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0438 \u0441\u043e\u0441\u0443\u0434\u0430 \u0437\u0430\u043f\u0443\u0441\u043a\u0430\u0435\u0442\u0441\u044f \u0441\u043b\u043e\u0436\u043d\u044b\u0439 \u043f\u0440\u043e\u0446\u0435\u0441\u0441 \u043e\u0441\u0442\u0430\u043d\u043e\u0432\u043a\u0438 \u043a\u0440\u043e\u0432\u043e\u0442\u0435\u0447\u0435\u043d\u0438\u044f, \u0441\u043e\u0441\u0442\u043e\u044f\u0449\u0438\u0439 \u0438\u0437 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u0430 \u0440\u0435\u0430\u043a\u0446\u0438\u0439 \u0441\u043e\u0441\u0443\u0434\u043e\u0432, \u0442\u0440\u043e\u043c\u0431\u043e\u0446\u0438\u0442\u043e\u0432, \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u044c\u043d\u044b\u0445 \u0431\u0435\u043b\u043a\u043e\u0432 \u043a\u0440\u043e\u0432\u0438 \u2013 \u043f\u0440\u043e\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u043e\u0432 \u0438 \u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u043e\u0432 (\u0441\u0432\u043e\u0440\u0430\u0447\u0438\u0432\u0430\u044e\u0449\u0438\u0445 \u0438 \u0440\u0430\u0437\u0436\u0438\u0436\u0430\u044e\u0449\u0438\u0445 \u043a\u0440\u043e\u0432\u044c). \u0426\u0435\u043b\u044c \u2013 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u0442\u044c \u0442\u0440\u043e\u043c\u0431, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u043f\u0440\u0435\u0434\u0443\u043f\u0440\u0435\u0434\u0438\u0442 \u0432\u044b\u0442\u0435\u043a\u0430\u043d\u0438\u0435 \u043a\u0440\u043e\u0432\u0438 \u0438\u0437 \u0441\u043e\u0441\u0443\u0434\u0430. \u041d\u043e, \u0437\u0430\u043f\u0443\u0441\u043a \u0441\u0432\u0435\u0440\u0442\u044b\u0432\u0430\u044e\u0449\u0435\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b \u0434\u043e\u043b\u0436\u0435\u043d \u0431\u044b\u0442\u044c \u043e\u0433\u0440\u0430\u043d\u0438\u0447\u0435\u043d, \u043d\u0435\u043b\u044c\u0437\u044f \u0434\u043e\u043f\u0443\u0441\u0442\u0438\u0442\u044c, \u0447\u0442\u043e\u0431 \u043c\u0435\u043b\u043a\u043e\u0435 \u0440\u0430\u043d\u0435\u043d\u0438\u0435 \u043f\u0440\u0438\u0432\u0435\u043b\u043e \u043a 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\u043f\u0440\u043e\u0442\u0435\u0438\u043d \u0421, \u0430\u043d\u0442\u0438\u0442\u0440\u043e\u043c\u0431\u0438\u043d III, \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439<\/li>\n<li>\u0435\u0441\u043b\u0438 \u0443 \u043f\u0440\u044f\u043c\u043e\u0433\u043e \u043a\u0440\u043e\u0432\u043d\u043e\u0433\u043e \u0440\u043e\u0434\u0441\u0442\u0432\u0435\u043d\u043d\u0438\u043a\u0430 \u0431\u044b\u043b \u0443\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d \u0432\u0440\u043e\u0436\u0434\u0435\u043d\u043d\u044b\u0439 \u0434\u0435\u0444\u0438\u0446\u0438\u0442 \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430 S<\/li>\n<\/ul>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[952],"product_tag":[],"class_list":{"0":"post-10307","1":"product","2":"type-product","3":"status-publish","5":"product_cat-teste-de-trombofilie","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10307","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10307"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10307"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10307"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10307"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10307"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}