{"id":10302,"date":"2020-04-23T04:02:25","date_gmt":"2020-04-23T01:02:25","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/amiloid-a-in-ser\/"},"modified":"2024-11-08T11:56:24","modified_gmt":"2024-11-08T09:56:24","slug":"amiloid-a-in-ser","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/amiloid-a-in-ser\/","title":{"rendered":"\u0410\u043c\u0438\u043b\u043e\u0438\u0434 \u0410 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043e\u0447\u043d\u044b\u0439 (\u0421\u0410\u0410)"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\">Amiloidul seric A (SAA) a fost descoperit\u00a0\u00een 1971 ca un constituent principal\u00a0\u00een depozitele de amiloid la pacien\u0163ii cu inflama\u0163ie persistent\u0103. Face parte din familia apolipoproteinelor asociate\u00a0\u00een plasm\u0103 cu lipoproteinele cu densitate mare (HDL) \u015fi prezint\u0103 mai multe izoforme, ce sunt inegal exprimate constitutiv sau ca r\u0103spuns la diver\u015fi stimuli inflamatori<sup>1<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Amiloidul A este o protein\u0103 de faz\u0103 acut\u0103, format\u0103 din 104 aminoacizi \u015fi av\u00e2nd o greutate molecular\u0103 de 12-14 kDa. Ca \u015fi proteina C reactiv\u0103 (CRP), este sintetizat \u00een principal\u00a0\u00een ficat ca r\u0103spuns la infec\u0163ie, inflama\u0163ie, leziuni tisulare sau stres, dar macrofagele, celulele endoteliale, epiteliale, leziunile arterosclerotice, tumorile \u015fi \u0163esutul sinovial pot fi site-uri extrahepatice de produc\u0163ie. SAA-1 constituie izoforma major\u0103<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\">At\u00e2t produ\u015fii bacterieni (de exemplu, lipopolizaharidul LPS) c\u00e2t \u015fi citokinele inflamatorii, cum ar fi IL-1\u03b2, IL-6 \u015fi TNF-\u03b1 induc sinteza SAA la nivelul hepatocitelor, macrofagelor tisulare \u015fi sinoviocitelor.<\/p>\n<p style=\"text-align: justify;\">Dup\u0103 sinteza SAA este eliberat\u00a0\u00een fluxul sanguin fiind \u00eencorporat apoi\u00a0\u00een particulele HDL. Nivelurile SAA crescute pot \u00eenlocui apolipoproteina A1 (apo-A1) \u015fi modifica compozitia HDL. Astfel, se poate produce o alterare a func\u0163iei acestei lipoproteine cu pierderea propriet\u0103\u0163ilor ateroprotective. La concentra\u0163ii crescute SAA poate, de asemenea, s\u0103 se disocieze de HDL \u015fi s\u0103 genereze frac\u0163iuni lipoproteice ce con\u0163in\u00a0\u00een principal Apo-A1 \u015fi SAA s\u0103race\u00a0\u00een lipide. Aceast\u0103 form\u0103 de SAA produs\u0103 de macrofagele \u015fi sinoviocitele de la locurile inflama\u0163iei exercit\u0103 numeroase ac\u0163iuni proinflamatorii<sup>3<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Complexele circulante SAA-HDL sunt asociate cu func\u0163ii importante \u00een procesele inflamatorii, metabolismul \u015fi transportul HDL-colesterolului \u015fi, prin urmare, SAA a fost implicat \u00een mai multe condi\u0163ii patologice, cum ar fi ateroscleroza, artrita reumatoid\u0103, boala Alzheimer \u015fi cancerul.<\/p>\n<p style=\"text-align: justify;\">Procesele inflamatorii acute determin\u0103 o cre\u015ftere rapid\u0103 \u015fi intens\u0103 a nivelului plasmatic de amiloid A, astfel c\u0103 \u00een decurs de 24 ore valorile serice de SAA pot fi chiar \u015fi de 1000 ori mai ridicate fa\u0163\u0103 de cele \u00eenregistrate \u00een condi\u0163ii normale, f\u0103c\u00e2nd din aceast\u0103 protein\u0103 un marker sensibil al evalu\u0103rii inflama\u0163iei.<\/p>\n<p style=\"text-align: justify;\">SAA circulant ac\u0163ioneaz\u0103 ca un chemoatractant pentru neutrofile, monocite \u015fi limfocite T \u00een diverse leziuni \u015fi ajut\u0103 \u00een procesul de regenerare a \u0163esuturilor prin activarea metaloproteinazelor matriceale, cum ar fi colagenaza \u015fi strolemizina. \u00a0Prin legarea de HDL, SAA mediaz\u0103 eliberarea de lipide la locul injuriei \u00een vederea utiliz\u0103rii acestora \u00een procesele de regenerare tisular\u0103. Pe de alt\u0103 parte, complexul SAA-HDL serve\u015fte \u015fi la eliminarea excesului de colesterol eliberat de c\u0103tre \u0163esutul afectat.<\/p>\n<p style=\"text-align: justify;\">Complexul SAA-HDL este implicat \u015fi \u00een activit\u0103\u0163i anti-inflamatorii prin inhibarea func\u0163iei limfocitelor, a febrei induse de TNF-alfa \u015fi IL-1 \u015fi a agreg\u0103rii plachetare. Amiloidul A inhib\u0103, de asemenea, r\u0103spunsul oxidativ specific proceselor inflamatorii \u015fi previne deteriorarea oxidativ\u0103 a \u0163esutului.<\/p>\n<p style=\"text-align: justify;\">Niveluri serice crescute de amiloid A se pot observa la pacien\u0163ii ce prezint\u0103 at\u00e2t inflama\u0163ii acute c\u00e2t \u015fi cronice.<\/p>\n<p style=\"text-align: justify;\">\u00cen condi\u0163iile acute, SAA \u00eenregistreaz\u0103 cre\u015fteri mai rapide \u015fi mai mari dec\u00e2t CRP. De asemenea,\u00a0\u00een compara\u0163ie cu CRP, SAA prezint\u0103 aceea\u015fi tendin\u0163\u0103 de cre\u015ftere at\u00e2t\u00a0\u00een infec\u0163iile virale c\u00e2t \u015fi\u00a0\u00een cele bacteriene<sup>2;4<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Nivelurile serice de SAA crescute constant ca urmare a bolilor inflamatorii prelungite \u015fi repetate pot contribui uneori la apari\u0163ia unei boli reactive, progresive, poten\u0163ial letale, caracterizat\u0103 prin \u00eempachet\u0103ri defectuoase ale amiloidului A, cunoscut\u0103 sub numele de <i>\u0430\u043c\u0438\u043b\u043e\u0438\u0434\u043e\u0437<\/i><i> AA<\/i>. In aceast\u0103 form\u0103 de boal\u0103, AA, fragmentul N terminal rezultat din clivarea amiloidului A, poate forma depozite de amiloid \u00een ficat, rinichi sau splin\u0103<sup>4<\/sup>. Mai multe studii au ar\u0103tat c\u0103 transformarea SAA \u00een fibrilele de amiloid se produce \u00een urma interac\u0163iunii specifice cu heparan sulfatul \u2013 un glicozaminoglican component al matricei extracelulare.<\/p>\n<p style=\"text-align: justify;\">Bolile inflamatorii cum ar fi artrita reumatoid\u0103, artrita juvenil\u0103, spondilita anchilozant\u0103, febra mediteraneean\u0103 familial\u0103, scleroza sistemic\u0103 progresiv\u0103, infec\u0163iile cronice (tuberculoza \u015fi osteomielita), precum \u015fi neoplaziile (boala Hodgkin, carcinomul renal) sunt afec\u0163iuni ce predispun\u00a0 la dezvoltarea amiloidozei AA. Deoarece mul\u0163i pacien\u0163i care prezint\u0103 condi\u0163ii inflamatorii severe \u015fi de lung\u0103 durat\u0103 nu dezvolt\u0103 depuneri tisulare de amiloid, factorii de risc pentru apari\u0163ia amiloidozei AA nu sunt cunoscu\u0163i. Au fost implica\u0163i factori genetici, de mediu \u015fi iatrogeni<sup>5<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Mai multe studii au ar\u0103tat c\u0103 nivelurile crescute ale SAA sunt asociate cu bolile cardiovasculare. Astfel, a fost descris\u0103 o corela\u0163ie independent\u0103 str\u00e2ns\u0103 \u00eentre concentra\u0163iile serice de SAA \u015fi evenimentele cardiovasculare viitoare, \u00eentr-un mod similar cu cel descris pentru proteina C reactiv\u0103 \u00eenalt sensibil\u0103 (hs-CRP). De asemenea nivelul SAA a fost asociat independent \u00eens\u0103 moderat cu boala coronarian\u0103 angiografic\u0103; aceast\u0103 asociere nu a fost valabil\u0103 pentru hs-CRP<sup>6<\/sup>.<\/p>\n<p style=\"text-align: justify;\">\u00centr-un alt studiu recent publicat s-a concluzionat c\u0103 nivelurile ini\u0163iale de SAA \u015fi CRP la pacien\u0163ii nou diagnostica\u0163i cu diabet zaharat tip I au avut valoare predictiv\u0103 asupra dezvolt\u0103rii micro- \u015fi macroalbuminuriei\u00a0\u00een decurs de 30 ani de monitorizare, sus\u0163in\u00e2nd teoria referitoare la rolul inflama\u0163iei\u00a0\u00een progresia nefropatiei diabetice<sup>7<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Diagnosticul precoce al rejetului de gref\u0103 dup\u0103 transplantul renal este deosebit de important. A fost demonstrat c\u0103 SAA este marker sensibil al rejetului. De\u015fi nu este specific, faptul ca CRP nu \u00eenregistreaz\u0103 cre\u015fteri la pacien\u0163ii cu respingerea grefei care primesc ciclosporin\u0103, nivelul SAA ajut\u0103 la diferen\u0163ierea rejetului de o infec\u0163ie<sup>8<\/sup>.<\/p>\n<p style=\"text-align: justify;\">O alt\u0103 constatare legat\u0103 de SAA este aceea c\u0103 nivelurile serice crescute ale acestui marker se coreleaz\u0103 cu procesul de carcinogenez\u0103 \u015fi cu mai multe tipuri de afec\u0163iuni neoplazice (cancer pulmonar, cancer esofagian, cancer de colon, cancer de endometru, tumori ovariene epiteliale). Din acest motiv modific\u0103rile concentra\u0163iei SAA\u00a0ar indica progresul \u015fi malignitatea bolii, precum \u015fi r\u0103spunsurile gazdei<sup>9<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><b><i>Recomand\u0103ri pentru determinarea amoloidului A<\/i><\/b><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2013 evaluarea proceselor inflamatorii<sup>1<\/sup>;<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2013 evaluarea riscului de amiloidoz\u0103 secundar\u0103<sup>5<\/sup>;<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2013 evaluarea riscului de evenimente cardiace viitoare<sup>6<\/sup>;<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2013 diagnosticarea \u015fi predic\u0163ia rejetului de gref\u0103\u00a0\u00een transplantul renal<sup>8<\/sup>;<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2013\u00a0monitorizarea disemin\u0103rii unui proces tumoral<sup>1;9<\/sup>.<\/div>\n<p style=\"text-align: justify;\"><b><i>Preg\u0103tire pacient <\/i><\/b><i>-<\/i>nu este necesar\u0103 o preg\u0103tire special\u0103<sup>10<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><b><i>Specimen recoltat <\/i><\/b><i>- <\/i>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c<sup>10<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><b><i>Recipient de recoltare <\/i><\/b><i>- <\/i>vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator<sup>10<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><b><i>Prelucrare necesar\u0103 dup\u0103 recoltare <\/i><\/b><i>-<\/i>se separ\u0103 serul prin centrifugare; se lucreaz\u0103 serul proasp\u0103t; dac\u0103 acest lucru nu este posibil, serul se p\u0103streaz\u0103 la 2-8\u00b0C sau la -20\u00b0C<sup>10<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><b><i>Volum prob\u0103<\/i><\/b> \u2013 1 mL ser<sup>10<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><b><i>Cauze de respingere<\/i><\/b> <b><i>a probei \u2013 <\/i><\/b>specimen intens hemolizat<sup>10<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><b><i>Stabilitate prob\u0103 <\/i><\/b><i>- <\/i>serul separat este stabil <i>7 zile<\/i> la 2-8\u00b0C; <i>timp \u00eendelungat<\/i> la -20\u00b0C sau la -70\u00b0C<sup>10<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><b><i>Metod\u0103 <\/i><\/b><i>-<\/i><span style=\"text-decoration: underline;\">nefelometric\u0103<\/span><span style=\"text-decoration: underline;\"><sup>10<\/sup><\/span>.<\/p>\n<p style=\"text-align: justify;\"><b><i>Valori de referin\u0163\u0103 <\/i><\/b><i>- <\/i>&lt;10 mg\/L<sup>10<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><b><i>Interpretarea rezultatelor<\/i><\/b><\/p>\n<ul style=\"text-align: justify;\">\n<li>Cre\u015fteri SAA\u00a0\u00een intervalul 10-100 mg\/L sunt \u00eent\u00e2lnite\u00a0\u00een infec\u0163ii virale, lupusul eritematos sistemic, inflama\u0163ii localizate, leziuni tisulare din cistit\u0103 \u015fi infarctul cerebral<sup>1<\/sup>. SAA cre\u015fte mai frecvent dec\u00e2t CRP\u00a0\u00een infec\u0163iile virale (spre exemplu\u00a0\u00een dou\u0103 treimi din cazurile de r\u0103ceala comun\u0103)<sup>11<\/sup>.<\/li>\n<li>Cre\u015fteri SAA\u00a0\u00een intervalul 100-1000 mg\/L se \u00eenregistreaz\u0103 \u00een infec\u0163iile bacteriene \u015fi fungice, tumori maligne invazive (SAA prezint\u0103 cele mai mari cre\u015fteri\u00a0\u00een tumorile metastazante), infarctul miocardic acut, boli autoimune cum ar fi artrita reumatoid\u0103 \u015fi vasculitele<sup>1<\/sup>. In artrita reumatoid\u0103 SAA de\u0163ine un rol important\u00a0\u00een stabilirea gradului de activitate a bolii \u015fi\u00a0\u00een evaluarea riscului de amiloidoza secundar\u0103<sup>11<\/sup>.<\/li>\n<li>\u00cen amiloidoza AA tratamentul afec\u0163iunii inflamatorii subiacente care reduce nivelurile SAA &lt;10 mg\/L poate opri progresia bolii \u015fi induce o recuperare lent\u0103 a func\u0163iei renale<sup>5<\/sup>.<\/li>\n<li>\u00cen cazul transplantului de organe valorile &gt; 100 mg\/L indica rejetul. Pe lang\u0103 respingerea grefei renale, SAA mai este utilizat \u015fi\u00a0\u00een diagnosticul rejetului\u00a0\u00een transplantul hepatic, de m\u0103duv\u0103 osoas\u0103 precum \u015fi\u00a0\u00een transplantul simultan de rinichi \u015fi pancreas<sup>1<\/sup>. In cazul rejetului din transplantul de cord SAA \u00eenregistreaz\u0103 o sensibilitate &lt;70%<sup>11<\/sup>.<\/li>\n<li>La persoanele cu angin\u0103 instabil\u0103 \u015fi infarct miocardic SAA prezint\u0103 o sensibilitate similar\u0103 cu cea a CRP sau chiar mai mare\u00a0\u00een evaluarea riscului de apari\u0163ie a unor evenimente cardiace noi<sup>11<\/sup>.<\/li>\n<\/ul>\n<div style=\"text-align: justify;\"><b><i>Limite \u015fi interferen\u0163e<\/i><\/b><\/div>\n<div style=\"text-align: justify;\">Ob\u0163inerea unor concentra\u0163ii SAA crescute la pacien\u0163ii cu boli inflamatorii cronice reprezint\u0103 doar una din premizele dezvolt\u0103rii depozitelor de amiloid<sup>11<\/sup>.<\/div>\n<p style=\"text-align: justify;\" align=\"center\"><span style=\"font-size: 10pt;\"><strong>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/strong><\/span><\/p>\n<div style=\"text-align: justify;\">1. <span style=\"font-size: 10pt;\">Jovanovi\u0107 Dijana B. Serum amyloid a in clinical practice. In Srpski Arhiv za Celokupno Lekarstvo, vol.132, Issue 7-8, pg 267-271.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">2. SAA, Human, ELISA kit. <a href=\"http:\/\/www.hycultbiotech.com\/\" rel=\"nofollow noopener\" target=\"_blank\">www.hycultbiotech.com<\/a>, Febr. 2013. Reference Type: Internet Communication.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">3. Rong L. He, Jian Zhou, Crystal Z. Hanson, Jia Chen, Ni Cheng and Richard D. Ye. Z. Hanson, Jia Chen, Ni Cheng and Richard D. Ye. Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2. In <i>Blood,<\/i> 2009 113: 429-437.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">4. Amyloid A, Serum, Human, US Biological. www.usbio.net, Febr. 2013. Reference Type: Internet Communication.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">5. Richa Dhawan. AA (Inflammatory) Amyloidosis. http:\/\/emedicine.medscape.com. Update August 2011. Reference Type: Internet Communication.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">6. Delia Johnson, PhD; Kevin E. Kip, PhD; Oscar C. Marroquin, MD; Paul M Ridker, MD; Sheryl F. Kelsey, PhD; Leslee J. Shaw, PhD; Carl J. Pepine, MD; Barry Sharaf, MD; C. Noel Bairey Merz, MD; George Sopko, MD; Marian B. Olson, MS; Steven E. Reis,\u00a0\u00a0MD. Serum Amyloid A as a Predictor of Coronary Artery Disease and Cardiovascular Outcome \u00a0in Women: the National Heart, Lung, and Blood Institute-Sponsored Women\u2019s Ischemia Syndrome Evaluation (WISE). In <i>Circulation <\/i>2004 Feb 17;109(6):726-32.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">7. Anne Julie Overgaard, James N. McGuire, Peter Hovind, Hans_henrik Parving, Peter Rossing, Flemming Pociot. Serum amyloid\u00a0 A and C-reactive protein levels may predict microalbuminuria and macroalbuminuria in newly diagnosed type 1 diabetic patients.\u00a0In\u00a0 J<i>ournal Of Diabetes and its Complications<\/i>, vol. 27, Issue 1, January\u2013February 2013, Pages 59\u201363.\u00a0 \u00a0\u00a0<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">8. A. Hartmann, TC Eide, P Fauchald,\u00a0 O Bentdal, J Herbert, JR Gallimore, MB Pepys. Serum amyloid A protein is a clinically useful indicator of acute renal allograft rejection. In Nephrology Dialysis Transplantation, Volume 12, Issue 1, pp 161-166.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">9. Chibo Liu. Serum Amyloid A Protein in Clinical Cancer Diagnosis. In Pathology &amp; Oncology Research, April 2012, Volume 18,\u00a0Issue 2. pp 117-121.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">10. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2013. Ref Type: Catalog.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">11. G. T\u00f6pfer, G. Trefz, B Zawta. Proteins \u2013 Questions and Answers for Medical Diagnostics., Roche Diagnostics GmbH, 2000.<\/span><\/div>","protected":false},"excerpt":{"rendered":"<p>\u0421\u044b\u0432\u043e\u0440\u043e\u0442\u043e\u0447\u043d\u044b\u0439 \u0430\u043c\u0438\u043b\u043e\u0438\u0434 \u0410 \u0431\u044b\u043b \u043e\u0442\u043a\u0440\u044b\u0442 \u0432 1971 \u0433\u043e\u0434\u0443 \u043a\u0430\u043a \u043a\u043e\u043c\u043f\u043e\u043d\u0435\u043d\u0442 \u0430\u043c\u0438\u043b\u043e\u0438\u0434\u043d\u044b\u0445 \u043e\u0442\u043b\u043e\u0436\u0435\u043d\u0438\u0439 (\u0447\u0440\u0435\u0437\u043c\u0435\u0440\u043d\u043e\u0435 \u043d\u0430\u043a\u043e\u043f\u043b\u0435\u043d\u0438\u0435 \u0430\u043c\u0438\u043b\u043e\u0438\u0434\u043d\u044b\u0445 \u0431\u0435\u043b\u043a\u043e\u0432 \u0432 \u0442\u043a\u0430\u043d\u044f\u0445) \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u0435\u043c. \u0410\u043c\u0438\u043b\u043e\u0438\u0434 \u2014 \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u0438\u0442\u0435\u043b\u044c \u0441\u0435\u043c\u0435\u0439\u0441\u0442\u0432\u0430 \u0430\u043f\u043e\u043b\u0438\u043f\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u043e\u0432, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u0435\u0442\u0441\u044f \u0441 \u043b\u0438\u043f\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u043c\u0438 \u0432\u044b\u0441\u043e\u043a\u043e\u0439 \u043f\u043b\u043e\u0442\u043d\u043e\u0441\u0442\u0438 (\u041b\u041f\u0412\u041f) \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0438 \u043a\u0440\u043e\u0432\u0438, \u043e\u0431\u0440\u0430\u0437\u0443\u044f \u043d\u0435\u0441\u043a\u043e\u043b\u044c\u043a\u043e \u0438\u0437\u043e\u0444\u043e\u0440\u043c, \u0443\u0440\u043e\u0432\u043d\u0438 \u043a\u043e\u0442\u043e\u0440\u044b\u0445 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\u0442\u0440\u0435\u0431\u0443\u0435\u0442\u0441\u044f<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[1000,953],"product_tag":[],"class_list":{"0":"post-10302","1":"product","2":"type-product","3":"status-publish","5":"product_cat-biochimie-generala-sange-urina","6":"product_cat-teste-de-biochimie","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10302","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10302"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10302"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10302"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10302"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10302"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}