{"id":10298,"date":"2020-04-23T04:02:18","date_gmt":"2020-04-23T01:02:18","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/glutation-peroxidaza-gpx\/"},"modified":"2025-01-31T14:27:52","modified_gmt":"2025-01-31T12:27:52","slug":"glutation-peroxidaza-gpx","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/glutation-peroxidaza-gpx\/","title":{"rendered":"\u0413\u043b\u0443\u0442\u0430\u0442\u0438\u043e\u043d\u043f\u0435\u0440\u043e\u043a\u0441\u0438\u0434\u0430\u0437\u0430 (GPx)"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/span><\/p>\n

Glutation peroxidaza (GPX) face parte dintr-o familie de enzime ce catalizeaz\u0103 degradarea hidroperoxizilor organici rezulta\u0163i din procesele metabolice normale \u015fi asigur\u0103 protec\u0163ia proteinelor, lipidelor \u015fi acizilor nucleici fa\u0163\u0103 de ac\u0163iunea moleculelor oxidante, utiliz\u00e2nd ca donator de electroni glutationul sau, \u00een anumite cazuri, tioredoxina sau glutaredoxina.<\/span><\/p>\n

Comparativ cu superoxid dismutaza \u015fi catalaza, care se g\u0103sesc \u00een celule\u00a0\u00een cantit\u0103\u0163i relativ mari, dar constante, glutation peroxidaza este de asemenea prezent\u0103 \u00een toate \u0163esuturile, dar\u00a0\u00een cantitate variabil\u0103, deoarece este indus\u0103 enzimatic. Acest fapt a fost constatat\u00a0\u00een pl\u0103m\u00e2nii \u015fi hematiile fum\u0103torilor, deoarece se cunoa\u015fte faptul c\u0103 fumul de \u0163igar\u0103 con\u0163ine mari cantit\u0103\u0163i de radicali liberi, oxizi de azot \u015fi hidroperoxizi, ce ac\u0163ioneaz\u0103 ca substrat al peroxidazei2<\/sup>.<\/span><\/p>\n

GPX este o enzim\u0103 seleniu-dependent\u0103, ce se g\u0103se\u015fte \u00een citosol (70%), dar \u015fi\u00a0\u00een mitocondrii (30%). Este de ne\u00eenlocuit\u00a0\u00een arsenalul antioxidant,\u00a0\u00een special\u00a0\u00een mitocondrii, deoarece acestea nu con\u0163in catalaz\u0103 pentru metabolizarea peroxidului. GPX asigur\u0103, de asemenea, protec\u0163ie fa\u0163\u0103 de hidroperoxizii organici (implica\u0163i\u00a0\u00een modific\u0103ri ale lipidelor de la nivelul peretelui vascular care promoveaz\u0103 aterogeneza) \u015fi ajut\u0103 la regenerarea formei reduse a vitaminei C. Dezechilibre\u00a0\u00een nivelul GPX au fost observate odat\u0103 cu \u00eemb\u0103tr\u00e2nirea \u015fi \u00eentr-o varietate de tulbur\u0103ri cum ar fi cancerul, bolile cardiovasculare, diabetul zaharat, boala Alzheimer, stres oxidativ indus de alcool, colecistit\u0103 \u015fi urticarie10<\/sup>.<\/span><\/p>\n

P\u00e2n\u0103 \u00een prezent, prin analiza selenoproteinelor cu rol enzimatic, au fost identificate 8 izoforme ale glutation peroxidazei\u00a0\u00een corpul mamiferelor, notate GPX1,\u2026.GPX8, care difer\u0103 prin structura lor primar\u0103 \u015fi localizare\u00a0\u015fi sunt codificate de gene diferite2<\/sup>.<\/span><\/p>\n

Cu excep\u0163ia fosfolipid-hidroperoxidului GPX4, care este un monomer, toate celelalte izoforme sunt tetrameri compu\u015fi din patru subunit\u0103\u0163i identice. Glutation peroxidaza con\u0163ine 4 atomi de seleniu (lega\u0163i de reziduul cisteinil din pozi\u0163ia 35) pentru cele 4 subunit\u0103\u0163i polipeptidice, enzima av\u00e2nd o mas\u0103 molecular\u0103 de cca 85kDa. Atomii de seleniu de la nivelul situsului activ particip\u0103 direct la reducerea peroxidului, fiind esen\u0163iali \u00een sistemul de protec\u0163ie \u00eempotriva antioxidan\u0163ilor. Un deficit de seleniu, chiar ne\u00eensemnat, afecteaz\u0103 activitatea enzimei \u015fi determin\u0103 peroxidarea membranelor \u015fi cre\u015fterea permeabilit\u0103\u0163ii acestora.<\/span><\/p>\n

Glutation-peroxidaza 1 (GPX1) este izoforma cea mai abundent\u0103, localizat\u0103 \u00een citoplasma tuturor celulelor animale, este implicat\u0103 \u00een detoxifierea peroxidul de hidrogen \u015fi lipid-peroxidului, ac\u0163ion\u00e2nd ca o peroxinitrit reductaz\u0103. In lipsa acestei enzime antioxidante rezult\u0103 acumularea de specii reactive de oxigen care determin\u0103 deteriorarea ADN-ului, proteinelor \u015fi lipidelor. Dovezi clinice sugereaz\u0103 un poten\u0163ial rol al GPX1 \u00een aterogeneza asociat\u0103 diabetului zaharat.<\/span><\/p>\n

Polimorfisme identificate \u00een gena GPX1 care conduc la reducerea activit\u0103\u0163ii GPX1 se coreleaz\u0103 cu cre\u015fterea grosimii tunicii interne \u015fi medii a arterelor carotide, cu apari\u0163ia unui risc crescut de boli cardiovasculare \u015fi vasculare periferice la pacien\u0163ii cu diabet zaharat. Mai mult, studii suplimentare sugereaz\u0103 un rol protector al GPX1\u00a0\u00een procesul de aterogenez\u0103. Astfel, reducerea activit\u0103\u0163ii GPX1\u00a0\u00een eritrocite a fost asociat\u0103 cu un risc crescut de evenimente cardiovasculare \u015fi apari\u0163ia de pl\u0103ci aterosclerotice. Aceste studii sugereaz\u0103 faptul c\u0103 GPX1 este enzima cheie pentru protec\u0163ia vaselor \u00eempotriva stresului oxidativ \u015fi aterogenez\u01032;5<\/sup>.<\/span><\/p>\n

GPX2, cunoscut\u0103 \u015fi sub numele de GPX gastrointestinal\u0103 (GI-GPX), este o enzim\u0103 intracelular\u0103 exprimat\u0103 la nivelul epiteliului tractului gastrointestinal.<\/span><\/p>\n

GPX2 nu este uniform exprimat\u0103 \u00een intestin, fiind mai abundent\u0103 la nivelul criptelor \u015fi scade treptat spre suprafa\u0163a luminal\u0103 indic\u00e2nd un rol \u00een proliferarea celulelor. Expresia GPX2 este crescut\u0103 \u00een adenoamele colorectale, carcinoame \u015fi \u00een mucoasa esofagului Barrett. Expresia GPX2 nu este specific\u0103 pentru tractul gastrointestinal, fiind, de asemenea, crescut\u0103 \u00een timpul transform\u0103rii neoplazice a celulelor epiteliale scuamoase, \u00een adenocarcinoamele pulmonare la fum\u0103tori \u015fi \u00een cancerul de s\u00e2n. Rolul protector al GPX2 poate fi demonstrat prin faptul c\u0103 exprimarea sa este reglat\u0103 de factorul de transcriere Nrf2, care este, \u00een general, considerat citoprotector \u015fi previne tumorigeneza. GPX2 este capabil\u0103 s\u0103 inhibe ciclooxigenaza 2 (COX 2) \u015fi duce la sc\u0103derea produc\u0163iei de prostaglandine E2 (PGE2).<\/span><\/p>\n

Toate GPX investigate p\u00e2n\u0103 \u00een prezent au proprietatea de a inhiba activitatea COX prin eliminarea hidroperoxizilor. Activitatea COX necesit\u0103 hidroperoxid \u015fi nu mai poate produce PGE2\u00a0\u00een cazul\u00a0\u00een care acesta este\u00a0\u00een cantitate redus\u01031;9<\/sup>.<\/span><\/p>\n

Glutation-peroxidaza intervine, de asemenea, \u015fi \u00een reac\u0163ia de conversie a acidului arachidonic\u00a0\u00een leucotriene, sub ac\u0163iunea lipooxigenazei6<\/sup>.<\/span><\/p>\n

Glutation peroxidaza aflat\u0103 \u00een plasm\u0103 poart\u0103 denumirea de GPX3. Poate fi, de asemenea, g\u0103sit\u0103 \u00een rinichi, pl\u0103m\u00e2ni, inim\u0103, ficat, glanda mamar\u0103, placent\u0103 precum \u015fi\u00a0\u00een laptele matern. Deoarece controlul redox a fost implicat\u00a0\u00een apari\u0163ia disfunc\u0163iilor metabolice, m\u0103surarea GPX3\u00a0\u00een ser poate aduce unele beneficii\u00a0\u00een diagnosticul acestor afec\u0163iuni1;9<\/sup>.<\/span><\/p>\n

Glutation peroxidaza 4 (GPX4) este o enzim\u0103 antioxidant\u0103, care protejeaz\u0103 celulele \u00eempotriva peroxid\u0103rii lipidelor membranare, fiind exprimat\u0103\u00a0\u00een aproape orice celul\u0103 animal\u0103, dar la niveluri sc\u0103zute. Gena Gpx4 codific\u0103 pentru trei izoforme: o form\u0103 lung\u0103 (lGpx4), o form\u0103 scurt\u0103 (sGpx4) \u015fi una nuclear\u0103. Studiile genetice arat\u0103 c\u0103 forma nuclear\u0103 joac\u0103 un rol important\u00a0\u00een condensarea cromatinei la nivelul spermatozoizilor. Cu toate acestea, rolul in vivo<\/em> al lGpx4 \u015fi sGpx4, care se disting prin prezen\u0163a sau absen\u0163a unei peptide semnal al cap\u0103tului N-terminal, r\u0103m\u00e2ne neclar. Studii efectuate recent indic\u0103 faptul c\u0103 sGpx4 este izoform\u0103 major\u0103 \u00een \u0163esuturile somatice \u015fi este esen\u0163ial\u0103 pentru supravie\u0163uirea \u015fi protec\u0163ia \u00eempotriva apoptozei,\u00a0\u00een timp ce izoforma lGpx4 este predominant\u0103 \u00een testicule \u015fi este important\u0103\u00a0\u00een reglarea fertilit\u0103\u0163ii masculine2;3<\/sup>.<\/span><\/p>\n

Glutation peroxidaza 5 (GPX-5), cunoscut\u0103 \u015fi sub numele de glutation peroxidaza epididimal\u0103 secretorie, este o enzim\u0103 care la om este specific exprimat\u0103 \u00een tractul genital masculin (epididim) \u015fi joac\u0103 un rol important\u00a0\u00een protejarea membranelor spermatozoizilor de efectele nocive ale peroxid\u0103rii lipidice sau previne reac\u0163ia acrozomal\u0103 prematur\u01038<\/sup>.<\/span><\/p>\n

GPX5 \u015fi GPX6, identificate la mamifere, sunt \u00eenrudite cu GPX3, dar GPX5 nu con\u0163ine seleniu la nivelul situsului activ.<\/span><\/p>\n

GPX6 a fost identificat la oameni \u015fi porcine \u015fi se g\u0103se\u015fte la nivelul epiteliului olfactiv, fiind o enzim\u0103 dependent\u0103 de seleniu.<\/span><\/p>\n

Mai recent, o nou\u0103 fosfolipid hidroperoxid glutation peroxidaz\u0103 (PHGPx), care con\u0163ine cistein\u0103 la nivelul domeniului catalitic, a fost descris\u0103 la mamifere. Aceast\u0103 nonseleno-cisteina denumit\u0103 \u015fi NPGPx corespunde grupului 7 de GPX descris la mamifere. Are o mas\u0103 molecular\u0103 de aproximativ 22 kDa \u015fi o activitate enzimatic\u0103 redus\u0103 in vitro<\/em>. Expresia PHGPx a fost confirmat\u0103 \u00een multe \u0163esuturi, inclusiv\u00a0\u00een glanda mamar\u0103 \u00een curs de dezvoltare. NPGPx joac\u0103 un rol esen\u0163ial\u00a0\u00een cancerul de s\u00e2n, reduc\u00e2nd\u00a0\u00een celulele tumorale stresul oxidativ generat din metabolismul acizilor gra\u015fi polinesatura\u0163i. Expresia crescut\u0103 a NPGPx\u00a0\u00een celulele tumorale determin\u0103 rezisten\u0163\u0103 la moartea celular\u0103 indus\u0103 de acidul eicosapentanoic7<\/sup>.<\/span><\/p>\n

Recomand\u0103ri pentru determinarea glutation peroxidazei <\/em><\/strong>- \u00a0<\/strong><\/em>evaluarea stresului oxidativ2;4<\/sup>.<\/span><\/p>\n

Preg\u0103tire pacient <\/em><\/strong>\u2013 preferabil \u00e0 jeun (pe nem\u00e2ncate)4<\/sup>.<\/span><\/p>\n

Specimen recoltat <\/em><\/strong>\u2013 s\u00e2nge venos4<\/sup>.<\/span><\/p>\n

Recipient de recoltare <\/em><\/strong>\u2013 vacutainer s\u00e2nge EDTA4<\/sup>.<\/span><\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare<\/em><\/strong> \u2013 proba nu<\/strong> se centrifugheaz\u0103 \u015fi se men\u0163ine refrigerat\u0103.<\/span><\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 1 mL s\u00e2nge4<\/sup>.<\/span><\/p>\n

Cauze de respingere a probei <\/em><\/strong>\u2013 specimen coagulat sau intens hemolizat4<\/sup>.<\/span><\/p>\n

Stabilitate prob\u0103<\/em><\/strong> \u2013 s\u00e2ngele este stabil 1 lun\u0103 <\/em>la 2-4\u00b0C4<\/sup>. <\/span><\/p>\n

Metod\u0103<\/em><\/strong> - fotometric\u0103<\/span>; este analizat\u0103 activitatea enzimatic\u0103 \u00een eritrocite4<\/sup>.<\/span><\/p>\n

Valori de referin\u0163\u0103 <\/em><\/strong>- <\/em>4171 \u2013 10881 U\/L4<\/sup>.<\/span><\/p>\n

Interpretarea rezultatelor<\/em><\/strong><\/span><\/p>\n

Sc\u0103derea concentra\u0163iilor de glutation peroxidaz\u0103 se \u00eent\u00e2lne\u015fte\u00a0\u00een deficitul de seleniu, boli coronariene, beta-talasemie, diabet \u015fi dializ\u0103<\/span>4<\/sup>.<\/span><\/p>\n

\u00a0<\/span>\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Antje Banning, Anna Kipp, Stephanie Schmitmeier, Maria L\u00f6winger, Simone Florian, Susanne Krehl, Sophie Thalmann, Rene Thierbach, Pablo Steinberg and Regina Brigelius-Flohe. Glutathione Peroxidase Inhibits Cyclooxygenase-2\u2013Mediated Migration and Invasion of HT-29 Adenocarcinoma Cells but Supports Their Growth as Tumors in Nude Mice. In Cancer Res 68:9746-9753, 2008.<\/span><\/div>\n
2. Guoyao Wu, Yun-Zhong Fang, Sheng Yang, Joanne R. Lupton, and Nancy D. Turner. Glutathione Metabolism and Its Implications for Health. In J. Nutr. 134: 489\u2013492, 2004.<\/span><\/div>\n
3. Hanyu Liang, Si-Eun Yoo, Ren Na, Christi Walter, Arlan Richardson and Qitao Ran. The distinct in vivo roles of the long-form and short-form of glutathione peroxidase 4: the short-form is essential for somatic cell functions and the long-form is important for male fertility. In The FASEB Journal, 2009<\/span><\/div>\n
4. Laborator Synevo. Referin\u0163e specifice tehnologiei de lucru utilizate 2011. Ref Type: Catalog.<\/span><\/div>\n
5. Paul Lewis, Nada Stefanovic, Josefa Pete, Anna C. Calkin, Sara Giunti, Vicki, Thallas-Bonke, Karin A. Jandeleit-Dahm, Terri J. Allen, Ismail Kola, Mark E. Cooper, and Judy B. de Haan. Lack of the Antioxidant Enzyme Glutathione Peroxidase-1 Accelerates Atherosclerosis in Diabetic Apolipoprotein E\u2013Deficient Mice. In Circulation, 115:2178-2187, 2007<\/span><\/div>\n
6. Paula Drosescu, medic primar Medicina Sportiva Universitatea \u201cAl.I.Cuza\u201d Iasi Facultatea de Educatie Fizica si Sport. Importanta antioxidantilor in sanatate.<\/span><\/div>\n
7. Rogerio Margis, Christophe Dunand, Felipe K. Teixeira, and Marcia Margis-Pinheiro. Glutathione peroxidase family \u2013 an evolutionary overview. In FEBS Journal 275:3959\u20133970, 2008<\/span><\/div>\n
8. Talmud PJ, Drenos F, Shah S, et al. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. In Am. J. Hum. Genet. 85 (5): 628\u201342,.2009.<\/span><\/div>\n
9. www.alpco.com\/pdfs\/44\/44-GPXHU-E01.pdf<\/span><\/div>\n
10. www.genovadiagnostics.com\/files\/profile_assets\/referenced_materials\/oxstress2_supportguide.pdf<\/a>.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

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\u041a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u0430\u044f \u043e\u0446\u0435\u043d\u043a\u0430 \u0444\u0435\u0440\u043c\u0435\u043d\u0442\u0430 \u0433\u043b\u0443\u0442\u0430\u0442\u0438\u043e\u043d\u043f\u0435\u0440\u043e\u043a\u0441\u0438\u0434\u0430\u0437\u044b \u043e\u0441\u0443\u0449\u0435\u0441\u0442\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043c\u0435\u0442\u043e\u0434\u043e\u043c \u0432\u044b\u0441\u043e\u043a\u043e\u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0439 \u0436\u0438\u0434\u043a\u043e\u0441\u0442\u043d\u043e\u0439 \u0445\u0440\u043e\u043c\u0430\u0442\u043e\u0433\u0440\u0430\u0444\u0438\u0438. \u0410\u043d\u0430\u043b\u0438\u0437\u0443 \u043f\u043e\u0434\u0432\u0435\u0440\u0433\u0430\u044e\u0442\u0441\u044f \u044d\u0440\u0438\u0442\u0440\u043e\u0446\u0438\u0442\u044b \u043e\u0431\u0440\u0430\u0437\u0446\u0430 \u0432\u0435\u043d\u043e\u0437\u043d\u043e\u0439 \u043a\u0440\u043e\u0432\u0438, \u0438\u0437 \u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u043f\u0443\u0442\u0435\u043c \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u0438\u044f \u0441\u043b\u043e\u0436\u043d\u044b\u0445 \u0440\u0435\u0430\u043a\u0446\u0438\u0439 \u043d\u0430 \u043e\u0441\u043d\u043e\u0432\u0430\u043d\u0438\u0438 \u0444\u0438\u0437\u0438\u043a\u043e-\u0445\u0438\u043c\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0441\u0432\u043e\u0439\u0441\u0442\u0432 \u0432\u044b\u0434\u0435\u043b\u044f\u0435\u0442\u0441\u044f \u043d\u0443\u0436\u043d\u044b\u0439 \u0444\u0435\u0440\u043c\u0435\u043d\u0442. \u0417\u0430\u0442\u0435\u043c \u043f\u0440\u043e\u0438\u0441\u0445\u043e\u0434\u0438\u0442 \u043c\u0430\u0442\u0435\u043c\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043e\u0431\u0440\u0430\u0431\u043e\u0442\u043a\u0430 \u0435\u0433\u043e \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u0441\u043e\u0434\u0435\u0440\u0436\u0430\u043d\u0438\u044f \u0432 \u0415\u0434\/\u043b. \u041f\u043e\u043b\u0443\u0447\u0435\u043d\u043d\u044b\u0435 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u044e\u0442 \u0434\u0430\u0442\u044c \u043e\u0442\u0432\u0435\u0442 \u043d\u0430 \u0432\u043e\u043f\u0440\u043e\u0441 \u043e \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0439, \u0438\u0437\u0431\u044b\u0442\u043e\u0447\u043d\u043e\u0439 \u0438\u043b\u0438 \u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u043e\u0439 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 \u0433\u043b\u0443\u0442\u0430\u0442\u0438\u043e\u043d\u043f\u0435\u0440\u043e\u043a\u0441\u0438\u0434\u0430\u0437\u044b \u0432 \u043a\u043b\u0435\u0442\u043a\u0430\u0445 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430 \u0432 \u0446\u0435\u043b\u043e\u043c. \u0414\u043b\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u0432\u044b\u0431\u0440\u0430\u043d \u0430\u043d\u0430\u043b\u0438\u0437 \u0438\u043c\u0435\u043d\u043d\u043e \u044d\u0440\u0438\u0442\u0440\u043e\u0446\u0438\u0442\u043e\u0432 \u0432\u0441\u043b\u0435\u0434\u0441\u0442\u0432\u0438\u0435 \u0442\u043e\u0433\u043e, \u0447\u0442\u043e \u043f\u043e \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u0430\u043c \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u044b\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439 \u0438\u0437\u0432\u0435\u0441\u0442\u043d\u043e, \u0447\u0442\u043e \u0433\u043b\u0443\u0442\u0430\u0442\u0438\u043e\u043d\u043f\u0435\u0440\u043e\u043a\u0441\u0438\u0434\u0430\u0437\u0430 \u0432 \u043d\u0430\u0438\u0431\u043e\u043b\u044c\u0448\u0435\u043c \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0435 \u0441\u043e\u0434\u0435\u0440\u0436\u0438\u0442\u0441\u044f \u0432 \u043d\u0438\u0445, \u0430 \u0442\u0430\u043a\u0436\u0435 \u0432 \u043f\u0435\u0447\u0435\u043d\u0438 \u0438 \u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u0430\u0445, \u043d\u0438\u0436\u043d\u0438\u0445 \u043e\u0442\u0434\u0435\u043b\u0430\u0445 \u0434\u044b\u0445\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u043f\u0443\u0442\u0435\u0439.<\/p>\n

\u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f \u043f\u043e\u043b\u0443\u0447\u0435\u043d\u043d\u043e\u0433\u043e \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u0430 \u043e\u0441\u0443\u0449\u0435\u0441\u0442\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0442\u043e\u043b\u044c\u043a\u043e \u0432\u0440\u0430\u0447\u043e\u043c \u043d\u0430 \u043e\u0441\u043d\u043e\u0432\u0430\u043d\u0438\u0438 \u0432\u0441\u0435\u0445 \u0438\u043c\u0435\u044e\u0449\u0438\u0445\u0441\u044f \u0434\u0430\u043d\u043d\u044b\u0445 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043a\u0430\u0440\u0442\u0438\u043d\u044b, \u0430\u043d\u0430\u043c\u043d\u0435\u0437\u0430 \u0438 \u0441\u0432\u0435\u0434\u0435\u043d\u0438\u0439 \u0434\u0440\u0443\u0433\u0438\u0445 \u043c\u0435\u0442\u043e\u0434\u043e\u0432 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/p>\n

\u0414\u043b\u044f \u0447\u0435\u0433\u043e \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435?<\/strong><\/p>\n

    \n
  • \u0414\u043b\u044f \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u0430\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043d\u043e\u0433\u043e \u0441\u0442\u0430\u0442\u0443\u0441\u0430 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430.<\/li>\n
  • \u0414\u043b\u044f \u043e\u0446\u0435\u043d\u043a\u0438 \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u044f \u0430\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043d\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b \u043f\u0440\u0438 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445, \u0430\u0441\u0441\u043e\u0446\u0438\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u0441\u043e \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u0435\u043c \u0435\u0435 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438.<\/li>\n
  • \u0414\u043b\u044f \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u0431\u0430\u043b\u0430\u043d\u0441\u0430 \u043c\u0438\u043a\u0440\u043e\u044d\u043b\u0435\u043c\u0435\u043d\u0442\u043e\u0432 \u0438 \u0432\u0438\u0442\u0430\u043c\u0438\u043d\u043e\u0432, \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u044b\u0445 \u0434\u043b\u044f \u0440\u0430\u0431\u043e\u0442\u044b \u0430\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043d\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b.<\/li>\n
  • \u0414\u043b\u044f \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 \u0444\u0435\u0440\u043c\u0435\u043d\u0442\u0430\u0442\u0438\u0432\u043d\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b.<\/li>\n
  • \u0412 \u0446\u0435\u043b\u044f\u0445 \u043e\u0446\u0435\u043d\u043a\u0438 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u043a\u0443\u0440\u0441\u0430 \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u043c\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438.<\/li>\n<\/ul>\n

    \u041a\u043e\u0433\u0434\u0430 \u043d\u0430\u0437\u043d\u0430\u0447\u0430\u0435\u0442\u0441\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435?<\/strong><\/p>\n

      \n
    • \u041f\u0440\u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u0430\u0445 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u0440\u0430\u0431\u043e\u0442\u044b \u0430\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043d\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b.<\/li>\n
    • \u041f\u0440\u0438 \u0430\u0441\u0441\u043e\u0446\u0438\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u0441 \u0430\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043d\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u043e\u0439 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445: \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u043e\u0439 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438, \u0430\u043d\u0435\u043c\u0438\u0438, \u0441\u0430\u0445\u0430\u0440\u043d\u043e\u043c \u0434\u0438\u0430\u0431\u0435\u0442\u0435, \u043e\u043d\u043a\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043d\u043e\u0432\u043e\u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044f\u0445, \u043d\u0435\u0439\u0440\u043e\u0434\u0435\u0433\u0435\u043d\u0435\u0440\u0430\u0442\u0438\u0432\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445 \u0438 \u0434\u0440.<\/li>\n
    • \u041f\u0440\u0438 \u0434\u0435\u0444\u0438\u0446\u0438\u0442\u0435 \u0441\u0435\u043b\u0435\u043d\u0430 \u0432 \u0441\u043e\u0441\u0442\u0430\u0432\u0435 \u043f\u043e\u0441\u0442\u0443\u043f\u0430\u044e\u0449\u0435\u0439 \u0432 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c \u043f\u0438\u0449\u0438.<\/li>\n
    • \u041f\u0440\u0438 \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445 \u0444\u0435\u0440\u043c\u0435\u043d\u0442\u043d\u044b\u0445 \u0441\u0438\u0441\u0442\u0435\u043c.<\/li>\n
    • \u041f\u0440\u0438 \u043e\u043a\u043e\u043d\u0447\u0430\u043d\u0438\u0438 \u043a\u0443\u0440\u0441\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0434\u043b\u044f \u043e\u0446\u0435\u043d\u043a\u0438 \u0435\u0435 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438.<\/li>\n<\/ul>\n

      \u041a\u0430\u043a \u043f\u0440\u0430\u0432\u0438\u043b\u044c\u043d\u043e \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u0438\u0442\u044c\u0441\u044f \u043a \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044e?<\/strong><\/p>\n

        \n
      • \u0414\u0435\u0442\u044f\u043c \u0432 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0435 \u0434\u043e 1 \u0433\u043e\u0434\u0430 \u043d\u0435 \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0442\u044c \u043f\u0438\u0449\u0443 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 30-40 \u043c\u0438\u043d\u0443\u0442 \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/li>\n
      • \u041d\u0435 \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0442\u044c \u043f\u0438\u0449\u0443 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 2-3 \u0447\u0430\u0441\u043e\u0432 \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f, \u043c\u043e\u0436\u043d\u043e \u043f\u0438\u0442\u044c \u0447\u0438\u0441\u0442\u0443\u044e \u043d\u0435\u0433\u0430\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u0443\u044e \u0432\u043e\u0434\u0443.<\/li>\n
      • \u041d\u0435 \u043a\u0443\u0440\u0438\u0442\u044c \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 30 \u043c\u0438\u043d\u0443\u0442 \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/li>\n<\/ul>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[959],"product_tag":[],"class_list":{"0":"post-10298","1":"product","2":"type-product","3":"status-publish","5":"product_cat-vitamine-oligoelemente-stres-oxidativ","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10298","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10298"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10298"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10298"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10298"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10298"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}