{"id":10261,"date":"2020-04-23T04:01:14","date_gmt":"2020-04-23T01:01:14","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/interferon-gamma\/"},"modified":"2025-02-06T11:26:58","modified_gmt":"2025-02-06T09:26:58","slug":"interferon-gamma","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/interferon-gamma\/","title":{"rendered":"\u0418\u043d\u0442\u0435\u0440\u0444\u0435\u0440\u043e\u043d \u0433\u0430\u043c\u043c\u0430"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n

Interferonul gamma (IFN\u03b3), considerat principala citokin\u0103 responsabil\u0103 de imunitatea mediat\u0103 celular, este un activator major al macrofagelor7;10<\/sup>.<\/p>\n

Receptorul specific pentru IFN\u03b3 se afl\u0103 \u00een special pe suprafa\u0163a macrofagelor, celulelor NK (engl. natural killer<\/em>)10<\/sup>. Din punct de vedere structural, acest receptor apar\u0163ine superfamiliei receptorilor citokinici (de tip interferon); este un heterodimer compus din 2 subunit\u0103\u0163i, IFNGR1 \u015fi IFNGR2 (sau IFN\u03b3R\u03b1 \u015fi IFN\u03b3R\u03b2). Muta\u0163ii ale genelor ce codific\u0103 subunit\u0103\u0163ile IFNGR1 \u015fi IFNGR2 sunt responsabile de susceptibilitatea crescut\u0103 la infec\u0163ii cu mycobacterii \u015fi Salmonella10<\/sup>.<\/p>\n

Citokina IFN\u03b3 este o protein\u0103 homodimeric\u0103 format\u0103 din 143 aminoacizi, cu o greutate molecular\u0103 de 40-70 kDa9<\/sup>.<\/p>\n

IFN\u03b3 este produs \u00een principal de c\u0103tre limfocitele T helper de tip 1 (ca r\u0103spuns la stimularea antigenic\u0103 \u015fi mitogen\u0103), de celulele NK (consecutiv ac\u0163iunii IL-2, anticorpilor anti-CD16 \u015fi \u00een prezen\u0163a macrofagelor) \u015fi de celulele T citotoxice7;9;10<\/sup>.<\/p>\n

IFN\u03b3 mediaz\u0103 cre\u015fterea expresiei moleculelor de histocompatibilitate (MHC) de clas\u0103 I \u015fi II. IFN\u03b3 stimuleaz\u0103 \u00een principal prezentarea antigenului \u015fi produc\u0163ia de citokine a monocitelor, precum \u015fi celelalte func\u0163ii efectoare ale acestor celule: aderen\u0163a, fagocitoza, secre\u0163ia, arderile respiratorii \u015fi produc\u0163ia de NO (monoxid de azot). Astfel, IFN\u03b3 favorizeaz\u0103 acumularea macrofagelor la nivelul situsului r\u0103spunsului imun celular precum \u015fi abilitatea acestora de a distruge microorganismele intracelulare7;9;10<\/sup>. De asemenea IFN\u03b3 stimuleaz\u0103 \u015fi capacitatea altor celule de a distruge microorganisme, precum a celulelor NK \u015fi a neutrofilelor7<\/sup>. Asem\u0103n\u0103tor celorlal\u0163i interferoni (\u00een special INF\u03b1 \u015fi IFN\u03b2) inhib\u0103 replicarea viral\u01037;10<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea <\/em><\/strong>IFN\u03b3<\/em><\/strong>\u00a0<\/em><\/strong><\/p>\n

Nivelele cantitative ale IFN\u03b3 determinate \u00een diverse lichide biologice pot fi utilizate \u00een diagnosticarea unor afec\u0163iuni imune \u015fi \u00een monitorizarea tratamentelor, doar \u00een corela\u0163ie cu date clinice \u015fi paraclinice complementare. Deocamdat\u0103 nu sunt suficiente informa\u0163ii de ordin statistic necesare stabilirii indica\u0163iilor specifice ale determin\u0103rilor serice ale IFN\u03b3.<\/p>\n

Preg\u0103tire pacient <\/em><\/strong>\u2013 \u00e0 jeun (pe nem\u00e2ncate) sau postprandial6<\/sup>.<\/p>\n

Specimen recoltat <\/em><\/strong>\u2013 s\u00e2nge venos6<\/sup>.<\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator6<\/sup>.<\/p>\n

Cantitate recoltat\u0103 <\/em><\/strong>- <\/em>minim 0.5 mL ser6<\/sup>.<\/p>\n

Cauze de respingere a probei<\/em><\/strong> \u2013 specimen intens hemolizat, icteric, lipemic sau contaminat bacterian; probe care nu au sosit la laborator congelate6<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>- <\/em>se separ\u0103 serul prin centrifugare c\u00e2t mai repede dup\u0103 formarea complet\u0103 a coagulului, iar proba va fi imediat congelat\u0103 la -20\u00b0C; probele recoltate \u00een afara punctelor laboratorului vor fi transportate \u00een recipientul destinat probelor congelate6<\/sup>.<\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>- <\/em>serul este stabil 1 lun\u0103<\/em> la -20\u00b0C; nu decongela\u0163i\/recongela\u0163i6<\/sup>.<\/p>\n

Metod\u0103<\/em><\/strong> - EIA<\/span>6<\/sup>.<\/p>\n

Valori de referin\u0163\u0103 <\/em><\/strong>- <\/em>< 0.1 UI\/mL6<\/sup>.<\/p>\n

Interpretarea rezultatelor<\/em><\/strong><\/p>\n

Niveluri crescute ale marker-ului se \u00eent\u00e2lnesc \u00een:<\/p>\n

\u2013 artrita idiopatic\u0103 juvenil\u01038<\/sup>;<\/div>\n
\u2013 hepatita cronic\u0103 cu virus hepatic C (VHC), constat\u00e2ndu-se valori mai mari \u00een cazul asocierii consumului de alcool4<\/sup>;<\/div>\n
\u2013 rejetul de gref\u0103 (faza acut\u0103)2<\/sup>;<\/div>\n
\u2013 boala celiac\u01033<\/sup>;<\/div>\n
\u2013 boala Wilson5<\/sup>;<\/div>\n
\u2013 diabet zaharat de tip I (evolutiv)1<\/sup>.<\/div>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/strong><\/span><\/p>\n

1. Alizadeh B. Z., Hanifi-Moghaddam P., Eerligh P. et al, \u201cAssociation of interferong and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes\u201d, Clinical and Experimental Immunology. 2006; 145: 480\u2013484.<\/span><\/span><\/div>\n
2. Atalar K, Afzali B, Lord G et al, \u201cRelative roles of Th1 and Th17 effector cells in allograft rejection\u201d, Curr Opin Organ Transplant. 2009 Feb;14(1):23-9.<\/span><\/div>\n
3. Bergamaschi G., Markopoulos K., Albertini R. et al, \u201cAnemia of chronic disease and defective erythropoietin production in patients with celiac disease\u201c, Haematologica. 2008; 93(12): 1785-91.<\/span><\/div>\n
4. Castellano-Higuera Ana, Gonzalez -Reimers E., Aleman-Valls M. R. et al, \u201cCytokines and lipid peroxidation in alcoholics with chronic hepatitis C virus infection\u201d, Alcohol & Alcoholism. 2008; 43 (2):137\u2013142.<\/span><\/div>\n
5. Goyal M. K., Sinha S., Patil S. A. et al, \u201cDo cytokines have any role in Wilson\u2019s disease?\u201d, Clinical and Experimental Immunology. 2008; 154: 74\u201379.<\/span><\/div>\n
6. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog.<\/span><\/div>\n
7. N. Franklin Adkinson JR, Bruce S. Bocher. Cytokines in allergic inflammation. In Middleton\u2019s Allergy, Principles and Practice \u2013 Mosby Elsevier 7th-Ed 2008, 169.<\/span><\/div>\n
8. Prahalad S., Martins T. B., Tebo Anne E, \u201cElevated serum levels of soluble CD154 in children with juvenile idiopathic arthritis\u201d, Pediatric Rheumatology. 2008, 6:8.<\/span><\/div>\n
9. Richard A. McPetersen, Matthew R. Pincus. Immunology and immunopathology. In Henry\u2019s Clinical Diagnosis and Management by Laboratory Methods- Sauders Elsevier 21st-Ed 2007, 867.<\/span><\/div>\n
10. Robert R. Rich, Thomas A. Fleisher. Cytokines and cytokines receptors. In Clinical Immunology, Principles and Practice\u2013 Mosby Elsevier 3rd-Ed 2008, 143-149.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u0418\u043d\u0442\u0435\u0440\u0444\u0435\u0440\u043e\u043d \u0433\u0430\u043c\u043c\u0430 (IFN\u03b3), \u0441\u0447\u0438\u0442\u0430\u044e\u0449\u0438\u0439\u0441\u044f \u043e\u0441\u043d\u043e\u0432\u043d\u044b\u043c \u0446\u0438\u0442\u043e\u043a\u0438\u043d\u043e\u043c, \u043e\u0442\u0432\u0435\u0442\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u043c \u0437\u0430 \u043a\u043b\u0435\u0442\u043e\u0447\u043d\u044b\u0439 \u0438\u043c\u043c\u0443\u043d\u0438\u0442\u0435\u0442, \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043e\u0441\u043d\u043e\u0432\u043d\u044b\u043c \u0430\u043a\u0442\u0438\u0432\u0430\u0442\u043e\u0440\u043e\u043c \u043c\u0430\u043a\u0440\u043e\u0444\u0430\u0433\u043e\u0432 7; 10.<\/p>\n

\u0421\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440 \u0434\u043b\u044f IFN\u03b3 \u043d\u0430\u0445\u043e\u0434\u0438\u0442\u0441\u044f \u0432 \u043e\u0441\u043d\u043e\u0432\u043d\u043e\u043c \u043d\u0430 \u043f\u043e\u0432\u0435\u0440\u0445\u043d\u043e\u0441\u0442\u0438 \u043c\u0430\u043a\u0440\u043e\u0444\u0430\u0433\u043e\u0432 NK-\u043a\u043b\u0435\u0442\u043e\u043a (\u0435\u0441\u0442\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u043a\u0438\u043b\u043b\u0435\u0440\u043e\u0432) 10. \u0421\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u043d\u043e \u044d\u0442\u043e\u0442 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440 \u043f\u0440\u0438\u043d\u0430\u0434\u043b\u0435\u0436\u0438\u0442 \u043a \u0441\u0443\u043f\u0435\u0440\u0441\u0435\u043c\u0435\u0439\u0441\u0442\u0432\u0443 \u0446\u0438\u0442\u043e\u043a\u0438\u043d\u043e\u0432\u044b\u0445 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u043e\u0432 (\u0442\u0438\u043f\u0430 \u0438\u043d\u0442\u0435\u0440\u0444\u0435\u0440\u043e\u043d\u0430); \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 \u0441\u043e\u0431\u043e\u0439 \u0433\u0435\u0442\u0435\u0440\u043e\u0434\u0438\u043c\u0435\u0440, \u0441\u043e\u0441\u0442\u043e\u044f\u0449\u0438\u0439 \u0438\u0437 2 \u0441\u0443\u0431\u044a\u0435\u0434\u0438\u043d\u0438\u0446, IFNGR1 \u0438 IFNGR2 (\u0438\u043b\u0438 IFN\u03b3R\u03b1 \u0438 IFN\u03b3R\u03b2). \u041c\u0443\u0442\u0430\u0446\u0438\u0438 \u0432 \u0433\u0435\u043d\u0430\u0445, \u043a\u043e\u0434\u0438\u0440\u0443\u044e\u0449\u0438\u0445 \u0441\u0443\u0431\u044a\u0435\u0434\u0438\u043d\u0438\u0446\u044b IFNGR1 \u0438 IFNGR2, \u043e\u0442\u0432\u0435\u0442\u0441\u0442\u0432\u0435\u043d\u043d\u044b \u0437\u0430 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u0443\u044e \u0432\u043e\u0441\u043f\u0440\u0438\u0438\u043c\u0447\u0438\u0432\u043e\u0441\u0442\u044c \u043a \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044f\u043c \u043c\u0438\u043a\u043e\u0431\u0430\u043a\u0442\u0435\u0440\u0438\u044f\u043c\u0438 \u0438 \u0441\u0430\u043b\u044c\u043c\u043e\u043d\u0435\u043b\u043b\u0430\u043c\u0438 10.<\/p>\n

\u0426\u0438\u0442\u043e\u043a\u0438\u043d IFN\u03b3 \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 \u0441\u043e\u0431\u043e\u0439 \u0433\u043e\u043c\u043e\u0434\u0438\u043c\u0435\u0440\u043d\u044b\u0439 \u0431\u0435\u043b\u043e\u043a, \u0441\u043e\u0441\u0442\u043e\u044f\u0449\u0438\u0439 \u0438\u0437 143 \u0430\u043c\u0438\u043d\u043e\u043a\u0438\u0441\u043b\u043e\u0442, \u0441 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u043e\u0439 \u043c\u0430\u0441\u0441\u043e\u0439 40-70 \u043a\u0414\u0430 9.<\/p>\n

IFN\u03b3 \u043f\u0440\u043e\u0434\u0443\u0446\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u0433\u043b\u0430\u0432\u043d\u044b\u043c \u043e\u0431\u0440\u0430\u0437\u043e\u043c \u0445\u0435\u043b\u043f\u0435\u0440\u043d\u044b\u043c\u0438 T-\u043b\u0438\u043c\u0444\u043e\u0446\u0438\u0442\u0430\u043c\u0438 \u0442\u0438\u043f\u0430 1 (\u0432 \u043e\u0442\u0432\u0435\u0442 \u043d\u0430 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u043d\u0443\u044e \u0438 \u043c\u0438\u0442\u043e\u0433\u0435\u043d\u043d\u0443\u044e \u0441\u0442\u0438\u043c\u0443\u043b\u044f\u0446\u0438\u044e), NK-\u043a\u043b\u0435\u0442\u043a\u0430\u043c\u0438 (\u043f\u043e\u0434 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u043c IL-2, \u0430\u043d\u0442\u0438-CD16-\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430\u043c\u0438 \u0438 \u0432 \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0438 \u043c\u0430\u043a\u0440\u043e\u0444\u0430\u0433\u043e\u0432) \u0438 \u0446\u0438\u0442\u043e\u0442\u043e\u043a\u0441\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438 \u0422-\u043a\u043b\u0435\u0442\u043a\u0430\u043c\u0438 7; 9; 10.<\/p>\n

IFN\u03b3 \u043e\u043f\u043e\u0441\u0440\u0435\u0434\u0443\u0435\u0442 \u0443\u0432\u0435\u043b\u0438\u0447\u0435\u043d\u0438\u0435 \u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u0438 \u043c\u043e\u043b\u0435\u043a\u0443\u043b \u0433\u0438\u0441\u0442\u043e\u0441\u043e\u0432\u043c\u0435\u0441\u0442\u0438\u043c\u043e\u0441\u0442\u0438 \u043a\u043b\u0430\u0441\u0441\u043e\u0432 I \u0438 II (\u041c\u041d\u0421). IFN\u03b3 \u0433\u043b\u0430\u0432\u043d\u044b\u043c \u043e\u0431\u0440\u0430\u0437\u043e\u043c \u0441\u0442\u0438\u043c\u0443\u043b\u0438\u0440\u0443\u0435\u0442 \u043f\u0440\u0435\u0437\u0435\u043d\u0442\u0430\u0446\u0438\u044e \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430 \u0438 \u0432\u044b\u0440\u0430\u0431\u043e\u0442\u043a\u0443 \u0446\u0438\u0442\u043e\u043a\u0438\u043d\u043e\u0432 \u043c\u043e\u043d\u043e\u0446\u0438\u0442\u0430\u043c\u0438, \u0430 \u0442\u0430\u043a\u0436\u0435 \u0434\u0440\u0443\u0433\u0438\u0435 \u044d\u0444\u0444\u0435\u043a\u0442\u043e\u0440\u043d\u044b\u0435 \u0444\u0443\u043d\u043a\u0446\u0438\u0438 \u044d\u0442\u0438\u0445 \u043a\u043b\u0435\u0442\u043e\u043a: \u0430\u0434\u0433\u0435\u0437\u0438\u044e, \u0444\u0430\u0433\u043e\u0446\u0438\u0442\u043e\u0437, \u0441\u0435\u043a\u0440\u0435\u0446\u0438\u044e, \u0440\u0435\u0441\u043f\u0438\u0440\u0430\u0442\u043e\u0440\u043d\u044b\u0435 \u043e\u0436\u043e\u0433\u0438 \u0438 \u0432\u044b\u0440\u0430\u0431\u043e\u0442\u043a\u0443 NO (\u043c\u043e\u043d\u043e\u043e\u043a\u0441\u0438\u0434\u0430 \u0430\u0437\u043e\u0442\u0430). \u0422\u0430\u043a\u0438\u043c \u043e\u0431\u0440\u0430\u0437\u043e\u043c, IFN\u03b3 \u0441\u043f\u043e\u0441\u043e\u0431\u0441\u0442\u0432\u0443\u0435\u0442 \u043d\u0430\u043a\u043e\u043f\u043b\u0435\u043d\u0438\u044e \u043c\u0430\u043a\u0440\u043e\u0444\u0430\u0433\u043e\u0432 \u0432 \u043c\u0435\u0441\u0442\u0435 \u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0433\u043e \u043e\u0442\u0432\u0435\u0442\u0430, \u0430 \u0442\u0430\u043a\u0436\u0435 \u0438\u0445 \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u043e\u0441\u0442\u0438 \u0443\u043d\u0438\u0447\u0442\u043e\u0436\u0430\u0442\u044c \u0432\u043d\u0443\u0442\u0440\u0438\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u044b\u0435 \u043c\u0438\u043a\u0440\u043e\u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u044b 7; 9; 10. IFN\u03b3 \u0442\u0430\u043a\u0436\u0435 \u0441\u0442\u0438\u043c\u0443\u043b\u0438\u0440\u0443\u0435\u0442 \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u043e\u0441\u0442\u044c \u0434\u0440\u0443\u0433\u0438\u0445 \u043a\u043b\u0435\u0442\u043e\u043a \u0440\u0430\u0437\u0440\u0443\u0448\u0430\u0442\u044c \u043c\u0438\u043a\u0440\u043e\u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u044b, \u0442\u0430\u043a\u0438\u0435 \u043a\u0430\u043a NK-\u043a\u043b\u0435\u0442\u043a\u0438 \u0438 \u043d\u0435\u0439\u0442\u0440\u043e\u0444\u0438\u043b\u044b 7. \u041a\u0430\u043a \u0438 \u0434\u0440\u0443\u0433\u0438\u0435 \u0438\u043d\u0442\u0435\u0440\u0444\u0435\u0440\u043e\u043d\u044b (\u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e INF\u03b1 \u0438 IFN\u03b2), \u043e\u043d \u0438\u043d\u0433\u0438\u0431\u0438\u0440\u0443\u0435\u0442 \u0440\u0435\u043f\u043b\u0438\u043a\u0430\u0446\u0438\u044e \u0432\u0438\u0440\u0443\u0441\u0430 7; 10.<\/p>\n

\u0420\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u043f\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044e IFN\u03b3<\/strong><\/p>\n

\u041a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0435 \u0443\u0440\u043e\u0432\u043d\u0438 IFN\u03b3, \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u043d\u044b\u0435 \u0432 \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u044b\u0445 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0436\u0438\u0434\u043a\u043e\u0441\u0442\u044f\u0445, \u043c\u043e\u0433\u0443\u0442 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u0442\u044c\u0441\u044f \u0434\u043b\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0445 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0439 \u0438 \u0434\u043b\u044f \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0442\u043e\u043b\u044c\u043a\u043e \u0432 \u0441\u043e\u0447\u0435\u0442\u0430\u043d\u0438\u0438 \u0441 \u0434\u043e\u043f\u043e\u043b\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u043c\u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438 \u0438 \u043f\u0430\u0440\u0430\u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438 \u0434\u0430\u043d\u043d\u044b\u043c\u0438. \u0412 \u043d\u0430\u0441\u0442\u043e\u044f\u0449\u0435\u0435 \u0432\u0440\u0435\u043c\u044f \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e \u0441\u0442\u0430\u0442\u0438\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u0438, \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e\u0439 \u0434\u043b\u044f \u0443\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u0438\u044f \u043a\u043e\u043d\u043a\u0440\u0435\u0442\u043d\u044b\u0445 \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u0439 \u0434\u043b\u044f \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044f \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u0418\u0424\u041d\u03b3.<\/p>\n

\u041f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0430 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430<\/strong> – \u043d\u0430\u0442\u043e\u0449\u0430\u043a \u0438\u043b\u0438 \u043f\u043e\u0441\u043b\u0435 \u043f\u0440\u0438\u0435\u043c\u0430 \u043f\u0438\u0449\u0438 6.
\n\u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b<\/strong> – \u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c 6.
\n\u0422\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u0430\u044f \u0441\u0440\u0435\u0434\u0430, \u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0430<\/strong>– vacutainer \u0431\u0435\u0437 \u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430, \u0441 \/ \u0431\u0435\u0437 \u043e\u0442\u0434\u0435\u043b\u044f\u044e\u0449\u0435\u0433\u043e \u0433\u0435\u043b\u044f 6.
\n\u041e\u0431\u044a\u0435\u043c \u043e\u0431\u0440\u0430\u0437\u0446\u0430<\/strong> – \u043c\u0438\u043d\u0438\u043c\u0443\u043c 0,5 \u043c\u043b \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0438 6.
\n\u041f\u0440\u0438\u0447\u0438\u043d\u044b \u043e\u0442\u043a\u0430\u0437\u0430 \u043e\u0442 \u043f\u0440\u043e\u0431\u044b<\/strong>
\n– \u0441\u0438\u043b\u044c\u043d\u043e \u0433\u0435\u043c\u043e\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0439, \u0436\u0435\u043b\u0442\u0443\u0448\u043d\u044b\u0439, \u043b\u0438\u043f\u0435\u043c\u0438\u0447\u043d\u044b\u0439 \u0438\u043b\u0438 \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e \u0437\u0430\u0433\u0440\u044f\u0437\u043d\u0435\u043d\u043d\u044b\u0439 \u043e\u0431\u0440\u0430\u0437\u0435\u0446; \u043e\u0431\u0440\u0430\u0437\u0446\u044b, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u043d\u0435 \u043f\u043e\u0441\u0442\u0443\u043f\u0438\u043b\u0438 \u0432 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u0438\u044e, \u0437\u0430\u043c\u043e\u0440\u043e\u0436\u0435\u043d\u044b 6.<\/p>\n

\u041d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0430\u044f \u043e\u0431\u0440\u0430\u0431\u043e\u0442\u043a\u0430 \u043f\u043e\u0441\u043b\u0435 \u0441\u0431\u043e\u0440\u0430 \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430<\/strong> – \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0430 \u043e\u0442\u0434\u0435\u043b\u044f\u0435\u0442\u0441\u044f \u0446\u0435\u043d\u0442\u0440\u0438\u0444\u0443\u0433\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u043a\u0430\u043a \u043c\u043e\u0436\u043d\u043e \u0441\u043a\u043e\u0440\u0435\u0435 \u043f\u043e\u0441\u043b\u0435 \u043f\u043e\u043b\u043d\u043e\u0433\u043e \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044f \u0442\u0432\u043e\u0440\u043e\u0433\u0430, \u0438 \u043e\u0431\u0440\u0430\u0437\u0435\u0446 \u043d\u0435\u043c\u0435\u0434\u043b\u0435\u043d\u043d\u043e \u0437\u0430\u043c\u043e\u0440\u0430\u0436\u0438\u0432\u0430\u0435\u0442\u0441\u044f \u043f\u0440\u0438 -20 \u00b0 C; \u043e\u0431\u0440\u0430\u0437\u0446\u044b, \u0441\u043e\u0431\u0440\u0430\u043d\u043d\u044b\u0435 \u0432\u043d\u0435 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u044b\u0445 \u0442\u043e\u0447\u0435\u043a, \u0431\u0443\u0434\u0443\u0442 \u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0438\u0440\u043e\u0432\u0430\u0442\u044c\u0441\u044f \u0432 \u043a\u043e\u043d\u0442\u0435\u0439\u043d\u0435\u0440, \u043f\u0440\u0435\u0434\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u043d\u044b\u0439 \u0434\u043b\u044f \u0437\u0430\u043c\u043e\u0440\u043e\u0436\u0435\u043d\u043d\u044b\u0445 \u043e\u0431\u0440\u0430\u0437\u0446\u043e\u04326.
\n\u0421\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u043e\u0431\u0440\u0430\u0437\u0446\u0430<\/strong> – \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0430 \u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u0430 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 1 \u043c\u0435\u0441\u044f\u0446\u0430 \u043f\u0440\u0438 -20 \u00b0 \u0421; \u043d\u0435 \u0440\u0430\u0437\u043c\u043e\u0440\u0430\u0436\u0438\u0432\u0430\u0439\u0442\u0435 \/ \u0437\u0430\u043c\u043e\u0440\u0430\u0436\u0438\u0432\u0430\u0439\u0442\u0435 6.
\n\u041c\u0435\u0442\u043e\u0434<\/strong> – EIA6.<\/p>\n

\u0420\u0435\u0444\u0435\u0440\u0435\u043d\u0442\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f – <0,1 \u041c\u0415 \/ \u043c\u043b6.<\/p>\n

\u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/p>\n

\u041f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u0435 \u0443\u0440\u043e\u0432\u043d\u0438 \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u0432 \u043d\u0430\u0445\u043e\u0434\u044f\u0442\u0441\u044f \u0432:<\/p>\n

    \n
  • \u044e\u0432\u0435\u043d\u0438\u043b\u044c\u043d\u044b\u0439 \u0438\u0434\u0438\u043e\u043f\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u0440\u0442\u0440\u0438\u0442 8;<\/li>\n
  • \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0433\u0435\u043f\u0430\u0442\u0438\u0442 \u0441 \u0432\u0438\u0440\u0443\u0441\u043e\u043c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0421 (\u0412\u0413\u0421), \u043d\u0430\u0445\u043e\u0434\u044f\u0449\u0438\u0439 \u0431\u043e\u043b\u0435\u0435 \u0432\u044b\u0441\u043e\u043a\u0438\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f \u0432 \u0441\u043b\u0443\u0447\u0430\u0435 \u0430\u0441\u0441\u043e\u0446\u0438\u0430\u0446\u0438\u0438 \u043f\u043e\u0442\u0440\u0435\u0431\u043b\u0435\u043d\u0438\u044f \u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044f 4;<\/li>\n
  • \u043e\u0442\u0442\u043e\u0440\u0436\u0435\u043d\u0438\u0435 \u0442\u0440\u0430\u043d\u0441\u043f\u043b\u0430\u043d\u0442\u0430\u0442\u0430 (\u043e\u0441\u0442\u0440\u0430\u044f \u0444\u0430\u0437\u0430) 2;<\/li>\n
  • \u0446\u0435\u043b\u0438\u0430\u043a\u0438\u044f3;<\/li>\n
  • \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u0412\u0438\u043b\u044c\u0441\u043e\u043d\u0430 5;<\/li>\n
  • \u0434\u0438\u0430\u0431\u0435\u0442 I \u0442\u0438\u043f\u0430 (\u044d\u0432\u043e\u043b\u044e\u0446\u0438\u043e\u043d\u043d\u044b\u0439) 1.<\/li>\n<\/ul>\n

    \u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f
    \n1. Alizadeh B. Z., Hanifi-Moghaddam P., Eerligh P. et al, \u201cAssociation of interferong and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes\u201d, Clinical and Experimental Immunology. 2006; 145: 480\u2013484.
    \n2. Atalar K, Afzali B, Lord G et al, \u201cRelative roles of Th1 and Th17 effector cells in allograft rejection\u201d, Curr Opin Organ Transplant. 2009 Feb;14(1):23-9.
    \n3. Bergamaschi G., Markopoulos K., Albertini R. et al, \u201cAnemia of chronic disease and defective erythropoietin production in patients with celiac disease\u201c, Haematologica. 2008; 93(12): 1785-91.
    \n4. Castellano-Higuera Ana, Gonzalez -Reimers E., Aleman-Valls M. R. et al, \u201cCytokines and lipid peroxidation in alcoholics with chronic hepatitis C virus infection\u201d, Alcohol & Alcoholism. 2008; 43 (2):137\u2013142.
    \n5. Goyal M. K., Sinha S., Patil S. A. et al, \u201cDo cytokines have any role in Wilson\u2019s disease?\u201d, Clinical and Experimental Immunology. 2008; 154: 74\u201379.
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