{"id":10255,"date":"2020-04-23T04:01:03","date_gmt":"2020-04-23T01:01:03","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/progrp\/"},"modified":"2025-02-07T15:46:05","modified_gmt":"2025-02-07T13:46:05","slug":"progrp","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/progrp\/","title":{"rendered":"pro-GRP"},"content":{"rendered":"

Informa\u0163<\/em><\/strong>ii generale \u015fi recomand\u0103ri pentru determinarea <\/em><\/strong>pro-GRP<\/strong><\/span><\/p>\n

ProGRP este un precursor stabil al hormonului intestinal GRP (Gastrin Releasing Peptide <\/em>= peptidul care elibereaza gastrina). Astfel, neuropeptidul GRP, echivalentul la om al bombesinei amfibiene, este sintetizat ca un prohormon \u2013 proGRP \u2013 ce exist\u0103 \u00een 3 variante, cu 115, 118 \u015fi, respectiv, 125 aminoacizi. Regiunea proGRP-98 este comun\u0103 tutoror celor 3 variante, iar anticorpii \u00eendrepta\u0163i \u00eempotriva acestei secven\u0163e au fost folosi\u0163i \u00een dezvoltarea testelor care determin\u0103 proGRP \u00een ser.<\/span><\/p>\n

Niveluri crescute de proGRP au fost detectate\u00a0\u00een cancerul pulmonar cu celule mici (SCLC), av\u00e2nd o sensibilitate \u015fi specificitate \u00eenalt\u0103 pentru acest tip de tumor\u01034<\/sup>. Valorile ProGRP se coreleaz\u0103 cu extinderea tumorii; astfel s-a constatat c\u0103 \u00een cazurile de boal\u0103 limitat\u0103 sensibilitatea markerului este de 58.3%, pe c\u00e2nd\u00a0\u00een cele extinse sensibilitatea atinge 95.5%3<\/sup>.<\/span><\/p>\n

Studiile clinice au indicat c\u0103 proGRP \u015fi enolaza neuron-specific\u0103 (NSE) de\u0163in un rol complementar \u00een diagnosticul \u015fi prognosticul SCLC. Astfel, proGRP este mai sensibil dec\u00e2t NSE pentru diagnosticul SCLC (inclusiv\u00a0\u00een diferen\u0163ierea fa\u0163\u0103 de cancerul pulmonar altul dec\u00e2t cel cu celule mici),\u00a0\u00een timp ce NSE are valoare superioar\u0103 ca factor de prognostic5<\/sup>.<\/span><\/p>\n

Un studiu retrospectiv recent a analizat valoarea diagnostic\u0103 unic\u0103 \u015fi combinat\u0103 a marker-ilor CEA, Cyfra 21-1, NSE \u015fi ProGRP la 1747 pacien\u0163i cu tumori pulmonare de origine necunoscut\u0103. In total, 99.8% dintre pacien\u0163ii cu cancer pulmonar au eliberat cel pu\u0163in unul din cei 4 biomarkeri (la valori care au dep\u0103\u015fit mediana lotului de control); pentru diferen\u0163ierea afec\u0163iunilor pulmonare maligne de cele benigne, fiecare marker a atins o specificitate pentru tumori de 100% la valori crescute: CEA 20 ng\/mL, Cyfra 21-1 40 ng\/mL, NSE 45 ng\/mL, ProGRP 250 pg\/mL. La o specificitate de >99% ProGRP a atins cea mai \u00eenalta eficacitate diagnostic\u0103 pentru SCLC (valoare predictiv\u0103 pozitiv\u0103 57%), iar CEA a prezentat cea mai mare capacitate de a detecta tumori maligne\u00a0\u00een general (17%) \u015fi adenocarcinoame pulmonare\u00a0\u00een mod special (29%). Marker-ul Cyfra 21-1 a fost dominant pentru cancerul cu celule scuamoase (12%). Folosirea combinat\u0103 a celor 4 markeri a avut valoare predictiv\u0103 pozitiv\u0103 de 50% pentru tumorile pulmonare maligne, 44% pentru NSCLC, 36% pentru carcinoamele ce celule scuamoase, 53% pentru adenocarcinoame \u015fi, respectiv 78%, pentru SCLC. In concluzie, la pacien\u0163ii cu tumori pulmonare de origine necunoscut\u0103, folosirea combinat\u0103 a celor 4 markeri este util\u0103\u00a0\u00een diferen\u0163ierea proceselor maligne de cele benigne \u015fi a celor primare, de cele secundare1<\/sup>.<\/span><\/p>\n

Preg\u0103tire pacient <\/em><\/strong>- <\/em>\u00e0 jeun (pe nem\u00e2ncate) sau postprandial2<\/sup>.<\/span><\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c2<\/sup>.<\/span><\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator2<\/sup>.<\/span><\/p>\n

Cantitate recoltat\u0103 <\/em><\/strong>- <\/em>minim 0.5 mL ser2<\/sup>.<\/span><\/p>\n

Cauze de respingere a probei<\/em><\/strong> \u2013 specimen intens hemolizat, icteric, lipemic sau contaminat bacterian; probe care nu au sosit la laborator congelate; nu sunt acceptate probe de plasm\u01032<\/sup>.<\/span><\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>- <\/em>se separ\u0103 serul prin centrifugare c\u00e2t mai repede dup\u0103 formarea complet\u0103 a coagulului; dac\u0103 proba nu poate fi analizat\u0103 imediat va fi congelat\u0103 la -20\u00b0C; probele recoltate \u00een afara sediului laboratorului vor fi transportate\u00a0\u00een recipientul destinat probelor congelate2<\/sup>.<\/span><\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>- <\/em>serul este stabil 1 lun\u0103<\/em> la -20\u00b0C; nu decongela\u0163i\/recongela\u0163i2<\/sup>.<\/span><\/p>\n

Metod\u0103 <\/em><\/strong>- imunochimic\u0103 cu detec\u0163ie prin chemiluminiscen\u0163\u0103 (CLIA)<\/span>1<\/sup>.<\/span><\/p>\n

Valori de referin\u0163\u0103<\/em><\/strong>1<\/sup> \u2013 <30 ng\/mL.\u00a0\u00a0\u00a0\u00a0\u00a0<\/span><\/p>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/span><\/div>\n
Insuficien\u0163a renal\u0103 reprezint\u0103 sursa cea mai frecvent\u0103 de rezultate fals-pozitive, de aceea evaluarea func\u0163iei renale trebuie efectuat\u0103 obligatoriu \u00eenaintea determin\u0103rii ProGRP3<\/sup>.<\/span><\/div>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Christine Gruber et al. CEA, CYFRA 21-1, NSE, and ProGRP in the diagnosis of lung cancer: a multivariate approach \/ CEA, CYFRA 21-1, NSE und ProGRP in der Diagnostik des Lungenkarzinoms: eine multivariate Analyse. In Laboratoriums Medizn, . Volume 32, Issue 5, Pages 361\u2013371, 2008.<\/span><\/div>\n
2. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog.<\/span><\/div>\n
3. Rafael Molina, Jose M. Auge, Julian Alicarte, Xavier Filella, Nuria Vi\u00f1olas, Antonio M. Ballesta. Pro-Gastrin-Releasing Peptide in Patients with Benign and Malignant Diseases. In Tumor Biol 2004;25:56-61.<\/span><\/div>\n
4. Stieber P; Dienemann H; Schalhorn A; Schmitt U M; Reinmiedl J; Hofmann K; Yamaguchi K. Pro-gastrin-releasing peptide (ProGRP)\u2013a useful marker in small cell lung carcinomas. In Anticancer research 1999;19(4A):2673-8.<\/span><\/div>\n
5. T. Shibayama. Complementary roles of pro-gastrin-releasing peptide (ProGRP) and neuron specific enolase (NSE) in diagnosis and prognosis of small-cell lung cancer (SCLC). In Lung Cancer, Volume 32, Issue 1, Pages 61-69, 2001.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u0413\u0430\u0441\u0442\u0440\u0438\u043d-\u0432\u044b\u0441\u0432\u043e\u0431\u043e\u0436\u0434\u0430\u044e\u0449\u0438\u0439 \u043f\u0435\u043f\u0442\u0438\u0434 (GRP) – \u0433\u043e\u0440\u043c\u043e\u043d \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a\u0430, \u043f\u0435\u043f\u0442\u0438\u0434, \u0441\u043e\u0441\u0442\u043e\u044f\u0449\u0438\u0439 \u0438\u0437 27 \u0430\u043c\u0438\u043d\u043e\u043a\u0438\u0441\u043b\u043e\u0442, \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u043d\u043e \u0438 \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u043e \u043f\u043e\u0434\u043e\u0431\u043d\u044b\u0439 \u0421-\u043a\u043e\u043d\u0446\u0435\u0432\u043e\u043c\u0443 \u0443\u0447\u0430\u0441\u0442\u043a\u0443 \u0431\u043e\u043c\u0431\u0435\u0437\u0438\u043d\u0430.<\/p>\n

GRP \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0443\u0435\u0442 \u0432 \u0442\u043a\u0430\u043d\u044f\u0445 \u043c\u043e\u0437\u0433\u0430, \u0432 \u043d\u0435\u0440\u0432\u043d\u044b\u0445 \u0432\u043e\u043b\u043e\u043a\u043d\u0430\u0445, \u0432 \u043d\u0435\u0439\u0440\u043e\u044d\u043d\u0434\u043e\u043a\u0440\u0438\u043d\u043d\u044b\u0445 \u043a\u043b\u0435\u0442\u043a\u0430\u0445, \u043a\u043b\u0435\u0442\u043a\u0430\u0445 \u0416\u041a\u0422 \u0438 \u043b\u0435\u0433\u043a\u0438\u0445. \u0412 \u0444\u0438\u0437\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0443\u0441\u043b\u043e\u0432\u0438\u044f\u0445 \u043e\u043d \u0441\u0442\u0438\u043c\u0443\u043b\u0438\u0440\u0443\u0435\u0442 \u0441\u0435\u043a\u0440\u0435\u0446\u0438\u044e \u0441\u043e\u043b\u044f\u043d\u043e\u0439 \u043a\u0438\u0441\u043b\u043e\u0442\u044b \u0438 \u0433\u0430\u0441\u0442\u0440\u0438\u043d\u0430. \u041e\u0442\u043c\u0435\u0447\u0435\u043d\u043e, \u0447\u0442\u043e \u0433\u0430\u0441\u0442\u0440\u0438\u043d-\u0440\u0438\u043b\u0438\u0437\u0438\u043d\u0433 \u043f\u0435\u043f\u0442\u0438\u0434 \u0432 \u0431\u043e\u043b\u044c\u0448\u043e\u043c \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0435 \u043c\u043e\u0436\u0435\u0442 \u0441\u0435\u043a\u0440\u0435\u0442\u0438\u0440\u043e\u0432\u0430\u0442\u044c\u0441\u044f \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u043c\u0438 \u043a\u043b\u0435\u0442\u043a\u0430\u043c\u0438 \u043f\u0440\u0438 \u043c\u0435\u043b\u043a\u043e\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u043c \u0440\u0430\u043a\u0435 \u043b\u0435\u0433\u043a\u0438\u0445 (\u041c\u041a\u0420\u041b), \u043e\u0434\u043d\u0430\u043a\u043e \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u0435 GRP \u0432 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u043c\u0430\u0440\u043a\u0435\u0440\u0430 \u0434\u043b\u044f \u0440\u0443\u0442\u0438\u043d\u043d\u044b\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439 \u0437\u0430\u0442\u0440\u0443\u0434\u043d\u0435\u043d\u043e \u0438\u0437-\u0437\u0430 \u0435\u0433\u043e \u043d\u0435\u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u0438 \u0432 \u043a\u0440\u043e\u0432\u0438 \u0438 \u0441\u043b\u043e\u0436\u043d\u043e\u0441\u0442\u0438 \u0435\u0433\u043e \u0432\u044b\u0434\u0435\u043b\u0435\u043d\u0438\u044f.<\/p>\n

\u0412 \u043d\u0430\u0441\u0442\u043e\u044f\u0449\u0435\u0435 \u0432\u0440\u0435\u043c\u044f \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0442\u0435\u0441\u0442 \u0434\u043b\u044f \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044f ProGRP (\u043f\u0440\u043e\u0433\u0430\u0441\u0442\u0440\u0438\u043d-\u0432\u044b\u0441\u0432\u043e\u0431\u043e\u0436\u0434\u0430\u044e\u0449\u0438\u0439 \u043f\u0435\u043f\u0442\u0438\u0434) – \u0431\u043e\u043b\u0435\u0435 \u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0433\u043e \u0431\u0435\u043b\u043a\u0430 – \u043f\u0440\u0435\u0434\u0448\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u0438\u043a\u0430 \u0433\u043e\u0440\u043c\u043e\u043d\u0430, \u0442\u0430\u043a\u0436\u0435 \u044f\u0432\u043b\u044f\u044e\u0449\u0435\u0433\u043e\u0441\u044f \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u044b\u043c \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u043c \u0434\u043b\u044f \u041c\u041a\u0420\u041b.<\/p>\n

\u041e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u0443\u0440\u043e\u0432\u043d\u044f ProGRP \u0437\u043d\u0430\u0447\u0438\u043c\u043e \u0438 \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0442\u044c \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u043e \u0432 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435, \u043b\u0435\u0447\u0435\u043d\u0438\u0438, \u043f\u0440\u043e\u0433\u043d\u043e\u0437\u0435 \u0438 \u0440\u0430\u043d\u043d\u0435\u043c \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u0438 \u0440\u0435\u0446\u0438\u0434\u0438\u0432\u043e\u0432 \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u041c\u041a\u0420\u041b. \u0420\u0435\u0434\u043a\u043e \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u0435\u0442\u0441\u044f \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435 ProGRP \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0434\u043e\u0431\u0440\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u043c\u0438 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u043c\u0438 \u043b\u0435\u0433\u043a\u0438\u0445 (\u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0431\u0440\u043e\u043d\u0445\u0438\u0442, \u0444\u0438\u0431\u0440\u043e\u0437 \u043b\u0435\u0433\u043a\u0438\u0445) \u0438 \u043f\u0440\u0438 \u043f\u043e\u0447\u0435\u0447\u043d\u043e\u0439 \u0434\u0438\u0441\u0444\u0443\u043d\u043a\u0446\u0438\u0438.<\/p>\n\n\n\n\n\n\n\n\n\n\n
\u041f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c<\/b><\/td>\n\u0425\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0430<\/b><\/td>\n<\/tr>\n
\u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b<\/b><\/td>\n\u0412\u0435\u043d\u043e\u0437\u043d\u0430\u044f\u00a0\u043a\u0440\u043e\u0432\u044c<\/td>\n<\/tr>\n
\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438\u00a0\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430<\/b><\/td>\n\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n
\u0422\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u0430\u044f\u00a0\u0441\u0440\u0435\u0434\u0430,\u00a0\u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0430<\/b><\/td>\n\u0412\u0430\u043a\u0443\u0442\u0430\u0439\u043d\u0435\u0440\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0433\u0435\u043b\u0435\u0432\u043e\u0439\u00a0\u0444\u0430\u0437\u044b<\/td>\n<\/tr>\n
\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u0438\u00a0\u0443\u0441\u043b\u043e\u0432\u0438\u044f\u00a0\u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0438\u0440\u043e\u0432\u043a\u0438,\u00a0\u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c\u00a0\u043f\u0440\u043e\u0431\u044b<\/b><\/td>\n\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n
\u041c\u0435\u0442\u043e\u0434\u00a0\u0442\u0435\u0441\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f<\/b><\/td>\n\u0418\u043c\u043c\u0443\u043d\u043e\u0445\u0438\u043c\u0438\u0447\u0435\u0441\u043a\u0438\u0439\u00a0\u0441\u00a0\u0445\u0435\u043c\u0438\u043b\u044e\u043c\u0438\u043d\u0435\u0441\u0446\u0435\u043d\u0442\u043d\u043e\u0439\u00a0\u0434\u0435\u0442\u0435\u043a\u0446\u0438\u0435\u0439\u00a0(CLIA)<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n
\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u00a0\u043a\u00a0\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044e<\/b><\/td>\n<\/tr>\n
\u041f\u0440\u043e\u0433\u0430\u0441\u0442\u0440\u0438\u043d-\u0440\u0438\u043b\u0438\u0437\u0438\u043d\u0433\u00a0\u043f\u0435\u043f\u0442\u0438\u0434\u00a0(ProGRP) –\u00a0\u043e\u0434\u0438\u043d\u00a0\u0438\u0437\u00a0\u043c\u0430\u0440\u043a\u0435\u0440\u043e\u0432\u00a0\u043c\u0435\u043b\u043a\u043e\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u0433\u043e\u00a0\u0440\u0430\u043a\u0430\u00a0\u043b\u0435\u0433\u043a\u0438\u0445<\/b><\/p>\n

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\u00b7\u00a0\u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435\u00a0\u0444\u0443\u043d\u043a\u0446\u0438\u0438\u00a0\u043f\u043e\u0447\u0435\u043a\u00a0(\u0425\u041f\u041d)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[923],"product_tag":[],"class_list":{"0":"post-10255","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-tumorali","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10255","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10255"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10255"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10255"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10255"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10255"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}