{"id":10154,"date":"2020-04-23T03:58:10","date_gmt":"2020-04-23T00:58:10","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/mannose-binding-lectin-mbl-in-ser\/"},"modified":"2025-02-05T16:06:04","modified_gmt":"2025-02-05T14:06:04","slug":"mannose-binding-lectin-mbl-in-ser","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/mannose-binding-lectin-mbl-in-ser\/","title":{"rendered":"\u041b\u0435\u043a\u0442\u0438\u043d, \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u044e\u0449\u0438\u0439 \u043c\u0430\u043d\u043d\u043e\u0437\u0443 (MBL2)"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n

Mannose binding lectin<\/em> (MBL) este o glicoprotein\u0103 polimorf\u0103 care activeaz\u0103 complementul dup\u0103 legarea specific\u0103, dependent\u0103 de calciu, a manozei \u015fi a N-acetil glucozaminei1<\/sup>. Este implicat\u0103 \u00een cea de a treia cale de activare a complementului, recent descris\u0103 sub denumirea de calea lectinelor<\/em>2<\/sup>.<\/em><\/p>\n

MBL face parte din familia colectinelor, proteine ce sunt caracterizate prin prezen\u0163a \u00een aceea\u015fi subunitate at\u00e2t a unor structuri colagenice c\u00e2t \u015fi a unor domenii de lectine.<\/p>\n

Este sintetizat\u0103 \u00een ficat \u015fi este asem\u0103n\u0103toare din punct de vedere structural cu frac\u0163iunea C1q. Forma circulant\u0103 (func\u0163ional\u0103) este alc\u0103tuit\u0103 din oligomeri ai unor subunit\u0103\u0163i care sunt asociate cu o serin proteaz\u0103 (MASP); sunt descrise 2 serin proteaze care leag\u0103 MBL \u015fi care sunt similare din punct de vedere structural \u015fi func\u0163ional cu C1r \u015fi C1s3;4<\/sup>.<\/p>\n

MBL are o afinitate crescut\u0103 pentru structuri repetitive de carbohidra\u0163i ce con\u0163in manoz\u0103 (carbohidra\u0163i \u201epatogenici\u201d) de pe suprafa\u0163a a numeroase microorganisme; \u00een acela\u015fi timp proteina nu recunoa\u015fte carbohidra\u0163i cum ar fi galactoza \u015fi acidul sialic ce reprezint\u0103 zaharuri terminale exprimate pe glicoproteinele mamiferelor. Datorit\u0103 acestor propriet\u0103\u0163i, MBL este capabil\u0103 s\u0103 discrimineze self-ul<\/em> \u043c\u0438\u043a\u0440\u043e\u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u043e\u0432 non-self<\/em>. Studiile au raportat ca MBL reac\u0163ioneaz\u0103 cu o varietate larg\u0103 de bacterii Gram pozitive \u015fi Gram negative acapsulare, virusuri, levuri, mycobacterii, parazi\u0163i \u015fi protozoare2;3<\/sup>.<\/p>\n

Dup\u0103 recunoa\u015fterea carbohidratului ligand MBL adopt\u0103 o modificare conforma\u0163ional\u0103 care conduce la activarea celor dou\u0103 serin-proteaze MASP-1 \u015fi MASP-2. Dup\u0103 activare, MASP-2 cliveaz\u0103 C4 pentru a genera aceea\u015fi C3 convertaz\u0103 (C4b2a) din calea clasic\u0103. MASP-1 are capacitatea de a cliva C3, suger\u00e2nd c\u0103 ar putea provoca direct activarea c\u0103ii alterne. Dup\u0103 formarea C3 convertazei, activarea complementului decurge \u00een acela\u015fi fel ca pe calea clasic\u0103, cu posibila recrutare \u015fi a c\u0103ii alterne2;5<\/sup>.<\/p>\n

Legarea MBL de agen\u0163ii patogeni \u015fi activarea complementului conduce la liza microorganismelor \u015fi la eliminarea rapid\u0103 a acestora prin celulele fagocitare ale sistemului imun (granulocite, monocite\/macrofage). A fost descris\u0103 o interac\u0163iune \u00eentre MBL legat\u0103 de membranele \u0163int\u0103 \u015fi un receptor specific de pe suprafa\u0163a acestor celule care faciliteaz\u0103 \u00eendep\u0103rtarea microorganismelor (opsonizare) 2;3<\/sup>.<\/p>\n

Calea lectinelor mai poate fi activat\u0103 de c\u0103tre unele complexe antigen-anticorp. Astfel, s-a demonstrat c\u0103 o frac\u0163iune a moleculelor IgG c\u0103reia \u00eei lipsesc reziduurile de galactoz\u0103 terminal\u0103 (IgG-G0), cum este cea \u00eent\u00e2lnit\u0103 \u00een plasma pacien\u0163ilor cu poliartrita reumatoid\u0103, are proprietatea de a interac\u0163iona cu\u00a0 MBL \u015fi activa complementul.<\/p>\n

Se pare c\u0103 reglarea c\u0103ii lectinelor este mediat\u0103 de c\u0103tre C1 inhibitor \u015fi alfa2-macroglobulina2<\/sup>.<\/p>\n

Recent a fost depistat\u0103 \u015fi a o activitate anti-tumoral\u0103 a MBP denumit\u0103 citotoxicitate mediat\u0103 celular dependent\u0103 de mannose-binding lectin (MDCC). Aceast\u0103 activitate nu necesit\u0103 activarea complementului ci implicarea unor celule imune. S-a demonstrat de asemenea c\u0103 MBP este exprimat\u0103 selectiv la nivelul celulelor epiteliale din intestinul sub\u0163ire, fapt ce sugereaz\u0103 c\u0103 aceast\u0103 protein\u0103 de\u0163ine un rol important de ap\u0103rare local\u0103 a gazdei1<\/sup>.<\/p>\n

Deoarece MBL apar\u0163ine celor mai importante componente ale r\u0103spunsului imun, un deficit al acestei\u00a0proteine de faz\u0103 acut\u0103 este asociat cu o activitate opsonofagocitic\u0103 redus\u0103 \u015fi \u00een consecin\u0163\u0103 cu o predispozi\u0163ie crescut\u0103 pentru infec\u0163ii recurente rezistente la tratament. Nivelurile serice sc\u0103zute de MBL sunt condi\u0163ionate genetic<\/strong>3.<\/sup><\/p>\n

Gena care codific\u0103 MBL este situat\u0103 pe cromozomul 10, con\u0163ine 4 exoni \u015fi prezint\u0103 4 alele (variante genetice) care influen\u0163eaz\u0103 semnificativ concentra\u0163ia seric\u0103 de MBL: tipul MBL s\u0103lbatic denumit alela A\u00a0 \u015fi 3 forme mutante B, C, D. Formele B, C, D rezult\u0103 ca urmare a unor muta\u0163ii punctiforme inactivatoare la nivelul exonului 1 al genei MBL; proteinele formeaz\u0103 mai greu oligomeri \u015fi astfel prezint\u0103 o activitate redus\u0103 de activare a complementului. O treime din popula\u0163ia Europei Centrale este heterozigot\u0103 pentru cel pu\u0163in una din aceste muta\u0163ii, ceea ce se poate corela cu o predispozi\u0163ie crescut\u0103 la infec\u0163ii. Defectele homozigote (BB, CC, DD) apar la 0,3% din popula\u0163ia european\u0103 \u015fi au drept consecin\u0163\u0103 un deficit aproape complet de MBL. Au mai fost descrise 2 polimorfisme \u00een zona reglatoare a promotorului genei MBL care de asemenea cauzeaz\u0103 un nivel seric sc\u0103zut de MBL \u015fi sunt responsabile de efectele clinice3;4<\/sup>.<\/p>\n

MBL induce \u015fi fagocitoza materialului celular apoptotic \u015fi a complexelor imune. In deficitul de MBL resturile celulare nefagocitate se acumuleaz\u0103 \u015fi sunt o surs\u0103 de autoantigene. In plus se accept\u0103 faptul c\u0103 pacien\u0163ii cu deficit de MBL pot fi infecta\u0163i cu agen\u0163i patogeni care joac\u0103 rol \u00een patogeneza bolilor autoimune induse de ace\u015ftia. La pacien\u0163ii cu lupus eritematos sistemic, artrita reumatoid\u0103 sau sindrom Sj\u00f6gren s-au g\u0103sit niveluri sc\u0103zute de MBL \u015fi ace\u015fti pacien\u0163i sunt mai frecvent purt\u0103tori de muta\u0163ii \u00een gena MBL.<\/p>\n

Doar nivelurile sc\u0103zute de MBL sunt relevante pentru un defect de imunitate; concentra\u0163iile crescute indic\u0103 o infec\u0163ie activ\u0103. Tratamentele de substitu\u0163ie cu concentrate de MBL recombinate sau ob\u0163inute din plasm\u0103 se afl\u0103 \u00eenc\u0103 \u00een stadiul de testare clinic\u0103. Pacien\u0163ii cu niveluri sc\u0103zute de MBL ar trebui s\u0103 primeasc\u0103 vaccinari profilactice, mai ales fa\u0163\u0103 de virusurile gripale, Haemophilus influenzae<\/em> \u0438 Streptococcus pneumoniae<\/em>3<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea MBL <\/em><\/strong>\u2013 evaluarea pacien\u0163ilor (copii sau adul\u0163i) cu istoric de infec\u0163ii recurente, mai ales \u00een prezen\u0163a unui status imun aparent normal (formula leucocitar\u0103 normal\u0103, imunoglobuline serice normale) 3;4<\/sup>.<\/p>\n

Preg\u0103tire pacient <\/em><\/strong>- <\/em>\u00e0 jeun3<\/sup>.<\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c3<\/sup>.<\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator3<\/sup>.<\/p>\n

Cantitate recoltata\u0103<\/em><\/strong>- <\/em>minim 0.5 mL ser3<\/sup>.<\/p>\n

Cauze de respingere a probei<\/em><\/strong> \u2013 specimen intens hemolizat, icteric, lipemic sau contaminat bacterian3<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>- <\/em>se separ\u0103 serul prin centrifugare \u015fi se transport\u0103 \u00een condi\u0163ii de refrigerare3<\/sup>.<\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>- <\/em>2 saptamani la -20\u00b0C3<\/sup>.<\/p>\n

Metod\u0103 <\/em><\/strong>- ELISA<\/span>3<\/sup>.<\/p>\n

Valori de referin\u0163\u0103 <\/em><\/strong>- <\/em>>450 ng\/mL3<\/sup>.<\/p>\n

Interpretarea rezultatelor<\/em><\/strong><\/p>\n

Un nivel sc\u0103zut de MBL \u00een ser (<450 ng\/mL) se asociaz\u0103 cu o predispozi\u0163ie crescut\u0103 pentru\u00a0infec\u0163ii cu bacterii \u015fi fungi (mai ales Candida albicans<\/em>) datorit\u0103 defectelor func\u0163ionale ale complementului.<\/div>\n
Un defect MBL poate fi de asemenea cauza unei elimin\u0103ri virale sc\u0103zute sau prelungite (de exemplu \u00een cazul infec\u0163iilor cu virus herpetic tip 2).<\/div>\n
Spre deosebire de defectele\u00a0homozigote clinic evidente (MBL in ser <50 ng\/mL), cele heterozigote se exprim\u0103 clinic numai \u00een contextul unor boli de baz\u0103 sau tratamente (infec\u0163ii cronice, radioterapie, chimioterapie, terapie imunosupresoare) sau \u00een asociere cu alte anomalii \u00eenn\u0103scute ale sistemului imun (deficit de imunoglobuline sau de subclase IgG, alele C4 nule). Tablourile clinice tipice sunt candidoza recidivant\u0103 sau infec\u0163iile bacteriene, ca de exemplu infec\u0163iile agresive cu pneumococ sau infec\u0163iile recurente de c\u0103i respiratorii3<\/sup>.<\/div>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n

MBL este o protein\u0103 de faz\u0103 acut\u0103 indus\u0103 \u00een cursul unei infec\u0163ii; dac\u0103 testarea se efectueaz\u0103 \u00een aceast\u0103 situa\u0163ie este posibil ca un deficit latent de MBL s\u0103 fie mascat. De aceea, \u00een cazul unui rezultat normal sau aflat \u00een zona de grani\u0163\u0103 (450-1500 ng\/mL), \u00een prezen\u0163a unei suspiciuni clinice de deficit se recomand\u0103 testarea genetic\u0103 pentru MBL deoarece aceasta nu este influen\u0163at\u0103 de activitatea imun\u01033<\/sup>. Identificarea unui deficit MBL nu exclude alte etiologii care ar predispune la o susceptibilitate crescut\u0103 la infec\u0163ii4<\/sup>.<\/div>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Francesco Dati & Erwin Metzmann. Complement System. In Proteins Laboratory Testing and Clinical Use, Media Print Taunusdruck GmbH, Frankfurt am Main; 2005, 29-30.<\/span><\/span><\/div>\n
2. H. Davis Massey, Richard A. McPherson. Mediators of Inflammation: Complement, Cytokines, and Adhesion Molecules. In Henry\u2019s Clinical Diagnosis and Management by Laboratory Methods, Saunders- Elsevier, 21st Edition, 852.<\/span><\/div>\n
3. Laborator Synevo. Referin\u0163e specifice tehnologiei de lucru utilizate. 2010. Ref Type: Catalog.<\/span><\/div>\n
4. Mayo Clinic\/Mayo Medical Laboratories. Test Catalogs and Guides. Mannose-Binding Lectin, Serum. www.mayomedicallaboratories.com. Ref Type: Internet Communication<\/span><\/div>\n
5. Terry W. Du Clos, Carolyne Mold. Complement and complement deficiencies. In Clinical Immunology. Principles and Practice, Mosby, Elsevier, Third Edition, 2008, 308.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u0414\u043e 10 % \u043b\u044e\u0434\u0435\u0439 \u0438\u043c\u0435\u044e\u0442 \u043f\u0440\u0435\u0434\u0440\u0430\u0441\u043f\u043e\u043b\u043e\u0436\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u043a \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u044b\u043c \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u043c \u0438\u0437-\u0437\u0430 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u0438 \u0432\u0430\u0436\u043d\u043e\u0439 \u0441\u043e\u0441\u0442\u0430\u0432\u043b\u044f\u044e\u0449\u0435\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b \u0432\u0440\u043e\u0436\u0434\u0451\u043d\u043d\u043e\u0433\u043e \u0438\u043c\u043c\u0443\u043d\u0438\u0442\u0435\u0442\u0430 \u2013 \u043c\u0430\u043d\u043d\u043e\u0437\u0441\u0432\u044f\u0437\u044b\u0432\u0430\u044e\u0449\u0435\u0433\u043e \u043b\u0435\u043a\u0442\u0438\u043d\u0430 (\u041c\u0421\u041b).<\/p>\n

\u041c\u0430\u043d\u043d\u043e\u0437\u0441\u0432\u044f\u0437\u044b\u0432\u0430\u044e\u0449\u0438\u0439 \u043b\u0435\u043a\u0442\u0438\u043d \u0441\u0438\u043d\u0442\u0435\u0437\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u0432 \u043f\u0435\u0447\u0435\u043d\u0438 \u0438 \u0441\u043e\u0441\u0442\u043e\u0438\u0442 \u0438\u0437 4 \u0434\u043e\u043c\u0435\u043d\u043e\u0432: N-\u043a\u043e\u043d\u0446\u0435\u0432\u043e\u0433\u043e \u0434\u043e\u043c\u0435\u043d\u0430 (\u0431\u043e\u0433\u0430\u0442\u043e\u0433\u043e \u0446\u0438\u0441\u0442\u0435\u0438\u043d\u043e\u043c), \u043a\u043e\u043b\u043b\u0430\u0433\u0435\u043d\u043e\u043f\u043e\u0434\u043e\u0431\u043d\u043e\u0433\u043e \u0434\u043e\u043c\u0435\u043d\u0430, \u0421-\u043a\u043e\u043d\u0446\u0435\u0432\u043e\u0433\u043e \u0434\u043e\u043c\u0435\u043d\u0430 (\u0441\u0432\u044f\u0437\u044b\u0432\u0430\u044e\u0449\u0435\u0433\u043e\u0441\u044f \u0441 \u0443\u0433\u043b\u0435\u0432\u043e\u0434\u0430\u043c\u0438) \u0438 \u0441\u043e\u0435\u0434\u0438\u043d\u044f\u044e\u0449\u0435\u0433\u043e \u043f\u043e\u0441\u043b\u0435\u0434\u043d\u0438\u0435 2 \u0434\u043e\u043c\u0435\u043d\u0430 \u0443\u0447\u0430\u0441\u0442\u043a\u0430 \u2013 \u0434\u043e\u043c\u0435\u043d “\u0448\u0435\u0438”.<\/p>\n

\u041c\u0421\u041b \u0441\u043f\u043e\u0441\u043e\u0431\u0435\u043d \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u0442\u044c\u0441\u044f \u0441 \u0441\u0430\u0445\u0430\u0440\u0430\u043c\u0438 \u043d\u0430 \u043f\u043e\u0432\u0435\u0440\u0445\u043d\u043e\u0441\u0442\u0438 \u043c\u0438\u043a\u0440\u043e\u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u043e\u0432, \u0440\u0430\u0441\u043f\u043e\u0437\u043d\u0430\u0432\u0430\u044f \u0443\u0433\u043b\u0435\u0432\u043e\u0434\u044b \u043c\u0430\u043d\u043d\u043e\u0437\u0443 \u0438 N-\u0430\u0446\u0435\u0442\u0438\u043b\u0433\u043b\u044e\u043a\u043e\u0437\u0430\u043c\u0438\u043d. \u0422\u0430\u043a\u0438\u043c \u043e\u0431\u0440\u0430\u0437\u043e\u043c, \u0437\u0430\u043f\u0443\u0441\u043a\u0430\u0435\u0442\u0441\u044f \u043e\u0434\u0438\u043d \u0438\u0437 \u043e\u0441\u043d\u043e\u0432\u043d\u044b\u0445 \u043f\u0443\u0442\u0435\u0439 \u0430\u043a\u0442\u0438\u0432\u0430\u0446\u0438\u0438 \u0441\u0438\u0441\u0442\u0435\u043c\u044b \u043a\u043e\u043c\u043f\u043b\u0435\u043c\u0435\u043d\u0442\u0430 \u2013 \u043b\u0435\u043a\u0442\u0438\u043d\u043e\u0432\u044b\u0439 \u043f\u0443\u0442\u044c, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u0441\u043f\u043e\u0441\u043e\u0431\u0441\u0442\u0432\u0443\u0435\u0442 \u0443\u0434\u0430\u043b\u0435\u043d\u0438\u044e \u043f\u0430\u0442\u043e\u0433\u0435\u043d\u043e\u0432 \u0441 \u043f\u043e\u043c\u043e\u0449\u044c\u044e \u043a\u043e\u043c\u043f\u043b\u0435\u043c\u0435\u043d\u0442\u043e\u043f\u043e\u0441\u0440\u0435\u0434\u043e\u0432\u0430\u043d\u043d\u043e\u0433\u043e \u0444\u0430\u0433\u043e\u0446\u0438\u0442\u043e\u0437\u0430.<\/p>\n

\u0412 \u0440\u0435\u0430\u043a\u0446\u0438\u0438 \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u044e\u0442 \u0443\u0447\u0430\u0441\u0442\u0438\u0435 \u0431\u0435\u043b\u043a\u0438, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0440\u0430\u0431\u043e\u0442\u0430\u044e\u0442 \u0432\u043c\u0435\u0441\u0442\u0435 \u0434\u043b\u044f \u0443\u043d\u0438\u0447\u0442\u043e\u0436\u0435\u043d\u0438\u044f \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0439 \u0438 \u0434\u0440\u0443\u0433\u0438\u0445 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u043e\u0432. \u041c\u0421\u041b \u0446\u0438\u0440\u043a\u0443\u043b\u0438\u0440\u0443\u0435\u0442 \u0432 \u043a\u0440\u043e\u0432\u0438 \u0432 \u043d\u0435\u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0439 \u0444\u043e\u0440\u043c\u0435. \u041a\u043e\u0433\u0434\u0430 \u043e\u043d \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u043e\u0432\u0430\u043d, \u043e\u043d \u043f\u0440\u0438\u0432\u043e\u0434\u0438\u0442 \u0432 \u0434\u0432\u0438\u0436\u0435\u043d\u0438\u0435 \u0446\u0435\u043f\u043d\u0443\u044e \u0440\u0435\u0430\u043a\u0446\u0438\u044e, \u043a\u043e\u043d\u0435\u0447\u043d\u044b\u0435 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u044b \u043a\u043e\u0442\u043e\u0440\u043e\u0439 \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u044b \u0443\u043d\u0438\u0447\u0442\u043e\u0436\u0430\u0442\u044c \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0438 \u0438 \u0434\u0440\u0443\u0433\u0438\u0435 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u044b (\u0432\u0438\u0440\u0443\u0441\u044b, \u0433\u0440\u0438\u0431\u044b).<\/p>\n

\u0423\u0440\u043e\u0432\u0435\u043d\u044c \u041c\u0421\u041b \u043d\u0430 96 % \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u0435\u0442\u0441\u044f \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438 \u0444\u0430\u043a\u0442\u043e\u0440\u0430\u043c\u0438. \u0415\u0433\u043e \u0434\u0435\u0444\u0438\u0446\u0438\u0442 \u043c\u043e\u0436\u0435\u0442 \u0432\u043e\u0437\u043d\u0438\u043a\u043d\u0443\u0442\u044c \u0432 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u0435 \u043e\u0434\u043d\u043e\u0433\u043e \u0438\u043b\u0438 \u043d\u0435\u0441\u043a\u043e\u043b\u044c\u043a\u0438\u0445 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u0439 \u0432 \u0433\u0435\u043d\u0435\u00a0MBL2<\/em>, \u0441\u043e\u0441\u0442\u043e\u044f\u0449\u0435\u043c \u0438\u0437 4 \u044d\u043a\u0437\u043e\u043d\u043e\u0432, \u043a\u0430\u0436\u0434\u044b\u0439 \u0438\u0437 \u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u043a\u043e\u0434\u0438\u0440\u0443\u0435\u0442 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u043d\u044b\u0439 \u0434\u043e\u043c\u0435\u043d \u0431\u0435\u043b\u043a\u0430 \u041c\u0421\u041b. \u0423\u0447\u0430\u0441\u0442\u043e\u043a \u0414\u041d\u041a \u0432 \u0440\u0435\u0433\u0443\u043b\u044f\u0442\u043e\u0440\u043d\u043e\u0439 \u043e\u0431\u043b\u0430\u0441\u0442\u0438 \u0433\u0435\u043d\u0430\u00a0MBL2<\/em>, \u0432 \u043a\u043e\u0442\u043e\u0440\u043e\u043c \u043f\u0440\u043e\u0438\u0441\u0445\u043e\u0434\u0438\u0442 \u0437\u0430\u043c\u0435\u043d\u0430 \u0433\u0443\u0430\u043d\u0438\u043d\u0430 (G) \u043d\u0430 \u0446\u0438\u0442\u043e\u0437\u0438\u043d (\u0421), \u043d\u0430\u0437\u044b\u0432\u0430\u0435\u0442\u0441\u044f \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u043c G(-550)C. \u0415\u0441\u043b\u0438 \u0432 \u0434\u0430\u043d\u043d\u043e\u0439 \u043f\u043e\u0437\u0438\u0446\u0438\u0438 \u043d\u0430\u0445\u043e\u0434\u0438\u0442\u0441\u044f \u0433\u0443\u0430\u043d\u0438\u043d, \u0442\u0430\u043a\u043e\u0439 \u0432\u0430\u0440\u0438\u0430\u043d\u0442 \u0433\u0435\u043d\u0430 \u043e\u0431\u043e\u0437\u043d\u0430\u0447\u0430\u0435\u0442\u0441\u044f \u043a\u0430\u043a\u00a0\u0417<\/strong>, \u0430 \u0435\u0441\u043b\u0438 \u0446\u0438\u0442\u043e\u0437\u0438\u043d \u2013\u00a0\u041c<\/strong>-\u0432\u0430\u0440\u0438\u0430\u043d\u0442. \u0412 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u0435 \u0442\u0430\u043a\u043e\u0439 \u0437\u0430\u043c\u0435\u043d\u044b \u043c\u0435\u043d\u044f\u0435\u0442\u0441\u044f \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440 \u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u0438 \u0433\u0435\u043d\u0430. \u041a\u043b\u0438\u043d\u0438\u043a\u043e-\u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u044b\u043c \u043f\u0440\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u0435\u043c \u0434\u0430\u043d\u043d\u043e\u0433\u043e \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 \u0431\u0435\u043b\u043a\u0430 \u041c\u0421\u041b \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438.<\/p>\n

\u041f\u0440\u0438 \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u0438 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 \u0438 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u0438 \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u044b \u043c\u0430\u043d\u043d\u043e\u0437\u0441\u0432\u044f\u0437\u044b\u0432\u0430\u044e\u0449\u0435\u0433\u043e \u0431\u0435\u043b\u043a\u0430 \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u0443\u0432\u0435\u043b\u0438\u0447\u0438\u0432\u0430\u0435\u0442\u0441\u044f \u0440\u0438\u0441\u043a \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0442\u044f\u0436\u0435\u043b\u044b\u0445 \u0444\u043e\u0440\u043c \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u044b\u0445 \u0438 \u0432\u0438\u0440\u0443\u0441\u043d\u044b\u0445 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0439 \u0443 \u0434\u0435\u0442\u0435\u0439 \u0438 \u0432\u0437\u0440\u043e\u0441\u043b\u044b\u0445 (\u043f\u043d\u0435\u0432\u043c\u043e\u043d\u0438\u0438, \u043e\u0442\u0438\u0442\u0430, \u0441\u0435\u043f\u0441\u0438\u0441\u0430, \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0434\u0438\u0430\u0440\u0435\u0438), \u043f\u043e\u0432\u044b\u0448\u0430\u0435\u0442\u0441\u044f \u0432\u043e\u0441\u043f\u0440\u0438\u0438\u043c\u0447\u0438\u0432\u043e\u0441\u0442\u044c \u043a \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430\u043c \u0412 \u0438 \u0421, \u0412\u0418\u0427, \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u043d\u043e \u0437\u0430\u0442\u044f\u0436\u043d\u043e\u0435 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u043e-\u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 \u0441 \u0440\u0435\u0446\u0438\u0434\u0438\u0432\u0430\u043c\u0438.<\/p>\n

\u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0433\u0435\u043d\u043e\u0442\u0438\u043f\u043e\u0432 \u043f\u043e \u0433\u0435\u043d\u0443\u00a0MBL2<\/em>\u00a0\u0432 \u0433\u0440\u0443\u043f\u043f\u0435 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u043c \u0412 \u0438 \u0433\u0440\u0443\u043f\u043f\u0435 \u0437\u0434\u043e\u0440\u043e\u0432\u044b\u0445 \u043b\u044e\u0434\u0435\u0439 \u043f\u043e\u043a\u0430\u0437\u0430\u043b\u043e \u0441\u0443\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0435 \u0443\u0432\u0435\u043b\u0438\u0447\u0435\u043d\u0438\u0435 \u0447\u0430\u0441\u0442\u043e\u0442\u044b \u0430\u043b\u043b\u0435\u043b\u044f L \u0438 \u0434\u0440\u0443\u0433\u0438\u0445 \u0430\u043b\u043b\u0435\u043b\u0435\u0439, \u0430\u0441\u0441\u043e\u0446\u0438\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u0441 \u043d\u0438\u0437\u043a\u0438\u043c\u0438 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u044f\u043c\u0438 \u041c\u0421\u041b \u0432 \u043a\u0440\u043e\u0432\u0438.<\/p>\n

\u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435, \u043f\u043e\u0441\u0432\u044f\u0449\u0435\u043d\u043d\u043e\u0435 \u0430\u043d\u0430\u043b\u0438\u0437\u0443 \u0433\u0435\u043d\u043e\u0442\u0438\u043f\u0430 \u043f\u043e \u0433\u0435\u043d\u0443\u00a0MBL2<\/em>\u00a0\u0438 \u043f\u0440\u0438\u0441\u043e\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044e \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438 \u043f\u0440\u0438 \u043f\u043b\u0430\u0441\u0442\u0438\u043a\u0435 \u0441\u0443\u0441\u0442\u0430\u0432\u043e\u0432, \u043f\u043e\u043a\u0430\u0437\u0430\u043b\u043e, \u0447\u0442\u043e \u043d\u043e\u0441\u0438\u0442\u0435\u043b\u0438 \u0430\u043b\u043b\u0435\u043b\u044f L \u0438\u043c\u0435\u044e\u0442 \u0431\u043e\u043b\u044c\u0448\u0438\u0439 \u0440\u0438\u0441\u043a \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0434\u0430\u043d\u043d\u043e\u0433\u043e \u043e\u0441\u043b\u043e\u0436\u043d\u0435\u043d\u0438\u044f \u043f\u043e\u0441\u043b\u0435 \u043e\u043f\u0435\u0440\u0430\u0446\u0438\u0438, \u0447\u0435\u043c \u043d\u043e\u0441\u0438\u0442\u0435\u043b\u0438 \u0430\u043b\u043b\u0435\u043b\u044f \u041d.<\/p>\n

\u041c\u0421\u041b \u0442\u0430\u043a\u0436\u0435 \u0443\u0447\u0430\u0441\u0442\u0432\u0443\u0435\u0442 \u0432 \u0437\u0430\u0449\u0438\u0442\u0435 \u043e\u0442 \u0446\u0438\u0442\u043e\u043c\u0435\u0433\u0430\u043b\u043e\u0432\u0438\u0440\u0443\u0441\u043d\u043e\u0439 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438 \u0443 \u0434\u0435\u0442\u0435\u0439, \u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u044b \u0441 \u0430\u043b\u043b\u0435\u043b\u0435\u043c L \u043f\u043e\u0434\u0432\u0435\u0440\u0436\u0435\u043d\u044b \u0431\u043e\u043b\u044c\u0448\u0435\u043c\u0443 \u0440\u0438\u0441\u043a\u0443 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0434\u0430\u043d\u043d\u043e\u0433\u043e \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u0447\u0435\u043c \u043d\u043e\u0441\u0438\u0442\u0435\u043b\u0438 \u0430\u043b\u043b\u0435\u043b\u044f H.<\/p>\n

\u0414\u0435\u0444\u0438\u0446\u0438\u0442 \u043b\u0435\u043a\u0442\u0438\u043d\u0430 \u043f\u0440\u0438\u0432\u043e\u0434\u0438\u0442 \u043a \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u0438 \u0441\u0438\u0441\u0442\u0435\u043c \u0432\u0440\u043e\u0436\u0434\u0451\u043d\u043d\u043e\u0433\u043e \u0438\u043c\u043c\u0443\u043d\u0438\u0442\u0435\u0442\u0430 \u0443 \u0434\u0435\u0442\u0435\u0439 \u0432 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0435 \u0434\u043e 1,5 \u043b\u0435\u0442, \u0447\u0435\u043c \u043c\u043e\u0436\u043d\u043e \u043e\u0431\u044a\u044f\u0441\u043d\u0438\u0442\u044c \u0447\u0430\u0441\u0442\u043e\u0435 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435 \u0443 \u043d\u0438\u0445 \u043d\u0430 \u0444\u043e\u043d\u0435 \u043d\u0435\u0441\u0444\u043e\u0440\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0433\u043e \u043f\u0440\u0438\u043e\u0431\u0440\u0435\u0442\u0435\u043d\u043d\u043e\u0433\u043e \u0438\u043c\u043c\u0443\u043d\u0438\u0442\u0435\u0442\u0430 \u0440\u0435\u0446\u0438\u0434\u0438\u0432\u0438\u0440\u0443\u044e\u0449\u0438\u0445 \u041e\u0420\u0417, \u043f\u043d\u0435\u0432\u043c\u043e\u043d\u0438\u0439 \u0438 \u0431\u0440\u043e\u043d\u0445\u0438\u0442\u043e\u0432, \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e \u0443 \u043d\u043e\u0441\u0438\u0442\u0435\u043b\u0435\u0439 \u043c\u0438\u043d\u043e\u0440\u043d\u044b\u0445 \u0430\u043b\u043b\u0435\u043b\u0435\u0439 \u0433\u0435\u043d\u0430\u00a0MBL2<\/em>.<\/p>\n

\u0412\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u0435 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0439 \u0432 \u0433\u0435\u043d\u0435 \u043f\u043e\u0437\u0432\u043e\u043b\u0438\u0442 \u0441\u0432\u043e\u0435\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e \u043d\u0430\u0447\u0430\u0442\u044c \u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0443 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439, \u0430 \u0442\u0430\u043a\u0436\u0435, \u0447\u0442\u043e \u043d\u0435 \u043c\u0435\u043d\u0435\u0435 \u0432\u0430\u0436\u043d\u043e, \u043f\u0440\u0438 \u043d\u0430\u043b\u0438\u0447\u0438\u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043e\u0432 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0438\u0442\u044c\u0441\u044f \u0441 \u0438\u0445 \u043f\u0440\u0438\u0447\u0438\u043d\u0430\u043c\u0438.<\/p>\n

\u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/strong><\/p>\n

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    \n
  • H\/H \u2013 \u0430\u0441\u0441\u043e\u0446\u0438\u0438\u0440\u043e\u0432\u0430\u043d \u0441 \u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u044b\u043c \u0443\u0440\u043e\u0432\u043d\u0435\u043c \u041c\u0421\u041b \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435<\/li>\n
  • H\/L \u2013 \u043f\u0440\u043e\u043c\u0435\u0436\u0443\u0442\u043e\u0447\u043d\u044b\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u041c\u0421\u041b<\/li>\n
  • L\/L \u2013 \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u0441\u043d\u0438\u0436\u0435\u043d\u043d\u044b\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u041c\u0421\u041b<\/li>\n<\/ul>\n

    \u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u0434\u043e\u043b\u0436\u043d\u0430 \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u044c\u0441\u044f \u0432\u0440\u0430\u0447\u043e\u043c \u0432 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u0435 \u0441 \u0434\u0440\u0443\u0433\u0438\u043c\u0438 \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438, \u0430\u043d\u0430\u043c\u043d\u0435\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438, \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438 \u0438 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u044b\u043c\u0438 \u0434\u0430\u043d\u043d\u044b\u043c\u0438.<\/p>\n

    \u041a\u0430\u043a \u043f\u0440\u0430\u0432\u0438\u043b\u044c\u043d\u043e \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u0438\u0442\u044c\u0441\u044f \u043a \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044e?<\/strong><\/p>\n

    \u0421\u043f\u0435\u0446\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438 \u043d\u0435 \u0442\u0440\u0435\u0431\u0443\u0435\u0442\u0441\u044f.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[967],"product_tag":[],"class_list":{"0":"post-10154","1":"product","2":"type-product","3":"status-publish","5":"product_cat-teste-pentru-evaluarea-sistemului-complementului","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10154"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10154"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10154"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10154"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}