{"id":10144,"date":"2020-04-23T04:57:52","date_gmt":"2020-04-23T01:57:52","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/antigen-legionella-pneumophila-in-urina\/"},"modified":"2025-02-07T13:36:22","modified_gmt":"2025-02-07T11:36:22","slug":"antigen-legionella-pneumophila-in-urina","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/antigen-legionella-pneumophila-in-urina\/","title":{"rendered":"\u0410\u043d\u0442\u0438\u0433\u0435\u043d \u041b\u0435\u0433\u0438\u043e\u043d\u0435\u043b\u043b\u0430 (Legionella pneumophila) \u0432 \u043c\u043e\u0447\u0435"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong>\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/strong><\/p>\n<p style=\"text-align: justify;\">Din genul <em>Legionella<\/em> fac parte bacili Gram-negativi mici, sub\u0163iri, aerobi, nesporula\u0163i, mobili prin unul sau mai mul\u0163i flageli polari<sup>3<\/sup>. \u00cen cadrul genului sunt descrise p\u00e2n\u0103 \u00een prezent 45 specii, dintre care <em>Legionella pneumophila<\/em> este cea mai important\u0103 specie patogen\u0103 pentru om<sup>1<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Legionelele sunt foarte larg r\u0103sp\u00e2ndite\u00a0\u00een natur\u0103 mai ales \u00een medii apoase (lacuri, r\u00e2uri, soluri umede) \u015fi sunt capabile s\u0103 supravie\u0163uiasc\u0103 \u00een condi\u0163ii foarte variate (conducte de aer condi\u0163ionat \u015fi turnuri de r\u0103cire a apei potabile, re\u0163eaua instala\u0163iilor de ap\u0103 cald\u0103, umidificatoare de aer, bazine de scurgere, echipamente tehnico-medicale din spitale). Speciile de Legionella pot s\u0103 infecteze \u015fi s\u0103 se multiplice \u00een unele specii de amoebe (Hartmannella, Acanthamoeba \u015fi Naegleria spp.), protozoare (Tetrahymena) precum \u015fi \u00een interiorul biofilmelor (microcolonii bacteriene din canalele de ap\u0103). Aceast\u0103 proprietate contribuie la supravie\u0163uirea legionelelor \u00een mediu<sup>1;3<\/sup>. \u00cen plus, Legionella pneumophila exist\u0103 sub dou\u0103 forme distincte \u00een celulele Hela:<\/p>\n<ul>\n<li style=\"text-align: justify;\">o form\u0103 asem\u0103n\u0103toare chistului, aflat\u0103 \u00eentr-o stare metabolic\u0103 dormant\u0103, cu un poten\u0163ial infectant ridicat \u015fi rezisten\u0163a la antibiotice \u015fi detergen\u0163i;<\/li>\n<li style=\"text-align: justify;\">o form\u0103 intracelular\u0103 replicativ\u0103, asem\u0103n\u0103toare bacteriilor crescute pe agar<sup>1<\/sup><span style=\"font-size: 16px;\">.<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\">Denumirea de Legionella provine de la prima epidemie de pneumonie sever\u0103, cu un num\u0103r mare de decese, care s-a produs printre participan\u0163ii la Conven\u0163ia Anual\u0103 din 1976 a Legiunii Americane a fo\u015ftilor combatan\u0163i care s-a desf\u0103\u015furat la Philadelphia. Bacteriile care au determinat aceast\u0103 epidemie au fost izolate \u00een 1977 \u015fi denumite Legionella pneumophila, iar boala a intrat \u00een patologie ca <em>legioneloza<\/em> \u0438\u043b\u0438 <em>boala legionarilor<sup>3<\/sup><\/em>.<\/p>\n<p style=\"text-align: justify;\">Infec\u0163iile induse de Legionella sunt dob\u00e2ndite exclusiv din surse exterioare, legate de mediu; nu au fost descrise cazuri de transmitere prin contact interuman. Principala modalitate de transmitere a infec\u0163iei este inhalarea de aerosoli de ap\u0103 contaminat\u0103, at\u00e2t la locurile de munc\u0103, c\u00e2t \u015fi \u00een spitale<sup>1;3;4<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Infec\u0163iile cu Legionella pot \u00eembr\u0103ca forme clinice variate: de la cazuri asimptomatice p\u00e2n\u0103 la forme severe de boal\u0103, pulmonare sau extrapulmonare, uneori letale. Pot fi afectate at\u00e2t persoane normale c\u00e2t \u015fi cele debilitate sau imunodeprimate (v\u00e2rstnici, mari fum\u0103tori, persoane spitalizate, cu afec\u0163iuni respiratorii preexistente sau care se afl\u0103 sub corticoterapie). Boala pulmonar\u0103 poate s\u0103 apar\u0103 sporadic (ca pneumonie comunitar\u0103, legionelele fiind responsabile de 3-8% din cazuri) sau \u00een epidemii. <span style=\"text-decoration: underline;\">Pneumonia<\/span> apare mai frecvent la persoanele imunodeprimate \u015fi se caracterizeaz\u0103 printr-o evolu\u0163ie progresiv\u0103 care \u00een absen\u0163a tratamentului se poate extinde la mai mul\u0163i lobi pulmonari. Boala debuteaz\u0103 dup\u0103 o perioad\u0103 de incuba\u0163ie de de 2-10 zile cu febr\u0103, frisoane, tulbur\u0103ri respiratorii, tuse, confuzie. Histologic, este prezent un infiltrat alveolar cu neutrofile \u015fi macrofage, \u00eenso\u0163it de fibrin\u0103 \u015fi extravazare de hematii. O form\u0103 mai u\u015foar\u0103 de manifestare a infec\u0163iei este <span style=\"text-decoration: underline;\">febra Pontiac<\/span> (denumit\u0103 dup\u0103 locul primei epidemii care a avut loc la Pontiac-Michigan) care este \u00eent\u00e2lnit\u0103 \u00een special la persoanele imunocompetente. Aceasta evolueaz\u0103 ca o infec\u0163ie respiratorie asem\u0103n\u0103toare gripei, dup\u0103 o incuba\u0163ie de 6-12 ore: febr\u0103, frisoane, mialgii, stare de curbatur\u0103, cefalee, tuse u\u015foar\u0103. <span style=\"text-decoration: underline;\">Manifest\u0103rile extrapulmonare<\/span> ale infec\u0163iei cu Legionella pneumophila sunt rare, fiind reprezentate \u00een special de endocardite, encefalite sau infec\u0163ii ale pl\u0103gilor<sup>1;3;4;5<\/sup>. Pneumonia, febra Pontiac \u015fi infec\u0163iile extrapulmonare constituie cele 3 manifest\u0103ri clinice primare ale legionelozei.<\/p>\n<p style=\"text-align: justify;\">Aproximativ 85% din cazurile documentate de legioneloza sunt produse de Legionella pneumophila. De\u015fi sunt cunoscute 15 serogrupuri de L. pneumophila, serogrupurile 1 \u015fi 6 sunt r\u0103spunz\u0103toare de p\u00e2n\u0103 la 75% din cazurile de legioneloz\u0103<sup>5<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Mecanismele exacte prin care Legionella pneumophila cauzeaz\u0103 boala nu sunt complet elucidate, totu\u015fi este cunoscut faptul c\u0103 abilitatea acesteia de a se sustrage fagocitoze de\u0163ine un rol semnificativ \u00een apari\u0163ia bolii. \u00a0De asemenea, existen\u0163a unui sistem imun celular competent este important \u00een eliminarea infec\u0163iei. Limfocitele T activate produc limfokine care stimuleaz\u0103 activitatea antimicrobian\u0103 a macrofagelor, \u00eempiedic\u00e2nd astfel replicarea intracelulara a bacteriei<sup>1<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Diagnosticul de certitutine a al infec\u0163iei este stabilit prin izolarea patogenului pe un mediu de cultur\u0103 special: agar tamponat cu c\u0103rbune \u015fi extract de drojdie (BCYE) la pH 6.9. De asemenea, prelevatele respiratorii pot fi examinate microscopic printr-o tehnic\u0103 de imunofluorescen\u0163\u0103 direct\u0103 cu anticorpi specifici, dar sensibilitatea metodei este redus\u0103 (25-70%). Datorit\u0103 caracterului intersti\u0163ial al pneumoniei este adesea dificil s\u0103 se recolteze sputa de la pacient. \u00cen absen\u0163a procedurilor invazive (ex. lavaj bronhoalveolar) pot fi utile detec\u0163ia antigenului Legionella \u00een urin\u0103 sau testele serologice cu determinarea in dinamic\u0103 a titrurilor de anticorpi.<\/p>\n<p style=\"text-align: justify;\">\u00cen 1979 s-a constat c\u0103 \u00een urina pacien\u0163ilor cu boala legionarilor este prezent un antigen solubil specific. Acest antigen este detectabil la 3 zile dup\u0103 debutul simptomelor, fiind astfel un marker precoce de diagnostic, cu o sensibilitate de 70-80% \u015fi o specificitate de 97-100%<sup>5<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Diagnosticul serologic este cel mai adesea retrospectiv deoarece seroconversia se produce \u00een c\u00e2teva s\u0103pt\u0103m\u00e2ni; confirmarea bolii se realizeaz\u0103 prin cre\u015fterea de patru ori a titrului anticorpilor (&gt; 1\/128) \u00een dou\u0103 probe perechi: prima recoltat\u0103 \u00een faza acut\u0103 a bolii, cealalt\u0103 la un interval de 2-3 s\u0103pt\u0103m\u00e2ni<sup>2;3<\/sup>. Sunt disponibile \u015fi teste imunoenzimatice care detecteaz\u0103 separat anticorpii de tip IgG \u015fi IgM<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Preg\u0103tire pacient<\/em><\/strong> \u2013 testul nu necesit\u0103 o preg\u0103tire prealabil\u0103<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Specimen recoltat <\/em><\/strong><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"text-decoration: underline;\">Antigen Legionella<\/span> \u2013 o prob\u0103 de urin\u0103 spontan\u0103.<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"text-decoration: underline;\">Serologie Legionella<\/span> \u2013 s\u00e2nge venos<sup>2<\/sup>.<\/div>\n<p style=\"text-align: justify;\"><strong><em>Recipient de recoltare<\/em><\/strong><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"text-decoration: underline;\">Antigen Legionella<\/span> \u2013 eprubet\u0103 pentru urin\u0103.<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"text-decoration: underline;\">Serologie Legionella<\/span> \u2013 vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator<sup>2<\/sup>.<\/div>\n<p style=\"text-align: justify;\"><strong><em>Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"text-decoration: underline;\">Antigen Legionella<\/span> \u2013 nu este necesar\u0103.<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"text-decoration: underline;\">Serologie Legionella<\/span> \u2013 se separ\u0103 serul prin centrifugare<sup>2<\/sup>.<\/div>\n<p style=\"text-align: justify;\"><strong><em>Volum prob\u0103<\/em><\/strong><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"text-decoration: underline;\">Antigen Legionella<\/span> \u2013 10 mL.<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"text-decoration: underline;\">Serologie Legionella<\/span> \u2013 minim 2 mL ser<sup>2<\/sup>.<\/div>\n<p style=\"text-align: justify;\"><strong><em>Cauze de respingere a probei<\/em><\/strong><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"text-decoration: underline;\">Antigen Legionella<\/span> \u2013 specimen care nu a fost p\u0103strat la 2-8\u00b0C, specimen contaminat cu materii fecale.<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"text-decoration: underline;\">Serologie Legionella<\/span> \u2013 specimen hemolizat, lipemic sau contaminat bacterian<sup>2<\/sup>.<strong><em>\u00a0<\/em><\/strong><\/div>\n<p style=\"text-align: justify;\"><strong><em>Stabilitate prob\u0103<\/em><\/strong><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"text-decoration: underline;\">Antigen Legionella<\/span>\u00a0 \u2013 urina este stabil\u0103 14 zile la 2-8\u00baC.<strong><em>\u00a0<\/em><\/strong><\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"text-decoration: underline;\">Serologie Legionella<\/span> \u2013 serul separat este stabil <em>c\u00e2teva ore<\/em> la temperatura camerei; <em>c\u00e2teva zile<\/em> la 2-8\u00baC; o perioad\u0103\u00a0mai \u00eendelungat\u0103 la \u201320\u00baC<sup>2<\/sup>.<\/div>\n<p style=\"text-align: justify;\"><strong><em>Metod\u0103<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"text-decoration: underline;\">Antigen Legionella<\/span>\u00a0- <span style=\"text-decoration: underline;\">metoda imunoenzimatic\u0103 (EIA<\/span>). Este detectat antigenul Legionella pneumophila serogrup 1.<\/p>\n<p style=\"text-align: justify;\"><span style=\"text-decoration: underline;\">Serologie Legionella<\/span> \u2013 Pot fi folosite 2 metode:<\/p>\n<p style=\"text-align: justify; padding-left: 30px;\">a) <span style=\"text-decoration: underline;\">imunofluorescen\u0163a indirect\u0103<sup>2<\/sup><\/span>. Reactivul de baz\u0103 con\u0163ine 3 amestecuri antigenice provenite de la: Legionella pneumophila serogrupuri 1-6, Legionella pneumophila serogrupuri 7-14, alte tipuri de Legionella: L. bozmanii, L. dumofii, L. gormanii, L. longbeachae, L. micdadei, L. jordanis. Aceast\u0103 constela\u0163ie antigenic\u0103 faciliteaz\u0103 diagnosticul serologic a peste\u00a099% din cazurile de legioneloz\u0103<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify; padding-left: 30px;\">b) <span style=\"text-decoration: underline;\">imunoenzimatic\u0103 (EIA)<\/span>. Reactivul con\u0163ine un amestec antigenic provenit de la Legionella pneumophila serogrupuri 1-7. Sunt detecta\u0163i cantitativ anticorpii de tip IgG \u015fi IgM cu o sensibilitate \u015fi o specificitate de 94.3% \u015fi\u00a0respectiv 82.5%.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Valori de referin\u0163\u0103<\/em><\/strong><strong><em>\u00a0<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"text-decoration: underline;\">Antigen Legionella<\/span>\u00a0 \u2013 Negativ.<\/p>\n<p style=\"text-align: justify;\"><span style=\"text-decoration: underline;\">Serologie Legionella<\/span><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\">a) &lt; 1\/128: Negativ<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">b) Legionella IgG: &lt;50 U\/mL<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">\u00a0\u00a0\u00a0\u00a0 Legionella IgM: 120 U\/mL<sup>2<\/sup><\/div>\n<p style=\"text-align: justify;\"><strong><em>Interpretarea rezultatelor<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"text-decoration: underline;\">Antigen Legionella<\/span><\/p>\n<p style=\"text-align: justify;\">Prezen\u0163a antigenului \u00een urin\u0103 confirm\u0103 infec\u0163ia recent\u0103 sau \u00een antecedente cu Legionella pneumophila serogrup 1.<\/p>\n<p style=\"text-align: justify;\"><span style=\"text-decoration: underline;\">Serologie Legionella<\/span><\/p>\n<p style=\"text-align: justify;\">a) Este sumarizat\u0103 \u00een tabelul de mai jos:<\/p>\n<table class=\"wp-block-table w-100\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td valign=\"top\" width=\"225\">\n<p style=\"text-align: center;\"><span style=\"font-size: 12pt;\"><strong>Titru<\/strong><\/span><\/p>\n<\/td>\n<td valign=\"top\" width=\"225\">\n<p style=\"text-align: center;\"><span style=\"font-size: 12pt;\"><strong>Tip rezultat<\/strong><\/span><\/p>\n<\/td>\n<td valign=\"top\" width=\"225\">\n<p style=\"text-align: center;\"><span style=\"font-size: 12pt;\"><strong>Interpretare<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"225\">\n<p style=\"text-align: center;\"><span style=\"font-size: 12pt;\">&lt; 1\/128<\/span><\/p>\n<\/td>\n<td valign=\"top\" width=\"225\">\n<p style=\"text-align: center;\"><span style=\"font-size: 12pt;\">Negativ<\/span><\/p>\n<\/td>\n<td style=\"text-align: justify;\" valign=\"top\" width=\"225\">\n<p style=\"text-align: left;\"><span style=\"font-size: 12pt;\">Nu au fost detecta\u0163i anticorpi specifici.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"225\">\n<p style=\"text-align: center;\"><span style=\"font-size: 12pt;\">1\/128 \u2013 1\/256<\/span><\/p>\n<\/td>\n<td valign=\"top\" width=\"225\">\n<p style=\"text-align: center;\"><span style=\"font-size: 12pt;\">Echivoc<\/span><\/p>\n<\/td>\n<td style=\"text-align: justify;\" valign=\"top\" width=\"225\">\n<p style=\"text-align: left;\"><span style=\"font-size: 12pt;\">A fost detectat un titru foarte sc\u0103zut de anticorpi specifici\u00a0:<\/span><\/p>\n<div style=\"text-align: left;\"><span style=\"font-size: 12pt;\">\u2013 titru restant post-infec\u0163ie;<\/span><\/div>\n<div style=\"text-align: left;\"><span style=\"font-size: 12pt;\">\u2013 infec\u0163ie \u00een stadiu precoce.<\/span><\/div>\n<p style=\"text-align: left;\"><span style=\"font-size: 12pt;\">Se recomand\u0103 retestarea peste 2-3 s\u0103pt\u0103m\u00e2ni.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"225\">\n<p style=\"text-align: center;\"><span style=\"font-size: 12pt;\">&gt; 1\/256<\/span><\/p>\n<\/td>\n<td valign=\"top\" width=\"225\">\n<p style=\"text-align: center;\"><span style=\"font-size: 12pt;\">Pozitiv<\/span><\/p>\n<\/td>\n<td style=\"text-align: justify;\" valign=\"top\" width=\"225\">\n<p style=\"text-align: left;\"><span style=\"font-size: 12pt;\">Probabilitate de infec\u0163ie recent\u0103. Se recomand\u0103 retestarea peste 2-3 s\u0103pt\u0103m\u00e2ni.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: justify;\">b) O seroconversie IgG\/IgM negativ \u2192 pozitiv sau ob\u0163inerea unor titruri \u00eenalte IgG\/IgM \u00een seruri-perechi este sugestiv\u0103 pentru legioneloz\u0103<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"text-decoration: underline;\">Antigen Legionella<\/span><\/p>\n<p style=\"text-align: justify;\">Un rezultat negativ <strong>nu<\/strong> infirm\u0103 o infec\u0163ie cu Legionella. Acesta se poate datora urm\u0103toarelor cauze:<\/p>\n<ul>\n<li>existen\u0163a unui foarte sc\u0103zut de antigen \u00een prob\u0103 sub limita de detec\u0163ie a metodei;<\/li>\n<li>infec\u0163ia este determinat\u0103 de alte serogrupuri de L. pneumophila sau de alte tipuri de Legionella;<\/li>\n<li>interferen\u0163a determinat\u0103 de tratamentul diuretic;<\/li>\n<li>excre\u0163ie antigenic\u0103 mult diminuat\u0103 la unii pacien\u0163i la care s-a ini\u0163iat tratamentul antibiotic specific.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\">Excre\u0163ia urinar\u0103 a antigenului prezint\u0103 varia\u0163ii individuale; la unele persoane poate persista p\u00e2n\u0103 la un an dup\u0103 infec\u0163ia acut\u0103, astfel c\u0103 \u00een aceste cazuri un rezultat pozitiv indic\u0103 o infec\u0163ie \u00een antecedente. De aceea, orice rezultat trebuie interpretat \u00een contextul clinic al pacientului<sup>4;5<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><span style=\"text-decoration: underline;\">Serologie Legionella<\/span><\/p>\n<p style=\"text-align: justify;\">Un rezultat negativ <strong>nu<\/strong> infirm\u0103 o infec\u0163ie cu Legionella deoarece uneori este nevoie de o perioad\u0103 de 4-6 s\u0103pt\u0103m\u00e2ni pentru a se ob\u0163ine titruri detectabile ale anticorpilor. \u00cen unele cazuri nivelurile anticorpilor pot s\u0103 devin\u0103 nedetectabile \u00een decurs de o lun\u0103, sau tratamentul antibiotic precoce poate suprima r\u0103spunsul umoral. Mai mult, unele persoane nu dezvolt\u0103 anticorpi peste limita de detec\u0163ie a metodei.<\/p>\n<p style=\"text-align: justify;\">Un singur rezultat pozitiv indic\u0103 doar expunerea imunologic\u0103 f\u0103r\u0103 a preciza momentul contract\u0103rii infec\u0163iei. De\u015fi titrurile &gt;1\/ 512 sunt sugestive pentru o legioneloza acut\u0103 este nevoie de testarea\u00a0\u00een dinamic\u0103. Acela\u015fi lucru este valabil \u015fi \u00een cazul detec\u0163iei anticorpilor prin metoda imunoenzimatic\u0103<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: small;\">\u00a0<\/span><strong><span style=\"font-size: 10pt;\">\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n<div style=\"text-align: justify;\"><span style=\"font-size: small;\">1. <span style=\"font-size: 10pt;\">Betty A.Forbes, Daniel F.Sahm, Alice S.Weissfeld. Legionella. In Bailey and Scott\u2019s Diagnostic Microbiology. Mosby, USA, 11 ed. 2002; 37: 424-429.<\/span><\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">2. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">3. Olga-Mihaela Dorobat. Genul Legionella. In Bacteriologie Medical\u0103. Universitatea \u201cTitu Maiorescu\u201d, Romania ed. 2006.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">4. Richard A. McPetersen, Matthew R. Pincus Medical Bacteriology. In Henry\u2019s Clinical Diagnosis and Management by Laboratory Methods- Sauders Elsevier 21-Ed 2007- pg 1039, 1040.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">5. Mayo Clinic. Mayo Medical Laboratories. Test Catalog: Legionella pneumophila, Antibody, Serum. Legionella Antigen, Urine. www.mayomedicallaboratories.com. Ref Type: Internet Communication.<\/span><\/div>","protected":false},"excerpt":{"rendered":"<p>\u041b\u0435\u0433\u0438\u043e\u043d\u0435\u043b\u043b\u0435\u0437 \u2014 \u0432\u044b\u0437\u044b\u0432\u0430\u0435\u0442\u0441\u044f \u0432\u043e\u0437\u0431\u0443\u0434\u0438\u0442\u0435\u043b\u0435\u043c Legionella pneumophila, \u044d\u0442\u043e \u043e\u0441\u0442\u0440\u043e\u0435 \u0440\u0435\u0441\u043f\u0438\u0440\u0430\u0442\u043e\u0440\u043d\u043e\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435, \u0441\u043e\u043f\u0440\u043e\u0432\u043e\u0436\u0434\u0430\u044e\u0449\u0435\u0435\u0441\u044f \u043b\u0438\u0445\u043e\u0440\u0430\u0434\u043a\u043e\u0439 (\u043b\u0438\u0445\u043e\u0440\u0430\u0434\u043a\u0430 \u041f\u043e\u043d\u0442\u0438\u0430\u043a) \u0438 \u043f\u0440\u043e\u0442\u0435\u043a\u0430\u0435\u0442 \u043a\u0430\u043a \u043e\u0441\u0442\u0440\u0430\u044f \u0440\u0435\u0441\u043f\u0438\u0440\u0430\u0442\u043e\u0440\u043d\u0430\u044f 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