{"id":10140,"date":"2020-04-23T03:57:45","date_gmt":"2020-04-23T00:57:45","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/anticorpi-anti-suprarenala\/"},"modified":"2025-02-05T16:12:15","modified_gmt":"2025-02-05T14:12:15","slug":"anticorpi-anti-suprarenala","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/anticorpi-anti-suprarenala\/","title":{"rendered":"\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0441\u0442\u0435\u0440\u043e\u0438\u0434\u043f\u0440\u043e\u0434\u0443\u0446\u0438\u0440\u0443\u044e\u0449\u0438\u043c \u043a\u043b\u0435\u0442\u043a\u0430\u043c"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong><em>\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">Anticorpii antisuprarenal\u0103 sunt autoanticorpi \u00eendrepta\u0163i \u00eempotriva celulelor din zona cortical\u0103 a suprarenalei. 60-75% dintre pacien\u0163ii cu boala Addison idiopatic\u0103 prezint\u0103 \u00een ser acest tip de anticorpi, afec\u0163iunea fiind diagnosticat\u0103 la persoane cu v\u00e2rsta \u00eentre 20 \u015fi 50 ani, predominant la femeile peste 30 ani.<\/p>\n<p style=\"text-align: justify;\">45% din pacien\u0163ii asimptomatici cu anticorpi antisuprarenal\u0103 prezen\u0163i \u00een ser vor dezvolta \u00een urm\u0103torii 2-3 ani insuficien\u0163\u0103 suprarenalian\u0103. Boala Adddison asociat\u0103 cu autoanticorpi este de cele mai multe ori acompaniat\u0103 de alte afec\u0163iuni autoimune, cum ar fi tiroidita, anemia pernicioas\u0103 sau diabetul zaharat dependent de insulin\u0103.<\/p>\n<p style=\"text-align: justify;\">Autoanticorpii antisuprarenal\u0103 mai pot fi \u00eent\u00e2lni\u0163i la 5-17% dintre pacien\u0163ii cu tuberculoz\u0103 suprarenalian\u0103, infec\u0163ii fungice sau metastaze de glande suprarenale, precum \u015fi \u00een 38% din cazurile neclasificate de insuficien\u0163\u0103 suprarenalian\u0103. Anticorpii antisuprarenal\u0103 pot fi observa\u0163i de asemenea \u00een hipoparatiroidismul idiopatic (28% din cazuri) \u015fi \u00een boala Hashimoto (7%)<sup>1;3<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Recomand\u0103ri pentru determinarea anticorpilor antisuprarenal\u0103 <\/em><\/strong>\u2013 evaluarea pacien\u0163ilor cu insuficien\u0163\u0103 suprarenalien\u0103 \u015fi boala Addison<sup>3<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Preg\u0103tire pacient<\/em><\/strong> \u2013 \u00e0 jeun (pe nem\u00e2ncate)<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Specimen recoltat<\/em><\/strong> \u2013 s\u00e2nge venos<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Recipient de recoltare <\/em><\/strong><em>-<\/em> vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Prelucrare necesar\u0103 dup\u0103 recoltare<\/em><\/strong><em> - <\/em>se separ\u0103 serul prin centrifugare<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Cantitate recoltat\u0103 <\/em><\/strong>\u2013 1 mL<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Cauze\u00a0 de respingere a probei<\/em><\/strong> <em>- <\/em>specimen intens hemolizat\/lipemic\/contaminat bacterian<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Stabilitate prob\u0103 <\/em><\/strong>\u2013 serul separat este stabil <em>7 zile<\/em> la 2-4\u00b0C \u015fi <em>1 lun\u0103 <\/em>la -20\u00b0C<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Metod\u0103<\/em><\/strong> - <span style=\"text-decoration: underline;\">imunofluorescen\u0163\u0103 indirect\u0103<sup>2<\/sup><\/span>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Valori de referin\u0163\u0103 <\/em><\/strong>\u2013 &lt;1\/10<sup>2<\/sup>.<strong><em> \u00a0<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">Rezultatele se exprim\u0103 sub form\u0103 de titru<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Interpretarea rezultatelor<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">Anticorpii antisuprarenal\u0103 sunt markeri pentru boala Addison idiopatic\u0103 \u015fi servesc la identificarea persoanelor cu risc de a dezvolta aceast\u0103 boal\u0103, \u00een special pacien\u0163ii care prezint\u0103 \u015fi alte afec\u0163iuni autoimune cum ar fi: hipoparatiroidism, boli tiroidiene, diabet insulino-dependent, anemie pernicioas\u0103 \u015fi insuficien\u0163\u0103 gonadal\u0103<sup>1<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: small;\">\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 10pt;\">\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">1. David J. Bylund, Robert M. Nakamura. Organ-Specific Autoimmune Diseases. In Henry\u2019s Clinical Diagnosis and Management by Laboratory Methods, Saunders-Elsevier, 21st Edition, 956.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">2. Laborator Synevo. Referin\u0163e specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: small;\"><span style=\"font-size: 10pt;\">3. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Antiadrenal Antibodies, Quantitative. www.labcorp.com 2010. Ref Type: Internet Communication<\/span>.<\/span><\/div>","protected":false},"excerpt":{"rendered":"<p>\u0410\u043d\u0442\u0438\u0430\u0434\u0440\u0435\u043d\u0430\u043b\u043e\u0432\u044b\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u044f\u044e\u0442 \u0441\u043e\u0431\u043e\u0439 \u0430\u0443\u0442\u043e\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430, \u043d\u0430\u043f\u0440\u0430\u0432\u043b\u0435\u043d\u043d\u044b\u0435 \u043f\u0440\u043e\u0442\u0438\u0432 \u043a\u043b\u0435\u0442\u043e\u043a \u043a\u043e\u0440\u044b \u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u043e\u0432. \u042d\u0442\u043e\u0442 \u0442\u0438\u043f \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u0441\u043e\u0434\u0435\u0440\u0436\u0438\u0442\u0441\u044f \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438 \u0443 60-75% \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0438\u0434\u0438\u043e\u043f\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u044c\u044e \u0410\u0434\u0434\u0438\u0441\u043e\u043d\u0430, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0440\u0443\u044e\u0442\u0441\u044f \u0443 \u043b\u044e\u0434\u0435\u0439 \u0432 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0435 \u043e\u0442 20 \u0434\u043e 50 \u043b\u0435\u0442, \u043f\u0440\u0435\u0438\u043c\u0443\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e \u0443 \u0436\u0435\u043d\u0449\u0438\u043d \u0441\u0442\u0430\u0440\u0448\u0435 30 \u043b\u0435\u0442. \u0423 45% \u0431\u0435\u0441\u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043d\u044b\u0445 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0430\u043d\u0442\u0438\u0430\u0434\u0440\u0435\u043d\u0430\u043b\u043e\u0432\u044b\u043c\u0438 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430\u043c\u0438, \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0443\u044e\u0449\u0438\u043c\u0438 \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435, \u0440\u0430\u0437\u0432\u0438\u0432\u0430\u0435\u0442\u0441\u044f \u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u043e\u0432\u0430\u044f \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u044c \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 \u0441\u043b\u0435\u0434\u0443\u044e\u0449\u0438\u0445 2-3 \u043b\u0435\u0442. \u0411\u043e\u043b\u0435\u0437\u043d\u044c \u0410\u0434\u0434\u0438\u0441\u043e\u043d\u0430, \u0441\u0432\u044f\u0437\u0430\u043d\u043d\u0430\u044f \u0441 \u0430\u0443\u0442\u043e\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430\u043c\u0438, \u0447\u0430\u0441\u0442\u043e \u0441\u043e\u043f\u0440\u043e\u0432\u043e\u0436\u0434\u0430\u0435\u0442\u0441\u044f \u0434\u0440\u0443\u0433\u0438\u043c\u0438 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u043c\u0438 \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u044f\u043c\u0438, \u0442\u0430\u043a\u0438\u043c\u0438 \u043a\u0430\u043a \u0442\u0438\u0440\u0435\u043e\u0438\u0434\u0438\u0442, \u043f\u0435\u0440\u043d\u0438\u0446\u0438\u043e\u0437\u043d\u0430\u044f \u0430\u043d\u0435\u043c\u0438\u044f \u0438\u043b\u0438 \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u043e\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u044b\u0439 \u0434\u0438\u0430\u0431\u0435\u0442.<\/p>\n<p>\u0410\u043d\u0442\u0438\u0430\u0434\u0440\u0435\u043d\u0430\u043b\u043e\u0432\u044b\u0435 \u0430\u0443\u0442\u043e\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u0442\u0430\u043a\u0436\u0435 \u043c\u043e\u0433\u0443\u0442 \u0431\u044b\u0442\u044c \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u044b \u0443 5-17% \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0442\u0443\u0431\u0435\u0440\u043a\u0443\u043b\u0435\u0437\u043e\u043c \u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u043e\u0432, \u0433\u0440\u0438\u0431\u043a\u043e\u0432\u044b\u043c\u0438 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044f\u043c\u0438 \u0438\u043b\u0438 \u043c\u0435\u0442\u0430\u0441\u0442\u0430\u0437\u0430\u043c\u0438 \u0432 \u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u0430\u0445, \u0430 \u0442\u0430\u043a\u0436\u0435 \u0432 38% \u043d\u0435\u0441\u0435\u043a\u0440\u0435\u0442\u043d\u044b\u0445 \u0441\u043b\u0443\u0447\u0430\u0435\u0432 \u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u043e\u0432\u043e\u0439 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u0438. \u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u0430\u043c \u043c\u043e\u0433\u0443\u0442 \u0442\u0430\u043a\u0436\u0435 \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u0442\u044c\u0441\u044f \u043f\u0440\u0438 \u0438\u0434\u0438\u043e\u043f\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u0433\u0438\u043f\u043e\u043f\u0430\u0440\u0430\u0442\u0438\u0440\u0435\u043e\u0437\u0435 (28% \u0441\u043b\u0443\u0447\u0430\u0435\u0432) \u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u0425\u0430\u0448\u0438\u043c\u043e\u0442\u043e (7%) 1; 3.<\/p>\n<p>\u0420\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u043f\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044e \u0430\u043d\u0442\u0438\u0430\u0434\u0440\u0435\u043d\u0430\u043b\u043e\u0432\u044b\u0445 \u0430\u043d\u0442\u0438\u0442\u0435\u043b &#8211; \u043e\u0446\u0435\u043d\u043a\u0430 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u043e\u0432\u043e\u0439 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u044c\u044e \u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u044c\u044e \u0410\u0434\u0434\u0438\u0441\u043e\u043d\u0430 3.<\/p>\n<p><strong>\u041f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0430 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430<\/strong> &#8211; \u043d\u0430\u0442\u043e\u0449\u0430\u043a 2.<br \/>\n<strong>\u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b<\/strong> &#8211; \u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c 2.<br \/>\n<strong>\u0422\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u0430\u044f \u0441\u0440\u0435\u0434\u0430, \u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0430<\/strong>&#8211; \u0432\u0430\u043a\u0443\u0443\u043c\u043d\u044b\u0439 \u0431\u0435\u0437 \u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430 \u0441 \/ \u0431\u0435\u0437 \u0433\u0435\u043b\u0435\u0432\u043e\u0433\u043e \u0441\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0440\u0430 2.<br \/>\n<strong>\u041d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0430\u044f \u043e\u0431\u0440\u0430\u0431\u043e\u0442\u043a\u0430 \u043f\u043e\u0441\u043b\u0435 \u0441\u0431\u043e\u0440\u0430 \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430<\/strong> &#8211; \u043e\u0442\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0438 \u0446\u0435\u043d\u0442\u0440\u0438\u0444\u0443\u0433\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435\u043c 2.<br \/>\n<strong>\u041e\u0431\u044a\u0435\u043c \u043e\u0431\u0440\u0430\u0437\u0446\u0430<\/strong>&#8211; 1 \u043c\u043b 2.<br \/>\n<strong>\u041f\u0440\u0438\u0447\u0438\u043d\u044b \u043e\u0442\u0442\u043e\u0440\u0436\u0435\u043d\u0438\u044f \u043e\u0431\u0440\u0430\u0437\u0446\u0430<\/strong> &#8211; \u0433\u0435\u043c\u043e\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0439 \/ \u043b\u0438\u043f\u0435\u043c\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \/ \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e \u0437\u0430\u0433\u0440\u044f\u0437\u043d\u0435\u043d\u043d\u044b\u0439 \u043e\u0431\u0440\u0430\u0437\u0435\u0446 2.<br \/>\n<strong>\u0421\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u043e\u0431\u0440\u0430\u0437\u0446\u0430<\/strong> &#8211; \u043e\u0442\u0434\u0435\u043b\u0435\u043d\u043d\u0430\u044f \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0430 \u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u0430 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 1 \u043c\u0435\u0441\u044f\u0446\u0430 \u043f\u0440\u0438 -20 \u00b0 C 2.<br \/>\n<strong>\u041c\u0435\u0442\u043e\u0434<\/strong> &#8211; \u043d\u0435\u043f\u0440\u044f\u043c\u0430\u044f \u0438\u043c\u043c\u0443\u043d\u043e\u0444\u043b\u044e\u043e\u0440\u0435\u0441\u0446\u0435\u043d\u0446\u0438\u044f 2.<\/p>\n<p><strong>\u0420\u0435\u0444\u0435\u0440\u0435\u043d\u0442\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f<\/strong> &#8211; 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\u043b\u044e\u0434\u0435\u0439 \u0441 \u0440\u0438\u0441\u043a\u043e\u043c \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0434\u0440\u0443\u0433\u0438\u043c\u0438 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u043c\u0438 \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u044f\u043c\u0438, \u0442\u0430\u043a\u0438\u043c\u0438 \u043a\u0430\u043a \u0433\u0438\u043f\u043e\u043f\u0430\u0440\u0430\u0442\u0438\u0440\u0435\u043e\u0437, \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435 \u0449\u0438\u0442\u043e\u0432\u0438\u0434\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b, \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u043e\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u044b\u0439 \u0434\u0438\u0430\u0431\u0435\u0442, \u043f\u0435\u0440\u043d\u0438\u0446\u0438\u043e\u0437\u043d\u0430\u044f \u0430\u043d\u0435\u043c\u0438\u044f \u0438 \u0433\u043e\u043d\u0430\u0434\u0430\u043b\u044c\u043d\u0430\u044f \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u044c.<\/p>\n<p>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<br \/>\n1. David J. Bylund, Robert M. Nakamura. Organ-Specific Autoimmune Diseases. In Henry\u2019s Clinical Diagnosis and Management by Laboratory Methods, Saunders-Elsevier, 21st Edition, 956.<br \/>\n2. \u041b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u0438\u044f Synevo. \u041a\u043e\u043d\u043a\u0440\u0435\u0442\u043d\u044b\u0435 \u0441\u0441\u044b\u043b\u043a\u0438 \u043d\u0430 \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0440\u0430\u0431\u043e\u0442\u044b \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u044b 2010. Ref Type: Catalog.<br \/>\n3. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Antiadrenal Antibodies, Quantitative. www.labcorp.com 2010. 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