{"id":10136,"date":"2020-04-23T03:57:39","date_gmt":"2020-04-23T00:57:39","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/alfa-1-microglobulina-in-urina\/"},"modified":"2025-01-31T14:02:18","modified_gmt":"2025-01-31T12:02:18","slug":"alfa-1-microglobulina-in-urina","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/alfa-1-microglobulina-in-urina\/","title":{"rendered":"\u0410\u043b\u044c\u0444\u0430-1-\u043c\u0438\u043a\u0440\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d \u0432 \u043c\u043e\u0447\u0435"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong><em>\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">Alfa1-microglobulina este o glicoprotein\u0103 cu greutate molecular\u0103 mic\u0103 (26 kDa) sintetizat\u0103 la nivelul ficatului, ce face parte din superfamilia proteinelor lipocalin. \u00cen plasm\u0103 formeaz\u0103 complexe cu IgA. Forma nelegat\u0103 este filtrat\u0103 la nivel glomerular \u015fi reabsorbit\u0103 par\u0163ial \u00een tubii proximali, unde este metabolizat\u0103. \u00cen condi\u0163ii normale, datorit\u0103 reabsorb\u0163iei tubulare, doar o mic\u0103 parte se g\u0103se\u015fte\u00a0\u00een urina final\u0103<strong>, <\/strong>de aceea, orice cre\u015ftere a excre\u0163iei urinare a alfa1-microglobulinei indic\u0103 fie o modificare morfologic\u0103, fie una func\u0163ional\u0103 la nivelul tubului proximal.<\/p>\n<p style=\"text-align: justify;\">Cre\u015fterile serice ale alfa 1-microglobulinei sunt asociate cu cre\u015fteri ale IgA sau afec\u0163iuni hepatice, nefiind semnificative \u00een depistarea modific\u0103rilor tubulo\u2013intersti\u0163iale<sup>1;2;3<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Recomand\u0103ri pentru determinarea de alfa1-microglobulin\u0103<\/em><\/strong><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2013 screening-ul\u00a0tubulopatiilor<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2013 monitorizarea evolu\u0163iei leziunilor sau disfunc\u0163iilor tubulare<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2013 detectarea disfunc\u0163iilor renale cronice asimptomatice<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2013 nefrite intersti\u0163iale<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2013 pielonefrite<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2013 tubulopatii ereditare<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2013 sindrom Fanconi<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2013 gut\u0103<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2013 nefropatii induse de medicamente<\/div>\n<div style=\"text-align: left; padding-left: 30px;\">\u2013 boala Wilson<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2013 sindrom Sj\u0151gren<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2013 evaluarea func\u0163iei renale dup\u0103 transplant<sup>4<\/sup><\/div>\n<p><strong><em>Preg\u0103tire pacient<\/em><\/strong> \u2013 nu este necesar\u0103<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Specimen recoltat<\/em><\/strong> \u2013\u00a0o prob\u0103 de urin\u0103 spontan\u0103 (preferabil prima urin\u0103 de diminea\u0163\u0103)<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Recipient de recoltare <\/em><\/strong><em>-<\/em> eprubeta pentru urin\u0103<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Prelucrare necesar\u0103 dup\u0103 recoltare<\/em><\/strong><em> - <\/em>nu se adaug\u0103 acizi sau conservan\u0163i<sup>2<\/sup>; specimenul se centrifugheaz\u0103 la temperatura camerei<sup>2;3<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Cantitate recoltat\u0103<\/em><\/strong> \u2013 10 mL<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Cauze\u00a0 de respingere a probei<\/em><\/strong> <em>- <\/em>specimene congelate<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Stabilitate prob\u0103<\/em><\/strong><em> - <\/em><em>7 zile <\/em>la 2-8\u00baC<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Metod\u0103 <\/em><\/strong><em>- <\/em><span style=\"text-decoration: underline;\">nefelometric\u0103<\/span><sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Valori de referin\u0163\u0103 <\/em><\/strong>\u2013 &lt; 12 mg\/L<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Interpretarea rezultatelor <\/em><\/strong><\/p>\n<div style=\"text-align: justify;\">Modific\u0103ri ale excre\u0163iei urinare de alfa1-microglobulin\u0103 se \u00eenregistreaz\u0103 \u00een afec\u0163iuni tubulare, nefrite intersti\u0163iale, pielonefrite, tubulopatii ereditare, intoxica\u0163ii cu metale grele sau expunere la medicamente nefrotoxice.<\/div>\n<div style=\"text-align: justify;\">Glomerulopatiile \u015fi vasculopatiile renale se asociaz\u0103 adesea cu leziuni tubulare determin\u00e2nd cre\u015fteri ale concentra\u0163iei urinare de alfa1-microglobulin\u0103.<\/div>\n<div style=\"text-align: justify;\">La pacien\u0163ii cu infec\u0163ii urinare, prezen\u0163a alfa1-microglobulinei \u00een urin\u0103 indic\u0103 o afectare renal\u0103 (pielonefrita).<\/div>\n<div style=\"text-align: justify;\">O cale alternativ\u0103 la dozarea alfa1-microglobulinei este determinarea proteinei transportoare a retinolului (RBP), deoarece nu exist\u0103 studii care s\u0103 demonstreze superioritatea unui test fa\u0163\u0103 de cel\u0103lalt<sup>3<\/sup>.<\/div>\n<div style=\"text-align: justify;\"><\/div>\n<div style=\"text-align: justify;\"><strong><em>Limite \u015fi interferen\u0163e<\/em><\/strong><\/div>\n<div style=\"text-align: justify;\">Rezultatele testului pot fi modificate dac\u0103\u00a0specimenele con\u0163in particule (celule, cristale etc.) sau au turbiditatea modificat\u0103<sup>1<\/sup>.<\/div>\n<p style=\"text-align: justify;\"><span style=\"font-size: small;\">\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: small;\">\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n<div style=\"text-align: justify;\"><span style=\"font-size: small;\">1. ARUP Laboratories. Test Directory: Alpha-1-Microglobulin, Urine. www.aruplab.com 2015. Ref Type: Internet Communication.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: small;\">2. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2015. Ref Type: Catalog<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: small;\">3. Mayo Clinic\/Mayo Medical Laboratories.\u00a0 Test Catalog. Alpha-1-Microglobulin, Random, Urine. <a href=\"http:\/\/www.mayomedicallaboratories.com\/\" rel=\"nofollow noopener\" target=\"_blank\">www.mayomedicallaboratories.com<\/a>. Ref Type: Internet Communication<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: small;\"><span style=\"font-size: medium;\">4. <\/span><\/span><span style=\"font-size: small;\">Lothar Thomas. Urinary Proteins. In Clinical Laboratory Diagnostics-Use and Assessment of Clinical Laboratory Results. TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany, 1 Ed., 1998, 382-399.<\/span><\/div>","protected":false},"excerpt":{"rendered":"<p><em><strong>\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/strong><\/em><\/p>\n<p>\u0410\u043b\u044c\u0444\u04301-\u043c\u0438\u043a\u0440\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 \u0441\u043e\u0431\u043e\u0439 \u043d\u0438\u0437\u043a\u043e\u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0439 \u0433\u043b\u0438\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d (26 \u041a\u0414\u0410), \u0441\u0438\u043d\u0442\u0435\u0437\u0438\u0440\u0443\u0435\u043c\u044b\u0439 \u0432 \u043f\u0435\u0447\u0435\u043d\u0438, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0447\u0430\u0441\u0442\u044c\u044e \u0441\u0443\u043f\u0435\u0440\u0441\u0435\u043c\u0435\u0439\u0441\u0442\u0432\u0430 \u0431\u0435\u043b\u043a\u043e\u0432 \u043b\u0438\u043f\u043e\u043a\u0430\u043b\u0438\u043d\u0430. \u0412 \u043f\u043b\u0430\u0437\u043c\u0435 \u043e\u0431\u0440\u0430\u0437\u0443\u044e\u0442 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u044b \u0421 IgA. \u041d\u0435\u0441\u0432\u044f\u0437\u0430\u043d\u043d\u0430\u044f \u0444\u043e\u0440\u043c\u0430 \u0444\u0438\u043b\u044c\u0442\u0440\u0443\u0435\u0442\u0441\u044f \u043d\u0430 \u043a\u043b\u0443\u0431\u043e\u0447\u043a\u043e\u0432\u043e\u043c \u0443\u0440\u043e\u0432\u043d\u0435 \u0438 \u0447\u0430\u0441\u0442\u0438\u0447\u043d\u043e \u0440\u0435\u0430\u0431\u0441\u043e\u0440\u0431\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u0432 \u043f\u0440\u043e\u043a\u0441\u0438\u043c\u0430\u043b\u044c\u043d\u044b\u0445 \u043a\u0430\u043d\u0430\u043b\u044c\u0446\u0430\u0445, \u0433\u0434\u0435 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u0438\u0440\u0443\u0435\u0442\u0441\u044f. \u0412 \u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u044b\u0445 \u0443\u0441\u043b\u043e\u0432\u0438\u044f\u0445 \u0438\u0437-\u0437\u0430 \u0440\u0435\u0430\u0431\u0441\u043e\u0440\u0431\u0446\u0438\u0438 \u043a\u0430\u043d\u0430\u043b\u044c\u0446\u0435\u0432 \u0432 \u043a\u043e\u043d\u0435\u0447\u043d\u043e\u0439 \u043c\u043e\u0447\u0435 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u0432\u0430\u0435\u0442\u0441\u044f \u043b\u0438\u0448\u044c \u043d\u0435\u0431\u043e\u043b\u044c\u0448\u0430\u044f \u0447\u0430\u0441\u0442\u044c, \u043f\u043e\u044d\u0442\u043e\u043c\u0443 \u043b\u044e\u0431\u043e\u0435 \u0443\u0432\u0435\u043b\u0438\u0447\u0435\u043d\u0438\u0435 \u044d\u043a\u0441\u043a\u0440\u0435\u0446\u0438\u0438 \u0430\u043b\u044c\u0444\u04301-\u043c\u0438\u043a\u0440\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u0430 \u0441 \u043c\u043e\u0447\u043e\u0439 \u0443\u043a\u0430\u0437\u044b\u0432\u0430\u0435\u0442 \u043b\u0438\u0431\u043e \u043d\u0430 \u043c\u043e\u0440\u0444\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0435, \u043b\u0438\u0431\u043e \u043d\u0430 \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0435 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u0435 \u043f\u0440\u043e\u043a\u0441\u0438\u043c\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u043a\u0430\u043d\u0430\u043b\u0430.<\/p>\n<p>\u0423\u0432\u0435\u043b\u0438\u0447\u0435\u043d\u0438\u0435 \u0430\u043b\u044c\u0444\u0430-1-\u043c\u0438\u043a\u0440\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u0430 \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438 \u0441\u0432\u044f\u0437\u0430\u043d\u043e \u0441 \u0443\u0432\u0435\u043b\u0438\u0447\u0435\u043d\u0438\u0435\u043c IgA \u0438\u043b\u0438 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435\u043c \u043f\u0435\u0447\u0435\u043d\u0438, \u0447\u0442\u043e \u043d\u0435 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u043c \u0434\u043b\u044f \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u0442\u0443\u0431\u0443\u043b\u043e\u2013\u0438\u043d\u0442\u0435\u0440\u0441\u0442\u0438\u0446\u0438\u0430\u043b\u044c\u043d\u044b\u0445 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u0439 1;2;3.<\/p>\n<p><em><strong>\u0420\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u043f\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044e \u0430\u043b\u044c\u0444\u04301-\u043c\u0438\u043a\u0440\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u0430<\/strong><\/em><\/p>\n<ul>\n<li>\u0441\u043a\u0440\u0438\u043d\u0438\u043d\u0433 \u0442\u0443\u0431\u0443\u043b\u043e\u043f\u0430\u0442\u0438\u0439<\/li>\n<li>\u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433 \u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0441\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u044f \u0438\u043b\u0438 \u0434\u0438\u0441\u0444\u0443\u043d\u043a\u0446\u0438\u0438 \u043a\u0430\u043d\u0430\u043b\u044c\u0446\u0435\u0432<\/li>\n<li>\u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u0438\u0435 \u0431\u0435\u0441\u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043d\u043e\u0439 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043f\u043e\u0447\u0435\u0447\u043d\u043e\u0439 \u0434\u0438\u0441\u0444\u0443\u043d\u043a\u0446\u0438\u0438<\/li>\n<li>\u0438\u043d\u0442\u0435\u0440\u0441\u0442\u0438\u0446\u0438\u0430\u043b\u044c\u043d\u044b\u0439 \u043d\u0435\u0444\u0440\u0438\u0442<\/li>\n<li>\u043f\u0438\u0435\u043b\u043e\u043d\u0435\u0444\u0440\u0438\u0442<\/li>\n<li>\u043d\u0430\u0441\u043b\u0435\u0434\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0435 \u0442\u0443\u0431\u0443\u043b\u043e\u043f\u0430\u0442\u0438\u0438<\/li>\n<li>\u0441\u0438\u043d\u0434\u0440\u043e\u043c \u0424\u0430\u043d\u043a\u043e\u043d\u0438<\/li>\n<li>\u043f\u043e\u0434\u0430\u0433\u0440\u0430<\/li>\n<li>\u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e-\u0438\u043d\u0434\u0443\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0435 \u043d\u0435\u0444\u0440\u043e\u043f\u0430\u0442\u0438\u0438<\/li>\n<li>\u0411\u043e\u043b\u0435\u0437\u043d\u044c \u0412\u0438\u043b\u044c\u0441\u043e\u043d\u0430<\/li>\n<li>\u0441\u0438\u043d\u0434\u0440\u043e\u043c \u0428\u0435\u0433\u0440\u0435\u043d\u0430<\/li>\n<li>\u043e\u0446\u0435\u043d\u043a\u0430 \u0444\u0443\u043d\u043a\u0446\u0438\u0438 \u043f\u043e\u0447\u0435\u043a \u043f\u043e\u0441\u043b\u0435 \u0442\u0440\u0430\u043d\u0441\u043f\u043b\u0430\u043d\u0442\u0430\u0446\u0438\u0438 4<\/li>\n<\/ul>\n<p><strong>\u041f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0430 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430<\/strong> &#8211; \u043d\u0435 \u0442\u0440\u0435\u0431\u0443\u0435\u0442\u0441\u044f 2.<\/p>\n<p><strong>\u0421\u043e\u0431\u0440\u0430\u043d\u043d\u044b\u0439 \u043e\u0431\u0440\u0430\u0437\u0435\u0446<\/strong>-\u041e\u0431\u0440\u0430\u0437\u0435\u0446 \u0441\u043f\u043e\u043d\u0442\u0430\u043d\u043d\u043e\u0439 \u043c\u043e\u0447\u0438 (\u043f\u0440\u0435\u0434\u043f\u043e\u0447\u0442\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u043f\u0435\u0440\u0432\u0430\u044f \u0443\u0442\u0440\u0435\u043d\u043d\u044f\u044f \u043c\u043e\u0447\u0430)2.<\/p>\n<p><strong>\u041a\u043e\u043d\u0442\u0435\u0439\u043d\u0435\u0440 \u0434\u043b\u044f \u0441\u0431\u043e\u0440\u0430 \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430<\/strong>-\u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0430 \u0434\u043b\u044f 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1.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[954,953],"product_tag":[],"class_list":{"0":"post-10136","1":"product","2":"type-product","3":"status-publish","5":"product_cat-proteine-specifice-in-ser-si-urina","6":"product_cat-teste-de-biochimie","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10136","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10136"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10136"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10136"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10136"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10136"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}