{"id":10122,"date":"2020-04-23T04:57:15","date_gmt":"2020-04-23T01:57:15","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/virusul-hepatitei-e-anticorpi-igg-igm-westernblot\/"},"modified":"2025-02-07T16:14:01","modified_gmt":"2025-02-07T14:14:01","slug":"virusul-hepatitei-e-anticorpi-igg-igm-westernblot","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/virusul-hepatitei-e-anticorpi-igg-igm-westernblot\/","title":{"rendered":"\u0412\u0438\u0440\u0443\u0441 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0415 - \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 IgG, IgM (\u0412\u0435\u0441\u0442\u0435\u0440\u043d\u0431\u043b\u043e\u0442)"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/span><\/p>\n

Virusul hepatitei E (HEV), recent inclus \u00een genul Hepevirus <\/em>al familiei Hepeviridae<\/em>, cauzeaz\u0103 o infec\u0163ie acut\u0103, de obicei, autolimitant\u0103. Este un virus sferic, lipsit de \u00eenveli\u015f, cu diametru de 27-34 nm, alc\u0103tuit dintr-un genom ARN monocatenar cu polaritate pozitiv\u0103. Sunt descrise 4 genotipuri majore \u015fi un singur serotip. Genomul prezint\u0103 3 cadre de citire (open reading frames = ORF): ORF1 codific\u0103 metiltransferaza, proteaza, helicaza \u015fi replicaza; ORF 2 codific\u0103 proteina capsidei; ORF3 codific\u0103 o protein\u0103 a c\u0103rei func\u0163ie nu a fost definit\u01034<\/sup>.<\/span><\/p>\n

HEV se transmite pe cale fecal-oral\u0103; consumul de ap\u0103 potabil\u0103 contaminat\u0103 cu fecale este responsabil de apari\u0163ia majorit\u0103\u0163ii epidemiilor. Transmiterea direct\u0103 de la o persoan\u0103 la alta este neobi\u015fnuit\u0103. Transmiterea pe cale sexual\u0103 sau prin transfuzii nu a fost dovedit\u01031;4<\/sup>.<\/span><\/p>\n

Hepatita cu virus hepatitic E este endemic\u0103 \u00een Asia de sud-est \u015fi central\u0103, cu mai multe focare \u00een Orientul Mijlociu, Africa de nord \u015fi de vest \u015fi Mexic, datorita condi\u0163iilor de igien\u0103 deficitar\u0103. In \u0163\u0103rile dezvoltate infec\u0163iile HEV apar \u00een special la persoanele care au c\u0103l\u0103torit \u00een zonele unde boala este endemic\u0103.<\/span><\/p>\n

Recent au fost descrise \u00een \u0163\u0103rile industrializate cazuri de infec\u0163ii HEV sporadice, \u00een absen\u0163a c\u0103l\u0103toriilor \u00een str\u0103in\u0103tate, adesea cu evolu\u0163ie subclinic\u0103 sau asimptomatic\u0103. Majoritatea acestor cazuri denumite \u201cautohtone\u201d sunt asociate cu genotipul 3 HEV care prezint\u0103 o omologie marcat\u0103 a secven\u0163elor cu genotipul 3 izolat de la porcine. Se ia astfel \u00een considerarea posibilitatea unor infec\u0163ii zoonotice transmise de la porcine sau alte animale. Cazurile severe apar la adul\u0163ii tineri sau de v\u00e2rst\u0103 mijlocie (3%), dar mortalitatea este sc\u0103zut\u0103, cu excep\u0163ia femeilor gravide infectate \u00een ultimul trimestru de sarcin\u0103 (mortalitate aproximativ 20%).<\/span><\/p>\n

Tabloul clinic este asem\u0103n\u0103tor celui din hepatita A. Dup\u0103 o perioad\u0103 de incuba\u0163ie ce dureaz\u0103 \u00eentre 15 \u015fi 60 de zile, pacien\u0163ii infecta\u0163i cu HEV dezvolt\u0103 semne \u015fi simptome de hepatit\u0103 (febr\u0103, hepatomegalie, cre\u015fterea moderat\u0103 a transaminazelor), cu apari\u0163ia anticorpilor anti-HEV de tip IgM\u00a0\u00een ser, urmate de nivele detectabile de anticorpi anti-HEV IgG\u00a0\u00een termen de c\u00e2teva zile. Anticorpii anti-HEV IgM pot r\u0103m\u00e2ne pozitivi p\u00e2n\u0103 la 6 luni de la debutul simptomelor,\u00a0\u00een timp ce anticorpii de tip IgG persist\u0103, de obicei, ani de la infec\u0163ie. Viremia \u015fi excre\u0163ia virusului\u00a0\u00een fecale apar\u00a0\u00een faza preicteric\u0103 \u015fi continu\u0103 \u015fi\u00a0\u00een faza clinic\u0103. Urm\u0103rirea pe termen \u00eendelungat a pacien\u0163ilor cu hepatit\u0103 E acut\u0103 a infirmat posibilitatea croniciz\u0103rii infec\u0163iei \u015fi existen\u0163a st\u0103rii de carrier1;2;3<\/sup>.<\/span><\/p>\n

Recomand\u0103ri pentru determinarea HEV: <\/em><\/strong><\/span><\/p>\n

\u2013 detectarea infec\u0163iei recente cu virus hepatitic E;<\/span><\/div>\n
\u2013 monitorizarea pacien\u0163ilor postinfec\u0163ie3<\/sup>.\u00a0<\/em><\/strong><\/span><\/div>\n

Preg\u0103tire pacient <\/em><\/strong>\u2013 preferabil \u00e0 jeun (pe nem\u00e2ncate)1<\/sup>.<\/span><\/p>\n

Specimen recoltat <\/em><\/strong>\u2013 s\u00e2nge venos1<\/sup>.<\/span><\/p>\n

Recipient de recoltare <\/em><\/strong>\u2013 vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator1<\/sup>.<\/span><\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>\u2013 se separ\u0103 serul prin centrifugare \u00een ziua recolt\u0103rii1<\/sup>.<\/span><\/p>\n

Volum prob\u0103 <\/em><\/strong>\u2013 minim 2 mL ser1<\/sup>.<\/span><\/p>\n

Cauze de respingere a probei <\/em><\/strong>\u2013\u00a0 specimen intens hemolizat; specimen contaminat bacterian1<\/sup>.<\/span><\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>\u2013 serul este stabil 6 zile<\/em> \u00een condi\u0163ii ambientale; 7 zile la 2-8\u00b0C; timp \u00eendelungat<\/em> la -20\u00b0C; evita\u0163i decongelarea\/recongelarea repetat\u01031<\/sup>.<\/span><\/p>\n

Metod\u0103 <\/em><\/strong>- Imunoblot<\/span><\/span><\/p>\n

Testul utilizeaz\u0103 antigene recombinate purificate, relevante serologic, care sunt separate pe baza greut\u0103\u0163ii moleculare prin electroforeza \u00een gel de poliacrilamid\u0103 \u00een prezen\u0163a de sodium dodecil sulfat (SDS-PAGE) \u015fi transferate ulterior electroforetic pe o membran\u0103 de nitroceluloz\u0103 (Western blotting). Situsurile de legare libere de pe membran\u0103 sunt saturate cu o solu\u0163ie de proteine, dup\u0103 care matricea este sp\u0103lat\u0103 \u015fi t\u0103iat\u0103 \u00een f\u00e2\u015fii (strip-uri). Sunt detecta\u0163i separat anticorpii de tip IgG \u015fi IgM. Selectarea proteinelor omoloage de la dou\u0103 genotipuri diferite (genotipul 1 \u015fi 3) asigur\u0103 o sensibilitate \u00eenalt\u0103 chiar \u015fi pentru cazurile de infec\u0163ie provenite din zonele non-endemice (\u201cautohtone\u201d). Testul detecteaz\u0103 cele 4 genotipuri HEV \u015fi poate fi folosit at\u00e2t pentru screening-ul c\u00e2t \u015fi pentru confirmarea infec\u0163iei.<\/span><\/p>\n

Antigenele sunt reprezentate, \u00een ordinea fix\u0103rii pe strip, de:<\/span><\/p>\n

- O2N<\/strong>: por\u0163iunea N-terminal\u0103 a proteinei ORF2;<\/span><\/div>\n
- O2C<\/strong>: por\u0163iunea C-terminal\u0103 a proteinei ORF2;<\/span><\/div>\n
- O2M<\/strong>: por\u0163iunea mijlocie a proteinei ORF2;<\/span><\/div>\n
- O3<\/strong>: proteina ORF3.<\/span><\/div>\n

Intr-o prim\u0103 etap\u0103 strip-ul \u00eenc\u0103rcat cu antigenele HEV este incubat \u00eempreun\u0103 cu serul diluat al pacientului. Dup\u0103 o etap\u0103 de sp\u0103lare, strip-ul este incubat,\u00a0\u00een func\u0163ie de clasa de anticorpi testat\u0103, cu un conjugat anti-IgG sau anti-IgM uman marcat cu peroxidaz\u0103. Conjugatul se va ata\u015fa la complexul antigen-anticorp format. Dup\u0103 \u00eendep\u0103rtarea prin sp\u0103lare a conjugatului nelegat se adaug\u0103 solu\u0163ia de colorare \u2013 un sistem de detec\u0163ie enzimatic\u0103 colorimetric\u0103 care con\u0163ine peroxid de hidrogen. Dac\u0103 este prezent conjugatul legat, reac\u0163ia enzimatic\u0103 va genera un produs colorat albastru-\u00eenchis la nivelul benzilor ocupate de anticorpii specifici. Astfel, benzile vizualizate sunt rezultatul leg\u0103rii anticorpilor specifici de antigenele individuale recombinate de la nivelul strip-ului1<\/sup>.<\/span><\/p>\n

Valori de referin\u0163\u0103 \u015f<\/em><\/strong>i<\/em><\/strong> interpretarea rezultatelor<\/em><\/strong><\/span><\/p>\n

Fiecare strip con\u0163ine \u00een partea superioar\u0103 o band\u0103 de control care reprezint\u0103 controlul reac\u0163iei necesar pentru a confirma efectuarea corect\u0103 a testului.<\/span><\/p>\n

Intensitatea benzilor probelor este comparat\u0103 cu cea a benzii O2C a controlului slab pozitiv inclus obligatoriu la fiecare rulare. Sunt posibile urm\u0103toarele exprim\u0103ri semicantitative:<\/span><\/p>\n\n\n\n\n\n\n\n
\n

Intensitate band\u0103<\/strong><\/span><\/p>\n<\/td>\n

\n

Exprimare rezultat<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Absen\u0163a<\/span><\/p>\n<\/td>\n

\n

-<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Intensitate mai mic\u0103 dec\u00e2t cea a benzii O2C a controlului slab pozitiv<\/span><\/p>\n<\/td>\n

\n

+\/-<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Intensitate comparabil\u0103 cu cea a benzii O2C a controlului slab pozitiv<\/span><\/p>\n<\/td>\n

\n

+<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Intensitate mai mare dec\u00e2t cea a benzii O2C a controlului slab pozitiv<\/span><\/p>\n<\/td>\n

\n

++<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Interpretarea definitiv\u0103 a rezultatelor testului se face cu ajutorul unui software (dup\u0103 scanarea strip-urilor) care \u00een func\u0163ie de intensitate (de la \u2013 la\u00a0 ++) acord\u0103 un punctaj pentru fiecare band\u0103 a strip-ului de la 0 la 3.<\/span><\/p>\n

\u00a0In final este calculat\u0103 suma\u00a0punctelor acordate \u015fi se va genera rezultatul testului1<\/sup>:<\/span><\/p>\n\n\n\n\n\n\n
\n

Suma punctelor<\/strong><\/span><\/p>\n<\/td>\n

\n

Rezultat test Imunoblot IgG<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

<3<\/span><\/p>\n<\/td>\n

\n

Negativ<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

3<\/span><\/p>\n<\/td>\n

\n

Echivoc<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

>3<\/span><\/p>\n<\/td>\n

\n

Pozitiv<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/span><\/p>\n\n\n\n\n\n\n
\n

Suma punctelor<\/strong><\/span><\/p>\n<\/td>\n

\n

Rezultat test Imunoblot IgM<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

<5<\/span><\/p>\n<\/td>\n

\n

Negativ<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

5<\/span><\/p>\n<\/td>\n

\n

Echivoc<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

>5<\/span><\/p>\n<\/td>\n

\n

Pozitiv<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/div>\n
Ob\u0163inerea unui rezultat pozitiv pentru anticorpii anti-HEV de tip IgM confirm\u0103 diagnosticul de infec\u0163ie recent\u0103 (\u00een ultimele 6 luni).<\/span><\/div>\n
Ob\u0163inerea unui rezultat pozitiv pentru anticorpii anti-HEV de tip IgG indic\u0103 o infec\u0163ie \u00een antecedente sau o infec\u0163ie acut\u0103 \u00een faza de covalescen\u0163\u0103.<\/span><\/div>\n
In cursul infec\u0163iei acute se \u00eenregistreaz\u0103 o reactivitate a anticorpilor anti-HEV IgG cu toate componentele proteice ORF2 \u015fi ORF3. Intensit\u0103\u0163ile benzilor O2N \u015fi O3 scad\u00a0\u00een timp, \u00eens\u0103 intensitatea benzii O2C cre\u015fte progresiv, astfel ca\u00a0\u00een cazul infec\u0163iilor vechi anti-HEV IgG sunt \u00eendrepta\u0163i\u00a0\u00een principal asupra por\u0163iunii C-terminale a proteinei ORF23<\/sup>.<\/span><\/div>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/span><\/p>\n

Ob\u0163inerea unui rezultat negativ pentru anticorpii anti-HEV de tip IgM nu exclude \u00eentotdeauna o infec\u0163ie recent\u0103 (\u00een ultimele 6 luni) deoarece \u00a0ace\u015ftia sunt prezen\u0163i \u00een medie 6-7 s\u0103pt\u0103m\u00e2ni de la debutul infec\u0163iei (dar nu mai mult de 6 luni) la aproximativ 80% din pacien\u0163ii infecta\u0163i. La restul bolnavilor diagnosticul este stabilit \u00een urma detec\u0163iei ARN viral \u00een ser sau materii fecale.<\/span><\/div>\n
In unele cazuri anticorpii anti-HEV de tip IgG apar la 2-4 s\u0103pt\u0103m\u00e2ni de la debutul clinic \u015fi de aceea testarea trebuie repetat\u0103 pentru confirmarea prezen\u0163ei anticorpilor specifici2;3<\/sup>.<\/span><\/div>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/strong><\/span><\/p>\n

1. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate. 2010. Ref Type: Catalog<\/span><\/div>\n
2. Lothar Thomas. Hepatitis E. In Clinical Laboratory Diagnostics-Use and Assessment of Clinical Laboratory Results.<\/em> TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany, 1 Ed., 1998,1282-1284.<\/span><\/div>\n
3. Mayo Clinic\/Mayo Medical Laboratories. Test Catalog. Hepatitis E Antibody, IgM, IgG , Serum. www.mayomedicallaboratories.com. Ref Type: Internet Communication.<\/span><\/div>\n
4. Panda SK, Thakral SA, Rehman S. Hepatitis E virus. In Rev Med Virol <\/em>\u00a02007, 17<\/strong>(3):<\/strong>151-180.\u00a0<\/em><\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0432\u0438\u0440\u0443\u0441\u0443 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 E lgM, anti-HEV IgM \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u2014 \u0430\u043d\u0430\u043b\u0438\u0437, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u0441\u044f \u0434\u043b\u044f \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a\u043b\u0430\u0441\u0441\u043e\u0432 IgM \u043a \u0432\u0438\u0440\u0443\u0441\u0443 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 E, \u0441\u0432\u0438\u0434\u0435\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0443\u044e\u0449\u0438\u0445 \u043e\u0431 \u043e\u0441\u0442\u0440\u043e\u0439 \u0444\u0430\u0437\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f.<\/p>\n

\u0413\u0435\u043f\u0430\u0442\u0438\u0442 E \u2014 \u044d\u0442\u043e \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u0435 \u043f\u0435\u0447\u0435\u043d\u0438, \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043a\u0430\u0440\u0442\u0438\u043d\u0430 \u043a\u043e\u0442\u043e\u0440\u043e\u0433\u043e \u043e\u0447\u0435\u043d\u044c \u0441\u0445\u043e\u0436\u0430 \u0441 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u043c \u0410. \u0413\u0435\u043f\u0430\u0442\u0438\u0442 E \u043f\u0435\u0440\u0435\u0434\u0430\u0451\u0442\u0441\u044f \u0444\u0435\u043a\u0430\u043b\u044c\u043d\u043e-\u043e\u0440\u0430\u043b\u044c\u043d\u044b\u043c (\u0447\u0430\u0449\u0435 \u0432\u043e\u0434\u043d\u044b\u043c) \u043f\u0443\u0442\u0451\u043c, \u0442\u043e \u0435\u0441\u0442\u044c \u043f\u043e\u0441\u0440\u0435\u0434\u0441\u0442\u0432\u043e\u043c \u0437\u0430\u0440\u0430\u0436\u0451\u043d\u043d\u043e\u0439 \u043f\u0438\u0449\u0438.<\/p>\n

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\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f:<\/p>\n

    \n
  • \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0415;<\/li>\n
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  • \u0441\u0443\u0431\u0444\u0435\u0431\u0440\u0438\u043b\u0438\u0442\u0435\u0442 \u043f\u043e\u0441\u043b\u0435 \u043f\u043e\u0441\u0435\u0449\u0435\u043d\u0438\u044f \u044d\u043d\u0434\u0435\u043c\u0438\u0447\u043d\u044b\u0445 \u0440\u0435\u0433\u0438\u043e\u043d\u043e\u0432.<\/li>\n<\/ul>\n

    \u041f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0430 – \u041a\u0440\u043e\u0432\u044c \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0443\u0435\u0442\u0441\u044f \u0441\u0434\u0430\u0432\u0430\u0442\u044c \u0443\u0442\u0440\u043e\u043c, \u0432 \u043f\u0435\u0440\u0438\u043e\u0434 \u0441 8 \u0434\u043e 12 \u0447\u0430\u0441\u043e\u0432. \u0412\u0437\u044f\u0442\u0438\u0435 \u043a\u0440\u043e\u0432\u0438 \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0441\u044f \u043d\u0430\u0442\u043e\u0449\u0430\u043a, \u0441\u043f\u0443\u0441\u0442\u044f 4\u20136 \u0447\u0430\u0441\u043e\u0432 \u0433\u043e\u043b\u043e\u0434\u0430\u043d\u0438\u044f. \u0414\u043e\u043f\u0443\u0441\u043a\u0430\u0435\u0442\u0441\u044f \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u043b\u0435\u043d\u0438\u0435 \u0432\u043e\u0434\u044b \u0431\u0435\u0437 \u0433\u0430\u0437\u0430 \u0438 \u0441\u0430\u0445\u0430\u0440\u0430. \u041d\u0430\u043a\u0430\u043d\u0443\u043d\u0435 \u0441\u0434\u0430\u0447\u0438 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u0441\u043b\u0435\u0434\u0443\u0435\u0442 \u0438\u0437\u0431\u0435\u0433\u0430\u0442\u044c \u043f\u0438\u0449\u0435\u0432\u044b\u0445 \u043f\u0435\u0440\u0435\u0433\u0440\u0443\u0437\u043e\u043a.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[924],"product_tag":[],"class_list":{"0":"post-10122","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-virali","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10122","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10122"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10122"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10122"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10122"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10122"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}