{"id":10118,"date":"2020-04-23T04:57:05","date_gmt":"2020-04-23T01:57:05","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/antigenul-polipeptidic-tisular-tpa-tissue-polypeptide-antigen\/"},"modified":"2025-02-07T15:20:51","modified_gmt":"2025-02-07T13:20:51","slug":"tpa-antigen-polipeptidic-tisular","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/tpa-antigen-polipeptidic-tisular\/","title":{"rendered":"\u0422\u0420\u0410 (\u0442\u043a\u0430\u043d\u0435\u0432\u043e\u0439 \u043f\u043e\u043b\u0438\u043f\u0435\u043f\u0442\u0438\u0434\u043d\u044b\u0439 \u0430\u043d\u0442\u0438\u0433\u0435\u043d)"},"content":{"rendered":"

Informa\u0163ii generale \u015fi recomand\u0103ri pentru determinarea antigenului polipeptidic\u00a0tisular<\/em><\/strong><\/span><\/p>\n

TPA reprezint\u0103 o combina\u0163ie heterogen\u0103 de molecule cu masa molecular\u0103 cuprins\u0103 \u00eentre 20 \u015fi 45 kDa. A fost definit pentru prima oar\u0103 ca marker tumoral\u00a0\u00een 1957 de c\u0103tre Bjorklund4<\/sup>.<\/span><\/p>\n

Este un antigen universal asociat tumorilor deoarece prezint\u0103 valori crescute indiferent de localizarea acestora1;3<\/sup>.<\/span><\/p>\n

TPA este alc\u0103tuit dintr-un amestec de citocheratine<\/em>: 19 (44%), 18 (36%) \u015fi 8 (30%). Este prezent \u00een \u0163esuturile fetale, placent\u0103, epiteliul organelor cavitare. Are timp de \u00eenjum\u0103t\u0103\u0163ire o zi. Sintetizat de membrana celulelor canceroase umane este secretat activ\u00a0\u00een lichidele biologice1,3<\/sup>.<\/span><\/p>\n

Specificitatea TPA pentru diagnostic este medie\/slab\u0103. Poate fi folosit \u015fi ca marker unic \u00een cazurile \u00een care nu sunt disponibili al\u0163i markeri specifici, \u00eens\u0103 \u00een combina\u0163ie cu al\u0163i markeri tumorali specificitatea test\u0103rii cre\u015fte semnificativ. Spre deosebire de ceilal\u0163i markeri, a c\u0103ror concentra\u0163ie se coreleaz\u0103 cu masa tumoral\u0103, TPA indic\u0103 activitatea actual\u0103 a tumorii, de aceea este numit \u015fi \u201eantigen de proliferare\u201d. TPA este sintetizat \u00een faza S a ciclului celular, iar concentra\u0163ia TPA se coreleaz\u0103 cu proliferarea tisular\u0103. Valorile crescute se asociaz\u0103 cu procesele proliferative care pot fi de natur\u0103 benigna sau malign\u0103. Astfel, TPA indic\u0103 mai rapid \u015fi mai precis schimb\u0103rile survenite \u00een procesul malign, fiind util at\u00e2t \u00een monitorizarea terapiei c\u00e2t \u015fi \u00een depistarea recuren\u0163elor. Poate fi identificat \u00een urin\u0103, saliv\u0103, lichid de lavaj bronhoalveolar sau de ascit\u0103, aceste determin\u0103ri fiind de multe ori mai valoroase dec\u00e2t cele din ser.<\/span><\/p>\n

Fragmentele de citocheratin\u0103 au sensibilitate diferit\u0103 \u00een func\u0163ie de localizarea tumorii3<\/sup>:<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Localizarea tumorii<\/strong><\/span><\/p>\n<\/td>\n

\n

Sensibilitate %<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Pl\u0103m\u00e2ni- cu celule mici<\/span><\/p>\n<\/td>\n

\n

90-95<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Pl\u0103m\u00e2ni- altul dec\u00e2t cel cu celule mici<\/span><\/p>\n<\/td>\n

\n

90-95<\/span><\/p>\n<\/td>\n<\/tr>\n

\n
Mamar\u00a0\u2013 preoperator<\/span><\/div>\n
\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u2013 postoperator<\/span><\/div>\n<\/td>\n
\n
40-95<\/span><\/div>\n
75-85<\/span><\/div>\n<\/td>\n<\/tr>\n
\n

Ficat<\/span><\/p>\n<\/td>\n

\n

80-90<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Pancreas<\/span><\/p>\n<\/td>\n

\n

80-90<\/span><\/p>\n<\/td>\n<\/tr>\n

\n
Colon, rect \u2013 preoperator<\/span><\/div>\n
\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u2013 postoperator<\/span><\/div>\n<\/td>\n
\n
10-85<\/span><\/div>\n
70-80<\/span><\/div>\n<\/td>\n<\/tr>\n
\n

Vezic\u0103 urinar\u0103<\/span><\/p>\n<\/td>\n

\n

80-90<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Prostat\u0103<\/span><\/p>\n<\/td>\n

\n

80-90<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Ovar<\/span><\/p>\n<\/td>\n

\n

80-90<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Tiroid\u0103<\/span><\/p>\n<\/td>\n

\n

40-60<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Cap, g\u00e2t<\/span><\/p>\n<\/td>\n

\n

60-80<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Preg\u0103tire pacient\u00ad <\/em><\/strong>-<\/em> \u00e1 jeun (pe nem\u00e2ncate) sau postprandial; se va evita administrarea de izotopi radioactivi cu cel <\/span>pu\u0163in 48 ore \u00eenaintea recolt\u0103rii2<\/sup>.<\/span><\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c2<\/sup>.<\/span><\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator2<\/sup>.<\/span><\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare<\/em><\/strong> \u2013 se separ\u0103 serul prin centrifugare \u00een maxim 45 minute de la recoltare folosindu-se pentru separare o eprubet\u0103 de plastic; se lucreaz\u0103 serul proasp\u0103t; dac\u0103 acest lucru nu este posibil, serul se p\u0103streaz\u0103 la -20\u00b0C sau la -70\u00b0C2<\/sup><\/span>.<\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 minim 1 mL ser2<\/sup>.<\/span><\/p>\n

Cauze de respingere<\/em><\/strong> a probei:<\/em><\/strong><\/span><\/p>\n

\u2022 specimen hemolizat;<\/span><\/div>\n
\u2022 specimen expus la temperatur\u0103 ridicat\u0103;<\/span><\/div>\n
\u2022 specimen contaminat bacterian2<\/sup>.<\/span><\/div>\n

\u00a0Stabilitate prob\u0103 <\/em><\/strong>- <\/em>serul separat este stabil 2 luni<\/em> la -20\u00b0C sau la -70\u00b0C1;2<\/sup>. Nu decongela\u0163i\/recongela\u0163i2<\/sup>.<\/span><\/p>\n

\u00a0Metod\u0103 <\/em><\/strong>- radioimunologic\u0103 (RIA) 2<\/sup><\/span>.<\/span><\/p>\n

Valori de referin\u0163\u0103 <\/em><\/strong>-<\/em> 0-10 U\/L2<\/sup>.<\/span><\/p>\n

Limite \u015fi interferen\u0163e:<\/em><\/strong><\/span><\/p>\n

TPA cre\u015fte frecvent \u00een inflama\u0163ii, infec\u0163ii respiratorii, diabet, hepatit\u0103, ciroz\u0103 hepatic\u0103, pancreatit\u0103, insuficien\u0163\u0103 renal\u01033;4<\/sup>.<\/span><\/div>\n
Interferen\u0163e analitice se pot produce \u015fi la pacien\u0163ii trata\u0163i cu radioizotopi \u00eenainte de recoltarea s\u00e2ngelui2<\/sup>.<\/span><\/div>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f:<\/strong><\/span><\/p>\n

1. Concepcion Prados, Rodolfo Alvarez-Sala, Javier Gomez de Terreros- An evaluation of Tissue Polypeptide Antigen(TPA) in two brochoalveolar lavage fractions of lung cancer patients. In Japanese Journal of Clinical Oncology (2000) pg 215-220.<\/span><\/div>\n
2. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate. 2010. Ref Type: Catalog.<\/span><\/div>\n
3. Minodora Dobreanu. Aspecte metabolice \u00een prolifer\u0103ri maligne \u2013 markeri tumorali. In Biochimie clinic\u0103 \u2013 Implica\u0163ii practice, cap.16, 261-262<\/span><\/div>\n
4. Turkan Cetin; Arsu Oguz,Pelin Algar- The use of tissue polypeptide specific antigen as marker in liver disease. In Turk Journal of Gastroenterology. 2003 pg 177<\/span>-180.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

T\u0420\u0410 (\u0442\u043a\u0430\u043d\u0435\u0432\u043e\u0439 \u043f\u043e\u043b\u0438\u043f\u0435\u043f\u0442\u0438\u0434\u043d\u044b\u0439 \u0430\u043d\u0442\u0438\u0433\u0435\u043d) \u0441\u0447\u0438\u0442\u0430\u0435\u0442\u0441\u044f \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0430\u043b\u044c\u043d\u044b\u043c \u043e\u043d\u043a\u043e\u043c\u0430\u0440\u043a\u0435\u0440\u043e\u043c, \u043f\u043e\u043b\u0435\u0437\u043d\u044b\u043c \u0434\u043b\u044f \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433\u0430 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438: \u0440\u0430\u043a\u0430 \u043c\u043e\u0447\u0435\u0432\u043e\u0433\u043e \u043f\u0443\u0437\u044b\u0440\u044f, \u043c\u043e\u043b\u043e\u0447\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b, \u043c\u0435\u043b\u043a\u043e\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u0440\u0430\u043a\u0430 \u043b\u0435\u0433\u043a\u0438\u0445, \u0440\u0430\u043a\u0430 \u044f\u0438\u0447\u043d\u0438\u043a\u043e\u0432, \u0448\u0435\u0439\u043a\u0438 \u043c\u0430\u0442\u043a\u0438, \u043f\u0440\u043e\u0441\u0442\u0430\u0442\u044b.<\/p>\n

TPA \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043f\u043e\u043b\u0438\u043f\u0435\u043f\u0442\u0438\u0434\u043e\u043c \u0441 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u043e\u0439 \u043c\u0430\u0441\u0441\u043e\u0439 22 \u043a\u0414\u0430\u043b\u044c\u0442\u043e\u043d \u0438 \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0443\u0435\u0442 \u0432 \u0431\u043e\u043b\u044c\u0448\u0438\u043d\u0441\u0442\u0432\u0435 \u044d\u043f\u0438\u0442\u0435\u043b\u0438\u0430\u043b\u044c\u043d\u044b\u0445 \u043a\u043b\u0435\u0442\u043e\u043a, \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0441\u043e\u0441\u0442\u0430\u0432\u043d\u043e\u0439 \u0447\u0430\u0441\u0442\u044c\u044e \u043a\u0435\u0440\u0430\u0442\u0438\u043d\u043e\u0432 (\u044f\u0432\u043b\u044f\u0435\u0442 \u0441\u043e\u0431\u043e\u0439 \u0446\u0438\u0440\u043a\u0443\u043b\u0438\u0440\u0443\u044e\u0449\u0438\u0439 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441 \u0446\u0438\u0442\u043e\u043a\u0435\u0440\u0430\u0442\u0438\u043d\u043e\u0432 8, 18 \u0438 19), \u043e\u0442\u043d\u043e\u0441\u044f\u0449\u0438\u0439\u0441\u044f \u043a \u043f\u0440\u043e\u043c\u0435\u0436\u0443\u0442\u043e\u0447\u043d\u044b\u043c \u043d\u0438\u0442\u044f\u043c \u043d\u0435\u043a\u0432\u0430\u043c\u043e\u0437\u043d\u044b\u0445 \u044d\u043f\u0438\u0442\u0435\u043b\u0438\u0430\u043b\u044c\u043d\u044b\u0445 \u043a\u043b\u0435\u0442\u043e\u043a \u0432 \u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u044b\u0445 \u0438 \u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u0442\u043a\u0430\u043d\u044f\u0445. \u041d\u0430\u043b\u0438\u0447\u0438\u0435 TPA \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438 \u0438\u043b\u0438 \u0434\u0440\u0443\u0433\u0438\u0445 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0436\u0438\u0434\u043a\u043e\u0441\u0442\u044f\u0445 (\u0432 \u043c\u043e\u0447\u0435 \u2013 \u0440\u0430\u043a \u043c\u043e\u0447\u0435\u0432\u043e\u0433\u043e \u043f\u0443\u0437\u044b\u0440\u044f) \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u043c \u0443\u0432\u0435\u043b\u0438\u0447\u0435\u043d\u0438\u044f \u043e\u0431\u043c\u0435\u043d\u0430 \u0438 \u0430\u0443\u0442\u043e\u043b\u0438\u0437\u0430 \u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u043a\u043b\u0435\u0442\u043e\u043a, \u0447\u0442\u043e \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0435\u043c \u043f\u0440\u043e\u043b\u0438\u0444\u0435\u0440\u0430\u0446\u0438\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u0445 \u043a\u043b\u0435\u0442\u043e\u043a.<\/p>\n

TPA \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043e\u0442\u043b\u0438\u0447\u043d\u044b\u043c \u043f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0435\u043c \u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0439 \u043f\u0440\u043e\u043b\u0438\u0444\u0435\u0440\u0430\u0446\u0438\u0438, \u0445\u043e\u0442\u044f \u0438 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043d\u0435\u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u043e\u043d\u043a\u043e\u043c\u0430\u0440\u043a\u0435\u0440\u043e\u043c, \u043e\u043d \u043a\u043e\u0440\u0440\u0435\u043b\u0438\u0440\u0443\u0435\u0442 \u0441\u043e \u0441\u043a\u043e\u0440\u043e\u0441\u0442\u044c\u044e \u043f\u0440\u043e\u043b\u0438\u0444\u0435\u0440\u0430\u0446\u0438\u0438, \u043d\u043e \u043d\u0435 \u0441 \u0440\u0430\u0437\u043c\u0435\u0440\u043e\u043c \u043e\u043f\u0443\u0445\u043e\u043b\u0438.<\/p>\n

\u041f\u0435\u0440\u0438\u043e\u0434 \u043f\u043e\u043b\u0443\u0432\u044b\u0432\u0435\u0434\u0435\u043d\u0438\u044f \u0422\u0420\u0410 \u0441\u043e\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 1-2 \u0434\u043d\u044f \u0432 \u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e\u0441\u0442\u0438 \u043e\u0442 \u043b\u043e\u043a\u0430\u043b\u0438\u0437\u0430\u0446\u0438\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u0438.<\/p>\n

\u042d\u0442\u043e \u043c\u043e\u0436\u043d\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0438\u0442\u044c \u043f\u043e \u043c\u043e\u0447\u0435, \u0430\u0441\u0446\u0438\u0442\u043d\u043e\u0439 \u0436\u0438\u0434\u043a\u043e\u0441\u0442\u0438, \u0436\u0438\u0434\u043a\u043e\u0441\u0442\u0438 \u0431\u0440\u043e\u043d\u0445\u043e\u0430\u043b\u044c\u0432\u0435\u043e\u043b\u044f\u0440\u043d\u043e\u0439 \u043f\u0440\u043e\u043c\u044b\u0432\u043a\u0438 \u0438\u043b\u0438 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435.<\/p>\n

\u0420\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0443\u0435\u0442\u0441\u044f \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u0442\u044c TPA \u0434\u043b\u044f \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433\u0430 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u043f\u0440\u0438 \u0440\u0430\u043a\u0435 \u043c\u043e\u0447\u0435\u0432\u043e\u0433\u043e \u043f\u0443\u0437\u044b\u0440\u044f, \u043c\u043e\u043b\u043e\u0447\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b, \u043c\u0435\u043b\u043a\u043e\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u043c \u0440\u0430\u043a\u0435 \u043b\u0435\u0433\u043a\u0438\u0445, \u0440\u0430\u043a\u0435 \u044f\u0438\u0447\u043d\u0438\u043a\u043e\u0432, \u0448\u0435\u0439\u043a\u0435 \u043c\u0430\u0442\u043a\u0438, \u043f\u0440\u043e\u0441\u0442\u0430\u0442\u0435.<\/p>\n

\u041a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u044f TPA \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u0438 \u0434\u0440\u0443\u0433\u0438\u0445 \u0436\u0438\u0434\u043a\u043e\u0441\u0442\u044f\u0445 \u043a\u043e\u0440\u0440\u0435\u043b\u0438\u0440\u0443\u0435\u0442 \u0441\u043e \u0441\u043a\u043e\u0440\u043e\u0441\u0442\u044c\u044e \u043f\u0440\u043e\u043b\u0438\u0444\u0435\u0440\u0430\u0446\u0438\u0438 \u043a\u043b\u0435\u0442\u043e\u043a<\/p>\n

\u0421\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u043e\u0441\u0442\u044c TPA \u0434\u043b\u044f \u043f\u043e\u0434\u0434\u0435\u0440\u0436\u0430\u043d\u0438\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0437\u0430 \u0441\u043b\u0430\u0431\u0430.\u041f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0422\u0424\u041a \u043c\u043e\u0436\u043d\u043e \u0432\u044b\u044f\u0432\u0438\u0442\u044c \u043f\u0440\u0438 \u0434\u043e\u0431\u0440\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445, \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u0438 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445, \u0434\u0435\u043a\u043e\u043c\u043f\u0435\u043d\u0441\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u043c \u0446\u0438\u0440\u0440\u043e\u0437\u0435 \u043f\u0435\u0447\u0435\u043d\u0438, \u0441\u0430\u0445\u0430\u0440\u043d\u043e\u043c \u0434\u0438\u0430\u0431\u0435\u0442\u0435, \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044f\u0445 \u043d\u0438\u0436\u043d\u0438\u0445 \u0434\u044b\u0445\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u043f\u0443\u0442\u0435\u0439 (\u0418\u0422\u0420\u0418), \u043c\u043e\u0447\u0435\u043f\u043e\u043b\u043e\u0432\u044b\u0445 \u043f\u0443\u0442\u044f\u0445 \u0438 \u0442.\u0434.<\/p>\n

\u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u043d\u0430\u0437\u043d\u0430\u0447\u0430\u0435\u0442\u0441\u044f \u0434\u043b\u044f \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u044f \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0438 \u0434\u0438\u043d\u0430\u043c\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043d\u0430\u0431\u043b\u044e\u0434\u0435\u043d\u0438\u044f \u0441 \u0446\u0435\u043b\u044c\u044e \u0440\u0430\u043d\u043d\u0435\u0439 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0440\u0435\u0446\u0438\u0434\u0438\u0432\u043e\u0432 \u0438 \u043c\u0435\u0442\u0430\u0441\u0442\u0430\u0437\u043e\u0432.<\/p>\n

\u041a\u0430\u043a \u043f\u0440\u0430\u0432\u0438\u043b\u044c\u043d\u043e \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u0438\u0442\u044c\u0441\u044f \u043a \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044e?<\/p>\n

    \n
  1. \u041d\u0430\u0442\u043e\u0449\u0430\u043a (8-12 \u0447\u0430\u0441\u043e\u0432 \u0433\u043e\u043b\u043e\u0434\u0430\u043d\u0438\u044f);<\/li>\n
  2. \u0434\u043b\u044f \u0434\u0435\u0442\u0435\u0439 \u0434\u043e \u0434\u0432\u0443\u0445 \u043b\u0435\u0442 \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e \u0433\u043e\u043b\u043e\u0434\u0430\u043d\u0438\u0435 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 2-3 \u0447\u0430\u0441\u043e\u0432.<\/li>\n
  3. \u0417\u0430 \u0441\u0443\u0442\u043a\u0438 \u0438\u0441\u043a\u043b\u044e\u0447\u0438\u0442\u044c \u0444\u0438\u0437\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0438 \u044d\u043c\u043e\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0435 \u043d\u0430\u0433\u0440\u0443\u0437\u043a\u0438, \u043f\u0435\u0440\u0435\u0433\u0440\u0435\u0432 \u0438 \u043f\u0435\u0440\u0435\u043e\u0445\u043b\u0430\u0436\u0434\u0435\u043d\u0438\u0435, \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435 \u0441\u043f\u044f\u0449\u0435\u0433\u043e \u0440\u0435\u0436\u0438\u043c\u0430, \u0430\u0432\u0438\u0430\u043f\u0435\u0440\u0435\u043b\u0435\u0442\u044b, \u0438\u043d\u0441\u0442\u0440\u0443\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u044b\u0435 \u043c\u0435\u0442\u043e\u0434\u044b \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f (\u0423\u0417\u0418, \u0440\u0435\u043d\u0442\u0433\u0435\u043d \u0438 \u0434\u0440.), \u0444\u0438\u0437\u0438\u043e\u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043f\u0440\u043e\u0446\u0435\u0434\u0443\u0440\u044b, \u043c\u0430\u0441\u0441\u0430\u0436, \u043f\u0440\u0438\u0435\u043c \u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044f \u0438 \u043c\u0435\u0434\u0438\u043a\u0430\u043c\u0435\u043d\u0442\u043e\u0432 (\u043f\u043e\u0441\u043b\u0435\u0434\u043d\u0435\u0435 \u2013 \u0442\u043e\u043b\u044c\u043a\u043e \u043f\u043e \u0441\u043e\u0433\u043b\u0430\u0441\u043e\u0432\u0430\u043d\u0438\u044e \u0441 \u0432\u0440\u0430\u0447\u043e\u043c!).<\/li>\n<\/ol>\n

    \u0415\u0441\u043b\u0438 \u0438\u0441\u043a\u043b\u044e\u0447\u0438\u0442\u044c \u043f\u0440\u0438\u0435\u043c \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u043d\u0435\u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e, \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e \u043e\u0431 \u044d\u0442\u043e\u043c \u0441\u043e\u043e\u0431\u0449\u0438\u0442\u044c \u043f\u0440\u0438 \u043e\u0444\u043e\u0440\u043c\u043b\u0435\u043d\u0438\u0438 \u0437\u0430\u043a\u0430\u0437\u0430 \u0432 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u0438\u0438. \u0417\u0430 \u0447\u0430\u0441 \u043f\u0435\u0440\u0435\u0434 \u0437\u0430\u0431\u043e\u0440\u043e\u043c \u043a\u0440\u043e\u0432\u0438 \u043d\u0435\u043b\u044c\u0437\u044f \u043a\u0443\u0440\u0438\u0442\u044c. \u0412 \u0434\u0435\u043d\u044c \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u0434\u043e\u043f\u0443\u0441\u043a\u0430\u0435\u0442\u0441\u044f \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u043b\u0435\u043d\u0438\u0435 \u043d\u0435\u0431\u043e\u043b\u044c\u0448\u043e\u0433\u043e \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0430 \u0432\u043e\u0434\u044b. \u041f\u0435\u0440\u0435\u0434 \u043c\u0430\u043d\u0438\u043f\u0443\u043b\u044f\u0446\u0438\u043e\u043d\u043d\u044b\u043c\u0438 \u043f\u0440\u043e\u0446\u0435\u0434\u0443\u0440\u0430\u043c\u0438 \u0441\u043b\u0435\u0434\u0443\u0435\u0442 \u043f\u0440\u0438\u043d\u044f\u0442\u044c \u0443\u0434\u043e\u0431\u043d\u0443\u044e \u043f\u043e\u0437\u0443, \u0440\u0430\u0441\u0441\u043b\u0430\u0431\u0438\u0442\u044c\u0441\u044f \u0438 \u0443\u0441\u043f\u043e\u043a\u043e\u0438\u0442\u044c\u0441\u044f.<\/p>\n

    \u0427\u0442\u043e \u043c\u043e\u0436\u0435\u0442 \u043f\u043e\u0432\u043b\u0438\u044f\u0442\u044c \u043d\u0430 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442? \u0418\u0437-\u0437\u0430 \u0445\u0438\u043c\u0438\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442 \u0430\u043d\u0430\u043b\u0438\u0437\u0430 \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0442\u044c \u043e\u0442\u0440\u0438\u0446\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u043c.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[923],"product_tag":[],"class_list":{"0":"post-10118","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-tumorali","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10118","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10118"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10118"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10118"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10118"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10118"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}