{"id":10116,"date":"2020-04-23T03:57:01","date_gmt":"2020-04-23T00:57:01","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/tumor-m2-pk-izoenzima-m2-piruvatkinaza-in-plasma\/"},"modified":"2025-02-07T15:12:30","modified_gmt":"2025-02-07T13:12:30","slug":"tumor-m2-pk-izoenzima-m2-piruvatkinaza-in-plasma","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/tumor-m2-pk-izoenzima-m2-piruvatkinaza-in-plasma\/","title":{"rendered":"\u041e\u043f\u0443\u0445\u043e\u043b\u044c M2 PK (\u0438\u0437\u043e\u0444\u0435\u0440\u043c\u0435\u043d\u0442 \u043f\u0438\u0440\u0443\u0432\u0430\u0442\u043a\u0438\u043d\u0430\u0437\u044b M2) \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/span><\/p>\n

Piruvat kinaza<\/em> \u2013 PK catalizeaz\u0103 ultima etap\u0103 din calea glicolitic\u0103 (responsabil\u0103 de produc\u0163ia net\u0103 de energie). Diferite izoenzime PK sunt exprimate \u00een func\u0163ie de rolul metabolic al diverselor \u0163esuturi. M2-PK este izoenzim\u0103 caracteristic\u0103 celulelor proliferante (normale + tumorale), fiind prezent\u0103 sub 2 forme:\u00a0 <\/span><\/p>\n

\u2192 tetrameric\u0103 (activ\u0103, converte\u015fte glucoza \u00een piruvat \u015fi lactat);<\/span><\/div>\n
\u2192 dimeric\u0103 (inactiv\u0103, predomin\u0103 \u00een celulele tumorale), denumit\u0103 Tumor M2-PK<\/strong>.<\/span><\/div>\n

Dimerizarea M2-PK \u00een celulele tumorale este indus\u0103 prin interac\u0163iunea direct\u0103 cu diverse oncoproteine. <\/em>Prezen\u0163a predominant\u0103 a formei dimerice determin\u0103 acumularea fosfometaboli\u0163ilor, care nu mai sunt supu\u015fi ac\u0163iunii PK, conduc\u00e2nd la ini\u0163ierea sintezei de acizi nucleici, fosfolipide \u015fi aminoacizi necesari celulelor tumorale.<\/span><\/p>\n

Tumor M2-PK nu<\/span> este un marker tumoral cu specificitate de organ; nivelul s\u0103u reflect\u0103 statusul metabolic specific al celulelor tumorale. Tumor M2-PK este eliberat \u00een s\u00e2nge \u015fi, de asemenea, \u00een scaun, \u00een cazul pacien\u0163ilor cu adenoame sau tumori de tract digestiv inferior. Testul utilizeaz\u0103 anticorpi monoclonali specifici formei dimerice a M2-PK \u015fi prezint\u0103 dou\u0103 indica\u0163ii majore:<\/span><\/p>\n

\u2013 detectarea \u00een materiile fecale<\/span> este util\u0103 \u00een screening-ul tumorilor colorectale;<\/span><\/div>\n
\u2013 detectarea \u00een plasm\u0103<\/span>, \u00eempreun\u0103 cu cea a markerilor tumorali conven\u0163ionali, poate fi folosit\u0103 \u00een diagnosticul \u015fi monitorizarea evolu\u0163iei diverselor tumori digestive.<\/span><\/div>\n

Cele dou\u0103 teste Tumor M2-PK sunt deopotriv\u0103 inovatoare \u015fi unice, \u00eentruc\u00e2t m\u0103soar\u0103 activitatea metabolic\u0103 a tumorii, care la r\u00e2ndul ei reprezint\u0103 m\u0103sura agresivit\u0103\u0163ii tumorii. In consecin\u0163\u0103, testele Tumor M2-PK pot fi foarte eficiente\u00a0\u00een monitorizarea efectelor terapiei, detect\u00e2nd posibilele rec\u0103deri sau metastaze \u015fi furnizez\u0103 informa\u0163ii utile care pot ajuta at\u00e2t\u00a0\u00een screening-ul c\u00e2t \u015fi\u00a0\u00een diagnosticul anumitor tumori2;7<\/sup>.<\/span><\/p>\n

Deoarece Tumor M2-PK reprezint\u0103 un marker al activit\u0103\u0163ii metabolice, cre\u015fteri ale concentra\u0163iei sale \u00een plasm\u0103 sunt \u00eent\u00e2lnite \u00een diverse tipuri de tumori: gastrointestinale, mamare, pulmonare, renale \u015fi prostatice.<\/span><\/p>\n

Exist\u0103 dou\u0103 modalit\u0103\u0163i de utilizare a marker-ului:<\/span><\/p>\n

\u2013 detec\u0163ia diverselor tipuri de tumori,\u00a0\u00een combina\u0163ie cu al\u0163i markeri tumorali (pentru a cre\u015fte sensibilitatea);<\/span><\/div>\n
\u2013 monitorizarea pacien\u0163ilor pentru evaluarea succesului terapiei \u015fi detec\u0163ia recuren\u0163elor tumorale (modific\u0103rile concentra\u0163iei Tumor M2\u2013PK reflect\u0103 schimb\u0103rile de la nivelul tumorii).<\/span><\/div>\n

Studiile efectuate au demonstrat relevan\u0163a clinic\u0103 a determin\u0103rii Tumor M2\u2013PK \u00een plasm\u0103.<\/span><\/p>\n

Astfel, datele pentru Tumor M2-PK din 8 studii au fost comparate cu cele pentru al\u0163i markeri tumorali gastrointestinali. La o valoare cut-off diagnostic\u0103 de 15 U\/mL<\/strong>, sensibilitatea, specificitatea, valoarea predictiv\u0103 pozitiv\u0103 \u015fi negativ\u0103 pentru Tumor M2-PK \u00een plasm\u0103 EDTA au fost:<\/span><\/p>\n

\u00a0\u00a0\u00a0 \u2192 57.3%, 89%, 85.7% si 64.8% pentru cancerul colorectal;<\/span><\/div>\n
\u00a0\u00a0\u00a0 \u2192 62.1%, 89%, 88% si 64% pentru cancerul gastric \u015fi esofagian;<\/span><\/div>\n
\u00a0\u00a0\u00a0 \u2192 72.5%, 89%, 58% si 94% pentru cancerul pancreatic.<\/span><\/div>\n

Concluzia a fost c\u0103 Tumor M2-PK circulant este mult mai crescut \u00een tumorile digestive \u00een compara\u0163ie cu markerii tumorali conven\u0163ionali<\/span>4;7<\/sup>.\u00a0Mai mult, Schultze a ar\u0103tat c\u0103 se ob\u0163ine o cre\u015ftere semnificativ\u0103 a sensibilit\u0103\u0163ii detec\u0163iei dac\u0103 Tumor M2\u2013PK este utilizat \u00een combina\u0163ie cu markerii tradi\u0163ionali (CEA\u00a0\u00een cazul tumorilor colorectale, CA 72-4\u00a0\u00een cancerul gastric \u015fi CA 19-9\u00a0\u00een cancerul pancreatic \u015fi cel esofagian)9<\/sup>.<\/span><\/p>\n

In 3 studii separate, Schneider \u015fi colaboratorii s\u0103i au ar\u0103tat c\u0103 Tumor M2\u2013PK poate constitui un marker valoros pentru detec\u0163ia \u015fi monitorizarea cancerului pulmonar8<\/sup>.<\/span><\/p>\n

Unul dintre primele studii efectuate cu acest marker a inclus pacien\u0163i av\u00e2nd carcinom renal; valorile Tumor M2\u2013PK au fost semnificativ crescute la ace\u015fti pacien\u0163i \u00een compara\u0163ie cu persoanele s\u0103n\u0103toase. Autorii studiului au eviden\u0163iat corela\u0163ia str\u00e2ns\u0103 \u00eentre nivelul markerului \u015fi stadiul tumorii. Un studiu ulterior al lui Oremek a indicat de asemenea o discriminare \u00eenalt semnificativ\u0103 \u00eentre pacien\u0163ii cu tumori renale \u015fi cei cu nefrit\u0103 pe baza valorilor Tumor M2\u2013PK6<\/sup>. In cazul interven\u0163iilor chirurgicale, Wechsel a ar\u0103tat c\u0103 la majoritatea pacien\u0163ilor nivelurile marker-ului revin la normal \u00een decurs de 6 s\u0103pt\u0103m\u00e2ni (maximum 11 s\u0103pt\u0103m\u00e2ni) de la extirparea cu succes a tumorii \u015fi se men\u0163in la valori crescute dac\u0103 au survenit recuren\u0163e sau metastaze10<\/sup>.<\/span><\/p>\n

Specimen recoltat<\/em><\/strong> \u2013 s\u00e2nge venos5;7<\/sup>.<\/span><\/p>\n

Recipient de recoltare<\/em><\/strong> \u2013 vacutainer cu EDTA5;7<\/sup>.<\/span><\/p>\n

Cantitate recoltat\u0103<\/em><\/strong> \u2013 c\u00e2t permite vacuumul5;7<\/sup>.<\/span><\/p>\n

Cauze de respingere a probei<\/em><\/strong> \u2013 specimen hemolizat5;7<\/sup>.<\/span><\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>- <\/em>\u00een maxim 4 ore de la recoltare se separ\u0103 plasma prin centrifugare 15 minute la 1500 x g [g = (1118 + 10-8<\/sup>) x (raza \u00een cm) x (rpm)2<\/sup>]. Se congeleaz\u0103 la \u2013 20\u00b0C p\u00e2n\u0103 \u00een momentul efectu\u0103rii testului. Probele de plasm\u0103 recoltate\u00a0\u00een alte centre dec\u00e2t laboratorul Grozovici vor fi transportate\u00a0\u00een recipientul destinat probelor congelate5<\/sup>.<\/span><\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>- <\/em>plasma este stabil\u0103 12 luni<\/em> la -20\u00b0C; nu decongela\u0163i\/recongela\u0163i5<\/sup>.<\/span><\/p>\n

Metod\u0103 <\/em><\/strong>- ELISA<\/span>5;7<\/sup>.<\/span><\/p>\n

Valori de referin\u0163\u0103 <\/em><\/strong>- <\/em><15 U\/mL5;7<\/sup>.<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Carolin Tonus et al. Colorectal cancer screening by non-invasive metabolic biomarker fecal tumor M2-PK. In World J Gastroenterol 2006 November 21; 12(43): 7007-701.<\/span><\/div>\n
2. Eigenbrodt, E et al. (1992). A double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells. In Critical Reviews in Oncogenesis, pp 91 -115 [M Perucho, editor. Boca Raton, FL: CRC Press.<\/span><\/div>\n
3. Ewald N et al. Fecal pyruvate kinase-M2 (tumor M2- PK) measurement: a new screening concept for colorectal cancer. In Anticancer Res. 2007<\/span><\/div>\n
4. Kumar Z et al. Tumor M2-pyruvat kinase: a gastrointestinal cancer marker. In Eur J Gastroenterol Hepatolog 2007.<\/span><\/div>\n
5. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog.<\/span><\/div>\n
6. Oremek, GM et al. (2000). Value of Tumor M2 (Tu M2-PK) in Patients with Renal Carcinoma. In Anticancer Research, 20: 5095-5098.<\/span><\/div>\n
7. Phil Allcock \u2013 ScheBo Biotech. www.schebo.co.uk<\/span><\/div>\n
8. Schneider, J et al. (2000). Quantitative Detection of Tumor M2-Pyruvate Kinase in Plasma of Patients with Lung Cancer in Comparison to Other Lung Diseases. In Cancer Detection and Prevention, 24: 531-535.<\/span><\/div>\n
9. Schulze, G. (2000). The Tumor Marker Tumor M2-PK: An Application in the Diagnosis of Gastrointestinal Cancer. In Anticancer Research, 20: 4961-4964.<\/span><\/div>\n
10. Wechsel, HW et al. (1999). Marker for Renal Cell Carcinoma (RCC): The Dimeric Form of Pyruvate Kinase Type M2 (Tu M2-PK). In Anticancer Research, 19: 2583-2590.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u041f\u0438\u0440\u0443\u0432\u0430\u0442\u043a\u0438\u043d\u0430\u0437\u0430-PK \u043a\u0430\u0442\u0430\u043b\u0438\u0437\u0438\u0440\u0443\u0435\u0442 \u043f\u043e\u0441\u043b\u0435\u0434\u043d\u044e\u044e \u0441\u0442\u0430\u0434\u0438\u044e \u0433\u043b\u0438\u043a\u043e\u043b\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043f\u0443\u0442\u0438 (\u043e\u0442\u0432\u0435\u0442\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u0437\u0430 \u0447\u0438\u0441\u0442\u043e\u0435 \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0441\u0442\u0432\u043e \u044d\u043d\u0435\u0440\u0433\u0438\u0438). \u0420\u0430\u0437\u043b\u0438\u0447\u043d\u044b\u0435 \u0438\u0437\u043e\u044d\u043d\u0437\u0438\u043c\u044b PK \u0432\u044b\u0440\u0430\u0436\u0435\u043d\u044b \u0432 \u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e\u0441\u0442\u0438 \u043e\u0442 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0440\u043e\u043b\u0438 \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u044b\u0445 \u0442\u043a\u0430\u043d\u0435\u0439. M2-PK \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0438\u0437\u043e\u0444\u0435\u0440\u043c\u0435\u043d\u0442\u043e\u043c, \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u043d\u044b\u043c \u0434\u043b\u044f \u043f\u0440\u043e\u043b\u0438\u0444\u0435\u0440\u0438\u0440\u0443\u044e\u0449\u0438\u0445 (\u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u044b\u0445 + \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u0445) \u043a\u043b\u0435\u0442\u043e\u043a, \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0443\u044e\u0449\u0438\u0445 \u0432 2 \u0444\u043e\u0440\u043c\u0430\u0445:<\/p>\n

\u2192 \u0442\u0435\u0442\u0440\u0430\u043c\u0435\u0440\u043d\u044b\u0439 (\u0430\u043a\u0442\u0438\u0432\u043d\u044b\u0439, \u043f\u0440\u0435\u043e\u0431\u0440\u0430\u0437\u0443\u0435\u0442 \u0433\u043b\u044e\u043a\u043e\u0437\u0443 \u0432 \u043f\u0438\u0440\u0443\u0432\u0430\u0442 \u0438 \u043b\u0430\u043a\u0442\u0430\u0442);
\n\u2192 \u0434\u0438\u043c\u0435\u0440\u043d\u044b\u0439 (\u043d\u0435\u0430\u043a\u0442\u0438\u0432\u043d\u044b\u0439, \u043f\u0440\u0435\u043e\u0431\u043b\u0430\u0434\u0430\u0435\u0442 \u0432 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u0445 \u043a\u043b\u0435\u0442\u043a\u0430\u0445), \u043d\u0430\u0437\u044b\u0432\u0430\u0435\u043c\u044b\u0439 \u043e\u043f\u0443\u0445\u043e\u043b\u044c\u044e M2-PK.<\/p>\n

\u0414\u0438\u043c\u0435\u0440\u0438\u0437\u0430\u0446\u0438\u044f M2-PK \u0432 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u0445 \u043a\u043b\u0435\u0442\u043a\u0430\u0445 \u0438\u043d\u0434\u0443\u0446\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u043f\u0440\u044f\u043c\u044b\u043c \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u043c \u0441 \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u044b\u043c\u0438 \u043e\u043d\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u043c\u0438. \u041f\u0440\u0435\u043e\u0431\u043b\u0430\u0434\u0430\u044e\u0449\u0435\u0435 \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0435 \u0434\u0438\u043c\u0435\u0440\u043d\u043e\u0439 \u0444\u043e\u0440\u043c\u044b \u0432\u044b\u0437\u044b\u0432\u0430\u0435\u0442 \u043d\u0430\u043a\u043e\u043f\u043b\u0435\u043d\u0438\u0435 \u0444\u043e\u0441\u0444\u043e\u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043e\u0432, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0431\u043e\u043b\u044c\u0448\u0435 \u043d\u0435 \u043f\u043e\u0434\u0432\u0435\u0440\u0433\u0430\u044e\u0442\u0441\u044f \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044e \u041f\u041a, \u0447\u0442\u043e \u043f\u0440\u0438\u0432\u043e\u0434\u0438\u0442 \u043a \u0438\u043d\u0438\u0446\u0438\u0430\u0446\u0438\u0438 \u0441\u0438\u043d\u0442\u0435\u0437\u0430 \u043d\u0443\u043a\u043b\u0435\u0438\u043d\u043e\u0432\u044b\u0445 \u043a\u0438\u0441\u043b\u043e\u0442, \u0444\u043e\u0441\u0444\u043e\u043b\u0438\u043f\u0438\u0434\u043e\u0432 \u0438 \u0430\u043c\u0438\u043d\u043e\u043a\u0438\u0441\u043b\u043e\u0442, \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u044b\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u043c \u043a\u043b\u0435\u0442\u043a\u0430\u043c.<\/p>\n

\u041e\u043f\u0443\u0445\u043e\u043b\u044c M2-PK \u043d\u0435 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u043c \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u043c \u0441\u043e \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u043e\u0441\u0442\u044c\u044e \u043a \u043e\u0440\u0433\u0430\u043d\u0430\u043c; \u0435\u0433\u043e \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u043e\u0442\u0440\u0430\u0436\u0430\u0435\u0442 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0441\u0442\u0430\u0442\u0443\u0441 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u0445 \u043a\u043b\u0435\u0442\u043e\u043a. \u041e\u043f\u0443\u0445\u043e\u043b\u044c M2-PK \u0432\u044b\u0434\u0435\u043b\u044f\u0435\u0442\u0441\u044f \u0432 \u043a\u0440\u043e\u0432\u044c, \u0430 \u0442\u0430\u043a\u0436\u0435 \u0432 \u0441\u0442\u0443\u043b \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0430\u0434\u0435\u043d\u043e\u043c\u0430\u043c\u0438 \u0438\u043b\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u043c\u0438 \u043d\u0438\u0436\u043d\u0438\u0445 \u043e\u0442\u0434\u0435\u043b\u043e\u0432 \u043f\u0438\u0449\u0435\u0432\u0430\u0440\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0433\u043e \u0442\u0440\u0430\u043a\u0442\u0430. \u0412 \u0442\u0435\u0441\u0442\u0435 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u044e\u0442\u0441\u044f \u043c\u043e\u043d\u043e\u043a\u043b\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430, \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u044b\u0435 \u043a \u0434\u0438\u043c\u0435\u0440\u043d\u043e\u0439 \u0444\u043e\u0440\u043c\u0435 M2-PK, \u0438 \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u044b \u0434\u0432\u0430 \u043e\u0441\u043d\u043e\u0432\u043d\u044b\u0445 \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f:<\/p>\n

    \n
  • \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u0438\u0435 \u0432 \u0444\u0435\u043a\u0430\u043b\u0438\u044f\u0445 \u043f\u043e\u043b\u0435\u0437\u043d\u043e \u043f\u0440\u0438 \u0441\u043a\u0440\u0438\u043d\u0438\u043d\u0433\u0435 \u043a\u043e\u043b\u043e\u0440\u0435\u043a\u0442\u0430\u043b\u044c\u043d\u044b\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0439;<\/li>\n
  • \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u0438\u0435 \u0432 \u043f\u043b\u0430\u0437\u043c\u0435, \u043d\u0430\u0440\u044f\u0434\u0443 \u0441 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u0438\u0435\u043c \u043e\u0431\u044b\u0447\u043d\u044b\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u0445 \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u0432, \u043c\u043e\u0436\u0435\u0442 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u0442\u044c\u0441\u044f \u0434\u043b\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0438 \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433\u0430 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u044b\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0439 \u043f\u0438\u0449\u0435\u0432\u0430\u0440\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b.<\/li>\n<\/ul>\n

    \u0414\u0432\u0430 \u0442\u0435\u0441\u0442\u0430 \u043e\u043f\u0443\u0445\u043e\u043b\u0438 M2-PK \u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u0438\u043d\u043d\u043e\u0432\u0430\u0446\u0438\u043e\u043d\u043d\u044b\u043c\u0438 \u0438 \u0443\u043d\u0438\u043a\u0430\u043b\u044c\u043d\u044b\u043c\u0438, \u043f\u043e\u0441\u043a\u043e\u043b\u044c\u043a\u0443 \u043e\u043d\u0438 \u0438\u0437\u043c\u0435\u0440\u044f\u044e\u0442 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u0443\u044e \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c \u043e\u043f\u0443\u0445\u043e\u043b\u0438, \u043a\u043e\u0442\u043e\u0440\u0430\u044f, \u0432 \u0441\u0432\u043e\u044e \u043e\u0447\u0435\u0440\u0435\u0434\u044c, \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 \u0441\u043e\u0431\u043e\u0439 \u043c\u0435\u0440\u0443 \u0430\u0433\u0440\u0435\u0441\u0441\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u0438. \u0421\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u043d\u043e, \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u0435 \u0442\u0435\u0441\u0442\u044b M2-PK \u043c\u043e\u0433\u0443\u0442 \u0431\u044b\u0442\u044c \u043e\u0447\u0435\u043d\u044c \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u044b\u043c\u0438 \u0432 \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433\u0435 \u044d\u0444\u0444\u0435\u043a\u0442\u043e\u0432 \u0442\u0435\u0440\u0430\u043f\u0438\u0438, \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u0438\u0438 \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u044b\u0445 \u0440\u0435\u0446\u0438\u0434\u0438\u0432\u043e\u0432 \u0438\u043b\u0438 \u043c\u0435\u0442\u0430\u0441\u0442\u0430\u0437\u043e\u0432 \u0438 \u043f\u0440\u0435\u0434\u043e\u0441\u0442\u0430\u0432\u043b\u0435\u043d\u0438\u0438 \u043f\u043e\u043b\u0435\u0437\u043d\u043e\u0439 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u0438, \u043a\u043e\u0442\u043e\u0440\u0430\u044f \u043c\u043e\u0436\u0435\u0442 \u043f\u043e\u043c\u043e\u0447\u044c \u043a\u0430\u043a \u0432 \u0441\u043a\u0440\u0438\u043d\u0438\u043d\u0433\u0435, \u0442\u0430\u043a \u0438 \u0432 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u043d\u044b\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u04392;7.<\/p>\n

    \u041f\u043e\u0441\u043a\u043e\u043b\u044c\u043a\u0443 \u043e\u043f\u0443\u0445\u043e\u043b\u044c M2-PK \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u043c \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438, \u0443\u0432\u0435\u043b\u0438\u0447\u0435\u043d\u0438\u0435 \u0435\u0435 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 \u0432 \u043f\u043b\u0430\u0437\u043c\u0435 \u0432\u0441\u0442\u0440\u0435\u0447\u0430\u0435\u0442\u0441\u044f \u043f\u0440\u0438 \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u044b\u0445 \u0442\u0438\u043f\u0430\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0439: \u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e-\u043a\u0438\u0448\u0435\u0447\u043d\u044b\u0445, \u043c\u043e\u043b\u043e\u0447\u043d\u044b\u0445, \u043b\u0435\u0433\u043e\u0447\u043d\u044b\u0445, \u043f\u043e\u0447\u0435\u0447\u043d\u044b\u0445 \u0438 \u043f\u0440\u043e\u0441\u0442\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445.<\/p>\n

    \u0415\u0441\u0442\u044c \u0434\u0432\u0430 \u0441\u043f\u043e\u0441\u043e\u0431\u0430 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u0442\u044c \u043c\u0430\u0440\u043a\u0435\u0440:<\/p>\n

      \n
    • \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u0438\u0435 \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u044b\u0445 \u0442\u0438\u043f\u043e\u0432 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0439 \u0432 \u0441\u043e\u0447\u0435\u0442\u0430\u043d\u0438\u0438 \u0441 \u0434\u0440\u0443\u0433\u0438\u043c\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u043c\u0438 \u043c\u0430\u0440\u043a\u0435\u0440\u0430\u043c\u0438 (\u0434\u043b\u044f \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u044f \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u0438);<\/li>\n
    • \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0434\u043b\u044f \u043e\u0446\u0435\u043d\u043a\u0438 \u0443\u0441\u043f\u0435\u0445\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0438 \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u0440\u0435\u0446\u0438\u0434\u0438\u0432\u043e\u0432 \u043e\u043f\u0443\u0445\u043e\u043b\u0438 (\u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u0438 M2\u2013PK \u043e\u0442\u0440\u0430\u0436\u0430\u044e\u0442 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0432 \u043e\u043f\u0443\u0445\u043e\u043b\u0438).<\/li>\n<\/ul>\n

      \u041f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u043d\u044b\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u043f\u0440\u043e\u0434\u0435\u043c\u043e\u043d\u0441\u0442\u0440\u0438\u0440\u043e\u0432\u0430\u043b\u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0443\u044e \u0437\u043d\u0430\u0447\u0438\u043c\u043e\u0441\u0442\u044c \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044f \u043e\u043f\u0443\u0445\u043e\u043b\u0438 M2-PK \u0432 \u043f\u043b\u0430\u0437\u043c\u0435.<\/p>\n

      \u0422\u0430\u043a\u0438\u043c \u043e\u0431\u0440\u0430\u0437\u043e\u043c, \u0434\u0430\u043d\u043d\u044b\u0435 \u0434\u043b\u044f \u043e\u043f\u0443\u0445\u043e\u043b\u0438 M2-PK \u0438\u0437 8 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439 \u0441\u0440\u0430\u0432\u043d\u0438\u0432\u0430\u043b\u0438\u0441\u044c \u0441 \u0434\u0430\u043d\u043d\u044b\u043c\u0438 \u0434\u043b\u044f \u0434\u0440\u0443\u0433\u0438\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u0445 \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u0432 \u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e-\u043a\u0438\u0448\u0435\u0447\u043d\u043e\u0433\u043e \u0442\u0440\u0430\u043a\u0442\u0430. \u041f\u0440\u0438 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0438 \u043e\u0442\u0441\u0435\u0447\u0435\u043d\u0438\u044f 15 \u0415\u0434\/ \u043c\u043b \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c, \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u043e\u0441\u0442\u044c, \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0435 \u0438 \u043e\u0442\u0440\u0438\u0446\u0430\u0442\u0435\u043b\u044c\u043d\u043e\u0435 \u043f\u0440\u043e\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435 \u0434\u043b\u044f \u043e\u043f\u0443\u0445\u043e\u043b\u0438 M2-PK \u0432 \u043f\u043b\u0430\u0437\u043c\u0435 EDTA \u0431\u044b\u043b\u0438:<\/p>\n

      \u2192 57.3%, 89%, 85.7% \u0438 64.8% \u0434\u043b\u044f \u043a\u043e\u043b\u043e\u0440\u0435\u043a\u0442\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0440\u0430\u043a\u0430;
      \n\u2192 62.1%, 89%, 88% \u0438 64% \u0434\u043b\u044f \u0440\u0430\u043a\u0430 \u0436\u0435\u043b\u0443\u0434\u043a\u0430 \u0438 \u043f\u0438\u0449\u0435\u0432\u043e\u0434\u0430;
      \n\u2192 72.5%, 89%, 58% \u0438 94% \u0434\u043b\u044f \u0440\u0430\u043a\u0430 \u043f\u043e\u0434\u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b.<\/p>\n

      \u0412\u044b\u0432\u043e\u0434 \u0437\u0430\u043a\u043b\u044e\u0447\u0430\u043b\u0441\u044f \u0432 \u0442\u043e\u043c, \u0447\u0442\u043e \u0446\u0438\u0440\u043a\u0443\u043b\u0438\u0440\u0443\u044e\u0449\u0430\u044f \u043e\u043f\u0443\u0445\u043e\u043b\u044c M2-PK \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u0432\u044b\u0448\u0435 \u0432 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445 \u043f\u0438\u0449\u0435\u0432\u0430\u0440\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b \u043f\u043e \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u044e \u0441 \u043e\u0431\u044b\u0447\u043d\u044b\u043c\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u043c\u0438 \u043c\u0430\u0440\u043a\u0435\u0440\u0430\u043c\u0438 4;7.\u00a0\u041a\u0440\u043e\u043c\u0435 \u0442\u043e\u0433\u043e, \u0428\u0443\u043b\u044c\u0446\u0435 \u043f\u043e\u043a\u0430\u0437\u0430\u043b, \u0447\u0442\u043e \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0435 \u0443\u0432\u0435\u043b\u0438\u0447\u0435\u043d\u0438\u0435 \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u0438 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u0438\u044f \u0434\u043e\u0441\u0442\u0438\u0433\u0430\u0435\u0442\u0441\u044f, \u0435\u0441\u043b\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u044c M2\u2013PK \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0432 \u0441\u043e\u0447\u0435\u0442\u0430\u043d\u0438\u0438 \u0441 \u0442\u0440\u0430\u0434\u0438\u0446\u0438\u043e\u043d\u043d\u044b\u043c\u0438 \u043c\u0430\u0440\u043a\u0435\u0440\u0430\u043c\u0438 (\u0432 \u0441\u043b\u0443\u0447\u0430\u0435 \u043a\u043e\u043b\u043e\u0440\u0435\u043a\u0442\u0430\u043b\u044c\u043d\u044b\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0439, CA 72-4 \u043f\u0440\u0438 \u0440\u0430\u043a\u0435 \u0436\u0435\u043b\u0443\u0434\u043a\u0430 \u0438 CA 19-9 \u043f\u0440\u0438 \u0440\u0430\u043a\u0435 \u043f\u043e\u0434\u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b \u0438 \u043f\u0438\u0449\u0435\u0432\u043e\u0434\u0430)9.<\/p>\n

      \u0412 3 \u043e\u0442\u0434\u0435\u043b\u044c\u043d\u044b\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f\u0445 \u0428\u043d\u0430\u0439\u0434\u0435\u0440 \u0438 \u0435\u0433\u043e \u0441\u043e\u0442\u0440\u0443\u0434\u043d\u0438\u043a\u0438 \u043f\u043e\u043a\u0430\u0437\u0430\u043b\u0438, \u0447\u0442\u043e \u043e\u043f\u0443\u0445\u043e\u043b\u044c M2\u2013PK \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0442\u044c \u0446\u0435\u043d\u043d\u044b\u043c \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u043c \u0434\u043b\u044f \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u0438 \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433\u0430 \u0440\u0430\u043a\u0430 \u043b\u0435\u0433\u043a\u0438\u0445 8.<\/p>\n

      \u041e\u0434\u043d\u043e \u0438\u0437 \u043f\u0435\u0440\u0432\u044b\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439, \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u043d\u044b\u0445 \u0441 \u044d\u0442\u0438\u043c \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u043c, \u0432\u043a\u043b\u044e\u0447\u0430\u043b\u043e \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u043f\u043e\u0447\u0435\u0447\u043d\u043e\u0439 \u043a\u0430\u0440\u0446\u0438\u043d\u043e\u043c\u043e\u0439; \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f \u043e\u043f\u0443\u0445\u043e\u043b\u0438 M2\u2013PK \u0431\u044b\u043b\u0438 \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u044b \u0443 \u044d\u0442\u0438\u0445 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u043f\u043e \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u044e \u0441\u043e \u0437\u0434\u043e\u0440\u043e\u0432\u044b\u043c\u0438 \u043b\u044e\u0434\u044c\u043c\u0438. \u0410\u0432\u0442\u043e\u0440\u044b \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u0432\u044b\u044f\u0432\u0438\u043b\u0438 \u0442\u0435\u0441\u043d\u0443\u044e \u043a\u043e\u0440\u0440\u0435\u043b\u044f\u0446\u0438\u044e \u043c\u0435\u0436\u0434\u0443 \u0443\u0440\u043e\u0432\u043d\u0435\u043c \u043c\u0430\u0440\u043a\u0435\u0440\u0430 \u0438 \u0441\u0442\u0430\u0434\u0438\u0435\u0439 \u043e\u043f\u0443\u0445\u043e\u043b\u0438. \u041f\u043e\u0441\u043b\u0435\u0434\u0443\u044e\u0449\u0435\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u041e\u0440\u0435\u043c\u0435\u043a\u0430 \u0442\u0430\u043a\u0436\u0435 \u043f\u043e\u043a\u0430\u0437\u0430\u043b\u043e \u0432\u044b\u0441\u043e\u043a\u0443\u044e \u0437\u043d\u0430\u0447\u0438\u043c\u0443\u044e \u0434\u0438\u0441\u043a\u0440\u0438\u043c\u0438\u043d\u0430\u0446\u0438\u044e \u043c\u0435\u0436\u0434\u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430\u043c\u0438 \u0441 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u043c\u0438 \u043f\u043e\u0447\u0435\u043a \u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430\u043c\u0438 \u0441 \u043d\u0435\u0444\u0440\u0438\u0442\u043e\u043c \u043d\u0430 \u043e\u0441\u043d\u043e\u0432\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0439 \u043e\u043f\u0443\u0445\u043e\u043b\u0438 M2\u2013PK6. \u0412 \u0441\u043b\u0443\u0447\u0430\u0435 \u0445\u0438\u0440\u0443\u0440\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0432\u043c\u0435\u0448\u0430\u0442\u0435\u043b\u044c\u0441\u0442\u0432 \u0432\u0435\u043a\u0441\u0435\u043b\u044c \u043f\u043e\u043a\u0430\u0437\u0430\u043b, \u0447\u0442\u043e \u0443 \u0431\u043e\u043b\u044c\u0448\u0438\u043d\u0441\u0442\u0432\u0430 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0443\u0440\u043e\u0432\u043d\u0438 \u043c\u0430\u0440\u043a\u0435\u0440\u0430 \u0432\u043e\u0437\u0432\u0440\u0430\u0449\u0430\u044e\u0442\u0441\u044f \u043a \u043d\u043e\u0440\u043c\u0435 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 6 \u043d\u0435\u0434\u0435\u043b\u044c (\u043c\u0430\u043a\u0441\u0438\u043c\u0443\u043c 11 \u043d\u0435\u0434\u0435\u043b\u044c) \u043f\u043e\u0441\u043b\u0435 \u0443\u0441\u043f\u0435\u0448\u043d\u043e\u0433\u043e \u0443\u0434\u0430\u043b\u0435\u043d\u0438\u044f \u043e\u043f\u0443\u0445\u043e\u043b\u0438 \u0438 \u0441\u043e\u0445\u0440\u0430\u043d\u044f\u044e\u0442\u0441\u044f \u043f\u0440\u0438 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u0445 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f\u0445, \u0435\u0441\u043b\u0438 \u0440\u0435\u0446\u0438\u0434\u0438\u0432\u044b \u0438\u043b\u0438 \u043c\u0435\u0442\u0430\u0441\u0442\u0430\u0437\u044b \u043f\u0440\u043e\u0438\u0437\u043e\u0448\u043b\u0438 10.<\/p>\n

      \u0421\u043e\u0431\u0440\u0430\u043d\u043d\u044b\u0439 \u043e\u0431\u0440\u0430\u0437\u0435\u0446-\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c 5;7.<\/p>\n

      \u041a\u043e\u043d\u0442\u0435\u0439\u043d\u0435\u0440 \u0434\u043b\u044f \u0441\u0431\u043e\u0440\u0430 \u043e\u0431\u0440\u0430\u0437\u0446\u0430-vacutainer \u0441 EDTA5; 7.<\/p>\n

      \u0421\u043e\u0431\u0440\u0430\u043d\u043d\u043e\u0435 \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u043e – \u0441\u043a\u043e\u043b\u044c\u043a\u043e \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0435\u0442 \u0432\u0430\u043a\u0443\u0443\u043c5; 7.<\/p>\n

      \u041f\u0440\u0438\u0447\u0438\u043d\u044b \u043e\u0442\u0442\u043e\u0440\u0436\u0435\u043d\u0438\u044f \u043e\u0431\u0440\u0430\u0437\u0446\u0430-\u043e\u0431\u0440\u0430\u0437\u0435\u0446 \u0433\u0435\u043c\u043e\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d5; 7.<\/p>\n

      \u041d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0430\u044f \u043e\u0431\u0440\u0430\u0431\u043e\u0442\u043a\u0430 \u043f\u043e\u0441\u043b\u0435 \u0441\u0431\u043e\u0440\u0430 \u043e\u0431\u0440\u0430\u0437\u0446\u0430 – \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 \u043c\u0430\u043a\u0441\u0438\u043c\u0443\u043c 4 \u0447\u0430\u0441\u043e\u0432 \u043f\u043e\u0441\u043b\u0435 \u0441\u0431\u043e\u0440\u0430 \u043f\u043b\u0430\u0437\u043c\u044b \u043e\u0442\u0434\u0435\u043b\u044f\u044e\u0442 \u0446\u0435\u043d\u0442\u0440\u0438\u0444\u0443\u0433\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435\u043c, \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 15 \u043c\u0438\u043d\u0443\u0442 \u043f\u0440\u0438 1500 \u0445 \u0433 [\u0433 = (1118 + 10-8) \u0445 (\u0440\u0430\u0434\u0438\u0443\u0441 \u0432 \u0441\u043c) \u0445 (\u043e\u0431 \/ \u043c\u0438\u043d)2]. \u0417\u0430\u043c\u043e\u0440\u043e\u0437\u0438\u0442\u044c \u043f\u0440\u0438-20\u00b0C \u0434\u043e \u043c\u043e\u043c\u0435\u043d\u0442\u0430 \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u0438\u044f \u0442\u0435\u0441\u0442\u0430.<\/p>\n

      \u0421\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u043e\u0431\u0440\u0430\u0437\u0446\u0430-\u043f\u043b\u0430\u0437\u043c\u0430 \u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u0430 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 12 \u043c\u0435\u0441\u044f\u0446\u0435\u0432 \u043f\u0440\u0438 -20\u00b0C; \u043d\u0435 \u0440\u0430\u0437\u043c\u043e\u0440\u0430\u0436\u0438\u0432\u0430\u0442\u044c\/\u043f\u043e\u0432\u0442\u043e\u0440\u043d\u043e \u0437\u0430\u043c\u043e\u0440\u0430\u0436\u0438\u0432\u0430\u0442\u044c5.<\/p>\n

      \u041c\u0435\u0442\u043e\u0434-ELISA5; 7.<\/p>\n

      \u042d\u0442\u0430\u043b\u043e\u043d\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f – <15 \u0415\u0414 \/ \u043c\u043b5; 7.<\/p>\n

      \u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

      1. Carolin Tonus et al. Colorectal cancer screening by non-invasive metabolic biomarker fecal tumor M2-PK. In World J Gastroenterol 2006 November 21; 12(43): 7007-701.<\/span><\/div>\n
      2. Eigenbrodt, E et al. (1992). A double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells. In Critical Reviews in Oncogenesis, pp 91 -115 [M Perucho, editor. Boca Raton, FL: CRC Press.<\/span><\/div>\n
      3. Ewald N et al. Fecal pyruvate kinase-M2 (tumor M2- PK) measurement: a new screening concept for colorectal cancer. In Anticancer Res. 2007<\/span><\/div>\n
      4. Kumar Z et al. Tumor M2-pyruvat kinase: a gastrointestinal cancer marker. In Eur J Gastroenterol Hepatolog 2007.<\/span><\/div>\n
      5. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog.<\/span><\/div>\n
      6. Oremek, GM et al. (2000). Value of Tumor M2 (Tu M2-PK) in Patients with Renal Carcinoma. In Anticancer Research, 20: 5095-5098.<\/span><\/div>\n
      7. Phil Allcock \u2013 ScheBo Biotech. www.schebo.co.uk<\/span><\/div>\n
      8. Schneider, J et al. (2000). Quantitative Detection of Tumor M2-Pyruvate Kinase in Plasma of Patients with Lung Cancer in Comparison to Other Lung Diseases. In Cancer Detection and Prevention, 24: 531-535.<\/span><\/div>\n
      9. Schulze, G. (2000). The Tumor Marker Tumor M2-PK: An Application in the Diagnosis of Gastrointestinal Cancer. In Anticancer Research, 20: 4961-4964.<\/span><\/div>\n
      10. Wechsel, HW et al. (1999). Marker for Renal Cell Carcinoma (RCC): The Dimeric Form of Pyruvate Kinase Type M2 (Tu M2-PK). In Anticancer Research, 19: 2583-2590.<\/span><\/div>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[923],"product_tag":[],"class_list":{"0":"post-10116","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-tumorali","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10116","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10116"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10116"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10116"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10116"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10116"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}