{"id":10115,"date":"2020-04-23T03:56:59","date_gmt":"2020-04-23T00:56:59","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/her-2-neu-oncoproteina\/"},"modified":"2025-02-07T15:11:37","modified_gmt":"2025-02-07T13:11:37","slug":"her-2-neu-oncoproteina","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/her-2-neu-oncoproteina\/","title":{"rendered":"HER-2\/neu (\u043e\u043d\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d)"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/span><\/p>\n

Oncogena HER-2\/neu situat\u0103 pe cromozomul 17 codific\u0103 sinteza unei proteine transmembranare cu greutate molecular\u0103 de 185 kDa ce face parte din familia receptorilor tirozin-kinazici. Ace\u015fti receptori prezint\u0103 omologie structural\u0103 \u015fi func\u0163ional\u0103 cu receptorul pentru factorul de cre\u015ftere epidermal. 2 din cei 4 membrii ai familiei, HER-1 \u015fi HER-2\/neu, sunt frecvent asocia\u0163i cu cancerul de s\u00e2n. Factorii de cre\u015ftere care se leag\u0103 de receptorul HER-2 stimuleaz\u0103 cre\u015fterea \u015fi diviziunea celular\u0103. Amplificarea genei HER-2\/neu determin\u0103 acumularea receptorilor la nivelul suprafe\u0163ei celulare \u015fi are ca rezultat diviziunea celular\u0103 continu\u0103.<\/span><\/p>\n

Supraexpresia oncogenei HER-2\/neu se \u00eent\u00e2lne\u015fte \u00een 25-30% din cancerele mamare precum \u015fi \u00een cancerele ovariane, colorectale, pulmonare sau ale glandelor salivare.<\/span><\/p>\n

Determinarea seric\u0103 a HER-2\/neu este mult mai util\u0103 ca marker de prognostic dec\u00e2t de diagnostic, deoarece numai 5-10% din pacientele cu cancer de s\u00e2n au la momentul stabilirii diagnosticului valori crescute ale oncoproteinei. Concentra\u0163iile ridicate ale HER-2\/neu \u00eenregistrate \u00eenainte de \u00eenceperea tratamentului specific se asociaz\u0103 cu o mas\u0103 tumoral\u0103 mare, cu invazia ganglionilor limfatici \u015fi cu un stadiu avansat. Valorile plasmatice pre- \u015fi post-tratament pot fi folosite \u00een evaluarea r\u0103spunsului la chimioterapie, antagoni\u015fti hormonali, anticorpi monoclonali anti-HER-2\/neu: trastuzumab (Herceptin), cunoscut fiind faptul c\u0103 un nivel sc\u0103zut al oncoproteinei se asociaz\u0103 cu un r\u0103spuns complet sau de lung\u0103 durat\u0103.<\/span><\/p>\n

O dat\u0103 cu recunoa\u015fterea valorii sale predictive pentru prognostic \u015fi tratament, determinarea oncoproteinei HER-2\/neu a dob\u00e2ndit importan\u0163\u0103 clinic\u0103 \u00een evaluarea pacientelor cu cancer mamar6;7;9<\/sup>.<\/span><\/p>\n

Recomand\u0103ri pentru determinarea HER-2\/neu <\/em><\/strong>\u2013 monitorizarea pacientelor cu cancer mamar metastatic; evaluarea pacien\u0163ilor cu alte tipuri de tumori (pulmonare, de prostat\u0103 sau vezic\u0103 urinar\u0103)6<\/sup>.\u00a0<\/em><\/strong><\/span><\/p>\n

Preg\u0103tire pacient <\/em><\/strong>\u2013 \u00e0 jeun (pe nem\u00e2ncate)5<\/sup>.<\/span><\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c5<\/sup>.<\/span><\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator5<\/sup>.<\/span><\/p>\n

Cantitate recoltat\u0103 <\/em><\/strong>- <\/em>c\u00e2t permite vacuumul5<\/sup>.<\/span><\/p>\n

Cauze de respingere a probei<\/em><\/strong> \u2013 specimen hemolizat5<\/sup>.<\/span><\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>- <\/em>se separ\u0103 serul prin centrifugare; se lucreaz\u0103 serul proasp\u0103t; dac\u0103 acest lucru nu este posibil, serul se p\u0103streaz\u0103 la 2-8\u00b0C sau la -20\u00b0C5<\/sup>.<\/span><\/p>\n

Metod\u0103 <\/em><\/strong>- ELISA<\/span>5<\/sup><\/span>.<\/span><\/p>\n

Valori de referin\u0163\u0103 <\/em><\/strong>- <\/em><15.2 \u03bcg\/L2<\/sup>.<\/span><\/p>\n

Interpretarea rezultatelor<\/em><\/strong><\/span><\/p>\n

Rezultatele acestui test nu pot fi interpretate ca dovad\u0103 cert\u0103 a prezen\u0163ei sau absen\u0163ei bolii maligne, de aceea valoarea seric\u0103 a Her-2-Neu ar trebui s\u0103 fie folosit\u0103 ca parte a unei evalu\u0103ri globale care s\u0103 includ\u0103 teste clinice \u015fi paraclinice.<\/span><\/p>\n

In cazurile de cancer mamar metastatic, 92% dintre pacientele care au nivele serice de Her-2-Neu >37\u00b5g\/L sunt \u00a0HER-2 pozitive la examenul imunohistochimic, \u00een timp ce doar 27% dintre paciente cu valori mai mici de 37\u00b5g\/L prezint\u0103 celule tumorale HER-2 pozitive.<\/span><\/p>\n

Monitorizarea valorilor circulante ale Her-2-Neu reprezint\u0103 un important instrument \u00een evaluarea prognosticului, estimarea r\u0103spunsului la tratament, precum \u015fi detectarea precoce a progresiei bolii,\u00a0\u00een scopul interven\u0163iei\u00a0\u00een timp util cu un tratament adecvat1;2;7<\/sup>.<\/span><\/p>\n

Cre\u015fterea seric\u0103 a oncoproteinei HER-2\/neu se coreleaz\u0103 cu prezen\u0163a cancerului de prostat\u0103 \u00een stadiul metastatic \u015fi poate indica un risc crescut de deces la pacien\u0163ii cu orhiectomie. Determinarea plasmatic\u0103 a HER-2\/neu este o alternativ\u0103 minim invaziv\u0103 de identificare a poten\u0163ialilor candida\u0163i pentru tratamentul cu antiorpi monoclonali anti-HER-2\/neu4<\/sup>.<\/span><\/p>\n

Prezen\u0163a seric\u0103 a oncoproteinei HER-2\/neu \u00een stadiul I al adenocarcinomului pulmonar poate prezice gradul de\u00a0 agresivitate al tumorii. Recuren\u0163ele tumorale timpurii au fost frecvent asociate cu excesul de HER-2\/neu la ace\u015fti pacien\u0163i. Numeroase studii au ar\u0103tat c\u0103 supraexpresia genei HER-2\/neu se asociaz\u0103 cu rezisten\u0163a multipl\u0103 la medicamente, prognostic prost \u015fi supravie\u0163uire scurt\u0103, iar m\u0103surarea HER-2\/neu ar trebui considerat\u0103 un marker important pentru estimarea recuren\u0163elor \u015fi metastazarea precoce3<\/sup>.<\/span><\/p>\n

Exprimarea oncogenei HER-2\/neu se afl\u0103 \u00een rela\u0163ie direct\u0103 cu carcinomul de vezic\u0103 urinar\u0103 cu celule tranzi\u0163ionale. Studii suplimentare efectuate pe o perioad\u0103 mai lung\u0103 vor putea determina rolul Her-2-Neu ca factor de prognostic\u00a0\u00een acest tip de tumor\u01038<\/sup>.<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. ARUP Laboratories. Test Directory: HER-2\/neu, Serum. www.aruplab.com 2010. Ref Type: Internet Communication.<\/span><\/div>\n
2. Carney WP, Neumann R, Lipton A, Leitzel K, Ali S, Price CP.; Potential clinical utility of serum HER-2\/neu oncoprotein concentrations in patients with breast cancer; Clin Chem. 2003;49(10):1579-98<\/span><\/div>\n
3. Chih-Cheng Hsieh, MDa,b, Kuan-Chih Chow, PhDa, Huei-Jyh Fahn, MDa,b, Chun-Ming Tsai, MDb, Wing-Yin Li, MDa, Min-Hsiung Huang, MDa,b, Liang-Shun Wang, MDa; Prognostic significance of HER-2\/neu overexpression in stage I adenocarcinoma of lung; Ann Thorac Surg 1998;66:1159-1163<\/span><\/div>\n
4. I. OSMAN, M. MIKHAIL, B. SHUCH, M. CLUTE, C. CHELI, F. GHANI, R. THIEL, S. TANEJA SERUM LEVELS OF SHED HER2\/NEU PROTEIN IN MEN WITH PROSTATE CANCER CORRELATE WITH DISEASE PROGRESSION The Journal of Urology, 2005, 174( 6), 2174-2177.<\/span><\/div>\n
5. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate. 2010. Ref Type: Catalog.<\/span><\/div>\n
6. Laboratory Corporation of America. Directory of Services and Interpretive Guide. HER-2\/neu, Quantitative, ELISA. www.labcorp.com 2010. Ref Type: Internet Communication.<\/span><\/div>\n
7. Mayo Clinic\/Mayo Medical Laboratories.Test Catalogs and Guides. HER-2\/neu, Quantitative, www.mayomedicallaboratories.com. Ref Type: Internet Communication.<\/span><\/div>\n
8. Mohammad Reza Jalali Nadoushan, Touraj Taheri, Neda Jouian, Farid Zaeri; Overexpression of HER-2\/neu Oncogene and Transitional Cell Carcinoma of Bladder; Urology Journal 2007:4(3):151<\/span><\/div>\n
9. Peng Lee, Matthew R. Pincus, Richard A. McPherson. In Henry\u2019s Clinical Diagnosis and Management by Laboratory Methods, Saunders-Elsevier, 21st Edition, 1361.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u041e\u043d\u043a\u043e\u0433\u0435\u043d HER-2\/neu, \u0440\u0430\u0441\u043f\u043e\u043b\u043e\u0436\u0435\u043d\u043d\u044b\u0439 \u043d\u0430 \u0445\u0440\u043e\u043c\u043e\u0441\u043e\u043c\u0435 17, \u043a\u043e\u0434\u0438\u0440\u0443\u0435\u0442 \u0441\u0438\u043d\u0442\u0435\u0437 \u0442\u0440\u0430\u043d\u0441\u043c\u0435\u043c\u0431\u0440\u0430\u043d\u043d\u043e\u0433\u043e \u0431\u0435\u043b\u043a\u0430 \u0441 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u043e\u0439 \u043c\u0430\u0441\u0441\u043e\u0439 185 \u041a\u0414\u0410, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0447\u0430\u0441\u0442\u044c\u044e \u0441\u0435\u043c\u0435\u0439\u0441\u0442\u0432\u0430 \u0442\u0438\u0440\u043e\u0437\u0438\u043d\u043a\u0438\u043d\u0430\u0437\u043d\u044b\u0445 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u043e\u0432. \u042d\u0442\u0438 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u044b \u0434\u0435\u043c\u043e\u043d\u0441\u0442\u0440\u0438\u0440\u0443\u044e\u0442 \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u043d\u0443\u044e \u0438 \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u0443\u044e \u0433\u043e\u043c\u043e\u043b\u043e\u0433\u0438\u044e \u0441 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u043e\u043c \u044d\u043f\u0438\u0434\u0435\u0440\u043c\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0444\u0430\u043a\u0442\u043e\u0440\u0430 \u0440\u043e\u0441\u0442\u0430. 2 \u0438\u0437 4 \u0447\u043b\u0435\u043d\u044b \u0441\u0435\u043c\u044c\u0438, HER-1 \u0438 HER-2\/neu, \u0447\u0430\u0441\u0442\u043e \u0441\u0432\u044f\u0437\u0430\u043d\u044b \u0441 \u0440\u0430\u043a\u043e\u043c \u043c\u043e\u043b\u043e\u0447\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b. \u0424\u0430\u043a\u0442\u043e\u0440\u044b \u0440\u043e\u0441\u0442\u0430, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u044e\u0442\u0441\u044f \u0441 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u043e\u043c HER-2, \u0441\u0442\u0438\u043c\u0443\u043b\u0438\u0440\u0443\u044e\u0442 \u0440\u043e\u0441\u0442 \u0438 \u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u043a\u043b\u0435\u0442\u043e\u043a. \u0410\u043c\u043f\u043b\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u044f \u0433\u0435\u043d\u0430 HER-2\/neu \u0432\u044b\u0437\u044b\u0432\u0430\u0435\u0442 \u043d\u0430\u043a\u043e\u043f\u043b\u0435\u043d\u0438\u0435 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u043e\u0432 \u043d\u0430 \u043f\u043e\u0432\u0435\u0440\u0445\u043d\u043e\u0441\u0442\u0438 \u043a\u043b\u0435\u0442\u043a\u0438 \u0438 \u043f\u0440\u0438\u0432\u043e\u0434\u0438\u0442 \u043a \u043d\u0435\u043f\u0440\u0435\u0440\u044b\u0432\u043d\u043e\u043c\u0443 \u0434\u0435\u043b\u0435\u043d\u0438\u044e \u043a\u043b\u0435\u0442\u043e\u043a.<\/p>\n

\u0421\u0432\u0435\u0440\u0445\u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u044f \u043e\u043d\u043a\u043e\u0433\u0435\u043d\u0430 HER-2\/neu \u0432\u0441\u0442\u0440\u0435\u0447\u0430\u0435\u0442\u0441\u044f \u0432 25-30% \u0441\u043b\u0443\u0447\u0430\u0435\u0432 \u0440\u0430\u043a\u0430 \u043c\u043e\u043b\u043e\u0447\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b, \u0430 \u0442\u0430\u043a\u0436\u0435 \u043f\u0440\u0438 \u0440\u0430\u043a\u0435 \u044f\u0438\u0447\u043d\u0438\u043a\u043e\u0432, \u043a\u043e\u043b\u043e\u0440\u0435\u043a\u0442\u0430\u043b\u044c\u043d\u043e\u0433\u043e, \u043b\u0435\u0433\u043e\u0447\u043d\u043e\u0433\u043e \u0438\u043b\u0438 \u0441\u043b\u044e\u043d\u043d\u044b\u0445 \u0436\u0435\u043b\u0435\u0437.<\/p>\n

\u0421\u044b\u0432\u043e\u0440\u043e\u0442\u043e\u0447\u043d\u043e\u0435 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 HER-2\/neu \u0433\u043e\u0440\u0430\u0437\u0434\u043e \u0431\u043e\u043b\u0435\u0435 \u043f\u043e\u043b\u0435\u0437\u043d\u043e \u0432 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u043f\u0440\u043e\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043c\u0430\u0440\u043a\u0435\u0440\u0430, \u0447\u0435\u043c \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0435, \u043f\u043e\u0441\u043a\u043e\u043b\u044c\u043a\u0443 \u0442\u043e\u043b\u044c\u043a\u043e 5-10% \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0440\u0430\u043a\u043e\u043c \u043c\u043e\u043b\u043e\u0447\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b \u0438\u043c\u0435\u044e\u0442 \u043d\u0430 \u043c\u043e\u043c\u0435\u043d\u0442 \u043f\u043e\u0441\u0442\u0430\u043d\u043e\u0432\u043a\u0438 \u0434\u0438\u0430\u0433\u043d\u043e\u0437\u0430 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f \u043e\u043d\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430. \u0412\u044b\u0441\u043e\u043a\u0438\u0435 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 HER-2\/neu, \u0437\u0430\u0440\u0435\u0433\u0438\u0441\u0442\u0440\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0435 \u0434\u043e \u043d\u0430\u0447\u0430\u043b\u0430 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043b\u0435\u0447\u0435\u043d\u0438\u044f, \u0441\u0432\u044f\u0437\u0430\u043d\u044b \u0441 \u0431\u043e\u043b\u044c\u0448\u043e\u0439 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u043e\u0439 \u043c\u0430\u0441\u0441\u043e\u0439, \u0438\u043d\u0432\u0430\u0437\u0438\u0435\u0439 \u043b\u0438\u043c\u0444\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0443\u0437\u043b\u043e\u0432 \u0438 \u043f\u043e\u0437\u0434\u043d\u0435\u0439 \u0441\u0442\u0430\u0434\u0438\u0435\u0439. \u0417\u043d\u0430\u0447\u0435\u043d\u0438\u044f \u0434\u043e \u0438 \u043f\u043e\u0441\u043b\u0435 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0432 \u043f\u043b\u0430\u0437\u043c\u0435 \u043c\u043e\u0433\u0443\u0442 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u0442\u044c\u0441\u044f \u0434\u043b\u044f \u043e\u0446\u0435\u043d\u043a\u0438 \u043e\u0442\u0432\u0435\u0442\u0430 \u043d\u0430 \u0445\u0438\u043c\u0438\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044e, \u0430\u043d\u0442\u0430\u0433\u043e\u043d\u0438\u0441\u0442\u043e\u0432 \u0433\u043e\u0440\u043c\u043e\u043d\u043e\u0432, \u043c\u043e\u043d\u043e\u043a\u043b\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0445 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043f\u0440\u043e\u0442\u0438\u0432 HER-2\/neu: \u0442\u0440\u0430\u0441\u0442\u0443\u0437\u0443\u043c\u0430\u0431 (\u0413\u0435\u0440\u0446\u0435\u043f\u0442\u0438\u043d), \u0438\u0437\u0432\u0435\u0441\u0442\u043d\u044b\u0439 \u0442\u0435\u043c, \u0447\u0442\u043e \u043d\u0438\u0437\u043a\u0438\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u043e\u043d\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430 \u0441\u0432\u044f\u0437\u0430\u043d \u0441 \u043f\u043e\u043b\u043d\u044b\u043c \u0438\u043b\u0438 \u0434\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u043c \u043e\u0442\u0432\u0435\u0442\u043e\u043c.<\/p>\n

\u041f\u043e\u0441\u043b\u0435 \u043f\u0440\u0438\u0437\u043d\u0430\u043d\u0438\u044f \u0435\u0433\u043e \u043f\u0440\u043e\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0446\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u0434\u043b\u044f \u043f\u0440\u043e\u0433\u043d\u043e\u0437\u0430 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u043e\u043d\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430 HER-2\/neu \u043f\u0440\u0438\u043e\u0431\u0440\u0435\u043b\u043e \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435 \u043f\u0440\u0438 \u043e\u0446\u0435\u043d\u043a\u0435 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0440\u0430\u043a\u043e\u043c \u043c\u043e\u043b\u043e\u0447\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b6;7;9.<\/p>\n

\u0420\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u043f\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044e HER-2\/neu-\u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u043c\u0435\u0442\u0430\u0441\u0442\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0440\u0430\u043a\u043e\u043c \u043c\u043e\u043b\u043e\u0447\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b; \u043e\u0446\u0435\u043d\u043a\u0430 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0434\u0440\u0443\u0433\u0438\u043c\u0438 \u0442\u0438\u043f\u0430\u043c\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0439 (\u043b\u0435\u0433\u043a\u0438\u0445, \u043f\u0440\u043e\u0441\u0442\u0430\u0442\u044b \u0438\u043b\u0438 \u043c\u043e\u0447\u0435\u0432\u043e\u0433\u043e \u043f\u0443\u0437\u044b\u0440\u044f)6.<\/p>\n

\u041f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0430 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430-\u043d\u0430\u0442\u043e\u0449\u0430\u043a5.<\/p>\n

\u0421\u043e\u0431\u0440\u0430\u043d\u043d\u044b\u0439 \u043e\u0431\u0440\u0430\u0437\u0435\u0446-\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c 5.<\/p>\n

\u041a\u043e\u043d\u0442\u0435\u0439\u043d\u0435\u0440 \u0434\u043b\u044f \u0441\u0431\u043e\u0440\u0430 \u043e\u0431\u0440\u0430\u0437\u0446\u0430-vacutainer \u0431\u0435\u0437 \u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430, \u0441 \/ \u0431\u0435\u0437 \u0441\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0440\u043d\u043e\u0433\u043e \u0433\u0435\u043b\u044f 5.<\/p>\n

\u0421\u043e\u0431\u0440\u0430\u043d\u043d\u043e\u0435 \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u043e-\u0441\u043a\u043e\u043b\u044c\u043a\u043e \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0435\u0442 \u0432\u0430\u043a\u0443\u0443\u043c5.<\/p>\n

\u041f\u0440\u0438\u0447\u0438\u043d\u044b \u043e\u0442\u0442\u043e\u0440\u0436\u0435\u043d\u0438\u044f \u043e\u0431\u0440\u0430\u0437\u0446\u0430-\u043e\u0431\u0440\u0430\u0437\u0435\u0446 \u0433\u0435\u043c\u043e\u043b\u0438\u0437\u0430\u04425.<\/p>\n

\u0421\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u043e\u0431\u0440\u0430\u0437\u0446\u0430-\u043e\u0442\u0434\u0435\u043b\u044f\u0435\u0442 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0443 \u0446\u0435\u043d\u0442\u0440\u0438\u0444\u0443\u0433\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435\u043c; \u0440\u0430\u0431\u043e\u0442\u0430\u0435\u0442 \u0441\u0432\u0435\u0436\u0430\u044f \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0430; \u0435\u0441\u043b\u0438 \u044d\u0442\u043e \u043d\u0435\u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e, \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0430 \u0445\u0440\u0430\u043d\u0438\u0442\u0441\u044f \u043f\u0440\u0438 2-8 \u00b0 C \u0438\u043b\u0438 -20\u00b0C5.<\/p>\n

\u041c\u0435\u0442\u043e\u0434-ELISA5.<\/p>\n

\u042d\u0442\u0430\u043b\u043e\u043d\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f – <15.2 \u043c\u043a\u0433 \/ \u041b2.<\/p>\n

\u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/p>\n

\u0420\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b \u044d\u0442\u043e\u0433\u043e \u0442\u0435\u0441\u0442\u0430 \u043d\u0435 \u043c\u043e\u0433\u0443\u0442 \u0431\u044b\u0442\u044c \u0438\u0441\u0442\u043e\u043b\u043a\u043e\u0432\u0430\u043d\u044b \u043a\u0430\u043a \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u043d\u043e\u0435 \u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u043e \u043d\u0430\u043b\u0438\u0447\u0438\u044f \u0438\u043b\u0438 \u043e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u044f \u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u043f\u043e\u044d\u0442\u043e\u043c\u0443 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043e\u0447\u043d\u0430\u044f \u0446\u0435\u043d\u043d\u043e\u0441\u0442\u044c Her-2-Neu \u0434\u043e\u043b\u0436\u043d\u0430 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u0442\u044c\u0441\u044f \u043a\u0430\u043a \u0447\u0430\u0441\u0442\u044c \u043e\u0431\u0449\u0435\u0439 \u043e\u0446\u0435\u043d\u043a\u0438, \u0432\u043a\u043b\u044e\u0447\u0430\u044e\u0449\u0435\u0439 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0438 \u043f\u0430\u0440\u0430\u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0442\u0435\u0441\u0442\u044b.<\/p>\n

\u041f\u0440\u0438 \u043c\u0435\u0442\u0430\u0441\u0442\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u0440\u0430\u043a\u0435 \u043c\u043e\u043b\u043e\u0447\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b 92% \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0443\u0440\u043e\u0432\u043d\u044f\u043c\u0438 Her-2-Neu \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 >37 \u043c\u043a\u0433\/\u043b \u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f HER-2-\u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u043c\u0438 \u043f\u0440\u0438 \u0438\u043c\u043c\u0443\u043d\u043e\u0433\u0438\u0441\u0442\u043e\u0445\u0438\u043c\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438, \u0442\u043e\u0433\u0434\u0430 \u043a\u0430\u043a \u0442\u043e\u043b\u044c\u043a\u043e 27% \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441\u043e \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f\u043c\u0438 \u043c\u0435\u043d\u0435\u0435 37 \u043c\u043a\u0433\/\u043b \u0438\u043c\u0435\u044e\u0442 HER-2-\u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0435 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u0435 \u043a\u043b\u0435\u0442\u043a\u0438.<\/p>\n

\u041c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433 \u0446\u0438\u0440\u043a\u0443\u043b\u0438\u0440\u0443\u044e\u0449\u0438\u0445 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0439 Her-2-Neu \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0432\u0430\u0436\u043d\u044b\u043c \u0438\u043d\u0441\u0442\u0440\u0443\u043c\u0435\u043d\u0442\u043e\u043c \u0432 \u043e\u0446\u0435\u043d\u043a\u0435 \u043f\u0440\u043e\u0433\u043d\u043e\u0437\u0430, \u043e\u0446\u0435\u043d\u043a\u0435 \u043e\u0442\u0432\u0435\u0442\u0430 \u043d\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u0435, \u0430 \u0442\u0430\u043a\u0436\u0435 \u0440\u0430\u043d\u043d\u0435\u043c \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u0438 \u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0441\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u0441 \u0446\u0435\u043b\u044c\u044e \u0441\u0432\u043e\u0435\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0433\u043e \u0432\u043c\u0435\u0448\u0430\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0430 \u0441 \u0430\u0434\u0435\u043a\u0432\u0430\u0442\u043d\u044b\u043c \u043b\u0435\u0447\u0435\u043d\u0438\u0435\u043c 1;2;7.<\/p>\n

\u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435 \u0443\u0440\u043e\u0432\u043d\u044f \u043e\u043d\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430 HER-2\/neu \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438 \u043a\u043e\u0440\u0440\u0435\u043b\u0438\u0440\u0443\u0435\u0442 \u0441 \u043d\u0430\u043b\u0438\u0447\u0438\u0435\u043c \u043c\u0435\u0442\u0430\u0441\u0442\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0440\u0430\u043a\u0430 \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b \u0438 \u043c\u043e\u0436\u0435\u0442 \u0443\u043a\u0430\u0437\u044b\u0432\u0430\u0442\u044c \u043d\u0430 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u0439 \u0440\u0438\u0441\u043a \u0441\u043c\u0435\u0440\u0442\u0438 \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u043e\u0440\u0445\u0438\u044d\u043a\u0442\u043e\u043c\u0438\u0435\u0439. \u041e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 HER-2\/neu \u0432 \u043f\u043b\u0430\u0437\u043c\u0435 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043c\u0438\u043d\u0438\u043c\u0430\u043b\u044c\u043d\u043e \u0438\u043d\u0432\u0430\u0437\u0438\u0432\u043d\u043e\u0439 \u0430\u043b\u044c\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u043e\u0439 \u0438\u0434\u0435\u043d\u0442\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u0438 \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u044b\u0445 \u043a\u0430\u043d\u0434\u0438\u0434\u0430\u0442\u043e\u0432 \u0434\u043b\u044f \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u043c\u043e\u043d\u043e\u043a\u043b\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u043c\u0438 \u0430\u043d\u0442\u0438\u043e\u0440\u043f\u0438\u044f\u043c\u0438 \u043f\u0440\u043e\u0442\u0438\u0432 HER-2\/neu4.<\/p>\n

\u0421\u044b\u0432\u043e\u0440\u043e\u0442\u043e\u0447\u043d\u043e\u0435 \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0435 \u043e\u043d\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430 HER-2\/neu \u043d\u0430 I \u0441\u0442\u0430\u0434\u0438\u0438 \u0430\u0434\u0435\u043d\u043e\u043a\u0430\u0440\u0446\u0438\u043d\u043e\u043c\u044b \u043b\u0435\u0433\u043a\u043e\u0433\u043e \u043c\u043e\u0436\u0435\u0442 \u043f\u0440\u0435\u0434\u0441\u043a\u0430\u0437\u0430\u0442\u044c \u0441\u0442\u0435\u043f\u0435\u043d\u044c \u0430\u0433\u0440\u0435\u0441\u0441\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u0438. \u0420\u0430\u043d\u043d\u0438\u0435 \u0440\u0435\u0446\u0438\u0434\u0438\u0432\u044b \u043e\u043f\u0443\u0445\u043e\u043b\u0438 \u0447\u0430\u0441\u0442\u043e \u0431\u044b\u043b\u0438 \u0441\u0432\u044f\u0437\u0430\u043d\u044b \u0441 \u0438\u0437\u0431\u044b\u0442\u043a\u043e\u043c HER-2\/neu \u0443 \u044d\u0442\u0438\u0445 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432. \u041c\u043d\u043e\u0433\u043e\u0447\u0438\u0441\u043b\u0435\u043d\u043d\u044b\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u043f\u043e\u043a\u0430\u0437\u0430\u043b\u0438, \u0447\u0442\u043e \u0441\u0432\u0435\u0440\u0445\u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u044f \u0433\u0435\u043d\u0430 HER-2\/neu \u0441\u0432\u044f\u0437\u0430\u043d\u0430 \u0441 \u043c\u043d\u043e\u0436\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0439 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0439 \u0443\u0441\u0442\u043e\u0439\u0447\u0438\u0432\u043e\u0441\u0442\u044c\u044e, \u043f\u043b\u043e\u0445\u0438\u043c \u043f\u0440\u043e\u0433\u043d\u043e\u0437\u043e\u043c \u0438 \u043a\u043e\u0440\u043e\u0442\u043a\u043e\u0439 \u0432\u044b\u0436\u0438\u0432\u0430\u0435\u043c\u043e\u0441\u0442\u044c\u044e, \u0430 \u0438\u0437\u043c\u0435\u0440\u0435\u043d\u0438\u0435 HER-2\/neu \u0441\u043b\u0435\u0434\u0443\u0435\u0442 \u0440\u0430\u0441\u0441\u043c\u0430\u0442\u0440\u0438\u0432\u0430\u0442\u044c \u043a\u0430\u043a \u0432\u0430\u0436\u043d\u044b\u0439 \u043c\u0430\u0440\u043a\u0435\u0440 \u0434\u043b\u044f \u043e\u0446\u0435\u043d\u043a\u0438 \u0440\u0435\u0446\u0438\u0434\u0438\u0432\u043e\u0432 \u0438 \u0440\u0430\u043d\u043d\u0435\u0433\u043e \u043c\u0435\u0442\u0430\u0441\u0442\u0430\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f 3.<\/p>\n

\u042d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u044f \u043e\u043d\u043a\u043e\u0433\u0435\u043d\u0430 HER-2\/neu \u043d\u0430\u0445\u043e\u0434\u0438\u0442\u0441\u044f \u0432 \u043f\u0440\u044f\u043c\u043e\u0439 \u0441\u0432\u044f\u0437\u0438 \u0441 \u0442\u0440\u0430\u043d\u0437\u0438\u0446\u0438\u043e\u043d\u043d\u043e-\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u0439 \u043a\u0430\u0440\u0446\u0438\u043d\u043e\u043c\u043e\u0439 \u043c\u043e\u0447\u0435\u0432\u043e\u0433\u043e \u043f\u0443\u0437\u044b\u0440\u044f. \u0414\u0430\u043b\u044c\u043d\u0435\u0439\u0448\u0438\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f, \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u043d\u044b\u0435 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 \u0431\u043e\u043b\u0435\u0435 \u0434\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0433\u043e \u043f\u0435\u0440\u0438\u043e\u0434\u0430, \u0441\u043c\u043e\u0433\u0443\u0442 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0438\u0442\u044c \u0440\u043e\u043b\u044c Her-2-Neu \u043a\u0430\u043a \u043f\u0440\u043e\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0444\u0430\u043a\u0442\u043e\u0440\u0430 \u0432 \u044d\u0442\u043e\u043c \u0442\u0438\u043f\u0435 \u043e\u043f\u0443\u0445\u043e\u043b\u0438 8.<\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. ARUP Laboratories. Test Directory: HER-2\/neu, Serum. www.aruplab.com 2010. Ref Type: Internet Communication.<\/span><\/div>\n
2. Carney WP, Neumann R, Lipton A, Leitzel K, Ali S, Price CP.; Potential clinical utility of serum HER-2\/neu oncoprotein concentrations in patients with breast cancer; Clin Chem. 2003;49(10):1579-98<\/span><\/div>\n
3. Chih-Cheng Hsieh, MDa,b, Kuan-Chih Chow, PhDa, Huei-Jyh Fahn, MDa,b, Chun-Ming Tsai, MDb, Wing-Yin Li, MDa, Min-Hsiung Huang, MDa,b, Liang-Shun Wang, MDa; Prognostic significance of HER-2\/neu overexpression in stage I adenocarcinoma of lung; Ann Thorac Surg 1998;66:1159-1163<\/span><\/div>\n
4. I. OSMAN, M. MIKHAIL, B. SHUCH, M. CLUTE, C. CHELI, F. GHANI, R. THIEL, S. TANEJA SERUM LEVELS OF SHED HER2\/NEU PROTEIN IN MEN WITH PROSTATE CANCER CORRELATE WITH DISEASE PROGRESSION The Journal of Urology, 2005, 174( 6), 2174-2177.<\/span><\/div>\n
5. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate. 2010. Ref Type: Catalog.<\/span><\/div>\n
6. Laboratory Corporation of America. Directory of Services and Interpretive Guide. HER-2\/neu, Quantitative, ELISA. www.labcorp.com 2010. Ref Type: Internet Communication.<\/span><\/div>\n
7. Mayo Clinic\/Mayo Medical Laboratories.Test Catalogs and Guides. HER-2\/neu, Quantitative, www.mayomedicallaboratories.com. Ref Type: Internet Communication.<\/span><\/div>\n
8. Mohammad Reza Jalali Nadoushan, Touraj Taheri, Neda Jouian, Farid Zaeri; Overexpression of HER-2\/neu Oncogene and Transitional Cell Carcinoma of Bladder; Urology Journal 2007:4(3):151<\/span><\/div>\n
9. Peng Lee, Matthew R. Pincus, Richard A. McPherson. In Henry\u2019s Clinical Diagnosis and Management by Laboratory Methods, Saunders-Elsevier, 21st Edition, 1361<\/span><\/div>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[923],"product_tag":[],"class_list":{"0":"post-10115","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-tumorali","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10115","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10115"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10115"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10115"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10115"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10115"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}