{"id":10114,"date":"2020-04-23T03:56:58","date_gmt":"2020-04-23T00:56:58","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/ca-50\/"},"modified":"2025-02-07T15:10:45","modified_gmt":"2025-02-07T13:10:45","slug":"ca-50","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/ca-50\/","title":{"rendered":"CA 50"},"content":{"rendered":"

Informa\u0163ii generale \u015fi recomand\u0103ri pentru determinarea CA 50<\/em><\/strong><\/span><\/p>\n

Antigenul carbohidrat CA 50 (descris pentru prima dat\u0103 \u00een 1983 de Lindholm \u015fi colab.) se g\u0103se\u015fte \u00een membrana unor celule unde este legat fie de lipide (sub forma unor gangliozide), fie \u00a0de proteine cu greutate molecular\u0103 mare (sub form\u0103 de glicoproteine)4<\/sup>.<\/span><\/p>\n

Utilizat ca marker tumoral CA 50 nu are specificitate de organ, fiind constatate valori crescute \u00een diferite tumori maligne,\u00a0\u00een special gastrointestinale. Spre deosebire de CA 19-9, valori crescute de CA 50 pot fi \u00eent\u00e2lnite \u015fi\u00a0\u00een tumorile maligne ale pacien\u0163ilor Lewis negativi (a c\u0103ror celule nu pot sintetiza CA 19-9)1,4<\/sup>.<\/span><\/p>\n

In aplica\u0163iile clinice CA 50 are beneficii reduse pentru diagnostic, dar este foarte util \u00een urm\u0103rirea pacien\u0163ilor cu cancer pancreatic, av\u00e2nd sensibilitate \u015fi specificitate asem\u0103n\u0103toare cu CA 19-9 ( 77% pentru CA 19-9 \u015fi 69% pentru CA 50)1,2<\/sup>.<\/span><\/p>\n

In cancerul hepatic este comunicat\u0103 o sensibilitate mai mare (55%) pentru CA 50 dec\u00e2t pentru CA 19-9 (9%)2<\/sup>.<\/span><\/p>\n

Valori crescute ale CA 50 au fost \u00eent\u00e2lnite \u015fi\u00a0\u00een carcinoamele endometriale2<\/sup>.<\/span><\/p>\n

Preg\u0103tire pacient\u00ad <\/em><\/strong>-<\/em> \u00e0 jeun (pe nem\u00e2ncate) sau postprandial3<\/sup>.<\/span><\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c3<\/sup>.<\/span><\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator3<\/sup>.<\/span><\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare<\/em><\/strong> \u2013 se separ\u0103 serul prin centrifugare \u00een maxim 45 minute de la recoltare folosindu-se pentru separare o eprubet\u0103 de plastic; se lucreaz\u0103 serul proasp\u0103t; dac\u0103 acest lucru nu este posibil, serul se p\u0103streaz\u0103 la 2-8\u00b0C, la -20\u00b0C sau la -70\u00b0C3<\/sup>.<\/span><\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 minim 1 mL ser3<\/sup>.<\/span><\/p>\n

Cauze de respingere<\/em><\/strong> a probei<\/em><\/strong><\/span><\/p>\n

\u2022 specimen hemolizat;<\/span><\/div>\n
\u2022 specimen expus la temperatur\u0103 ridicat\u0103;<\/span><\/div>\n
\u2022 specimen contaminat bacterian3<\/sup>.<\/span><\/div>\n

Stabilitate prob\u0103 <\/em><\/strong>- <\/em>serul separat este stabil 7 zile<\/em> la temperatura camerei,\u00a0 14 zile<\/em> 2-8\u00b0C; dou\u0103 luni<\/em> la -20\u00b0C 1,2<\/sup>. Nu decongela\u0163i\/recongela\u0163i3<\/sup>.<\/span><\/p>\n

Metod\u0103 <\/em><\/strong>- LIA (metoda imunochimic\u0103 cu detec\u0163ie prin luminescen\u0163\u0103)<\/span>3<\/sup>.<\/span><\/p>\n

Valori de referin\u0163\u0103<\/em><\/strong> \u2013 0-25 U\/mL3<\/sup>.<\/span><\/p>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/span><\/p>\n

Valori moderat crescute de CA 50 au fost constatate \u015fi \u00een afec\u0163iuni hepatobiliare benigne1;2<\/sup>.<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u00a0<\/span>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Bunworasate U, Voravud N; CA 50: a tumor marker for gastrointestinal malignancies. In Journal of the Medical Association of Thailand. 1995, 255-270.<\/span><\/div>\n
2. Haglund C; Roberts PJ,Jalanko H, Kuusela P- Tumor markers CA 19-9 and CA 50 in digestiv tract malignancies. In Scandinavian Journal of Gastroenterology 1992, 169-174.<\/span><\/div>\n
3. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate. 2010. Ref Type: Catalog.<\/span><\/div>\n
4. Ulrika Harmenberg, Britta Wahren, Karl-Ludvig Wiechel. Tumor Markers Carbohydrate Antigens CA 19-9 and CA 50 and Carcinoebryonic Antigen in Pancreatic Cancer and Benign Disease of the Pancreatobiliary Tract .In Cancer Research 48\/1988 1985-1988.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u0423\u0433\u043b\u0435\u0432\u043e\u0434\u043d\u044b\u0439 \u0430\u043d\u0442\u0438\u0433\u0435\u043d CA 50 (\u0432\u043f\u0435\u0440\u0432\u044b\u0435 \u043e\u043f\u0438\u0441\u0430\u043d\u043d\u044b\u0439 \u0432 1983 \u0433\u043e\u0434\u0443 \u041b\u0438\u043d\u0434\u0445\u043e\u043b\u044c\u043c\u043e\u043c \u0438 \u0434\u0440.) \u041e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d \u0432 \u043c\u0435\u043c\u0431\u0440\u0430\u043d\u0435 \u043a\u043b\u0435\u0442\u043e\u043a, \u0433\u0434\u0435 \u043e\u043d \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u0435\u0442\u0441\u044f \u043b\u0438\u0431\u043e \u0441 \u043b\u0438\u043f\u0438\u0434\u0430\u043c\u0438 (\u0432 \u0444\u043e\u0440\u043c\u0435 \u0433\u0430\u043d\u0433\u043b\u0438\u043e\u0437\u0438\u0434\u043e\u0432), \u043b\u0438\u0431\u043e \u0441 \u0432\u044b\u0441\u043e\u043a\u043e\u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u043c\u0438 \u0431\u0435\u043b\u043a\u0430\u043c\u0438 (\u0432 \u0444\u043e\u0440\u043c\u0435 \u0433\u043b\u0438\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u043e\u0432).<\/p>\n

\u0418\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u043c\u044b\u0439 \u0432 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u043e\u0433\u043e \u043c\u0430\u0440\u043a\u0435\u0440\u0430 CA 50 \u043d\u0435 \u043e\u0431\u043b\u0430\u0434\u0430\u0435\u0442 \u043e\u0440\u0433\u0430\u043d\u043e\u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u043e\u0441\u0442\u044c\u044e, \u043f\u043e\u0441\u043a\u043e\u043b\u044c\u043a\u0443 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u0432\u0430\u044e\u0442\u0441\u044f \u0432\u044b\u0441\u043e\u043a\u0438\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f \u043f\u0440\u0438 \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u044b\u0445 \u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445, \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e \u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e-\u043a\u0438\u0448\u0435\u0447\u043d\u044b\u0445. \u0412 \u043e\u0442\u043b\u0438\u0447\u0438\u0435 \u043e\u0442 \u0421\u0410 19-9, \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f \u0421\u0410 50 \u0442\u0430\u043a\u0436\u0435 \u043c\u043e\u0433\u0443\u0442 \u0431\u044b\u0442\u044c \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u044b \u0432 \u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445 \u043e\u0442\u0440\u0438\u0446\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u041b\u044c\u044e\u0438\u0441\u0430 (\u043a\u043b\u0435\u0442\u043a\u0438 \u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u043d\u0435 \u043c\u043e\u0433\u0443\u0442 \u0441\u0438\u043d\u0442\u0435\u0437\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u0421\u0410 19-9) 1,4.<\/p>\n

\u0412 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f\u0445 CA 50 \u0438\u043c\u0435\u0435\u0442 \u043d\u0438\u0437\u043a\u0438\u0435 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043f\u0440\u0435\u0438\u043c\u0443\u0449\u0435\u0441\u0442\u0432\u0430, \u043d\u043e \u043e\u0447\u0435\u043d\u044c \u043f\u043e\u043b\u0435\u0437\u0435\u043d \u0434\u043b\u044f \u0441\u043b\u0435\u0434\u0443\u044e\u0449\u0438\u0445 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0440\u0430\u043a\u043e\u043c \u043f\u043e\u0434\u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b, \u0438\u043c\u0435\u044e\u0449\u0438\u0445 \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u0438 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u043e\u0441\u0442\u044c, \u0430\u043d\u0430\u043b\u043e\u0433\u0438\u0447\u043d\u044b\u0435 CA 19-9 (77% \u0434\u043b\u044f CA 19-9 \u0438 69% \u0434\u043b\u044f CA 50) 1,2 , \u041f\u0440\u0438 \u0440\u0430\u043a\u0435 \u043f\u0435\u0447\u0435\u043d\u0438 \u0431\u043e\u043b\u0435\u0435 \u0432\u044b\u0441\u043e\u043a\u0430\u044f \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c (55%) \u0441\u043e\u043e\u0431\u0449\u0430\u0435\u0442\u0441\u044f \u0434\u043b\u044f \u0421\u0410 50, \u0447\u0435\u043c \u0434\u043b\u044f \u0421\u0410 19-9 (9%) 2. \u041f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f CA 50 \u0431\u044b\u043b\u0438 \u0442\u0430\u043a\u0436\u0435 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u044b \u043f\u0440\u0438 \u043a\u0430\u0440\u0446\u0438\u043d\u043e\u043c\u0430\u0445 \u044d\u043d\u0434\u043e\u043c\u0435\u0442\u0440\u0438\u044f2.<\/p>\n

\u041f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0430 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430 – \u0433\u043e\u043b\u043e\u0434\u0430\u043d\u0438\u0435 (\u043d\u0430\u0442\u043e\u0449\u0430\u043a) \u0438\u043b\u0438 \u043f\u043e\u0441\u043b\u0435 \u043f\u0440\u0438\u0435\u043c\u0430 \u043f\u0438\u0449\u04383.
\n\u0421\u043e\u0431\u0440\u0430\u043d\u043d\u044b\u0439 \u043e\u0431\u0440\u0430\u0437\u0435\u0446 – \u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c3.
\n\u041a\u043e\u043d\u0442\u0435\u0439\u043d\u0435\u0440 \u0434\u043b\u044f \u0441\u0431\u043e\u0440\u0430 \u043e\u0431\u0440\u0430\u0437\u0446\u0430 – Vacutainer \u0431\u0435\u0437 \u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430, \u0441 \/ \u0431\u0435\u0437 \u043e\u0442\u0434\u0435\u043b\u044f\u044e\u0449\u0435\u0433\u043e \u0433\u0435\u043b\u044f3.
\n\u041d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0430\u044f \u043e\u0431\u0440\u0430\u0431\u043e\u0442\u043a\u0430 \u043f\u043e\u0441\u043b\u0435 \u0441\u0431\u043e\u0440\u0430 \u043e\u0431\u0440\u0430\u0437\u0446\u0430 – \u043e\u0442\u0434\u0435\u043b\u0438\u0442\u044c \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0443 \u0446\u0435\u043d\u0442\u0440\u0438\u0444\u0443\u0433\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 \u043c\u0430\u043a\u0441\u0438\u043c\u0443\u043c 45 \u043c\u0438\u043d\u0443\u0442 \u043f\u043e\u0441\u043b\u0435 \u0441\u0431\u043e\u0440\u0430, \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u044f \u043f\u043b\u0430\u0441\u0442\u0438\u043a\u043e\u0432\u0443\u044e \u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0443 \u0434\u043b\u044f \u0440\u0430\u0437\u0434\u0435\u043b\u0435\u043d\u0438\u044f; \u0441\u0432\u0435\u0436\u0430\u044f \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0430 \u043e\u0431\u0440\u0430\u0431\u043e\u0442\u0430\u043d\u0430; \u0435\u0441\u043b\u0438 \u044d\u0442\u043e \u043d\u0435\u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e, \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0430 \u0445\u0440\u0430\u043d\u0438\u0442\u0441\u044f \u043f\u0440\u0438 \u0442\u0435\u043c\u043f\u0435\u0440\u0430\u0442\u0443\u0440\u0435 2-8 \u00b0 C, -20 \u00b0 C \u0438\u043b\u0438 -70 \u00b0 C3.
\n\u041e\u0431\u044a\u0435\u043c \u0442\u0435\u0441\u0442\u0430 – \u043c\u0438\u043d\u0438\u043c\u0443\u043c 1 \u043c\u043b \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u04383.<\/p>\n

\u041f\u0440\u0438\u0447\u0438\u043d\u044b \u043e\u0442\u043a\u0430\u0437\u0430 \u043e\u0442 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f: \u0433\u0435\u043c\u043e\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0439 \u043e\u0431\u0440\u0430\u0437\u0435\u0446, \u043e\u0431\u0440\u0430\u0437\u0435\u0446, \u043f\u043e\u0434\u0432\u0435\u0440\u0436\u0435\u043d\u043d\u044b\u0439 \u0432\u043e\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044e \u0432\u044b\u0441\u043e\u043a\u043e\u0439 \u0442\u0435\u043c\u043f\u0435\u0440\u0430\u0442\u0443\u0440\u044b, \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e \u0437\u0430\u0433\u0440\u044f\u0437\u043d\u0435\u043d\u043d\u044b\u0439 \u043e\u0431\u0440\u0430\u0437\u0435\u04463.
\n\u0421\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u043e\u0431\u0440\u0430\u0437\u0446\u0430 – \u043e\u0442\u0434\u0435\u043b\u0435\u043d\u043d\u0430\u044f \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0430 \u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u0430 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 7 \u0434\u043d\u0435\u0439 \u043f\u0440\u0438 \u043a\u043e\u043c\u043d\u0430\u0442\u043d\u043e\u0439 \u0442\u0435\u043c\u043f\u0435\u0440\u0430\u0442\u0443\u0440\u0435, 14 \u0434\u043d\u0435\u0439 \u043f\u0440\u0438 2-8 \u00b0 C; \u0434\u0432\u0430 \u043c\u0435\u0441\u044f\u0446\u0430 \u043f\u0440\u0438 -20 \u00b0 \u0421 1.2. \u041d\u0435 \u0440\u0430\u0437\u043c\u043e\u0440\u0430\u0436\u0438\u0432\u0430\u0439\u0442\u0435 \/ \u0437\u0430\u043c\u043e\u0440\u0430\u0436\u0438\u0432\u0430\u0439\u0442\u04353.
\n\u041c\u0435\u0442\u043e\u0434 – \u041b\u0418\u0410 (\u0438\u043c\u043c\u0443\u043d\u043e\u0445\u0438\u043c\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u043c\u0435\u0442\u043e\u0434 \u0441 \u043b\u044e\u043c\u0438\u043d\u0435\u0441\u0446\u0435\u043d\u0442\u043d\u044b\u043c \u0434\u0435\u0442\u0435\u043a\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435\u043c)
\n\u041a\u043e\u043d\u0442\u0440\u043e\u043b\u044c\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f – 0-25 \u0415\u0434 \/ \u043c\u043b3.<\/p>\n

\u041f\u0440\u0435\u0434\u0435\u043b\u044b \u0438 \u043f\u043e\u043c\u0435\u0445\u0438<\/p>\n

\u0423\u043c\u0435\u0440\u0435\u043d\u043d\u043e \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f \u0421\u0410 50 \u0442\u0430\u043a\u0436\u0435 \u0431\u044b\u043b\u0438 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u044b \u043f\u0440\u0438 \u0434\u043e\u0431\u0440\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u0433\u0435\u043f\u0430\u0442\u043e\u0431\u0438\u043b\u0438\u0430\u0440\u043d\u044b\u0445 \u0440\u0430\u0441\u0441\u0442\u0440\u043e\u0439\u0441\u0442\u0432\u0430\u04451; 2.<\/p>\n

\u0421\u043f\u0438\u0441\u043e\u043a \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u043c\u043e\u0439 \u043b\u0438\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u044b
\n1. Bunworasate U, Voravud N; CA 50: \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u0439 \u043c\u0430\u0440\u043a\u0435\u0440 \u043f\u0440\u0438 \u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e-\u043a\u0438\u0448\u0435\u0447\u043d\u044b\u0445 \u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u043d\u043e\u0432\u043e\u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044f\u0445. \u0412 \u0436\u0443\u0440\u043d\u0430\u043b\u0435 \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0439 \u0430\u0441\u0441\u043e\u0446\u0438\u0430\u0446\u0438\u0438 \u0422\u0430\u0438\u043b\u0430\u043d\u0434\u0430. 1995, 255-270.
\n2. \u0425\u0430\u0433\u043b\u0443\u043d\u0434 \u0421; Roberts PJ, Jalanko H, Kuusela P- \u041e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u0435 \u043c\u0430\u0440\u043a\u0435\u0440\u044b CA 19-9 \u0438 CA 50 \u043f\u0440\u0438 \u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445 \u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e-\u043a\u0438\u0448\u0435\u0447\u043d\u043e\u0433\u043e \u0442\u0440\u0430\u043a\u0442\u0430. \u0412 \u0421\u043a\u0430\u043d\u0434\u0438\u043d\u0430\u0432\u0441\u043a\u043e\u043c \u0436\u0443\u0440\u043d\u0430\u043b\u0435 \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0438 1992, 169-174.
\n3. \u041b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u0438\u044f Synevo. \u041a\u043e\u043d\u043a\u0440\u0435\u0442\u043d\u044b\u0435 \u0441\u0441\u044b\u043b\u043a\u0438 \u043d\u0430 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u043c\u044b\u0435 \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0440\u0430\u0431\u043e\u0442\u044b. 2010. \u0422\u0438\u043f \u0441\u0441\u044b\u043b\u043a\u0438: \u041a\u0430\u0442\u0430\u043b\u043e\u0433.
\n4. \u0423\u043b\u044c\u0440\u0438\u043a\u0430 \u0425\u0430\u0440\u043c\u0435\u043d\u0431\u0435\u0440\u0433, \u0411\u0440\u0438\u0442\u0442\u0430 \u0412\u0430\u0440\u0435\u043d, \u041a\u0430\u0440\u043b-\u041b\u044e\u0434\u0432\u0438\u0433 \u0412\u0438\u0445\u0435\u043b\u044c. \u041e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u0435 \u043c\u0430\u0440\u043a\u0435\u0440\u044b \u0423\u0433\u043b\u0435\u0432\u043e\u0434\u043d\u044b\u0435 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u044b CA 19-9 \u0438 CA 50 \u0438 Carcinoebryonic Antigen \u043f\u0440\u0438 \u0440\u0430\u043a\u0435 \u043f\u043e\u0434\u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b \u0438 \u0434\u043e\u0431\u0440\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445 \u043f\u0430\u043d\u043a\u0440\u0435\u0430\u0442\u043e\u0431\u0438\u043b\u0438\u0430\u0440\u043d\u043e\u0433\u043e \u0442\u0440\u0430\u043a\u0442\u0430. In Cancer Research 48\/1988 1985-1988.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[923],"product_tag":[],"class_list":{"0":"post-10114","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-tumorali","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10114","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10114"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10114"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10114"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10114"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}