{"id":10113,"date":"2020-04-23T04:56:56","date_gmt":"2020-04-23T01:56:56","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/igf-binding-protein-3\/"},"modified":"2025-02-07T09:19:34","modified_gmt":"2025-02-07T07:19:34","slug":"igf-binding-protein-3","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/igf-binding-protein-3\/","title":{"rendered":"IGF-\u0441\u0432\u044f\u0437\u044b\u0432\u0430\u044e\u0449\u0438\u0439 \u0431\u0435\u043b\u043e\u043a 3"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/span><\/p>\n

IGF-\u0441\u0432\u044f\u0437\u044b\u0432\u0430\u044e\u0449\u0438\u0439 \u0431\u0435\u043b\u043e\u043a 3<\/strong> (IGFBP-3) este un peptid alc\u0103tuit din 264 aminoacizi, cu mas\u0103 molecular\u0103 de 29kDa, produs la nivelul ficatului, ce are rol \u00een transportul \u015fi controlul biodisponibilit\u0103\u0163ii IGF (\u00een special IGF-1, care este mediatorul major al efectelor anabolice \u015fi de promovare a cre\u015fterii ale hormonului de cre\u015ftere-GH). Aproximativ 95% din IGF-1 \u015fi IGF-2 sunt legate de IGFBP-3, ceea ce face din aceast\u0103 protein\u0103 principalul transportator al IGF \u00een plasm\u0103. Una din func\u0163iile principale al proteinei de legare este de a m\u0103ri timpul de \u00eenjum\u0103t\u0103\u0163ire al IGF de la 8 minute la mai multe ore. In acest fel, IGFBP-3 ac\u0163ioneaz\u0103 ca un stabilizator, oferind un nivel constant de IGF. Concentra\u0163ia seric\u0103 a IGFBP-3 este constant\u0103 peste 24 de ore, fiind totodat\u0103 dependent\u0103 de hormonul de cre\u015ftere (GH), ceea ce face detectarea IGFBP-3 foarte util\u0103 \u00een evaluarea secre\u0163iei de GH. Spre deosebire de secre\u0163ia GH, care este pulsatil\u0103 cu varia\u0163ii semnificative diurne, nivelele IGFBP-3 \u015fi IGF-1 prezint\u0103 doar fluctua\u0163ii minore.<\/span><\/p>\n

Nivele serice sc\u0103zute de IGFBP-3 \u015fi IGF-1 sunt observate \u00een deficitul sau rezisten\u0163a la hormonul de cre\u015ftere. In cazul \u00een care sunt dob\u00e2ndite \u00een copil\u0103rie, aceste modific\u0103ri determin\u0103 deficit statural. Lipsa GH \u00een copil\u0103rie poate fi o anomalie izolat\u0103 sau poate fi asociat\u0103 cu modific\u0103ri ale altor hormoni hipofizari. Deficien\u0163ele hormonale multiple pot fi determinate de prezen\u0163a unor tumori hipofizare sau hipotalamice sau pot ap\u0103rea ca rezultat al radioterapiei sau chimioterapiei intratecale efectuate pentru diverse afec\u0163iuni maligne.<\/span><\/p>\n

In copil\u0103rie cele mai multe cazuri de rezisten\u0163\u0103 la GH sunt u\u015foare sau moderate; cauzele variaz\u0103 de la alimenta\u0163ie deficitar\u0103 p\u00e2n\u0103 la\u00a0boli sistemice severe, cum ar fi insuficien\u0163a renal\u0103 cronic\u0103. Aceste persoane pot avea nivele de IGF-1 \u015fi IGFBP-3 \u00een intervalul de referin\u0163\u0103. Formele severe de rezisten\u0163\u0103 sunt rare \u015fi, de obicei, sunt cauza unor defecte de receptor. At\u00e2t deficitul de GH c\u00e2t \u015fi formele u\u015foare-medii de rezisten\u0163\u0103 la GH pot fi tratate cu preparate injectabile de GH uman recombinat (rhGH). Scopul terapiei de substitu\u0163ie cu GH atat la copii, c\u00e2t \u015fi la adul\u0163i este de a ob\u0163ine valori serice ale IGF-1 \u015fi IGFBP-3 \u00een intervalul de referin\u0163\u0103, \u00een mod ideal, \u00een treimea de mijloc. Nivele mai mari sunt rareori asociate cu avantaje terapeutice suplimentare \u015fi \u00a0pot conduce la reac\u0163ii adverse pe termen lung.<\/span><\/p>\n

Prevalen\u0163a \u015fi cauzele rezisten\u0163ei GH la adul\u0163i nu sunt suficient cunoscute, \u00een schimb deficitul de GH apare cel mai\u00a0 frecvent la pacien\u0163ii cu tumori hipofizare. Deficitul de GH la adult este asociat cu sc\u0103derea masei musculare \u015fi cre\u015fterea morbidit\u0103\u0163ii \u015fi mortalit\u0103\u0163ii cardiovasculare, iar tratamentul de substitu\u0163ie r\u0103m\u00e2ne o problem\u0103 controversat\u0103.<\/span><\/p>\n

Concentra\u0163ii serice crescute de IGFBP-3 \u015fi IGF-1 indic\u0103 fie o supraproduc\u0163ie de GH, fie o terapie excesiv\u0103 cu rhGH. Excesul endogen de GH este cauzat, \u00een principal, de adenoamele hipofizare secretante de GH \u015fi determin\u0103 gigantism, dac\u0103 este dob\u00e2ndit \u00eenainte de \u00eenchiderea cartilajelor de cre\u015ftere \u015fi acromegalie ulterior. Ambele afec\u0163iuni sunt asociate cu organomegalie generalizat\u0103, hipertensiune arterial\u0103, diabet zaharat, cardiomiopatie, osteoartrit\u0103, neuropatii de compresie, cre\u015fterea u\u015foar\u0103 a riscului de cancer \u015fi reducerea longevit\u0103\u0163ii.<\/span><\/p>\n

Avantajul determin\u0103rii IGFBP-3 fa\u0163\u0103 de IGF-1 este faptul c\u0103 prezint\u0103 nivele ridicate la copiii mici, fiind folosit pentru a diagnostica copiii cu statur\u0103 mic\u0103 \u015fi concentra\u0163ii normale ale hormonului de cre\u015ftere. IGFBP-3 este un parametru fiabil pentru monitorizarea eficacit\u0103\u0163ii tratamentului, fiind un test important al\u0103turi de m\u0103surarea de IGF-12;3;4<\/sup>.<\/span><\/p>\n

Recomand\u0103ri pentru determinarea IGFBP-3:<\/em><\/strong><\/span><\/p>\n

\u2013 diagnosticul tulbur\u0103rilor de cre\u015ftere;<\/span><\/div>\n
\u2013 diagnosticul deficitului de GH la adult;<\/span><\/div>\n
\u2013 monitorizarea tratamentului cu GH uman recombinat (rhGH);<\/span><\/div>\n
\u2013 diagnosticarea \u015fi monitorizarea acromegaliei \u015fi gigantismului (\u00eempreun\u0103 cu IGF-1 \u015fi GH)4<\/sup>.<\/span><\/div>\n

Preg\u0103tire pacient <\/em><\/strong>- <\/em>\u00e0 jeun (pe nem\u00e2ncate)1<\/sup>.<\/span><\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c1<\/sup>.<\/span><\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator1<\/sup>.<\/span><\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>- <\/em>se separ\u0103 serul prin centrifugare; se lucreaz\u0103 serul imediat; dac\u0103 acest lucru nu este posibil, serul se congeleaz\u01031<\/sup>.<\/span><\/p>\n

Volum prob\u0103 <\/em><\/strong>\u2013 1mL ser1<\/sup>.<\/span><\/p>\n

Cauze de respingere<\/em><\/strong> a probei<\/em><\/strong> \u2013 specimen intens hemolizat1<\/sup>.<\/span><\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>\u2013 1 lun\u0103<\/em> la -20\u00b0C; nu decongela\u0163i\/recongela\u0163i1<\/sup>.<\/span><\/p>\n

Metoda <\/em><\/strong>- imunochimica cu detec\u0163iei prin chemiluminiscen\u0163\u0103 (CLIA)1<\/sup><\/span>.<\/span><\/p>\n

Valori de referin\u0163\u0103 <\/em><\/strong>- <\/em>sunt dependente de sex \u015fi v\u00e2rst\u01031<\/sup>:<\/span><\/p>\n

Valori de referin\u0163\u0103 <\/i><\/b>- <\/i>sunt dependente de v\u00e2rst\u01031<\/sup>:<\/span>\u00a0<\/span><\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Varsta<\/b><\/td>\nValori<\/b><\/td>\n<\/tr>\n
1-7 zile<\/td>\n<0.7<\/td>\n<\/tr>\n
8-15 zile<\/td>\n0.5 \u2013 1.4<\/td>\n<\/tr>\n
16 zile \u2013 12 luni<\/td>\n0.7 \u2013 3.6<\/td>\n<\/tr>\n
1 \u2013 2 ani<\/td>\n0.8 \u2013 3.9<\/td>\n<\/tr>\n
2 \u2013 3 ani<\/td>\n0.9 \u2013 4.3<\/td>\n<\/tr>\n
3 \u2013 4 ani<\/td>\n1.0 \u2013 4.7<\/td>\n<\/tr>\n
4 \u2013 5 ani<\/td>\n1.1 \u2013 5.2<\/td>\n<\/tr>\n
5 \u2013 6 ani<\/td>\n1.3 \u2013 5.6<\/td>\n<\/tr>\n
6 \u2013 7 ani<\/td>\n1.4 \u2013 6.1<\/td>\n<\/tr>\n
7 \u2013 8 ani<\/td>\n1.6 \u2013 6.5<\/td>\n<\/tr>\n
8 \u2013 9 ani<\/td>\n1.8 \u2013 7.1<\/td>\n<\/tr>\n
9 \u2013 10 ani<\/td>\n2.1 \u2013 7.7<\/td>\n<\/tr>\n
10 \u2013 11 ani<\/td>\n2.4 \u2013 8.4<\/td>\n<\/tr>\n
11 \u2013 12 ani<\/td>\n2.7 \u2013 8.9<\/td>\n<\/tr>\n
12 \u2013 13 ani<\/td>\n3.1 \u2013 9.5<\/td>\n<\/tr>\n
13 \u2013 14 ani<\/td>\n3.3 \u2013 10<\/td>\n<\/tr>\n
14 \u2013 15 ani<\/td>\n3.5 \u2013 10<\/td>\n<\/tr>\n
15- 16 ani<\/td>\n3.4 \u2013 9.5<\/td>\n<\/tr>\n
16 \u2013 17 ani<\/td>\n3.2 \u2013 8.7<\/td>\n<\/tr>\n
17 \u2013 18 ani<\/td>\n3.1 \u2013 7.9<\/td>\n<\/tr>\n
18 \u2013 19 ani<\/td>\n2.9 \u2013 7.3<\/td>\n<\/tr>\n
19 \u2013 20 ani<\/td>\n2.9 \u2013 7.2<\/td>\n<\/tr>\n
20 \u2013 25 ani<\/td>\n3.4 \u2013 7.8<\/td>\n<\/tr>\n
25 \u2013 30 ani<\/td>\n3.5 \u2013 7.6<\/td>\n<\/tr>\n
30 \u2013 35 ani<\/td>\n3.5 \u2013 7.0<\/td>\n<\/tr>\n
35 \u2013 40 ani<\/td>\n3.4 \u2013 6.7<\/td>\n<\/tr>\n
40 \u2013 45 ani<\/td>\n3.3 \u2013 6.6<\/td>\n<\/tr>\n
45 \u2013 50 ani<\/td>\n3.3 \u2013 6.7<\/td>\n<\/tr>\n
50 \u2013 55 ani<\/td>\n3.4 \u2013 6.8<\/td>\n<\/tr>\n
55 \u2013 60 ani<\/td>\n3.4 \u2013 6.9<\/td>\n<\/tr>\n
60 \u2013 65 ani<\/td>\n3.2 \u2013 6.6<\/td>\n<\/tr>\n
65 \u2013 70 ani <\/span><\/td>\n3.0 \u2013 6.2<\/span><\/td>\n<\/tr>\n
70 \u2013 75 ani <\/span><\/td>\n2.8 \u2013 5.7<\/span><\/td>\n<\/tr>\n
75 \u2013 80 ani<\/span><\/td>\n2.5 \u2013 5.1<\/span><\/td>\n<\/tr>\n
80 \u2013 85 ani <\/span><\/td>\n2.2 \u2013 4.5<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Interpretarea rezultatelor<\/em><\/strong><\/span><\/p>\n

\u25cf Valorile serice ale IGFBP-3 pot fi influen\u0163ate de mai mul\u0163i factori: v\u00e2rst\u0103, dezvoltare sexual\u0103, nutri\u0163ie, func\u0163ia hepatic\u0103 \u015fi renal\u0103. IGFBP-3 cre\u015fte \u00een timpul copil\u0103riei precoce \u015fi pubert\u0103\u0163ii \u015fi apoi scade u\u015for la adult.<\/span><\/p>\n

\u25cf Concentra\u0163ia de IGFBP-3 scade \u00een perioadele de post \u015fi \u00een malnutri\u0163ia cronic\u0103. Nivelele serice ale IGFBP-3 sunt sc\u0103zute \u00een insuficien\u0163a hepatic\u0103 \u015fi diabetul zaharat, dar sunt crescute \u00een insuficien\u0163a renal\u0103 cronic\u0103.<\/span><\/p>\n

\u25cf In deficitul sau rezisten\u0163a sever\u0103 la GH, nivelul seric al IGF-1 \u015fi IGFBP-3 este sc\u0103zut \u00een raport cu intervalul de referin\u0163\u0103 corespunz\u0103tor limitei de v\u00e2rst\u0103.<\/span><\/p>\n

\u25cf Pacien\u0163ii cu deficit incomplet sau rezisten\u0163\u0103 u\u015foar\u0103 p\u00e2n\u0103 la moderat\u0103 pot avea valori plasmatice \u00een intervalul de referin\u0163\u0103.<\/span><\/p>\n

\u25cf Inregistrarea unor valori crescute de IGF-1 \u015fi IGFBP-3 sus\u0163ine diagnosticul de acromegalie sau gigantism la persoanele cu semne \u015fi simptome sugestive4<\/sup>.<\/span><\/p>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/span><\/p>\n

Valori discordante ale IGFBP-3 \u015fi IGF-1 pot ap\u0103rea, uneori, din cauza afec\u0163iunilor hepatice sau renale, dar acest lucru este mai pu\u0163in frecvent.<\/span><\/div>\n
Anticorpii heterofili prezen\u0163i \u00een serul pacien\u0163ilor pot interac\u0163iona cu imunoglobulinele incluse\u00a0\u00een componentele din kit \u015fi d\u0103 rezultate neconcludente4<\/sup>.<\/span><\/div>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate. 2010. Ref Type: Catalog.<\/span><\/div>\n
2. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Insulin-Like Growth Factor Binding Protein 3. www.labcorp.com 2010. Ref Type: Internet Communication.<\/span><\/div>\n
3. Lothar Thomas. Growth disorders. In Clinical Laboratory Diagnostics-Use and Assessment of Clinical Laboratory Results. TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany, 1 Ed., 1998, 1074-1077.<\/span><\/div>\n
4. Mayo Clinic\/Mayo Medical Laboratories. Test Catalog. Insulin-Like Growth Factor Binding Protein 3 (IGFBP-3), www.mayomedicallaboratories.com. Serum. Ref Type: Internet Communication.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

IGFBP-3 \u2014 \u044d\u0442\u043e \u043e\u0441\u043d\u043e\u0432\u043d\u043e\u0439 \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u044e\u0449\u0438\u0439 \u0431\u0435\u043b\u043e\u043a \u0434\u043b\u044f IGF-I \u0438 -II (\u0438\u043d\u0441\u0443\u043b\u0438\u043d\u043e\u043f\u043e\u0434\u043e\u0431\u043d\u043e\u0433\u043e \u0444\u0430\u043a\u0442\u043e\u0440\u0430 \u0440\u043e\u0441\u0442\u0430 1 \u0438 2) \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430, \u0443\u0447\u0430\u0441\u0442\u0432\u0443\u044e\u0449\u0438\u0439 \u0432 \u0440\u0435\u0433\u0443\u043b\u044f\u0446\u0438\u0438 \u0440\u043e\u0441\u0442\u0430 \u043a\u043b\u0435\u0442\u043e\u043a. \u0411\u043e\u043b\u0435\u0435 95% \u0438\u043c\u0435\u044e\u0449\u0435\u0433\u043e\u0441\u044f \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438 IGF-1 \u0441\u0432\u044f\u0437\u0430\u043d\u043e \u0441 \u0431\u0435\u043b\u043a\u0430\u043c\u0438-\u043d\u043e\u0441\u0438\u0442\u0435\u043b\u044f\u043c\u0438, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u043f\u043e\u0434\u0440\u0430\u0437\u0434\u0435\u043b\u044f\u044e\u0442\u0441\u044f \u043d\u0430 6 \u043a\u043b\u0430\u0441\u0441\u043e\u0432. \u041d\u0430\u0438\u0431\u043e\u043b\u0435\u0435 \u0432\u0430\u0436\u043d\u044b\u0439 \u0438\u0437 \u043d\u0438\u0445 \u2014 \u0431\u0435\u043b\u043e\u043a-\u043d\u043e\u0441\u0438\u0442\u0435\u043b\u044c IGFBP-3. \u0412 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043c\u043e\u043b\u044f\u0440\u043d\u0430\u044f \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u044f IGFBP-3 \u043f\u0440\u043e\u043f\u043e\u0440\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u0430 \u043c\u043e\u043b\u044f\u0440\u043d\u043e\u0439 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 \u043e\u0431\u0449\u0435\u0433\u043e \u0418\u0424\u0420 (I \u0438 II). \u041f\u043e\u043a\u0430\u0437\u0430\u043d\u043e, \u0447\u0442\u043e \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u043e\u0431\u0449\u0435\u0433\u043e \u0418\u0424\u0420 \u0441\u0438\u043b\u044c\u043d\u0435\u0435 \u0437\u0430\u0432\u0438\u0441\u0438\u0442 \u043e\u0442 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 \u0433\u043e\u0440\u043c\u043e\u043d\u0430 \u0440\u043e\u0441\u0442\u0430 (\u0413\u0420), \u0447\u0435\u043c \u0443\u0440\u043e\u0432\u043d\u0438 \u0418\u0424\u0420-I \u0438 -II \u043f\u043e \u043e\u0442\u0434\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u0438. \u041e\u0441\u043d\u043e\u0432\u043d\u043e\u0439 \u0433\u043e\u0440\u043c\u043e\u043d, \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0443\u044e\u0449\u0438\u0439 \u0441\u0438\u043d\u0442\u0435\u0437 IGFBP-3 \u2014 \u044d\u0442\u043e \u0433\u043e\u0440\u043c\u043e\u043d \u0440\u043e\u0441\u0442\u0430 (GH). \u0412 \u043e\u0442\u043b\u0438\u0447\u0438\u0435 \u043e\u0442 \u0433\u043e\u0440\u043c\u043e\u043d\u0430 \u0440\u043e\u0441\u0442\u0430, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u0432\u044b\u0441\u0432\u043e\u0431\u043e\u0436\u0434\u0430\u0435\u0442\u0441\u044f \u044d\u043f\u0438\u0437\u043e\u0434\u0438\u0447\u0435\u0441\u043a\u0438 \u0438 \u0447\u044c\u0435 \u0441\u043e\u0434\u0435\u0440\u0436\u0430\u043d\u0438\u0435 \u0432 \u043a\u0440\u043e\u0432\u0438 \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u043a\u043e\u043b\u0435\u0431\u043b\u0435\u0442\u0441\u044f \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 \u0441\u0443\u0442\u043e\u043a, \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u043e IGFBP-3 (\u0442\u0430\u043a\u0436\u0435 IGF-1) \u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e \u0438 \u0434\u043b\u044f \u0435\u0433\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044f \u043d\u0435 \u043d\u0430\u0434\u043e \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u044c \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u043d\u0430 \u0444\u043e\u043d\u0435 \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043f\u0440\u043e\u0431.<\/p>\n

IGFBP-3, \u0432 \u0442\u043e\u043c \u0447\u0438\u0441\u043b\u0435, \u0432 \u043c\u0435\u043d\u044c\u0448\u0435\u0439 \u0441\u0442\u0435\u043f\u0435\u043d\u0438 \u0437\u0430\u0432\u0438\u0441\u0438\u0442 \u043e\u0442 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430 \u043f\u043e \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u044e \u0441 \u0418\u0424\u0420-I. \u041f\u0440\u0438 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043a\u0435 \u0433\u043e\u0440\u043c\u043e\u043d\u0430 \u0440\u043e\u0441\u0442\u0430 \u0443\u0440\u043e\u0432\u0435\u043d\u044c IGFBP-3 \u043d\u0438\u0437\u043a\u0438\u0439. \u041f\u0440\u0438 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043a\u0435 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u043e\u0432 \u0434\u043b\u044f \u0433\u043e\u0440\u043c\u043e\u043d\u0430 \u0440\u043e\u0441\u0442\u0430 (GH) \u2014 \u043f\u0440\u0438 \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0435 \u041b\u0430\u0440\u043e\u043d\u0430, \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043f\u0435\u0447\u0435\u043d\u0438, \u0432 \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0438 \u0430\u043d\u0442\u0438-GH \u0430\u043d\u0442\u0438\u0442\u0435\u043b, \u043f\u0440\u0438 \u0433\u043e\u043b\u043e\u0434\u0430\u043d\u0438\u0438 \u0443\u0440\u043e\u0432\u0435\u043d\u044c IGFBP-3 \u0442\u0430\u043a\u0436\u0435 \u043f\u043e\u043d\u0438\u0436\u0430\u0435\u0442\u0441\u044f, \u0434\u0430\u0436\u0435 \u0432 \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0438 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u043e\u0439 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 \u0433\u043e\u0440\u043c\u043e\u043d\u0430 \u0440\u043e\u0441\u0442\u0430. \u041e\u0446\u0435\u043d\u043a\u0430 \u0443\u0440\u043e\u0432\u043d\u044f IGFBP-3 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0432\u0430\u0436\u043d\u044b\u043c \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0442\u0435\u0441\u0442\u043e\u043c \u043f\u0440\u0438 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438 GH-\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u044b\u0445 \u0431\u043e\u043b\u0435\u0437\u043d\u0435\u0439.<\/p>\n

\u0421\u043e\u0434\u0435\u0440\u0436\u0430\u043d\u0438\u0435 IGFBP-3 \u0443\u0432\u0435\u043b\u0438\u0447\u0435\u043d\u043e \u0443 \u0434\u0435\u0442\u0435\u0439 \u0438 \u0443 \u043f\u043e\u0434\u0440\u043e\u0441\u0442\u043a\u043e\u0432 \u043f\u0443\u0431\u0435\u0440\u0442\u0430\u0442\u043d\u043e\u0433\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430 (\u043d\u0430\u0438\u0431\u043e\u043b\u044c\u0448\u0435\u0435 \u0441\u043e\u0434\u0435\u0440\u0436\u0430\u043d\u0438\u0435 \u2014 \u0443 14-16-\u043b\u0435\u0442\u043d\u0438\u0445), \u043f\u043e \u0434\u043e\u0441\u0442\u0438\u0436\u0435\u043d\u0438\u0438 \u0441\u043e\u0432\u0435\u0440\u0448\u0435\u043d\u043d\u043e\u043b\u0435\u0442\u0438\u044f \u043f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c \u043d\u0430\u0447\u0438\u043d\u0430\u0435\u0442 \u043f\u043e\u043d\u0435\u043c\u043d\u043e\u0433\u0443 \u0441\u043d\u0438\u0436\u0430\u0442\u044c\u0441\u044f. \u041a\u0440\u043e\u043c\u0435 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430, \u0432\u043b\u0438\u044f\u044e\u0442 \u0442\u0430\u043a\u0436\u0435 \u043d\u0430 \u0435\u0433\u043e \u0441\u043e\u0434\u0435\u0440\u0436\u0430\u043d\u0438\u0435 \u043f\u043e\u043b\u043e\u0432\u043e\u0435 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435, \u043f\u0438\u0442\u0430\u043d\u0438\u0435, \u0444\u0443\u043d\u043a\u0446\u0438\u044f \u043f\u0435\u0447\u0435\u043d\u0438 \u0438 \u043f\u043e\u0447\u0435\u043a.<\/p>\n

\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f \u043a \u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044e:<\/p>\n

    \n
  • \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0439 \u0440\u043e\u0441\u0442\u0430 \u0443 \u0434\u0435\u0442\u0435\u0439;<\/li>\n
  • \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u044b \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043a\u0430 \u0433\u043e\u0440\u043c\u043e\u043d\u0430 \u0440\u043e\u0441\u0442\u0430 \u0443 \u0432\u0437\u0440\u043e\u0441\u043b\u044b\u0445;<\/li>\n
  • \u043f\u043e\u0434\u043e\u0437\u0440\u0435\u043d\u0438\u0435 \u043d\u0430 \u0433\u0438\u043f\u043e\u0444\u0443\u043d\u043a\u0446\u0438\u044e \u0433\u0438\u043f\u043e\u0444\u0438\u0437\u0430;<\/li>\n
  • \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u044c \u0437\u0430 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c\u044e \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0433\u043e\u0440\u043c\u043e\u043d\u043e\u043c \u0440\u043e\u0441\u0442\u0430;<\/li>\n
  • \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u044b \u0433\u0438\u0433\u0430\u043d\u0442\u0438\u0437\u043c\u0430 \u0443 \u0434\u0435\u0442\u0435\u0439 \u043b\u0438\u0431\u043e \u0430\u043a\u0440\u043e\u043c\u0435\u0433\u0430\u043b\u0438\u0438 \u0443 \u0432\u0437\u0440\u043e\u0441\u043b\u044b\u0445 (\u0432\u043c\u0435\u0441\u0442\u0435 \u0441 \u0442\u0435\u0441\u0442\u043e\u043c \u043d\u0430 \u043f\u043e\u0434\u0430\u0432\u043b\u0435\u043d\u0438\u0435 \u0433\u043e\u0440\u043c\u043e\u043d\u0430 \u0440\u043e\u0441\u0442\u0430);<\/li>\n
  • \u043f\u043e\u0441\u043b\u0435 \u043e\u043f\u0435\u0440\u0430\u0446\u0438\u0438 \u043f\u043e \u0443\u0434\u0430\u043b\u0435\u043d\u0438\u044e \u043e\u043f\u0443\u0445\u043e\u043b\u0438, \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u044f\u0449\u0435\u0439 \u0433\u043e\u0440\u043c\u043e\u043d \u0440\u043e\u0441\u0442\u0430 (\u0434\u043b\u044f \u043f\u043e\u0434\u0442\u0432\u0435\u0440\u0436\u0434\u0435\u043d\u0438\u044f \u043f\u043e\u043b\u043d\u043e\u0433\u043e \u0443\u0434\u0430\u043b\u0435\u043d\u0438\u044f);<\/li>\n
  • \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0439 \u0438\u043b\u0438 \u0440\u0430\u0434\u0438\u0430\u0446\u0438\u043e\u043d\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u043f\u043e\u0441\u043b\u0435 \u043e\u043f\u0435\u0440\u0430\u0442\u0438\u0432\u043d\u043e\u0433\u043e \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u043e\u043f\u0443\u0445\u043e\u043b\u0438;<\/li>\n
  • \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 \u043d\u0435\u0441\u043a\u043e\u043b\u044c\u043a\u0438\u0445 \u043b\u0435\u0442 \u043f\u043e\u0441\u043b\u0435 \u043e\u043f\u0435\u0440\u0430\u0446\u0438\u0438 \u043f\u043e \u0443\u0434\u0430\u043b\u0435\u043d\u0438\u044e \u043e\u043f\u0443\u0445\u043e\u043b\u0438, \u0434\u043b\u044f \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u044f \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0441\u0442\u0432\u0430 \u0433\u043e\u0440\u043c\u043e\u043d\u0430 \u0440\u043e\u0441\u0442\u0430 \u0438 \u0441\u0432\u043e\u0435\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0433\u043e \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0433\u043e \u0440\u0435\u0446\u0438\u0434\u0438\u0432\u0430.<\/li>\n<\/ul>\n

    \u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b \u0434\u043b\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f: \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0430 \u0432\u0435\u043d\u043e\u0437\u043d\u043e\u0439 \u043a\u0440\u043e\u0432\u0438.<\/p>\n

    \u041f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0430 \u043a \u0430\u043d\u0430\u043b\u0438\u0437\u0443 IGF<\/p>\n

    \u0412\u0430\u0436\u043d\u044b\u043c \u0443\u0441\u043b\u043e\u0432\u0438\u0435\u043c \u043e\u0431\u0435\u0441\u043f\u0435\u0447\u0435\u043d\u0438\u044f \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0430 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u043e\u0433\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u043a\u0440\u043e\u0432\u0438 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0432\u0437\u044f\u0442\u0438\u0435 \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430 \u043d\u0430\u0442\u043e\u0449\u0430\u043a, \u0432 \u0443\u0442\u0440\u0435\u043d\u043d\u0435\u0435 \u0432\u0440\u0435\u043c\u044f (\u0434\u043e 12:00);
    \n\u0417\u0430 12 \u0447\u0430\u0441\u043e\u0432 \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u0441\u043b\u0435\u0434\u0443\u0435\u0442 \u0438\u0441\u043a\u043b\u044e\u0447\u0438\u0442\u044c \u043f\u0440\u0438\u0435\u043c \u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044f, \u043a\u0443\u0440\u0435\u043d\u0438\u0435, \u043f\u0440\u0438\u0435\u043c \u043f\u0438\u0449\u0438, \u043e\u0433\u0440\u0430\u043d\u0438\u0447\u0438\u0442\u044c \u0444\u0438\u0437\u0438\u0447\u0435\u0441\u043a\u0443\u044e \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c;
    \n\u0423\u0442\u0440\u043e\u043c \u0432 \u0434\u0435\u043d\u044c \u0432\u0437\u044f\u0442\u0438\u044f \u043a\u0440\u043e\u0432\u0438 \u043d\u0430 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u043c\u043e\u0436\u043d\u043e \u0432\u044b\u043f\u0438\u0442\u044c \u0432\u043e\u0434\u0443;
    \n\u0418\u0441\u043a\u043b\u044e\u0447\u0438\u0442\u044c \u043f\u0440\u0438\u0435\u043c \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432; \u0435\u0441\u043b\u0438 \u043e\u0442\u043c\u0435\u043d\u0438\u0442\u044c \u043f\u0440\u0438\u0435\u043c \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432 \u043d\u0435\u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e, \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e \u043f\u0440\u043e\u0438\u043d\u0444\u043e\u0440\u043c\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u043e\u0431 \u044d\u0442\u043e\u043c \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u0438\u044e;
    \n\u0412\u0437\u044f\u0442\u0438\u0435 \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430 \u0436\u0435\u043b\u0430\u0442\u0435\u043b\u044c\u043d\u043e \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u044c \u0434\u043e \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u0438\u044f \u043b\u044e\u0431\u044b\u0445 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0445 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043c\u0430\u043d\u0438\u043f\u0443\u043b\u044f\u0446\u0438\u0439.<\/p>\n

    \u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/p>\n

    \u0420\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u044b\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439 \u043d\u0435 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u044b\u043c \u043e\u0441\u043d\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u0434\u043b\u044f \u043f\u043e\u0441\u0442\u0430\u043d\u043e\u0432\u043a\u0438 \u0434\u0438\u0430\u0433\u043d\u043e\u0437\u0430. \u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432 \u0438 \u043f\u043e\u0441\u0442\u0430\u043d\u043e\u0432\u043a\u0430 \u0434\u0438\u0430\u0433\u043d\u043e\u0437\u0430 \u043e\u0441\u0443\u0449\u0435\u0441\u0442\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0442\u043e\u043b\u044c\u043a\u043e \u043b\u0435\u0447\u0430\u0449\u0438\u043c \u0432\u0440\u0430\u0447\u043e\u043c.<\/p>\n

    \u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435 \u0443\u0440\u043e\u0432\u043d\u044f<\/p>\n

      \n
    • \u0430\u043a\u0440\u043e\u043c\u0435\u0433\u0430\u043b\u0438\u044f, \u0433\u0438\u0433\u0430\u043d\u0442\u0438\u0437\u043c;<\/li>\n
    • \u0425\u041f\u041d;<\/li>\n
    • \u043e\u043f\u0443\u0445\u043e\u043b\u044c \u0433\u0438\u043f\u043e\u0444\u0438\u0437\u0430;<\/li>\n
    • \u0440\u0435\u0446\u0438\u0434\u0438\u0432 \u043e\u043f\u0443\u0445\u043e\u043b\u0438 \u0433\u0438\u043f\u043e\u0444\u0438\u0437\u0430 \u043f\u043e\u0441\u043b\u0435 \u043e\u043f\u0435\u0440\u0430\u0442\u0438\u0432\u043d\u043e\u0433\u043e \u043b\u0435\u0447\u0435\u043d\u0438\u044f;<\/li>\n
    • \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u044c;<\/li>\n
    • \u043f\u0435\u0440\u0438\u043e\u0434 \u043f\u043e\u043b\u043e\u0432\u043e\u0433\u043e \u0441\u043e\u0437\u0440\u0435\u0432\u0430\u043d\u0438\u044f.<\/li>\n<\/ul>\n

      \u041f\u043e\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u0443\u0440\u043e\u0432\u043d\u044f<\/p>\n

        \n
      • \u0434\u0435\u0444\u0438\u0446\u0438\u0442 \u0433\u043e\u0440\u043c\u043e\u043d\u0430 \u0440\u043e\u0441\u0442\u0430;<\/li>\n
      • \u043a\u0430\u0440\u043b\u0438\u043a\u043e\u0432\u043e\u0441\u0442\u044c \u041b\u0430\u0440\u043e\u043d\u0430;<\/li>\n
      • \u043d\u0435\u0434\u043e\u0435\u0434\u0430\u043d\u0438\u0435 \u0438 \u0434\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0439 \u043f\u043e\u0441\u0442;<\/li>\n
      • \u043f\u0435\u0447\u0435\u043d\u043e\u0447\u043d\u0430\u044f \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u044c;<\/li>\n
      • \u0441\u0430\u0445\u0430\u0440\u043d\u044b\u0439 \u0434\u0438\u0430\u0431\u0435\u0442;<\/li>\n
      • \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u043f\u043e\u0447\u0435\u043a;<\/li>\n
      • \u0430\u043d\u043e\u0440\u0435\u043a\u0441\u0438\u044f .<\/li>\n<\/ul>\n

        \u0424\u0430\u043a\u0442\u043e\u0440\u044b, \u0432\u043b\u0438\u044f\u044e\u0449\u0438\u0435 \u043d\u0430 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442<\/p>\n

        \u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435: \u0430\u043c\u0444\u0435\u0442\u0430\u043c\u0438\u043d\u044b, \u0430\u0440\u0433\u0438\u043d\u0438\u043d, \u0434\u043e\u043f\u0430\u043c\u0438\u043d, \u044d\u0441\u0442\u0440\u043e\u0433\u0435\u043d\u044b, \u0433\u043b\u044e\u043a\u0430\u0433\u043e\u043d, \u0433\u0438\u0441\u0442\u0430\u043c\u0438\u043d, \u0438\u043d\u0441\u0443\u043b\u0438\u043d, \u043b\u0435\u0432\u043e\u0434\u043e\u043f\u0430, \u043c\u0435\u0442\u0438\u043b\u0434\u043e\u043f\u0430 \u0438 \u043d\u0438\u043a\u043e\u0442\u0438\u043d\u043e\u0432\u0430\u044f \u043a\u0438\u0441\u043b\u043e\u0442\u0430.<\/p>\n

        \u041f\u043e\u043d\u0438\u0436\u0435\u043d\u0438\u0435: \u043a\u043e\u0440\u0442\u0438\u043a\u043e\u0438\u0434\u044b \u0438 \u0444\u0435\u043d\u043e\u0442\u0438\u0430\u0437\u0438\u043d\u044b, \u0432\u044b\u0441\u043e\u043a\u0438\u0435 \u0434\u043e\u0437\u044b \u044d\u0441\u0442\u0440\u043e\u0433\u0435\u043d\u043e\u0432.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[913,911],"product_tag":[],"class_list":{"0":"post-10113","1":"product","2":"type-product","3":"status-publish","5":"product_cat-hormoni-implicati-in-procesul-de-crestere","6":"product_cat-markeri-endocrini","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10113","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10113"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10113"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10113"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10113"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10113"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}