{"id":10107,"date":"2020-04-23T03:56:46","date_gmt":"2020-04-23T00:56:46","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/serotonina-urinara\/"},"modified":"2025-02-07T09:13:59","modified_gmt":"2025-02-07T07:13:59","slug":"serotonina-urinara","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/serotonina-urinara\/","title":{"rendered":"\u0421\u0435\u0440\u043e\u0442\u043e\u043d\u0438\u043d \u0432 \u043c\u043e\u0447\u0435"},"content":{"rendered":"

Informa\u0163ii generale \u015fi recomand\u0103ri pentru determinarea serotoninei urinare<\/em><\/strong><\/span><\/p>\n

Serotonina (5-hidroxi-triptamina) este sintetizat\u0103 din aminoacidul esen\u0163ial triptofan via compusul intermediar 5-hidroxitriptofan (5-HTP). Produc\u0163ia are loc at\u00e2t \u00een sistemul nervos central unde serotonina ac\u0163ioneaz\u0103 ca neurotransmi\u0163\u0103tor c\u00e2t \u015fi \u00een celulele neuroectodermale, \u00een special celulele enterocromafine gastrointestinale.<\/span><\/p>\n

Serotonina eliberat\u0103 din celulele enterocromafine sub ac\u0163iunea unor stimuli varia\u0163i determin\u0103 cre\u015fterea fluxului sanguin gastrointestinal, motilitatea \u015fi secre\u0163ia de fluide. La primul pasaj hepatic, un procent variabil (30-80%) de serotonin\u0103 este metabolizat predominant \u00een acid 5-hidroxi-indolacetic (5-HIIA), care este excretat de rinichi. 90% din cantitatea r\u0103mas\u0103 este metabolizat\u0103 \u00een pl\u0103m\u00e2ni, de asemenea \u00een 5-HIIA. Restul de 10% este preluat \u015fi stocat de trombocite, de unde este eliberat \u00een cursul procesului de coagulare.<\/span><\/p>\n

Principalele afec\u0163iuni asociate cu cre\u015fteri semnificative de serotonin\u0103 sunt tumorile carcinoide, dezvoltate din celulele enterocromafine. Acestea sunt clasificate \u00een func\u0163ie de locul de origine a tumorii \u00een:<\/span><\/p>\n

\u2013 tumori derivate din partea cranial\u0103 a tubului digestiv primitiv: pancreatice, duodenale, gastrice, bron\u015fice;<\/span><\/div>\n
\u2013 tumori derivate din partea medial\u0103 a tubului digestiv primitiv: jejunale, ileale \u015fi la nivelul apendicelui;<\/span><\/div>\n
\u2013 tumori derivate din partea caudal\u0103 a tubului digestiv primitiv: \u00een colonul ascendent \u015fi rect;<\/span><\/div>\n
\u2013 tumori cu alte origini: timice, ovariene, renale, mamare.<\/span><\/div>\n

Enzima 5-HTP decarboxilaza care converte\u015fte 5-HTP \u00een serotonin\u0103 este prezent\u0103 \u00een tumorile carcinoide ale intestinului sub\u0163ire, dar este absent\u0103 sau se g\u0103se\u015fte \u00een cantit\u0103\u0163i reduse \u00een celelalte tipuri de tumori carcinoide.<\/span><\/p>\n

Serotonina urinar\u0103 este markerul care \u00eenregistreaz\u0103 cel mai pu\u0163in frecvent cre\u015fteri\u00a0\u00een toate tipurile de tumori carcinoide. Excep\u0163ie fac tumorile care secret\u0103 predominant 5-HTP \u015fi mai pu\u0163in serotonin\u0103 sau cromogranina A (\u00een special tumori localizate\u00a0\u00een partea cranial\u0103 a tubului digestiv primitiv). \u00cen aceste cazuri nivelurile de cromogranin\u0103 A, serotonin\u0103 seric\u0103 \u015fi 5-HIIA urinar nu sunt crescute, \u00eens\u0103 rinichiul poate converti 5-HTP\u00a0\u00een serotonin\u0103 determin\u00e2nd cre\u015fterea serotoninei urinare. Astfel, dozarea serotoninei urinare este important\u0103 at\u00e2t\u00a0\u00een diagnosticul c\u00e2t \u015fi\u00a0\u00een monitorizarea pacien\u0163ilor cu tumori carcinoide care secret\u0103\u00a0\u00een principal 5-HTP2<\/sup>.<\/span><\/p>\n

Preg\u0103tire pacient\u00ad <\/em><\/strong>-<\/em> se va evita consumul de banane, ananas, prune, kiwi, pepene galben, nuci, cacao, ro\u015fii, avocado, vinete, cu 72 ore \u00eenaintea recolt\u0103rii (deoarece aceste alimente con\u0163in serotonin\u0103 sau triptofan)2<\/sup>.<\/span><\/p>\n

Specimen recoltat\u00ad <\/em><\/strong>-<\/em> urina din 24 ore: la ora 7 diminea\u0163a pacientul urineaz\u0103 \u015fi nu re\u0163ine aceast\u0103 urin\u0103; apoi colecteaz\u0103 \u00eentr-un vas curat de 2-3 litri toate\u00a0emisiunile de urin\u0103 p\u00e2n\u0103 la ora 7 diminea\u0163a\u00a0\u00een ziua urm\u0103toare, inclusiv; omogenizeaz\u0103 (prin agitare) urina recoltat\u0103; m\u0103soar\u0103 \u00eentreaga cantitate; re\u0163ine aprox. 10 mL,\u00a0\u00een pahar de plastic de unic\u0103 folosin\u0163\u0103 pentru urin\u0103. Proba se \u0163ine la 2-8\u00baC\u00a0\u00een timpul colect\u0103rii \u015fi ulterior, p\u00e2n\u0103 se lucreaz\u0103 efectiv1<\/sup>.<\/span><\/p>\n

Recipient de recoltare <\/em><\/strong>\u2013 vas de 2-3 litri \u015fi pahar de plastic de unic\u0103 folosin\u0163\u0103 pentru urin\u0103, pe care se noteaz\u0103 cantitatea total\u0103 de urin\u0103 din 24 de ore1<\/sup>.<\/span><\/p>\n

Cantitate recoltat\u0103 <\/em><\/strong>\u2013 10 mL1<\/sup>.<\/span><\/p>\n

Cauze de respingere a probei <\/em><\/strong>\u2013 specimen care nu a fost p\u0103strat la 2-8\u00b0C1<\/sup>.<\/span><\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>\u2013 este de preferat s\u0103 se lucreze imediat; dac\u0103 acest lucru nu este posibil, proba se congeleaza la -20\u00b0C, dup\u0103 ce \u00een prealabil se adaug\u0103 acid clorhidric concentrat p\u00e2n\u0103 se ajunge la un pH <31<\/sup>.<\/span><\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>\u2013 10 zile la -20\u00b0C1<\/sup>.<\/span><\/p>\n

Metod\u0103 <\/em><\/strong>- cromatografie de lichide sub \u00eenalt\u0103 presiune (HPLC)<\/span>1<\/sup>.<\/span><\/p>\n

Valori de referin\u0163\u0103<\/em><\/strong> \u2013 50-250 \u03bcg\/24 h1<\/sup>.<\/span><\/p>\n

Limite \u015fi interferente<\/em><\/strong><\/span><\/p>\n

Medicamentele care pot afecta concentra\u0163ia de serotonin\u0103 urinar\u0103 sunt: inhibitorii de monoamin-oxidaz\u0103, preparatele cu litiu, metildopa, morfina \u015fi rezerpina.<\/span><\/div>\n
Consumul excesiv de nicotin\u0103 la marii fum\u0103tori poate determina false cre\u015fteri ale serotoninei urinare (cu 10-80\u00a0 \u03bcg\/24 h) datorit\u0103 reactivit\u0103\u0163ii \u00eencruci\u015fate cu principalul metabolit al nicotinei \u2013 cotinina2<\/sup>.<\/span><\/div>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate. 2010. Ref Type: Catalog<\/span><\/div>\n
2. Mayo Clinic\/Mayo Medical Laboratories. Test Catalog: Serotonin, 24 Hour, Urine. www.mayomedicallaboratories.com. Ref Type: Internet Communication.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

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    \n
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    \u041d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u043f\u0440\u0438\u0437\u043d\u0430\u043a\u0438 \u0438 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u044b \u0432\u043a\u043b\u044e\u0447\u0430\u044e\u0442 \u0432 \u0441\u0435\u0431\u044f:<\/p>\n

      \n
    • \u043f\u043e\u043a\u0440\u0430\u0441\u043d\u0435\u043d\u0438\u0435 \u043b\u0438\u0446\u0430, \u0448\u0435\u0438 \u0438 \u0433\u0440\u0443\u0434\u0438 (\u043e\u0431\u044b\u0447\u043d\u043e \u043d\u0430\u0447\u0438\u043d\u0430\u0435\u0442\u0441\u044f \u0432\u043d\u0435\u0437\u0430\u043f\u043d\u043e);<\/li>\n
    • \u041f\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u0435 \u0431\u0430\u0433\u0440\u043e\u0432\u044b\u0445 \u043f\u044f\u0442\u0435\u043d \u0438\u043b\u0438 \u0442\u043e\u043d\u043a\u0438\u0445 \u0441\u0435\u0442\u0447\u0430\u0442\u044b\u0445 \u043a\u0440\u043e\u0432\u0435\u043d\u043e\u0441\u043d\u044b\u0445 \u0441\u043e\u0441\u0443\u0434\u043e\u0432 \u043d\u0430 \u043d\u043e\u0441\u0443 \u0438 \u043d\u0430\u0434 \u0432\u0435\u0440\u0445\u043d\u0435\u0439 \u0433\u0443\u0431\u043e\u0439;<\/li>\n
    • \u0414\u0438\u0430\u0440\u0435\u044f, \u0442\u043e\u0448\u043d\u043e\u0442\u0430, \u0440\u0432\u043e\u0442\u0430;<\/li>\n
    • \u042d\u043f\u0438\u0437\u043e\u0434\u044b \u0443\u0447\u0430\u0449\u0435\u043d\u043d\u043e\u0433\u043e \u0441\u0435\u0440\u0434\u0446\u0435\u0431\u0438\u0435\u043d\u0438\u044f;<\/li>\n
    • \u0425\u0440\u0438\u043f\u044b, \u043a\u0430\u0448\u0435\u043b\u044c, \u043e\u0434\u044b\u0448\u043a\u0430.<\/li>\n<\/ul>\n

      \u041a\u0430\u043a \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u0438\u0442\u044c\u0441\u044f \u043a \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044e?<\/p>\n

        \n
      1. \u041d\u0435 \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0439\u0442\u0435 \u043f\u0438\u0449\u0443 \u0442\u0430\u043a\u0438\u0435 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u044b, \u043a\u0430\u043a \u0431\u0430\u043d\u0430\u043d\u044b, \u043e\u0440\u0435\u0445\u0438, \u043f\u043e\u043c\u0438\u0434\u043e\u0440\u044b, \u0430\u043d\u0430\u043d\u0430\u0441\u044b, \u0433\u0440\u0435\u0439\u043f\u0444\u0440\u0443\u0442\u044b, \u0441\u043c\u043e\u0440\u043e\u0434\u0438\u043d\u0430, \u043a\u0430\u043a\u0430\u043e, \u0441\u043b\u0438\u0432\u044b, \u0431\u0430\u043a\u043b\u0430\u0436\u0430\u043d\u044b, \u0434\u044b\u043d\u0438, \u0430\u0432\u043e\u043a\u0430\u0434\u043e \u0438 \u043a\u0438\u0432\u0438, \u043f\u043e \u043a\u0440\u0430\u0439\u043d\u0435\u0439 \u043c\u0435\u0440\u0435, \u0437\u0430 2 \u0434\u043d\u044f \u0434\u043e \u0442\u0435\u0441\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f.<\/li>\n
      2. \u0415\u0441\u043b\u0438 \u0432\u044b \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0435\u0442\u0435 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u044b \u0438\u0437 \u043a\u043b\u0430\u0441\u0441\u0430 \u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440\u043e\u0432 \u043c\u043e\u043d\u043e\u0430\u043c\u0438\u043d\u043e\u043a\u0441\u0438\u0434\u0430\u0437\u044b, \u0441\u043b\u0435\u0434\u0443\u0435\u0442 \u043f\u0440\u0435\u043a\u0440\u0430\u0442\u0438\u0442\u044c \u0438\u0445 \u043f\u0440\u0438\u0435\u043c \u0437\u0430 \u043d\u0435\u0434\u0435\u043b\u044e \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u043f\u043e\u0434 \u043d\u0430\u0431\u043b\u044e\u0434\u0435\u043d\u0438\u0435\u043c \u0432\u0440\u0430\u0447\u0430 (\u043f\u0435\u0440\u0435\u0434 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u0435\u043c \u043a\u0443\u0440\u0441\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u043f\u0440\u043e\u043a\u043e\u043d\u0441\u0443\u043b\u044c\u0442\u0438\u0440\u0443\u0439\u0442\u0435\u0441\u044c \u0441 \u0432\u0440\u0430\u0447\u043e\u043c!).<\/li>\n
      3. \u041f\u0440\u0438\u0435\u043c \u043b\u0438\u0442\u0438\u044f, \u043c\u0435\u0442\u0438\u043b\u0434\u043e\u043f\u044b, \u043c\u043e\u0440\u0444\u0438\u043d\u0430 \u0438 \u0440\u0435\u0437\u0435\u0440\u043f\u0438\u043d\u0430 \u043c\u043e\u0436\u0435\u0442 \u043f\u0440\u0438\u0432\u0435\u0441\u0442\u0438 \u043a \u043b\u043e\u0436\u043d\u043e\u043c\u0443 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u044e \u0443\u0440\u043e\u0432\u043d\u044f \u0441\u0435\u0440\u043e\u0442\u043e\u043d\u0438\u043d\u0430<\/li>\n<\/ol>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[923],"product_tag":[],"class_list":{"0":"post-10107","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-tumorali","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10107","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10107"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10107"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10107"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10107"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10107"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}