{"id":10102,"date":"2020-04-23T04:56:37","date_gmt":"2020-04-23T01:56:37","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/catecolamine-urinare\/"},"modified":"2025-02-07T09:10:29","modified_gmt":"2025-02-07T07:10:29","slug":"catecolamine-urinare","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/catecolamine-urinare\/","title":{"rendered":"\u041a\u0430\u0442\u0435\u0445\u043e\u043b\u0430\u043c\u0438\u043d\u044b \u0432 \u043c\u043e\u0447\u0435"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-size: medium;\"><strong><em>Informa\u0163ii generale \u015fi recomand\u0103ri pentru determinarea catecolaminelor urinare<\/em><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: medium;\">Tumorile neuroendocrine secretante sunt \u00een mod caracteristic asociate cu niveluri de catecolamine (substan\u0163e care con\u0163in un nucleu catecol \u00eempreun\u0103 cu o grupare amino) mult crescute fa\u0163\u0103 de limita superioar\u0103 a normalului.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: medium;\">Feocromocitomul este cea mai cunoscut\u0103 tumor\u0103 secretant\u0103 de catecolamine (adrenalina \u015fi noradrenalina) localizat\u0103 \u00een 90% din cazuri la nivelul medulosuprarenalei. Acest tip de tumor\u0103 poate s\u0103 apar\u0103 izolat sau \u00een cadrul unei neoplazii endocrine multiple. Tabloul clinic include hipertensiune arterial\u0103, survenit\u0103 adesea \u00een atacuri paroxistice \u015fi \u00eenso\u0163it\u0103 de tahicardie, dureri toracice, paloare, cefalee, grea\u0163\u0103. La aproximativ jum\u0103tate din pacien\u0163i hipertensiunea arterial\u0103 este sus\u0163inut\u0103.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: medium;\">Alte tipuri de tumori care pot induce ocazional hipertensiune arterial\u0103 paroxistic\u0103 sau persistent\u0103 sunt paraganglioamele.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: medium;\">Testul const\u0103 \u00een determinarea celor 3 frac\u0163iuni de catecolamine libere (neconjugate)\u00a0\u00een urina din 24 ore (adrenalina, noradrenalina \u015fi dopamina) \u015fi reprezint\u0103 un instrument util\u00a0\u00een diagnosticul feocromocitomului \u015fi a altor tumori derivate din creasta neural\u0103 (vezi anexa 10.1). De obicei este folosit ca un test de confirmare, dup\u0103 ob\u0163inerea unor valori crescute ale metanefrinelor plasmatice sau urinare. Valoarea diagnostic\u0103 este mai mare dac\u0103 probele sunt recoltate\u00a0\u00een cursul puseelor hipertensive. Deoarece produc\u0163ia tumoral\u0103 de catecolamine este intermitent\u0103, determinarea catecolaminelor\u00a0\u00een urina din 24 ore este mult mai important\u0103 dec\u00e2t testarea acestora\u00a0\u00een plasm\u0103<sup>2;3<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: medium;\"><strong><em>Preg\u0103tire pacient\u00ad <\/em><\/strong><em>-<\/em> se vor evita \u00eenaintea recolt\u0103rii: stresul fizic \u015fi emo\u0163ional, activitatea fizic\u0103 intens\u0103 \u015fi consumul de cafea. Este de preferat s\u0103 se \u00eentrerup\u0103 medica\u0163ia care poate produce interferen\u0163e cu 2 s\u0103pt\u0103m\u00e2ni \u00eenaintea recolt\u0103rii: anti-hipertensive (rezerpina, alfa-metildopa, alfa \u015fi beta-blocante, inhibitori ai enzimei de conversie), levodopa, inhibitori de monoamin-oxidaza, antidepresive triciclice, fenotiazine, bromocriptina, bronhodilatatoare, dezobstruante nazale \u015fi pastile pentru tuse)<sup>1<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: medium;\"><strong><em>Specimen recoltat\u00ad <\/em><\/strong><em>-<\/em> urina din 24 ore: la ora 7 diminea\u0163a pacientul urineaz\u0103 \u015fi nu re\u0163ine aceast\u0103 urin\u0103; apoi colecteaz\u0103 \u00eentr-un vas curat de 2-3 litri toate emisiunile de urin\u0103 p\u00e2n\u0103 la ora 7 diminea\u0163a\u00a0\u00een ziua urm\u0103toare, inclusiv; omogenizeaz\u0103 (prin agitare) urina recoltat\u0103; m\u0103soar\u0103 \u00eentreaga cantitate; re\u0163ine aprox. 10 mL,\u00a0\u00een pahar de plastic de unic\u0103 folosin\u0163\u0103 pentru urin\u0103. Proba se \u0163ine la 2-8\u00baC\u00a0\u00een timpul colect\u0103rii \u015fi ulterior, p\u00e2n\u0103 se lucreaz\u0103 efectiv<sup>1<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: medium;\"><strong><em>Recipient de recoltare <\/em><\/strong>\u2013 vas de 2-3 litri \u015fi pahar de plastic de unic\u0103 folosin\u0163\u0103 pentru urin\u0103, pe care se noteaz\u0103 cantitatea total\u0103 de urin\u0103 din 24 de ore<sup>1<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: medium;\"><strong><em>Cantitate recoltat\u0103 <\/em><\/strong>\u2013 10 mL<sup>1<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: medium;\"><strong><em>Cauze de respingere a probei <\/em><\/strong>\u2013 specimen care nu a fost p\u0103strat la 2-8\u00b0C<sup>1<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: medium;\"><b><i>Prelucrare necesar\u0103 dup\u0103 recoltare <\/i><\/b>\u2013 este de preferat s\u0103 se lucreze imediat; dac\u0103 acest lucru nu este posibil, proba se congeleaza la -20\u00b0C, dup\u0103 ce \u00een prealabil se adaug\u0103 acid clorhidric concentrat p\u00e2n\u0103 se ajunge la un pH &lt;3<sup>1<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: medium;\"><span style=\"color: #000000;\"><b><i>Stabilitate prob\u0103 <\/i><\/b><\/span>-\u00a0<i>1 s\u0103pt\u0103m\u00e2n\u0103 <\/i>la -20\u00b0C<sup>1<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: medium;\"><span style=\"color: #000000;\"><strong><em>Metod\u0103 <\/em><\/strong><\/span>- <span style=\"text-decoration: underline;\">HPLC (cromatografie de lichide sub \u00eenalt\u0103 presiune)<sup>1<\/sup><\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000; font-size: medium;\"><strong><em>Valori de referin\u0163\u0103<\/em><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"background-color: #ffffff; color: #333333; font-size: medium;\">Pentru fiecare metabolit sunt comunicate valori de referin\u0163\u0103 \u00een func\u0163ie de v\u00e2rst\u0103<sup>1<\/sup>:<\/span><\/p>\n<table class=\"wp-block-table w-100\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr style=\"height: 55px;\">\n<td style=\"height: 55px;\" valign=\"top\" width=\"163\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\"><strong>Grupe de v\u00e2rst\u0103<\/strong><\/span><\/p>\n<\/td>\n<td style=\"height: 55px;\" valign=\"top\" width=\"170\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\"><strong>Adrenalina (\u03bcg\/24h)<\/strong><\/span><\/p>\n<\/td>\n<td style=\"height: 55px;\" valign=\"top\" width=\"170\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\"><strong>Noradrenalina (\u03bcg\/24h)<\/strong><\/span><\/p>\n<\/td>\n<td style=\"height: 55px;\" valign=\"top\" width=\"170\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\"><strong>Dopamina (\u03bcg\/24h)<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n<tr style=\"height: 55px;\">\n<td style=\"height: 55px;\" valign=\"top\" width=\"163\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">0-1 an<\/span><\/p>\n<\/td>\n<td style=\"height: 55px;\" valign=\"top\" width=\"170\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">&lt;2.5<\/span><\/p>\n<\/td>\n<td style=\"height: 55px;\" valign=\"top\" width=\"170\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">&lt;10<\/span><\/p>\n<\/td>\n<td style=\"height: 55px;\" valign=\"top\" width=\"170\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">&lt;85<\/span><\/p>\n<\/td>\n<\/tr>\n<tr style=\"height: 55px;\">\n<td style=\"height: 55px;\" valign=\"top\" width=\"163\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">1-2 ani<\/span><\/p>\n<\/td>\n<td style=\"height: 55px;\" valign=\"top\" width=\"170\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">&lt;3.5<\/span><\/p>\n<\/td>\n<td style=\"height: 55px;\" valign=\"top\" width=\"170\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">4-29<\/span><\/p>\n<\/td>\n<td style=\"height: 55px;\" valign=\"top\" width=\"170\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">10-40<\/span><\/p>\n<\/td>\n<\/tr>\n<tr style=\"height: 55px;\">\n<td style=\"height: 55px;\" valign=\"top\" width=\"163\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">3-4 ani<\/span><\/p>\n<\/td>\n<td style=\"height: 55px;\" valign=\"top\" width=\"170\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">&lt;6<\/span><\/p>\n<\/td>\n<td style=\"height: 55px;\" valign=\"top\" width=\"170\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">8-45<\/span><\/p>\n<\/td>\n<td style=\"height: 55px;\" valign=\"top\" width=\"170\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">40-260<\/span><\/p>\n<\/td>\n<\/tr>\n<tr style=\"height: 50px;\">\n<td style=\"height: 50px;\" valign=\"top\" width=\"163\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">5-10 ani<\/span><\/p>\n<\/td>\n<td style=\"height: 50px;\" valign=\"top\" width=\"170\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">0.2-10<\/span><\/p>\n<\/td>\n<td style=\"height: 50px;\" valign=\"top\" width=\"170\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">13-65<\/span><\/p>\n<\/td>\n<td style=\"height: 50px;\" valign=\"top\" width=\"170\"><span style=\"font-size: 10pt;\">\u00a0<\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">65-400<\/span><\/p>\n<\/td>\n<\/tr>\n<tr style=\"height: 30.0487px;\">\n<td style=\"height: 30.0487px;\" valign=\"top\" width=\"163\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">11-15 ani<\/span><\/p>\n<\/td>\n<td style=\"height: 30.0487px;\" valign=\"top\" width=\"170\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">0.5-20<\/span><\/p>\n<\/td>\n<td style=\"height: 30.0487px;\" valign=\"top\" width=\"170\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">15-80<\/span><\/p>\n<\/td>\n<td style=\"height: 30.0487px;\" valign=\"top\" width=\"170\"><span style=\"font-size: 10pt;\">\u00a0<\/span><\/p>\n<p style=\"text-align: center;\">\n<\/td>\n<\/tr>\n<tr style=\"height: 38px;\">\n<td style=\"height: 38px;\" valign=\"top\" width=\"163\">\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt;\">&gt;16 ani<\/span><\/p>\n<\/td>\n<td style=\"height: 38px; text-align: center;\">&lt;20<\/td>\n<td style=\"height: 38px;\" valign=\"top\" width=\"170\">\n<p style=\"text-align: center;\">\n<\/td>\n<td style=\"height: 38px;\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div style=\"text-align: justify;\"><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: medium;\"><strong><em>Limite \u015fi interferen\u0163e<\/em><\/strong><\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: medium;\">De\u015fi testul este util \u00een diagnosticul neuroblastomului, aceast\u0103 condi\u0163ie este evaluat\u0103 mai adecvat prin determinarea combinat\u0103 de acid vanilmandelic \u015fi homovanilic<sup>2<\/sup>.<\/span><\/div>\n<p style=\"text-align: justify;\"><span style=\"font-size: medium;\">\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\" align=\"center\"><strong><span style=\"font-size: 10pt;\">\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">1. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate. 2014. Ref Type: Catalog.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">2. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Catecholamines, Fractionated, Urinary Free, 24H-Urine. <a href=\"http:\/\/www.labcorp.com\/\" rel=\"nofollow noopener\" target=\"_blank\">www.labcorp.com<\/a> 2014.\u00a0 Ref Type: Internet Communication.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">3. Richard A. McPetersen, Matthew R. Pincus Evaluation of Endocrine Function. In<\/span> <i>Henry\u2019s Clinical Diagnosis and Management by Laboratory Methods<\/i>\u2013 Sauders Elsevier 21-Ed 2007- pg 342-344.<\/div>\n<p style=\"text-align: justify;\">","protected":false},"excerpt":{"rendered":"<p>\u041a\u0430\u0442\u0435\u0445\u043e\u043b\u0430\u043c\u0438\u043d\u044b \u2013 \u044d\u0442\u043e \u0433\u0440\u0443\u043f\u043f\u0430 \u0441\u0445\u043e\u0434\u043d\u044b\u0445 \u0433\u043e\u0440\u043c\u043e\u043d\u043e\u0432, \u0432\u044b\u0440\u0430\u0431\u0430\u0442\u044b\u0432\u0430\u0435\u043c\u044b\u0445 \u043c\u043e\u0437\u0433\u043e\u0432\u044b\u043c \u0432\u0435\u0449\u0435\u0441\u0442\u0432\u043e\u043c \u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u043e\u0432. \u041e\u0441\u043d\u043e\u0432\u043d\u044b\u0435 \u043a\u0430\u0442\u0435\u0445\u043e\u043b\u0430\u043c\u0438\u043d\u044b: \u0434\u043e\u0444\u0430\u043c\u0438\u043d, \u0430\u0434\u0440\u0435\u043d\u0430\u043b\u0438\u043d (\u044d\u043f\u0438\u043d\u0435\u0444\u0440\u0438\u043d) \u0438 \u043d\u043e\u0440\u0430\u0434\u0440\u0435\u043d\u0430\u043b\u0438\u043d. \u041e\u043d\u0438 \u0432\u044b\u0431\u0440\u0430\u0441\u044b\u0432\u0430\u044e\u0442\u0441\u044f \u0432 \u043a\u0440\u043e\u0432\u044c \u0432 \u043e\u0442\u0432\u0435\u0442 \u043d\u0430 \u0444\u0438\u0437\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0438\u043b\u0438 \u044d\u043c\u043e\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0439 \u0441\u0442\u0440\u0435\u0441\u0441 \u0438 \u0443\u0447\u0430\u0441\u0442\u0432\u0443\u044e\u0442 \u0432 \u043f\u0435\u0440\u0435\u0434\u0430\u0447\u0435 \u043d\u0435\u0440\u0432\u043d\u044b\u0445 \u0438\u043c\u043f\u0443\u043b\u044c\u0441\u043e\u0432 \u0432 \u043c\u043e\u0437\u0433, \u0441\u043f\u043e\u0441\u043e\u0431\u0441\u0442\u0432\u0443\u044e\u0442 \u0432\u044b\u0441\u0432\u043e\u0431\u043e\u0436\u0434\u0435\u043d\u0438\u044e \u0433\u043b\u044e\u043a\u043e\u0437\u044b \u0438 \u0436\u0438\u0440\u043d\u044b\u0445 \u043a\u0438\u0441\u043b\u043e\u0442 \u0432 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u0438\u0441\u0442\u043e\u0447\u043d\u0438\u043a\u043e\u0432 \u044d\u043d\u0435\u0440\u0433\u0438\u0438, \u0440\u0430\u0441\u0448\u0438\u0440\u0435\u043d\u0438\u044e \u0431\u0440\u043e\u043d\u0445\u0438\u043e\u043b \u0438 \u0437\u0440\u0430\u0447\u043a\u043e\u0432. \u041d\u043e\u0440\u0430\u0434\u0440\u0435\u043d\u0430\u043b\u0438\u043d \u0441\u0443\u0436\u0430\u0435\u0442 \u043a\u0440\u043e\u0432\u0435\u043d\u043e\u0441\u043d\u044b\u0435 \u0441\u043e\u0441\u0443\u0434\u044b, \u043f\u043e\u0432\u044b\u0448\u0430\u044f \u043a\u0440\u043e\u0432\u044f\u043d\u043e\u0435 \u0434\u0430\u0432\u043b\u0435\u043d\u0438\u0435, \u0430 \u0430\u0434\u0440\u0435\u043d\u0430\u043b\u0438\u043d \u0443\u0447\u0430\u0449\u0430\u0435\u0442 \u0441\u0435\u0440\u0434\u0446\u0435\u0431\u0438\u0435\u043d\u0438\u0435 \u0438 \u0441\u0442\u0438\u043c\u0443\u043b\u0438\u0440\u0443\u0435\u0442 \u043e\u0431\u043c\u0435\u043d \u0432\u0435\u0449\u0435\u0441\u0442\u0432. 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\u0432\u044b\u0432\u043e\u0434\u044f\u0442\u0441\u044f \u0438\u0437 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430 \u0432\u043c\u0435\u0441\u0442\u0435 \u0441 \u043c\u043e\u0447\u043e\u0439.<\/p>\n<p>\u0412 \u043d\u043e\u0440\u043c\u0435 \u043a\u0430\u0442\u0435\u0445\u043e\u043b\u0430\u043c\u0438\u043d\u044b \u0438 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u044b \u0438\u0445 \u0440\u0430\u0441\u043f\u0430\u0434\u0430 \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0443\u044e\u0442 \u0432 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0435 \u0432 \u043d\u0435\u0431\u043e\u043b\u044c\u0448\u0438\u0445 \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0430\u0445. \u0418\u0445 \u0441\u043e\u0434\u0435\u0440\u0436\u0430\u043d\u0438\u0435 \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430\u0435\u0442 \u043d\u0430 \u043a\u043e\u0440\u043e\u0442\u043a\u043e\u0435 \u0432\u0440\u0435\u043c\u044f 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\u0442\u0440\u0430\u0434\u0438\u0446\u0438\u043e\u043d\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438).<\/li>\n<li>\u0415\u0441\u043b\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u044c \u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u043e\u0432 \u0438\u043b\u0438 \u043d\u0435\u0439\u0440\u043e\u044d\u043d\u0434\u043e\u043a\u0440\u0438\u043d\u043d\u0430\u044f \u043e\u043f\u0443\u0445\u043e\u043b\u044c \u0431\u044b\u043b\u0430 \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0430 \u043f\u0440\u0438 \u0441\u043a\u0430\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0438 \u043b\u0438\u0431\u043e \u0435\u0441\u043b\u0438 \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430 \u0435\u0441\u0442\u044c \u043d\u0430\u0441\u043b\u0435\u0434\u0441\u0442\u0432\u0435\u043d\u043d\u0430\u044f \u043f\u0440\u0435\u0434\u0440\u0430\u0441\u043f\u043e\u043b\u043e\u0436\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u043a \u0438\u0445 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044e.<\/li>\n<li>\u041f\u0440\u0438 \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u0435 \u0437\u0430 \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u0435\u043c \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0443\u0436\u0435 \u043f\u0440\u043e\u0445\u043e\u0434\u0438\u043b\u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u043e\u0442 \u0445\u0440\u043e\u043c\u0430\u0444\u0444\u0438\u043d\u043d\u043e\u0439 \u043e\u043f\u0443\u0445\u043e\u043b\u0438.<\/li>\n<\/ul>\n<p><strong id=\"subj3\" class=\"subj-header\">\u041a\u0430\u043a \u043f\u0440\u0430\u0432\u0438\u043b\u044c\u043d\u043e \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u0438\u0442\u044c\u0441\u044f \u043a \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044e?<\/strong><\/p>\n<ul>\n<li>\u0418\u0441\u043a\u043b\u044e\u0447\u0438\u0442\u044c \u0438\u0437 \u0440\u0430\u0446\u0438\u043e\u043d\u0430 \u0431\u0430\u043d\u0430\u043d\u044b, \u0430\u0432\u043e\u043a\u0430\u0434\u043e, \u0441\u044b\u0440, \u043a\u043e\u0444\u0435, \u0447\u0430\u0439, \u043a\u0430\u043a\u0430\u043e, \u043f\u0438\u0432\u043e \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 48 \u0447\u0430\u0441\u043e\u0432 \u0434\u043e \u0441\u0434\u0430\u0447\u0438 \u043c\u043e\u0447\u0438.<\/li>\n<li>\u041e\u0442\u043c\u0435\u043d\u0438\u0442\u044c \u0441\u0438\u043c\u043f\u0430\u0442\u043e\u043c\u0438\u043c\u0435\u0442\u0438\u043a\u0438 \u0437\u0430 14 \u0434\u043d\u0435\u0439 \u043f\u0435\u0440\u0435\u0434 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435\u043c (\u043f\u043e \u0441\u043e\u0433\u043b\u0430\u0441\u043e\u0432\u0430\u043d\u0438\u044e \u0441 \u0432\u0440\u0430\u0447\u043e\u043c).<\/li>\n<li>\u041f\u0440\u0435\u043a\u0440\u0430\u0442\u0438\u0442\u044c \u043f\u0440\u0438\u0435\u043c \u043c\u043e\u0447\u0435\u0433\u043e\u043d\u043d\u044b\u0445 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432 \u0437\u0430 48 \u0447\u0430\u0441\u043e\u0432 \u0434\u043e \u0441\u0434\u0430\u0447\u0438 \u043c\u043e\u0447\u0438 (\u043f\u043e \u0441\u043e\u0433\u043b\u0430\u0441\u043e\u0432\u0430\u043d\u0438\u044e \u0441 \u0432\u0440\u0430\u0447\u043e\u043c).<\/li>\n<li>\u0418\u0441\u043a\u043b\u044e\u0447\u0438\u0442\u044c \u0444\u0438\u0437\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0438 \u044d\u043c\u043e\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0435 \u043f\u0435\u0440\u0435\u043d\u0430\u043f\u0440\u044f\u0436\u0435\u043d\u0438\u0435 \u0432\u043e \u0432\u0440\u0435\u043c\u044f \u0441\u0431\u043e\u0440\u0430 \u0441\u0443\u0442\u043e\u0447\u043d\u043e\u0439 \u043c\u043e\u0447\u0438 (\u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 \u0441\u0443\u0442\u043e\u043a).<\/li>\n<li>\u041d\u0435 \u043a\u0443\u0440\u0438\u0442\u044c \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 \u0432\u0441\u0435\u0433\u043e \u043f\u0435\u0440\u0438\u043e\u0434\u0430 \u0441\u0431\u043e\u0440\u0430 \u0441\u0443\u0442\u043e\u0447\u043d\u043e\u0439 \u043c\u043e\u0447\u0438.<\/li>\n<\/ul>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[923],"product_tag":[],"class_list":{"0":"post-10102","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-tumorali","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10102"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10102"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10102"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10102"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}