{"id":10090,"date":"2020-04-23T03:56:18","date_gmt":"2020-04-23T00:56:18","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/anticorpi-anti-musk\/"},"modified":"2025-02-06T15:10:13","modified_gmt":"2025-02-06T13:10:13","slug":"anticorpi-anti-musk","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/anticorpi-anti-musk\/","title":{"rendered":"\u0410\u043d\u0442\u0438-MuSK \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430"},"content":{"rendered":"

Informa\u0163<\/em><\/strong>ii generale <\/em><\/strong><\/p>\n

Miastenia gravis<\/em> este o afec\u0163iune neuromuscular\u0103 caracterizat\u0103 prin asocierea de sl\u0103biciune muscular\u0103, fatigabilitate \u015fi prezen\u0163a anticorpilor anti-receptori pentru acetilcolin\u0103. Ace\u015fti anticorpi sunt prezen\u0163i doar la 80-90% dintre pacien\u0163ii cu miastenia gravis generalizat\u0103, restul fiind \u201csero-negativi\u201d (ace\u015fti pacien\u0163i nu prezint\u0103 nici hipertofia timusului). Recent s-a descris prezen\u0163a unor anticorpi anti-receptori pentru tirozinkinaza specific muscular\u0103 (anticorpi anti-MuSK) care pot fi prezen\u0163i (\u00een func\u0163ie de studii)\u00a0la 38-47% din pacien\u0163ii cu miastenia gravis sero-negativ\u0103. Tirozinkinaza muscular\u0103 reprezint\u0103 un constituent membranar indispensabil pentru realizarea jonc\u0163iunii musculare. Se consider\u0103 c\u0103 \u00een miastenia ocular\u0103 nu apar anticorpii anti MuSK. Prezen\u0163a lor, citat\u0103 de unele studii \u015fi \u00een miastenia ocular\u0103, se pare c\u0103 s-ar datora unui stadiu precoce de diagnostic al unei miastenii generalizate care apare mai tardiv dup\u0103 debutul ocular. Se consider\u0103 c\u0103 miastenia\u00a0cu anticorpi anti-MuSK\u00a0 este o form\u0103 relativ mai grav\u0103 de miastenie, care necesit\u0103 un tratament mai agresiv, bazat pe imunosupresoare \u015fi plasmaferez\u0103 (timectomia este controversat\u0103 \u015fi se pare c\u0103 nu aduce beneficii reale)2<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea anticorpilor anti-MuSK<\/em><\/strong><\/p>\n

\u2013 diagnosticul \u015fi prognosticul miasteniei gravis generalizate sero-negative;<\/div>\n
\u2013 monitorizarea tratamentului miasteniei gravis sero-negative2<\/sup>.<\/div>\n

Preg\u0103tire pacient\u00a0<\/em><\/strong>\u2013 cu 48 ore \u00eenainte de recoltare se evita administrarea de miorelaxante sau efectuarea unei anestezii generale2<\/sup>.<\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c1,3<\/sup>.<\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator1<\/sup>,2.<\/sup><\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare<\/em><\/strong> \u2013 se separ\u0103 serul prin centrifugare \u00een maxim 45 minute de la recoltare folosindu-se pentru separare o eprubet\u0103 de plastic2<\/sup>; se lucreaz\u0103 serul proasp\u0103t; dac\u0103 acest lucru nu este posibil, serul se p\u0103streaz\u0103 la 2-8\u00b0C, la -20\u00b0C sau la -70\u00b0C1<\/sup>.<\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 minim 2 mL ser1<\/sup>.<\/p>\n

Cauze de respingere<\/em><\/strong> a probei<\/em><\/strong><\/p>\n

\u2022 specimen expus la temperatur\u0103 ridicat\u01031<\/sup><\/div>\n
\u2022 specimen contaminat bacterian1<\/sup><\/div>\n
\u2022 prob\u0103 recoltat\u0103 pe anticoagulant sau contaminat\u0103 cu anticoagulant2<\/sup><\/div>\n

Stabilitate prob\u0103 <\/em><\/strong>- <\/em>serul separat este stabil 14 zile la 2-8\u00b0C; dou\u0103 luni<\/em> la -20\u00b0C 1,2<\/sup>. Nu decongela\u0163i\/recongela\u0163i1<\/sup>.<\/p>\n

Metod\u0103 <\/em><\/strong>- imunoenzimatic\u0103 (EIA)<\/span>1<\/sup>.<\/p>\n

Valori de referin\u0163\u0103 <\/em><\/strong>\u2013 <0.05 nmol\/L1<\/sup>.<\/p>\n

Interpretarea rezultatelor<\/em><\/strong><\/p>\n

Anticorpii anti-MuSK sunt prezen\u0163i \u00een titru detectabil la aproximativ 35-45% din pacien\u0163ii cu miastenia gravis generalizat\u0103 sero-negativ\u0103 \u015fi lipsesc la cei\u00a0cu miastenia ocular\u0103. Titrul de anticorpi are tendin\u0163a de a fi mai mare la femei \u015fi se constat\u0103 o corela\u0163ie \u00eentre nivelul anticorpilor \u015fi intensitatea sl\u0103biciunii musculare2<\/sup>.<\/p>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/div>\n
Rezultate fals pozitive se pot ob\u0163ine la pacien\u0163ii care \u00een ultimele 48 ore, \u00eenaintea recolt\u0103rii, au suferit o anestezie general\u0103 sau c\u0103rora li s-au adminstrat relaxante musculare2<\/sup>.<\/div>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog.<\/span><\/div>\n
2. Carsss J.B.; Hunt C.H.;-Anti-MuSk \u201cMyastenia Gravis Presenting with Purely Ocular Findings\u201d- 2005 \u2013 American Medical Association<\/span><\/div>\n
3. www.mayomedicallaboratories.com. Test Catalog: MuSK Antibodies. Ref Type: Internet Communication.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u041c\u044b\u0448\u0435\u0447\u043d\u043e-\u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0442\u0438\u0440\u043e\u0437\u0438\u043d\u043a\u0438\u043d\u0430\u0437\u0430 (MuSK) \u2013 \u0442\u0440\u0430\u043d\u0441\u043c\u0435\u043c\u0431\u0440\u0430\u043d\u043d\u044b\u0439 \u0431\u0435\u043b\u043e\u043a \u043f\u043e\u0441\u0442\u0441\u0438\u043d\u0430\u043f\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043c\u0435\u043c\u0431\u0440\u0430\u043d\u044b \u043d\u0435\u0440\u0432\u043d\u043e-\u043c\u044b\u0448\u0435\u0447\u043d\u043e\u0433\u043e \u0441\u0438\u043d\u0430\u043f\u0441\u0430, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u0438\u0433\u0440\u0430\u0435\u0442 \u0432\u0430\u0436\u043d\u0443\u044e \u0440\u043e\u043b\u044c \u0432 \u043a\u043b\u0430\u0441\u0442\u0435\u0440\u0438\u0437\u0430\u0446\u0438\u0438 \u0430\u0446\u0435\u0442\u0438\u043b\u0445\u043e\u043b\u0438\u043d\u043e\u0432\u044b\u0445 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u043e\u0432, \u0443\u0447\u0430\u0441\u0442\u0432\u0443\u0435\u0442 \u0432 \u0444\u043e\u0440\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0438 \u0441\u0438\u043d\u0430\u043f\u0441\u043e\u0432 \u0438 \u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u0432 \u0437\u0440\u0435\u043b\u043e\u043c \u043d\u0435\u0440\u0432\u043d\u043e-\u043c\u044b\u0448\u0435\u0447\u043d\u043e\u043c \u043e\u043a\u043e\u043d\u0447\u0430\u043d\u0438\u0438.<\/p>\n

\u041c\u0438\u0430\u0441\u0442\u0435\u043d\u0438\u044f \u2013 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435, \u043a\u043e\u0442\u043e\u0440\u043e\u0435 \u043e\u0431\u0443\u0441\u043b\u043e\u0432\u043b\u0435\u043d\u043e \u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0430\u044e\u0449\u0438\u043c \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u043c \u0430\u043d\u0442\u0438\u0442\u0435\u043b, \u043d\u0430\u043f\u0440\u0430\u0432\u043b\u0435\u043d\u043d\u044b\u0445 \u043a \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u0430\u043c \u043d\u0435\u0440\u0432\u043d\u043e-\u043c\u044b\u0448\u0435\u0447\u043d\u043e\u0433\u043e \u0441\u0438\u043d\u0430\u043f\u0441\u0430 (\u043e\u0431\u044b\u0447\u043d\u043e \u2013 \u043a \u0430\u0446\u0435\u0442\u0438\u043b\u0445\u043e\u043b\u0438\u043d\u043e\u0432\u043e\u043c\u0443 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0443). \u041f\u0440\u043e\u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043c\u044b\u0448\u0435\u0447\u043d\u043e\u0439 \u0441\u043b\u0430\u0431\u043e\u0441\u0442\u044c\u044e \u0438 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0443\u0442\u043e\u043c\u043b\u044f\u0435\u043c\u043e\u0441\u0442\u044c\u044e. \u0412 15% \u0441\u043b\u0443\u0447\u0430\u0435\u0432 \u043e\u0442\u043c\u0435\u0447\u0430\u0435\u0442\u0441\u044f \u0442\u043e\u043b\u044c\u043a\u043e \u043e\u043a\u0443\u043b\u044f\u0440\u043d\u0430\u044f (\u0433\u043b\u0430\u0437\u043d\u0430\u044f) \u0444\u043e\u0440\u043c\u0430 \u043c\u0438\u0430\u0441\u0442\u0435\u043d\u0438\u0438, \u043a\u043e\u0442\u043e\u0440\u0430\u044f \u043d\u0435 \u043f\u0435\u0440\u0435\u0445\u043e\u0434\u0438\u0442 \u0432 \u0433\u0435\u043d\u0435\u0440\u0430\u043b\u0438\u0437\u043e\u0432\u0430\u043d\u043d\u0443\u044e \u0444\u043e\u0440\u043c\u0443. \u041d\u043e \u0447\u0430\u0449\u0435, \u043d\u0430\u0447\u0438\u043d\u0430\u044f\u0441\u044c \u0441 \u0433\u043b\u0430\u0437\u043d\u044b\u0445 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043e\u0432, \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435 \u0441 \u0442\u0435\u0447\u0435\u043d\u0438\u0435\u043c \u0432\u0440\u0435\u043c\u0435\u043d\u0438 \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u044f\u0435\u0442\u0441\u044f \u043d\u0430 \u0434\u0440\u0443\u0433\u0438\u0435 \u043c\u044b\u0448\u0446\u044b. \u0427\u0430\u0441\u0442\u044b\u043c \u043f\u0440\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u0435\u043c \u043c\u0438\u0430\u0441\u0442\u0435\u043d\u0438\u0438 \u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u043c\u0438\u0430\u0441\u0442\u0435\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043a\u0440\u0438\u0437\u044b, \u0432\u043e\u0437\u043d\u0438\u043a\u0430\u044e\u0449\u0438\u0435 \u043d\u0430 \u0444\u043e\u043d\u0435 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438 \u0438\u043b\u0438 \u043f\u0440\u0438\u0435\u043c\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432, \u0441 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435\u043c \u043e\u0441\u0442\u0440\u043e\u0439 \u043c\u044b\u0448\u0435\u0447\u043d\u043e\u0439 \u0441\u043b\u0430\u0431\u043e\u0441\u0442\u0438. \u0423 20% \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u0430\u0441\u0441\u043e\u0446\u0438\u0438\u0440\u043e\u0432\u0430\u043d\u0430 \u0441 \u0442\u0438\u043c\u043e\u043c\u043e\u0439.<\/p>\n

\u0423 \u0431\u043e\u043b\u044c\u0448\u0438\u043d\u0441\u0442\u0432\u0430 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u044d\u0442\u043e \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435 \u043e\u0431\u0443\u0441\u043b\u043e\u0432\u043b\u0435\u043d\u043e \u0432\u044b\u0440\u0430\u0431\u043e\u0442\u043a\u043e\u0439 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a \u0430\u0446\u0435\u0442\u0438\u043b\u0445\u043e\u043b\u0438\u043d\u043e\u0432\u044b\u043c \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0430\u043c. \u0422\u0430\u043a\u0438\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043e\u0442\u043c\u0435\u0447\u0430\u044e\u0442 \u0443 80-90% \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0441 \u0433\u0435\u043d\u0435\u0440\u0430\u043b\u0438\u0437\u043e\u0432\u0430\u043d\u043e\u0439 \u043c\u0438\u0430\u0441\u0442\u0435\u043d\u0438\u0435\u0439, \u0443 80-90% \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0441 \u043f\u0430\u0440\u0430\u043d\u0435\u043e\u043f\u043b\u0430\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 (\u0442\u0438\u043c\u043e\u043c\u0430-\u0430\u0441\u0441\u043e\u0446\u0438\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0439) \u043c\u0438\u0430\u0441\u0442\u0435\u043d\u0438\u0435\u0439, \u0443 50% \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0441 \u043e\u043a\u0443\u043b\u044f\u0440\u043d\u043e\u0439 \u0444\u043e\u0440\u043c\u043e\u0439 \u043c\u0438\u0430\u0441\u0442\u0435\u043d\u0438\u0438. \u0423 10-20% \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0433\u0435\u043d\u0435\u0440\u0430\u043b\u0438\u0437\u043e\u0432\u0430\u043d\u043d\u043e\u0439 \u0444\u043e\u0440\u043c\u043e\u0439 \u043c\u0438\u0430\u0441\u0442\u0435\u043d\u0438\u0438 \u0438 \u0443 50% \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0433\u043b\u0430\u0437\u043d\u043e\u0439 \u0444\u043e\u0440\u043c\u043e\u0439 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0430\u0446\u0435\u0442\u0438\u043b\u0445\u043e\u043b\u0438\u043d\u043e\u0432\u043e\u043c\u0443 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0443 \u043d\u0435 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u0432\u0430\u044e\u0442, \u0443 \u0447\u0430\u0441\u0442\u0438 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f \u043e\u0431\u0443\u0441\u043b\u043e\u0432\u043b\u0435\u043d\u0430 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430\u043c\u0438 \u043a MuSK.<\/p>\n

\u0410\u043d\u0442\u0438-MuSK \u0432\u044b\u044f\u0432\u043b\u044f\u044e\u0442 \u0443 40-46% \u0441\u0435\u0440\u043e\u043d\u0435\u0433\u0430\u0442\u0438\u0432\u043d\u044b\u0445 \u043f\u043e \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430\u043c \u043a \u0430\u0446\u0435\u0442\u0438\u043b\u0445\u043e\u043b\u0438\u043d\u043e\u0432\u043e\u043c\u0443 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432, \u043e\u0431\u044b\u0447\u043d\u043e \u0430\u0441\u0441\u043e\u0446\u0438\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u0441 \u0433\u0435\u043d\u0435\u0440\u0430\u043b\u0438\u0437\u043e\u0432\u0430\u043d\u043d\u043e\u0439 \u0444\u043e\u0440\u043c\u043e\u0439 \u043c\u0438\u0430\u0441\u0442\u0435\u043d\u0438\u0438. \u0423 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u043c\u0438\u0430\u0441\u0442\u0435\u043d\u0438\u0435\u0439, \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u043f\u043e \u0430\u0443\u0442\u043e\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430\u043c \u043a MuSK (\u0447\u0430\u0449\u0435 \u044d\u0442\u043e \u0436\u0435\u043d\u0449\u0438\u043d\u044b), \u043e\u0442\u043c\u0435\u0447\u0430\u0435\u0442\u0441\u044f \u0442\u0435\u043d\u0434\u0435\u043d\u0446\u0438\u044f \u043a \u0431\u043e\u043b\u0435\u0435 \u0442\u044f\u0436\u0435\u043b\u043e\u043c\u0443 \u0442\u0435\u0447\u0435\u043d\u0438\u044e \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u0447\u0430\u0441\u0442\u043e\u0439 \u0432\u0441\u0442\u0440\u0435\u0447\u0430\u0435\u043c\u043e\u0441\u0442\u0438 \u043a\u0440\u0430\u043d\u0438\u043e\u0431\u0443\u043b\u044c\u0431\u0430\u0440\u043d\u044b\u0445, \u0434\u044b\u0445\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0439 \u0438 \u0441\u043b\u0430\u0431\u043e\u0441\u0442\u0438 \u043c\u044b\u0448\u0446 \u0448\u0435\u0438, \u0445\u043e\u0442\u044f \u044d\u0442\u0430 \u0433\u0440\u0443\u043f\u043f\u0430 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e \u0433\u0435\u0442\u0435\u0440\u043e\u0433\u0435\u043d\u043d\u0430. \u0418\u043c\u0435\u044e\u0442 \u043c\u0435\u0441\u0442\u043e \u0438\u043d\u0434\u0438\u0432\u0438\u0434\u0443\u0430\u043b\u044c\u043d\u044b\u0435 \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u043e\u0442\u0432\u0435\u0442\u0430 \u043d\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u044e.<\/p>\n

\u0412 \u0441\u043e\u043e\u0442\u0432\u0435\u0442\u0441\u0442\u0432\u0438\u0438 \u0441 \u0442\u0435\u043a\u0443\u0449\u0438\u043c\u0438 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u044f\u043c\u0438, \u0434\u043b\u044f \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u043e\u0433\u043e \u043f\u043e\u0434\u0442\u0432\u0435\u0440\u0436\u0434\u0435\u043d\u0438\u044f \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0434\u0438\u0430\u0433\u043d\u043e\u0437\u0430 \u043c\u0438\u0430\u0441\u0442\u0435\u043d\u0438\u0438 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u044e\u0442 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a \u0430\u0446\u0435\u0442\u0438\u043b\u0445\u043e\u043b\u0438\u043d\u043e\u0432\u043e\u043c\u0443 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0443, \u043f\u0440\u0438 \u0438\u0445 \u043e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0438 \u043f\u0440\u043e\u0432\u043e\u0434\u044f\u0442 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0430\u043d\u0442\u0438-MuSK.<\/p>\n

\u0421\u043f\u0435\u0446\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438 \u043d\u0435 \u0442\u0440\u0435\u0431\u0443\u0435\u0442\u0441\u044f. \u0420\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0443\u0435\u0442\u0441\u044f \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u044c \u0432\u0437\u044f\u0442\u0438\u0435 \u043a\u0440\u043e\u0432\u0438 \u043d\u0435 \u0440\u0430\u043d\u0435\u0435, \u0447\u0435\u043c \u0447\u0435\u0440\u0435\u0437 4 \u0447\u0430\u0441\u0430 \u043f\u043e\u0441\u043b\u0435 \u043f\u043e\u0441\u043b\u0435\u0434\u043d\u0435\u0433\u043e \u043f\u0440\u0438\u0435\u043c\u0430 \u043f\u0438\u0449\u0438.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[934,928],"product_tag":[],"class_list":{"0":"post-10090","1":"product","2":"type-product","3":"status-publish","5":"product_cat-autoanticorpi-in-afectiuni-neurologice","6":"product_cat-markeri-boli-autoimune","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10090","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10090"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10090"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10090"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10090"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10090"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}