{"id":10060,"date":"2020-04-23T03:55:18","date_gmt":"2020-04-23T00:55:18","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/factor-reumatoid-iga-igm\/"},"modified":"2025-02-05T15:32:33","modified_gmt":"2025-02-05T13:32:33","slug":"factor-reumatoid-iga-igm","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/factor-reumatoid-iga-igm\/","title":{"rendered":"\u0420\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u0439 \u0444\u0430\u043a\u0442\u043e\u0440 IgA, IgM"},"content":{"rendered":"

Informa\u0163<\/em><\/strong>ii generale<\/em><\/strong><\/p>\n

Factorii reumatoizi sunt un grup heterogen de autoanticorpi \u00eendrepta\u0163i \u00eempotriva determinan\u0163ilor antigenici\u00a0ai regiunii Fc\u00a0a moleculelor de IgG de origine uman\u0103 sau animal\u0103, care formeaz\u0103 complexe IgG-anti IgG \u00een ser sau \u00een lichidul sinovial1;2;4<\/sup>. Ace\u015fti autoanticorpi pot apar\u0163ine tuturor claselor de imunoglobuline, fiind reprezenta\u0163i de izotipurile Ig M (predominant), IgG \u015fi IgA1<\/sup>.<\/p>\n

Factorul reumatoid (FR) se \u00eent\u00e2lne\u015fte la aproximativ 70-90% dintre pacien\u0163ii cu poliartrit\u0103 reumatoid\u0103, astfel c\u0103 un rezultat negativ nu exclude diagnosticul;\u00a0poate precede apari\u0163ia manifest\u0103rilor clinice cu mai mul\u0163i ani, dar poate fi \u015fi absent \u00een momentul debutului, pozitiv\u00e2ndu-se \u00een primii doi ani de boal\u01035<\/sup>. Sinoviala constituie sursa principal\u0103 de FR6<\/sup>. In prezen\u0163a FR riscul de apari\u0163ie a artritei reumatoide la pacien\u0163ii s\u0103n\u0103to\u015fi este de 5-40 ori mai mare dec\u00e2t la persoanele seronegative5<\/sup>.<\/p>\n

Poliartrita reumatoid\u0103 este una din\u00a0 cele mai comune afec\u0163iuni reumatice inflamatorii, caracterizat\u0103 prin episoade acute inflamatorii, distruc\u0163ii cu deform\u0103ri articulare \u015fi impoten\u0163\u0103 func\u0163ional\u0103 progresiv\u0103. Diagnosticul este bazat pe criteriile ACR (American College of Rheumatology), \u00een care detec\u0163ia factorului reumatoid este unul din criteriile de laborator. Pacien\u0163ii seropozitivi au un risc mai mare dec\u00e2t cei seronegativi de a dezvolta artrit\u0103 eroziv\u0103 cu impoten\u0163\u0103 func\u0163ional\u0103 articular\u0103 \u015fi manifest\u0103ri extraarticulare cum ar fi: noduli reumatoizi, determinare pulmonar\u0103 de boal\u0103, vasculit\u0103, sindrom Felty (neutropenie \u015fi splenomegalie asociate cu artrit\u0103 reumatoid\u0103), polineuropatie, serozite \u015fi sindrom Sj\u00f6gren secundar2;4;5<\/sup>.<\/p>\n

Metodele de determinare prin latex aglutinare \u015fi nefelometrie detecteaz\u0103 predominant factorul reumatoid de tip Ig M. Metoda ELISA (enzyme-linked.imunosorbent assay) permite diferen\u0163ierea \u00eentre\u00a0izotipurile de factori reumatoizi IgM, IgA, IgG; este o tehnic\u0103 precis\u0103, cantitativ\u0103 \u015fi reproductibil\u0103 de depistare a FR, limitand astfel propor\u0163ia de artrite seronegative. Ob\u0163inerea unei valori crescute pentru un singur izotip FR poate s\u0103 nu constituie \u00eentotdeauna un factor de risc pentru dezvoltarea\u00a0unei artrite reumatoide (\u00een general se asociaz\u0103 dou\u0103 izotipuri)6<\/sup>.<\/p>\n

\u25cf FR tip IgM<\/strong> r\u0103m\u00e2ne unul din parametri esen\u0163iali pentru evaluarea pacien\u0163ilor, pe baza c\u0103ruia formele de artrit\u0103 reumatoid\u0103 sunt clasificate \u00een seropozitive \u015fi seronegative; de asemenea sunt identifica\u0163i acei pacien\u0163i care vor dezvolta mai rapid o form\u0103 de boal\u0103 eroziv\u0103, cu sau f\u0103r\u0103 manifest\u0103ri extraarticulare1<\/sup>.<\/p>\n

\u25cf FR tip IgA<\/strong> este un marker pentru poliartrita precoce \u015fi este responsabil pentru progresia radiologic\u0103 rapid\u0103 a bolii\u00a0\u015fi pentru dezvoltarea manifest\u0103rilor extraarticulare. Detec\u0163ia simultan\u0103 a dou\u0103 izotipuri pozitive IgA \u015fi IgM cre\u015fte specificitatea diagnosticului1;3<\/sup>.<\/p>\n

Determinarea FR \u00een lichidul sinovial poate fi efectuat\u0103 utiliz\u00e2nd metodele descrise anterior, dar datorit\u0103 vascozit\u0103\u0163ii sale crescute determinat\u0103 de acidul hialuronic este recomandat pretratamentul probei cu hialuronidaz\u0103. La pacien\u0163ii cu artrit\u0103 reumatoid\u0103 rezultatele determin\u0103rii FR \u00een lichidul sinovial sunt, \u00een cele mai multe cazuri, similare cu nivelurile din ser5<\/sup>.<\/p>\n

Aproximativ 10% dintre pacien\u0163ii cu artrit\u0103 reumatoid\u0103 r\u0103m\u00e2n seronegativi, chiar dac\u0103 au fost determinate toate izotipurile FR2;5<\/sup>. Unii factori reumatoizi se pot comporta ca proteine care precipita la frig (crioglobuline)4<\/sup>.<\/p>\n

\u00cen lupusul eritematos sistemic (LES) prevalen\u0163a FR este de 50%; a fost descris\u0103 o corela\u0163ie semnificativ\u0103 \u00eentre prezen\u0163a FR din clasa IgG \u015fi lipsa afect\u0103rii rinichiului, \u00een timp ce o corela\u0163ie moderat\u0103 a fost observat\u0103 \u00eentre prezen\u0163a FR din clasele IgM \u015fi IgA \u015fi manifest\u0103rile renale (FR din clasa IgG activeaz\u0103 mai pu\u0163in complementul dec\u00e2t FR din clasa IgM)7<\/sup>.<\/p>\n

De\u015fi numele o sugereaz\u0103, FR nu este patognomonic pentru poliartrita reumatoid\u0103 \u015fi nici m\u0103car strict pentru afec\u0163iunile reumatologice. Aproximativ 5% <\/strong>din popula\u0163ia s\u0103n\u0103toas\u0103 poate prezenta seropozitivitate pentru FR, iar acest procent cre\u015fte odat\u0103 cu \u00eenaintarea \u00een v\u00e2rst\u01036<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea FR IgM, IgA<\/em><\/strong> \u2013 utilitate \u00een diagnosticul diferen\u0163ial al diverselor tipuri de artrite \u015fi \u00een stabilirea prognosticului acestora4<\/sup>.<\/p>\n

Preg\u0103tire pacient <\/em><\/strong>- <\/em>\u00e0 jeun (pe nem\u00e2ncate) sau postprandial (dup\u0103 mese)3<\/sup>.\u00a0<\/em><\/strong><\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c3<\/sup>.\u00a0<\/em><\/strong><\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator3<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>- <\/em>se separ\u0103 serul prin centrifugare3<\/sup>.<\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 minim 1 mL ser3<\/sup>.<\/p>\n

Cauze de respingere<\/em><\/strong> a probei<\/em><\/strong><\/p>\n

\u2022 specimen hemolizat<\/div>\n
\u2022 specimen icteric, lipemic<\/div>\n
\u2022 specimen contaminat bacterian3<\/sup><\/div>\n

Stabilitate prob\u0103 <\/em><\/strong>- <\/em>serul separat este stabil 7 zile<\/em> la 2-8\u00baC \u015fi timp \u00eendelungat<\/em> la -20\u00baC. Nu decongela\u0163i\/recongela\u0163i3<\/sup>.<\/p>\n

Metod\u0103 <\/em><\/strong>- ELISA3<\/sup><\/span>.<\/p>\n

Valori de referin\u0163\u0103 <\/em><\/strong><\/p>\n

RF IgM: <20 UI\/mL<\/div>\n
RF IgA: <20 U\/mL3<\/sup><\/div>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n

Absen\u0163a factorului reumatoid nu exclude diagnosticul de poliartrit\u0103 reumatoid\u0103, \u00een special dac\u0103 s-a efectuat o singur\u0103 determinare. Un marker mai sensibil \u015fi mai specific sunt anticorpii anti-CCP2<\/sup>.<\/div>\n
De\u015fi nivelul anticorpilor poate \u00eenregistra o sc\u0103dere \u00een urma tratmentului, FR nu prezint\u0103 importan\u0163\u0103 pentru monitorizarea eficien\u0163ei terapeutice5<\/sup>. Dup\u0103 unele vaccin\u0103ri se poate \u00eenregistra o cre\u015ftere tranzitorie a factorului reumatoid1<\/sup>.<\/div>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Carlos Albertos von M\u00fchlen, Robert M. Nakamura. Clinical and Laboratory Evaluation of Systemic Rheumatic Diseases. In Henry\u2019s Clinical Diagnosis and Management by Laboratory Methods, Saunders-Elsevier, 21st Edition, 8, 922.<\/span><\/div>\n
2. Francesco Dati & Erwin Metzmann. Autoimmune Diseases. In Proteins Laboratory Testing and Clinical Use, Media Print Taunusdruck GmbH, Frankfurt am Main; 2005, 214, 225-226.<\/span><\/div>\n
3. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog.<\/span><\/div>\n
4. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Rheumatoid Arthritis, Factor www.labcorp.com<\/a> 2010. Ref Type: Internet Communication.<\/span><\/div>\n
5. Lothar Thomas. Autoantibodies in Systemic Rheumatic Diseases. In Clinical Laboratory Diagnostics-Use and Assessment of Clinical Laboratory Results. TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany, 1 Ed., 1998; 810-811.<\/span><\/div>\n
6. Ruxandra Ionescu. Abordarea pacientului cu boli reumatice. \u00cen Esen\u0163ialul \u00een Reumatologie. Editura Amaltea, 2007, 108.<\/span><\/div>\n
7. Tarkowski A, Westberg G. Rheumatoid Factors Isotzpes and Renal Disease in Systemic Lupus Erytematosus. In Scand J Rheumatology, 1987; 16: 309-12.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

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\u0420\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u0439 \u0444\u0430\u043a\u0442\u043e\u0440 \u2013 \u0430\u0443\u0442\u043e\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430, \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u044e\u0449\u0438\u0435\u0441\u044f \u0441 \u0441\u043e\u0431\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u043c\u0438 \u0438\u043c\u043c\u0443\u043d\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u0430\u043c\u0438. \u0425\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u043d\u044b \u0434\u043b\u044f \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u0433\u043e \u0430\u0440\u0442\u0440\u0438\u0442\u0430. \u0412\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u0435 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u0433\u043e \u0444\u0430\u043a\u0442\u043e\u0440\u0430 \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043e\u0434\u043d\u0438\u043c \u0438\u0437 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u044b\u0445 \u043a\u0440\u0438\u0442\u0435\u0440\u0438\u0435\u0432 \u044d\u0442\u043e\u0433\u043e \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f.<\/p>\n

\u0420\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u0439 \u0444\u0430\u043a\u0442\u043e\u0440 IgA \u0432\u0445\u043e\u0434\u0438\u0442 \u0432 \u0441\u0435\u043c\u0435\u0439\u0441\u0442\u0432\u043e \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u0445 \u0444\u0430\u043a\u0442\u043e\u0440\u043e\u0432 (\u0420\u0424), \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u0435\u043d\u043d\u044b\u0445 \u0430\u0443\u0442\u043e\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430\u043c\u0438 \u0440\u0430\u0437\u043d\u044b\u0445 \u0438\u0437\u043e\u0442\u0438\u043f\u043e\u0432, \u043d\u0430\u043f\u0440\u0430\u0432\u043b\u0435\u043d\u043d\u044b\u0445 \u043f\u0440\u043e\u0442\u0438\u0432 Fc-\u0444\u0440\u0430\u0433\u043c\u0435\u043d\u0442\u0430 \u0438\u043c\u043c\u0443\u043d\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u043e\u0432 G \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430.<\/p>\n

\u041d\u0430\u0438\u0431\u043e\u043b\u0435\u0435 \u0442\u0438\u043f\u0438\u0447\u043d\u044b\u043c \u0434\u043b\u044f \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u0433\u043e \u0430\u0440\u0442\u0440\u0438\u0442\u0430 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u0439 \u0444\u0430\u043a\u0442\u043e\u0440 IgM \u0442\u0438\u043f\u0430, \u043d\u043e \u043c\u043e\u0433\u0443\u0442 \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u043e\u0432\u0430\u0442\u044c \u0438 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u0435 \u0444\u0430\u043a\u0442\u043e\u0440\u044b IgA \u0438\u043b\u0438 IgG \u0442\u0438\u043f\u043e\u0432.<\/p>\n

\u0414\u0435\u0439\u0441\u0442\u0432\u0443\u044e\u0449\u0438\u0435 \u043c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u044b\u0435 \u043a\u043b\u0430\u0441\u0441\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u043e\u043d\u043d\u044b\u0435 \u043a\u0440\u0438\u0442\u0435\u0440\u0438\u0438 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u0433\u043e \u0430\u0440\u0442\u0440\u0438\u0442\u0430 2010 \u0433\u043e\u0434\u0430 (ACR\/EULAR, 2010) \u0432 \u0447\u0430\u0441\u0442\u0438 \u0441\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u0432 \u0432\u043a\u043b\u044e\u0447\u0430\u044e\u0442 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b \u0434\u0432\u0443\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439 \u2013 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u0433\u043e \u0444\u0430\u043a\u0442\u043e\u0440\u0430 IgM \u0438 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a \u0446\u0438\u043a\u043b\u0438\u0447\u0435\u0441\u043a\u043e\u043c\u0443 \u0446\u0438\u0442\u0440\u0443\u043b\u043b\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u043c\u0443 \u043f\u0435\u043f\u0442\u0438\u0434\u0443 \u2013 \u0410\u0426\u0426\u041f. \u0423 20% \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u043c \u0430\u0440\u0442\u0440\u0438\u0442\u043e\u043c \u0432\u044b\u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0442\u043e\u043b\u044c\u043a\u043e \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u0439 \u0444\u0430\u043a\u0442\u043e\u0440.<\/p>\n

\u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0420\u0424 IgA \u0442\u0438\u043f\u0430 \u0432 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u0433\u043e \u0430\u0440\u0442\u0440\u0438\u0442\u0430 \u043f\u0440\u0438\u043c\u0435\u043d\u044f\u044e\u0442 \u0432 \u0447\u0438\u0441\u043b\u0435 \u0432\u0441\u043f\u043e\u043c\u043e\u0433\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439.<\/p>\n

\u041f\u0440\u0438 \u043a\u0430\u043a\u0438\u0445 \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u044f\u0445 \u043f\u043e\u0432\u044b\u0448\u0430\u0435\u0442\u0441\u044f \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0420\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u0433\u043e \u0444\u0430\u043a\u0442\u043e\u0440\u0430, IgA<\/strong><\/p>\n

\u041f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0435 \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u0433\u043e \u0444\u0430\u043a\u0442\u043e\u0440\u0430 \u0438\u0437\u043e\u0442\u0438\u043f\u0430 IgA \u043e\u0434\u043d\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e \u0441 \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u0435\u043c \u0420\u0424 IgM \u0438 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a \u0446\u0438\u043a\u043b\u0438\u0447\u0435\u0441\u043a\u043e\u043c\u0443 \u0446\u0438\u0442\u0440\u0443\u043b\u043b\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u043c\u0443 \u043f\u0435\u043f\u0442\u0438\u0434\u0443, IgG \u0432\u044b\u0441\u043e\u043a\u043e \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u043e \u0434\u043b\u044f \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u0433\u043e \u0430\u0440\u0442\u0440\u0438\u0442\u0430.<\/p>\n

\u041f\u043e\u043c\u0438\u043c\u043e \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u0433\u043e \u0430\u0440\u0442\u0440\u0438\u0442\u0430, \u0420\u0424 IgA \u043c\u043e\u0436\u0435\u0442 \u0432\u044b\u044f\u0432\u043b\u044f\u0442\u044c\u0441\u044f \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u043f\u0440\u0438 IgA-\u0430\u0441\u0441\u043e\u0446\u0438\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u043c \u0432\u0430\u0441\u043a\u0443\u043b\u0438\u0442\u0435 (\u0433\u0435\u043c\u043e\u0440\u0440\u0430\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0432\u0430\u0441\u043a\u0443\u043b\u0438\u0442, \u043f\u0443\u0440\u043f\u0443\u0440\u0430 \u0428\u0435\u043d\u043b\u0435\u0439\u043d\u0430-\u0413\u0435\u043d\u043e\u0445\u0430).<\/p>\n

\u0421 \u043a\u0430\u043a\u043e\u0439 \u0446\u0435\u043b\u044c\u044e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u044e\u0442 \u0420\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u0439 \u0444\u0430\u043a\u0442\u043e\u0440, IgA<\/strong><\/p>\n

\u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u043a\u043b\u0430\u0441\u0441\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u0433\u043e \u0444\u0430\u043a\u0442\u043e\u0440\u0430, \u0432\u044b\u044f\u0432\u043b\u044f\u044e\u0449\u0435\u0435 \u043f\u0440\u0435\u0438\u043c\u0443\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e \u0420\u0424 IgM \u0442\u0438\u043f\u0430, \u0441\u043b\u0443\u0436\u0438\u0442 \u043e\u0441\u043d\u043e\u0432\u043d\u044b\u043c \u043c\u0435\u0442\u043e\u0434\u043e\u043c \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u0433\u043e \u0430\u0440\u0442\u0440\u0438\u0442\u0430. \u041d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043a\u043e\u043c \u0435\u0433\u043e \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0443\u043c\u0435\u0440\u0435\u043d\u043d\u0430\u044f \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u043e\u0441\u0442\u044c (75-85%), \u043f\u043e\u0441\u043a\u043e\u043b\u044c\u043a\u0443 \u043d\u0438\u0437\u043a\u0438\u0439 \u0442\u0438\u0442\u0440 \u0420\u0424 \u043c\u043e\u0436\u0435\u0442 \u0432\u043e\u0437\u043d\u0438\u043a\u0430\u0442\u044c \u043f\u0440\u0438 \u0432\u0438\u0440\u0443\u0441\u043d\u044b\u0445 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044f\u0445 (\u0432\u0438\u0440\u0443\u0441\u043d\u043e\u043c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0435 \u0421, \u043c\u043e\u043d\u043e\u043d\u0443\u043a\u043b\u0435\u043e\u0437\u0435 \u0438 \u0442. \u0434.), \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u044b\u0445 \u0440\u0435\u0432\u043c\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445, \u043e\u043d\u043a\u043e\u0433\u0435\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0431\u043e\u043b\u0435\u0437\u043d\u044f\u0445, \u0443 5-15% \u043b\u044e\u0434\u0435\u0439 \u0441\u0442\u0430\u0440\u0448\u0435 65 \u043b\u0435\u0442. \u0414\u043e\u043f\u043e\u043b\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u0445 \u0444\u0430\u043a\u0442\u043e\u0440\u043e\u0432 \u0440\u0430\u0437\u043d\u044b\u0445 \u0438\u0437\u043e\u0442\u0438\u043f\u043e\u0432, \u0432 \u0442\u043e\u043c \u0447\u0438\u0441\u043b\u0435 \u0420\u0424 IgA, \u043f\u043e\u0432\u044b\u0448\u0430\u0435\u0442 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u043e\u0441\u0442\u044c \u0442\u0435\u0441\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u0434\u043b\u044f \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u0433\u043e \u0430\u0440\u0442\u0440\u0438\u0442\u0430.<\/p>\n

\u0427\u0442\u043e \u043c\u043e\u0436\u0435\u0442 \u043f\u043e\u0432\u043b\u0438\u044f\u0442\u044c \u043d\u0430 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u00ab\u0420\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u0439 \u0444\u0430\u043a\u0442\u043e\u0440, IgA\u00bb<\/strong><\/p>\n

\u0412\u0440\u0435\u043c\u0435\u043d\u043d\u0430\u044f \u043f\u0440\u043e\u0434\u0443\u043a\u0446\u0438\u044f \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u0445 \u0444\u0430\u043a\u0442\u043e\u0440\u043e\u0432 \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0442\u044c \u0430\u0441\u0441\u043e\u0446\u0438\u0438\u0440\u043e\u0432\u0430\u043d\u0430 \u0441 \u0432\u0438\u0440\u0443\u0441\u043d\u044b\u043c\u0438, \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u044b\u043c\u0438 \u0438 \u043f\u0430\u0440\u0430\u0437\u0438\u0442\u0430\u0440\u043d\u044b\u043c\u0438 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044f\u043c\u0438. \u0423 \u043f\u043e\u0436\u0438\u043b\u044b\u0445 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0443\u0432\u0435\u043b\u0438\u0447\u0438\u0432\u0430\u0435\u0442\u0441\u044f \u0447\u0430\u0441\u0442\u043e\u0442\u0430 \u043b\u043e\u0436\u043d\u043e\u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432 \u0442\u0435\u0441\u0442\u0430.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[928,929],"product_tag":[],"class_list":{"0":"post-10060","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-boli-autoimune","6":"product_cat-markeri-pentru-afectiuni-reumatismale-si-vasculite","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10060","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10060"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10060"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10060"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10060"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10060"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}