{"id":10058,"date":"2020-04-23T03:55:15","date_gmt":"2020-04-23T00:55:15","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/anticorpi-anti-beta2-glicoproteina-1-iga-igg-igm\/"},"modified":"2025-07-01T07:57:09","modified_gmt":"2025-07-01T04:57:09","slug":"anticorpi-anti-beta2-glicoproteina-1-igg-igm","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/anticorpi-anti-beta2-glicoproteina-1-igg-igm\/","title":{"rendered":"\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0431\u0435\u0442\u04302-\u0433\u043b\u0438\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0443 1 (IgG, IgM)"},"content":{"rendered":"<p><strong><em>Informa\u0163ii generale \u2013 Anticorpi anti-beta2 glicoproteina 1 \u2013 IgG, IgM<\/em><\/strong><\/p>\n<p>Recent, un grup interna\u0163ional de consens a stabilit c\u0103 anticorpii anti-\u03b22 glicoprotein\u0103 1 de tip IgG \u015fi IgM s\u0103 fie inclu\u015fi \u00een criteriile de diagnostic ale sindromului antifosfolipidic. Prezen\u0163a unuia sau ambelor tipuri de anticorpi constituie un factor de risc independent pentru tromboz\u0103 \u015fi complica\u0163ii ale sarcinii<sup>3<\/sup>.<\/p>\n<p>Ca urmare a acestui fapt s-au dezvoltat teste imunoenzimatice care detecteaz\u0103 anticorpi ce se leag\u0103 de \u03b22 glicoproteina 1 \u00een absen\u0163a fosfolipidelor<sup>2<\/sup>.<\/p>\n<p>\u03b22 glicoproteina 1 (apolipoproteina H \u2013 \u03b22GP1 ) este un polipeptid alc\u0103tuit din 326 aminoacizi sintetizat de c\u0103tre hepatocite, celule endoteliale \u015fi trofoblast. Con\u0163ine 5 domenii omoloage, fiecare av\u00e2nd aproximativ 60 aminoacizi; domeniul 5 localizat la nivelul cap\u0103tului C terminal este format dintr-un nucleu hidrofob \u00eenconjurat de 14 reziduuri de aminoacizi \u00eenc\u0103rcate pozitiv care interac\u0163ioneaz\u0103 electrostatic cu fosfolipidele \u00eenc\u0103rcate negativ (ex. cardiolipina) din membranele plasmatice. In vivo, complexele formate din \u03b22GP1 \u015fi fosfolipide \u201cdemasc\u0103\u201d epitopi care reac\u0163ioneaz\u0103 cu autoanticorpi naturali<sup>4<\/sup>.<\/p>\n<p>In mod surprinz\u0103tor, anticorpii anti-cardiolipinici se leag\u0103 mai puternic de \u0163inta membranar\u0103 dac\u0103 cofactorul proteinogenic \u03b22GP1 este de asemenea prezent; \u00een plus exist\u0103 dovezi c\u0103 reactivitatea \u03b22GP1 este asociat\u0103 cu poten\u0163ialul patogenic al anticorpilor antifosfolipidici. Mai mult, unii anticorpi antifosfolipidici prezint\u0103 reactivitate \u00eempotriva acestui cofactor chiar \u00een absen\u0163a cardiolipinei, dac\u0103 o densitate mare de molecule \u03b22GP1 se ata\u015feaz\u0103\u00a0la nivelul unor suprafe\u0163e solide. Aceasta \u00eenseamn\u0103 c\u0103 exist\u0103 o categorie de pacien\u0163i cu sindrom antifosfolipidic care nu prezint\u0103 anticorpi anticardiolipinici, dar sunt pozitivi pentru anti-\u03b22GP1<sup>1<\/sup>.<\/p>\n<p>Cele 2 izotipuri de anti-\u03b22GP1 (IgG, IgM) au fost asociate cu tromboze. Anticorpii anticardiolipinici care nu necesit\u0103 prezen\u0163a \u03b22GP1 au de obicei un caracter tranzitoriu \u015fi nu sunt clinic semnificativ. Studiile arat\u0103 c\u0103 anticorpii anticardiolipinici asocia\u0163i cu infec\u0163ii nu sunt anti-\u03b22GP1 dependen\u0163i. Din acest motiv, testele care detecteaz\u0103 anti-\u03b22GP1 sunt mai specifice dec\u00e2t cele pentru anticorpi anticardiolipinici.<\/p>\n<p>Aproximativ 20% din pacien\u0163ii cu anticorpi anticardiolipinici negativi au un rezultat pozitiv pentru anti-\u03b22GPI<sup>2<\/sup>.<\/p>\n<p><strong><em>Recomand\u0103ri pentru determinarea anticorpilor anti-\u03b22 glicoproteina 1 (IgG, IgM)<\/em><\/strong><\/p>\n<ul>\n<li>episoade de\u00a0<a href=\"https:\/\/www.synevo.ro\/riscul-de-tromboza\/\" data-wpel-link=\"internal\" rel=\"nofollow noopener\" target=\"_blank\">tromboz\u0103<\/a>\u00a0venoas\u0103 sau arterial\u0103, survenite\u00a0\u00een special la pacien\u0163i tineri, \u00een absen\u0163a oric\u0103rui diagnostic alternativ sau a altei etiologii trombotice; complica\u0163ii ale sarcinii (una sau mai multe pierderi de sarcin\u0103 dup\u0103 s\u0103pt\u0103m\u00e2na 10 cu f\u0103t morfologic normal, una sau mai multe na\u015fteri premature \u00eenainte de s\u0103pt\u0103m\u00e2na 34 cauzate de\u00a0<a href=\"https:\/\/www.synevo.ro\/importanta-screening-ului-in-preeclampsie\/\" data-wpel-link=\"internal\" rel=\"nofollow noopener\" target=\"_blank\">preeclampsie<\/a>\u00a0sever\u0103 sau insuficien\u0163\u0103 placentar\u0103, sau 3 sau mai multe avorturi spontane \u00eenainte de s\u0103pt\u0103m\u00e2na 10 de sarcin\u0103 la care s-au exclus etiologiile cromozomiale, hormonale sau anatomice); evaluarea riscului trombotic la pacien\u0163ii diagnostica\u0163i cu boli de \u0163esut conjunctiv (\u00een special\u00a0<a href=\"https:\/\/www.synevo.ro\/lupus-eritematos-sistemic-o-boala-autoimuna\/\" target=\"_blank\" rel=\"noopener nofollow\" data-wpel-link=\"internal\">LES<\/a>); evaluarea unei trombocitopenii neexplicabile; evaluarea pacien\u0163ilor cu anticorpi anti-cardiolipinici pozitivi care nu prezint\u0103 criterii clinice certe de sindrom antifosfolipidic<sup>4<\/sup>.<\/li>\n<\/ul>\n<p><strong><em>Preg\u0103tire pacient\u00a0<\/em><\/strong>\u2013 jeun (pe nem\u00e2ncate) sau postprandial (dup\u0103 mese)<sup>1<\/sup>.<\/p>\n<p><strong><em>Specimen recoltat\u00a0<\/em><\/strong>\u2013 s\u00e2nge venos<sup>1<\/sup>.<\/p>\n<p><strong><em>Recipient de recoltare\u00a0<\/em><\/strong><em>-\u00a0<\/em>vacutainer f\u0103r\u0103 anticoagulant cu gel separator<sup>1<\/sup>.<\/p>\n<p><strong><em>Prelucrare necesar\u0103 dup\u0103 recoltare\u00a0<\/em><\/strong><em>-\u00a0<\/em>se separ\u0103 serul prin centrifugare<sup>1<\/sup>.<\/p>\n<p><strong><em>Volum prob\u0103<\/em><\/strong>\u00a0\u2013 minimum 1 mL ser<sup>1<\/sup>.<\/p>\n<p><strong><em>Cauze de respingere<\/em><\/strong>\u00a0<strong><em>a probei\u00a0<\/em><\/strong><em>\u2013 specimen intens hemolizat, lipemic sau care nu a fost p\u0103strat \u00een condi\u021bii optime.<\/em><sup>1<\/sup>.<\/p>\n<p><strong><em>Stabilitate prob\u0103\u00a0<\/em><\/strong><em>-<\/em>\u00a0timp de dou\u0103 s\u0103pt\u0103m\u00e2ni la 2-8\u00b0C, 6 luni la -20\u00b0C.<em>.<\/em><\/p>\n<p><strong><em>Metod\u0103<\/em><\/strong>\u00a0\u2013 FEIA.<\/p>\n<p><strong><em>Valori de referin\u0163\u0103:\u00a0<\/em><\/strong><\/p>\n<div><strong>Anticorpi anti-beta2 glicoproteina 1 IgG (U\/ml)<\/strong>:<\/div>\n<ul>\n<li>&lt;7 Negativ<\/li>\n<li>7-10 Echivoc<\/li>\n<li>&gt;10 Pozitiv<\/li>\n<\/ul>\n<div><strong>Anticorpi anti-beta2 glicoproteina 1 IgM (U\/ml):<\/strong><\/div>\n<ul>\n<li>&lt;7 Negativ<\/li>\n<li>7-10 Echivoc<\/li>\n<li>&gt;10 Pozitiv<\/li>\n<\/ul>\n<p><strong><em>Interpretarea rezultatelor<\/em><\/strong><\/p>\n<p>Ob\u0163inerea unor titruri crescute de anti-\u03b22GP1 (la cel pu\u0163in 2 determin\u0103ri efectuate la un interval de 12 s\u0103pt\u0103m\u00e2ni) la pacien\u0163i cu tablou clinic sugestiv sus\u0163ine diagnosticul de sindrom antifosfolipidic, chiar dac\u0103 s-au ob\u0163inut\u00a0<a title=\"rezultate\" href=\"https:\/\/www.synevo.ro\/rezultate\/\" data-wpel-link=\"internal\" rel=\"nofollow noopener\" target=\"_blank\">rezultate<\/a>\u00a0negative pentru anticoagulantul lupic \u015fi anticorpii anti-cardiolipinici<sup>2;3<\/sup>.<\/p>\n<p>Pe de alt\u0103 parte, ob\u0163inerea unui rezultat negativ pentru anti-\u03b22GP1 la pacien\u0163i cu anticorpi anti-cardiolipinici pozitivi, care \u00eens\u0103 nu prezint\u0103 criterii clinice certe, nu sus\u0163ine diagnosticul de sindrom anti-fosfolipidic<sup>2<\/sup>.<\/p>\n<p><strong><em>Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n<p>Ob\u0163inerea unui rezultat negativ pentru anti-\u03b22GP1 la un pacient cu tablou clinic sugestiv de sindrom antifosfolipidic nu exclude diagnosticul, fiind necesar\u0103 determinarea \u015fi a celorlate 2 teste care intr\u0103 \u00een criteriile diagnosticului de laborator: anticoagulantul lupic \u015fi anticorpii anticardiolipinici<sup>3;4<\/sup>.<\/p>\n<p><strong>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/strong><\/p>\n<div>1.\u00a0Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog<\/div>\n<div>2. Laboratory Corporation of America. Directory of Services and Interpretive Guide. \u03b2-2 Glycoprotein 1 Antibodies, IgA, IgG, IgM.\u00a0<a href=\"https:\/\/www.labcorp.com\/\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">www.labcorp.com<\/a>\u00a0. 2010. Ref Type: Internet Communication<\/div>\n<div>3. Miyakis S, Lockshin MD, Atsumi T, et al, \u201dInternational Consensus Statement on an Update of the Classification Criteria for Definite Antiphospholipid Syndrome (APS),\u201d J Thromb Haemost, 2006, 4(2):295-306.<\/div>\n<div>4.\u00a0<a href=\"https:\/\/www.mayomedicallaboratories.com\/\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">www.mayomedicallaboratories.com<\/a>. Test Catalog: Beta-2 Glycoprotein 1 Antibodies, IgA, IgG, IgM. Ref Type: Internet Communication.<\/div>","protected":false},"excerpt":{"rendered":"<p>\u041a\u0430\u0440\u0434\u0438\u043e\u043b\u0438\u043f\u0438\u043d\u043e\u0432\u044b\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430, \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u043d\u044b\u0435 \u0434\u043b\u044f \u0430\u043d\u0442\u0438\u0444\u043e\u0441\u0444\u043e\u043b\u0438\u043f\u0438\u0434\u043d\u043e\u0433\u043e \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0430, \u0434\u043b\u044f \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u043d\u0438\u044f \u0441 \u043a\u0430\u0440\u0434\u0438\u043e\u043b\u0438\u043f\u0438\u043d\u043e\u043c \u0442\u0440\u0435\u0431\u0443\u044e\u0442 \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u044f \u0431\u0435\u043b\u043a\u043e\u0432\u043e\u0433\u043e \u043a\u043e\u0444\u0430\u043a\u0442\u043e\u0440\u0430. \u0411\u0435\u0442\u0430-2-\u0433\u043b\u0438\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d 1 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IgM<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[928,930],"product_tag":[],"class_list":{"0":"post-10058","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-boli-autoimune","6":"product_cat-markeri-pentru-sindromul-antifosfolipidic","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10058","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10058"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10058"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10058"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10058"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10058"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}