{"id":10047,"date":"2020-04-23T03:54:56","date_gmt":"2020-04-23T00:54:56","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/lactoferin-in-materii-fecale\/"},"modified":"2025-02-05T15:22:01","modified_gmt":"2025-02-05T13:22:01","slug":"lactoferin-in-materii-fecale","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/lactoferin-in-materii-fecale\/","title":{"rendered":"\u041b\u0430\u043a\u0442\u043e\u0444\u0435\u0440\u0440\u0438\u043d \u0432 \u043a\u0430\u043b\u0435"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong><em>\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">Lactoferina este o protein\u0103 care leag\u0103 fierul, prezent\u0103\u00a0\u00een secre\u0163iile mucoase (saliv\u0103, lacrimi, lapte matern) \u015fi \u00een granulele specifice ale neutrofilelor. Se consider\u0103 c\u0103 exercit\u0103 o ac\u0163iune antibacterian\u0103.<\/p>\n<p style=\"text-align: justify;\">Lactoferina detectat\u0103 \u00een scaun este o m\u0103sur\u0103 direct\u0103 a migr\u0103rii chemotactice a granulocitelor din peretele intestinal \u00een lumen \u015fi, prin aceasta, un marker al unui proces inflamator celular. Deoarece lactoferina provine din r\u0103spunsul imun celular nespecific, nu are specificitate \u00een ceea ce prive\u015fte boala de baz\u0103, ci indic\u0103, \u00een general, prezen\u0163a \u015fi extinderea unei inflama\u0163ii.<\/p>\n<p style=\"text-align: justify;\">Determinarea este util\u0103 \u00een eviden\u0163ierea sau excluderea unui proces inflamator acut, ca \u00een infec\u0163iile bacteriene, dar \u015fi pentru monitorizarea activit\u0103\u0163ii \u00een boli inflamatorii cronice deja depistate, cum ar fi: boala Crohn, diverticulita, colita ulceroas\u0103<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Determinarea lactoferinei permite diagnosticul diferen\u0163ial \u00eentre tulbur\u0103rile func\u0163ionale intestinale \u00een care nu exist\u0103 activitate inflamatorie (sindromul de colon iritabil) de bolile organice. Astfel, conform studiilor efectuate, determinarea lactoferinei \u00een materiile fecale prezint\u0103 o sensibilitate de 86% \u015fi o specificitate de 100% pentru diferen\u0163ierea bolilor inflamatorii intestinale de sindromul de colon iritabil, dup\u0103 excluderea infec\u0163iilor \u015fi a cancerului colorectal<sup>2;3<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Lactoferina a fost folosit\u0103 \u015fi \u00een diagnosticul polipilor \u015fi tumorilor colorectale precum \u015fi a intoleran\u0163elor alimentare. Sensibilitatea \u00een cazul depist\u0103rii inflama\u0163iilor floride s-a dovedit \u00een studii mari a fi de ~90%, iar specificitatea de ~ 85%<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Un studiu recent care a inclus copii cu boala Crohn afla\u0163i \u00een tratament cu Infliximab a indicat faptul c\u0103 lactoferina fecal\u0103 reprezint\u0103 un biomarker sensibil \u015fi specific at\u00e2t pentru inflama\u0163ia intestinal\u0103 c\u00e2t \u015fi pentru evaluarea r\u0103spunsului la tratament<sup>4<\/sup>.<\/p>\n<p style=\"text-align: justify;\">\u00cen ceea ce prive\u015fte proctita acut\u0103 de iradiere, dintre cei 8 markeri testa\u0163i \u00een materiile fecale ale pacien\u0163ilor dintr-un studiu, doar lactoferina \u015fi calprotectina au prezentat concentra\u0163ii semnificativ crescute \u00een cursul radioterapiei, ceea ce a dus la indica\u0163ia c\u0103 acestea ar putea constitui markeri non-invazivi pentru proctita acut\u0103 indus\u0103 de iradiere<sup>1<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Recomand\u0103ri pentru determinarea lactoferinei fecale<\/em><\/strong><\/p>\n<ul>\n<li style=\"text-align: justify; padding-left: 30px;\">diferen\u0163ierea pacien\u0163ilor cu sindrom de colon iritabil de cei cu boli inflamatorii intestinale;<\/li>\n<li style=\"text-align: justify; padding-left: 30px;\">monitorizarea activit\u0103\u0163ii inflamatorii la pacien\u0163ii cu boli inflamatorii intestinale<sup>2;3<\/sup>.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong><em>Preg\u0103tire pacient<\/em><\/strong> \u2013 se va evita administrarea de antiinflamatoare nesteroidiene cu 2 zile \u00eenaintea recolt\u0103rii<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Specimen recoltat<\/em><\/strong> \u2013 materii fecale prospete, emise spontan \u00een orice moment al zilei<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Recipient de recoltare<\/em><\/strong> \u2013 recipient de unic\u0103 folosin\u0163\u0103 pentru fecale bine \u00eenchis cu capac; este interzis\u0103 ad\u0103ugarea de substan\u0163e conservante<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Volumul probei<\/em><\/strong> \u2013 aproximativ 2g<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Stabilitate prob\u0103<\/em><\/strong> - <em>7 zile<\/em> la 2-8\u00b0<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Metod\u0103<\/em> <\/strong>-\u00a0 <span style=\"text-decoration: underline;\">ELISA<\/span><sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Valori de referin\u0163\u0103 <\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">Negativ: &lt; 3 mg\/L<\/p>\n<p style=\"text-align: justify;\">Echivoc: 3 \u2013 7.3 mg\/L<\/p>\n<p style=\"text-align: justify;\">Pozitiv: &gt; 7.3 mg\/L<sup>2<\/sup><\/p>\n<div style=\"text-align: justify;\"><strong><em>Interpretarea rezultatelor<\/em><\/strong><\/div>\n<div style=\"text-align: justify;\">Ob\u0163inerea unui rezultat pozitiv indic\u0103 prezen\u0163a unei inflama\u0163ii intestinale<sup>3<\/sup>.<\/div>\n<p style=\"text-align: justify;\"><span style=\"font-size: small;\">\u00a0<\/span><\/p>\n<div style=\"text-align: justify;\"><strong><span style=\"font-size: 10pt;\">\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">1. A. Larsen et al. Faecal calprotectin and lactofferin as markers of acute radiation proctitis: a pilot study of eight stool markers. In Scandinavian Journal of of Gastroenterology, Volume 39, Number 11, Nov. 2004, 1113-1118(6).<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">2. Laborator Synevo. Referin\u0163e specifice tehnologiei de lucru utilizate 2015. Ref Type: Catalog.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">3. Quest Diagnostics. Test Menu. Lactofferin. Non-invasive differentiation of Irritable Bowel Syndrome (IBS) from Inflammatory Bowel Disease (IBD). Ref Type: Internet Communication.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">4. Stephan Buderus et al. Fecal Lactoferrin: A New Parameter to Monitor Infliximab Therapy. In Digestive Diseases and Sciences, Volume 49, Number 6, June 2004.<\/span><\/div>","protected":false},"excerpt":{"rendered":"<p>\u041b\u0430\u043a\u0442\u043e\u0444\u0435\u0440\u0440\u0438\u043d \u2013 \u0433\u043b\u0438\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d, \u0432\u044b\u0440\u0430\u0431\u0430\u0442\u044b\u0432\u0430\u0435\u043c\u044b\u0439 \u043d\u0435\u0439\u0442\u0440\u043e\u0444\u0438\u043b\u0430\u043c\u0438. \u042f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0435\u043c \u043e\u0441\u0442\u0440\u043e\u0439 \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0440\u0435\u0430\u043a\u0446\u0438\u0438 \u0438 \u0432\u044b\u0441\u0432\u043e\u0431\u043e\u0436\u0434\u0430\u0435\u0442\u0441\u044f \u0438\u0437 \u043b\u0435\u0439\u043a\u043e\u0446\u0438\u0442\u043e\u0432 \u043f\u0440\u0438 \u0438\u0445 \u0430\u043a\u0442\u0438\u0432\u0430\u0446\u0438\u0438 \u0438\u043b\u0438 \u0433\u0438\u0431\u0435\u043b\u0438.<\/p>\n<p>\u041f\u0440\u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u041a\u0440\u043e\u043d\u0430 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u044f \u0444\u0435\u043a\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u043b\u0430\u043a\u0442\u043e\u0444\u0435\u0440\u0440\u0438\u043d\u0430 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430\u0435\u0442 \u0432 \u0434\u0435\u0441\u044f\u0442\u043a\u0438 \u0438 \u0441\u043e\u0442\u043d\u0438 \u0440\u0430\u0437, \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u043f\u043e\u0432\u044b\u0448\u0430\u0435\u0442\u0441\u044f \u0432 \u043a\u0430\u043b\u0435 \u0438 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u043a\u0430\u043b\u044c\u043f\u0440\u043e\u0442\u0435\u043a\u0442\u0438\u043d\u0430. \u041f\u043e\u044d\u0442\u043e\u043c\u0443 \u0442\u0435\u0441\u0442 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043e\u0447\u0435\u043d\u044c \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u043c \u0438 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u044b\u043c \u043f\u0440\u0438 \u0434\u0430\u043d\u043d\u043e\u0439 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438.<\/p>\n<p>\u0424\u0435\u043a\u0430\u043b\u044c\u043d\u044b\u0439 \u043b\u0430\u043a\u0442\u043e\u0444\u0435\u0440\u0440\u0438\u043d \u0442\u0430\u043a\u0436\u0435 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u043c \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0434\u0438\u0430\u0440\u0435\u0438 \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432, \u043a\u043e\u0442\u043e\u0440\u0430\u044f \u0432\u044b\u0437\u0432\u0430\u043d\u0430, \u043d\u0430\u043f\u0440\u0438\u043c\u0435\u0440 Shigella, Salmonella, Campylobacter \u0438 Clostridium difficile.<\/p>\n<p><strong>\u041f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c \/ \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0430<\/strong><\/p>\n<p>\u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435 \u0443\u0440\u043e\u0432\u043d\u044f:<\/p>\n<ul>\n<li>\u0431\u043e\u043b\u0435\u0437\u043d\u044c \u041a\u0440\u043e\u043d\u0430 \u0438 \u043d\u0435\u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u044f\u0437\u0432\u0435\u043d\u043d\u044b\u0439 \u043a\u043e\u043b\u0438\u0442;<\/li>\n<li>\u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u044b\u0435 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438 \u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e-\u043a\u0438\u0448\u0435\u0447\u043d\u043e\u0433\u043e \u0442\u0440\u0430\u043a\u0442\u0430;<\/li>\n<li>\u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0435 \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u044f \u0441\u043b\u0438\u0437\u0438\u0441\u0442\u043e\u0439 \u043e\u0431\u043e\u043b\u043e\u0447\u043a\u0438 \u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e\u0433\u043e \u0442\u0440\u0430\u043a\u0442\u0430 \u043f\u0440\u0438 \u0446\u0435\u043b\u0438\u0430\u043a\u0438\u0438, \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u043e\u043c \u0433\u0430\u0441\u0442\u0440\u0438\u0442\u0435, \u0434\u0438\u0432\u0435\u0440\u0442\u0438\u043a\u0443\u043b\u0438\u0442\u0435, \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u044b\u0445 \u0438 \u0432\u0438\u0440\u0443\u0441\u043d\u044b\u0445 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044f\u0445 \u0416\u041a\u0422,<\/li>\n<li>\u043d\u043e\u0432\u043e\u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044f\u0445 \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a\u0430, \u043c\u0443\u043a\u043e\u0432\u0438\u0441\u0446\u0438\u0434\u043e\u0437\u0435, \u0430\u043b\u043b\u0435\u0440\u0433\u0438\u0438 \u043a \u043a\u043e\u0440\u043e\u0432\u044c\u0435\u043c\u0443 \u043c\u043e\u043b\u043e\u043a\u0443, \u043a\u0438\u0448\u0435\u0447\u043d\u043e\u043c \u043a\u0440\u043e\u0432\u043e\u0442\u0435\u0447\u0435\u043d\u0438\u0438.<\/li>\n<\/ul>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[928,938],"product_tag":[],"class_list":{"0":"post-10047","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-boli-autoimune","6":"product_cat-markeri-pentru-monitorizarea-evolutiei-si-tratamentului","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10047","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10047"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10047"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10047"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10047"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}