{"id":10039,"date":"2020-04-23T03:54:42","date_gmt":"2020-04-23T00:54:42","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/comp-cartilage-oligomeric-matrix-protein\/"},"modified":"2025-02-05T15:14:28","modified_gmt":"2025-02-05T13:14:28","slug":"comp-cartilage-oligomeric-matrix-protein","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/comp-cartilage-oligomeric-matrix-protein\/","title":{"rendered":"COMP (\u0431\u0435\u043b\u043e\u043a \u0445\u0440\u044f\u0449\u0435\u0432\u043e\u0433\u043e \u043e\u043b\u0438\u0433\u043e\u043c\u0435\u0440\u043d\u043e\u0433\u043e \u043c\u0430\u0442\u0440\u0438\u043a\u0441\u0430)"},"content":{"rendered":"<p><strong><em>Informa<\/em><\/strong><strong><em>\u0163<\/em><\/strong><strong><em>ii generale \u015fi recomand\u0103ri pentru determinarea COMP<\/em><\/strong><\/p>\n<p>CARTILAJ OLIGOMERIC MATRIX PROTEIN (COMP) reprezint\u0103 un marker serologic specific care evalueaz\u0103 gradul de degradare a cartilajului articular \u015fi turn-over-ul acestuia. Este detectabil at\u00e2t \u00een s\u00e2nge c\u00e2t \u015fi \u00een lichidul sinovial.<\/p>\n<p>Cartilajul articular este un tip de \u0163esut conjunctiv alc\u0103tuit din celule (condrocite) \u015fi o matrice extracelular\u0103. Matricea extracelular\u0103 este reprezentat\u0103 de ap\u0103 (75-80%) \u015fi un reziduu uscat format dintr-o re\u0163ea de macromolecule: colagen (50-60%), proteoglicani (20-25%), proteine necolagenice, enzime, factori de cre\u015ftere, lipide. Colagenul articular este reprezentat \u00een principal de colagenul de tip II \u015fi, \u00een mai mic\u0103 m\u0103sur\u0103, de alte tipuri (V, VI, IX, XI)<sup>1<\/sup>.<\/p>\n<p>COMP se g\u0103se\u015fte \u00een cartilajul articular \u00eentr-un procent de 0,5-1%, fiind o component\u0103 structural\u0103 a acestuia cu rol \u00een fibrilogeneza colagenului. Din punct de vedere biochimic, COMP este o glicoprotein\u0103 cu greutatea molecular\u0103 de 525 kD ce apar\u0163ine familiei de proteine denumite trombospondine \u015fi este alc\u0103tuit\u0103 din 5 subunit\u0103\u0163i identice legate prin pun\u0163i disulfidice. Una din func\u021biile principale ale acestei proteine este de de cataliza fibrilogeneza colagenului prin interac\u021biunea direct\u0103 cu fibrilele de colagen, iar la adult este implicat\u0103 \u00een stabilizarea matricei extracelulare ca urmare a interac\u021biunii cu molecule ce sunt ata\u0219ate la suprafa\u021ba fibrelor de colagen (matriline)<sup>2<\/sup>. COMP este sintetizat\u0103 \u00een sinoviocite \u015fi condrocite; se g\u0103se\u015fte de asemenea \u00een tendoane, menisc, cartilajul nazal \u015fi traheal<sup>3<\/sup>.<\/p>\n<p>Niveluri serice ridicate ale COMP se \u00eent\u00e2lnesc \u00een condi\u021bii de turn-over \u00a0crescut ale cartilajului articular asociate cu artropatii \u00een stadiu activ, cum ar fi artrita reumatoid\u0103 sau osteoartrita. Nivelul de COMP este mai mare \u00een lichidul sinovial dec\u00e2t \u00een s\u00e2nge, indic\u00e2nd eliberarea acestuia \u00een circula\u0163ie din articula\u0163iile afectate<sup>2<\/sup>. Administrarea la \u0219oareci a proteinei COMP provenit\u0103 de la \u0219obolan induce o artrit\u0103 cronic\u0103 sever\u0103, recurent\u0103, suger\u00e2nd faptul c\u0103 aceasta ar interveni \u00een dezvoltarea bolii articulare<sup>4<\/sup>.<\/p>\n<p>Studiile clinice au demonstrat c\u0103 nivelul de COMP nu se\u00a0 coreleaz\u0103 cu anticorpii anti-CCP, factorul reumatoid \u015fi markerii de inflama\u0163ie (proteina C reactiv\u0103 sau VSH)<sup>2<\/sup>. Nivelul crescut de COMP se asociaz\u0103 \u00een schimb cu un grad crescut al distruc\u0163iei articulare \u015fi are valoare predictiv\u0103 pentru distruc\u0163ia articular\u0103 activ\u0103. Astfel, testul COMP poate detecta stadiile timpurii ale degrad\u0103rii articulare (in artrita reumatoid\u0103 precoce)<sup>3<\/sup>. De asemenea, cre\u0219terile COMP \u00een primele 3 luni de la diagnostic \u00een artrita reumatoid\u0103 precoce pot identifica pacien\u021bii cu risc crescut de progresie important\u0103 a bolii \u00een urm\u0103torii 5 ani<sup>5<\/sup>.<\/p>\n<p>Determinarea \u00een dinamic\u0103 a nivelului seric COMP poate fi util\u0103 \u00een monitorizarea pacien\u021bilor cu artrit\u0103 reumatoid\u0103 ce primesc tratament cu antagoni\u0219ti de TNF-alfa (factor de necroz\u0103 tumoral\u0103 alfa). \u00centr-un studiu prospectiv s-a ar\u0103tat c\u0103 pacien\u021bii care au ob\u021binut remisiune clinic\u0103 a bolii (evaluat\u0103 cu ajutorul scorului de activitate DS-28) dup\u0103 6 luni de tratament\u00a0 cu etanercept au prezentat niveluri COMP semnificativ sc\u0103zute comparativ cu valorile bazale, \u00een timp ce viteza de sedimentare a hematiilor (VSH) \u0219i proteina C reactiv\u0103 (CRP) au \u00eenregistrat sc\u0103deri indiferent de statusul remisiunii<sup>6<\/sup>.<\/p>\n<p>De asemenea, COMP seric poate reprezenta un marker de diagnostic \u0219i de prognostic \u00een osteoartrita genunchiului, identific\u00e2nd pacien\u021bii cu risc crescut de progresie rapid\u0103 a acestei afec\u021biuni. Nivelul seric COMP r\u0103m\u00e2ne semnificativ crescut \u00een primii 3 ani de boal\u0103<sup>7<\/sup>.<\/p>\n<p>\u00centr-un studiu recent, administrarea de bifosfona\u021bi (clodronat) pentru tratamentul osteoartritei active erozive a m\u00e2inii timp de 6 luni a fost \u00eenso\u021bit\u0103 de amelioarea durerii \u0219i reducerea consumului de antiinflamatorii nesteroidiene al\u0103turi de sc\u0103derea semnificativ\u0103 a concentra\u021biilor serice COMP. Astfel, COMP poate servi ca instrument obiectiv de evaluare a efcien\u021bei tratamentului<sup>8<\/sup>.<\/p>\n<p>La pacien\u021bii cu scleroz\u0103 sistemic\u0103 nivelul seric COMP poate constitui un indicator util pentru afectarea articular\u0103 \u0219i permite stratificarea pacien\u021bilor \u00een func\u021bie de riscul de a dezvolta distruc\u021bie articular\u0103 \u0219i sindrom overlap scleroz\u0103 sistemic\u0103-artrit\u0103 reumatoid\u0103<sup>9<\/sup>.<\/p>\n<p>\u00cen concluzie, testul COMP poate fi folosit ca:<\/p>\n<ul>\n<li>Marker al distruc\u0163iei articulare actuale<\/li>\n<li>Factor de prognostic pentru degradarea cartilajului articular<\/li>\n<li>Monitorizarea tratamentului artritei reumatoide cu antagoni\u015fti de TNF-alfa cu posibil\u0103 identificare a non-responder-ilor la tratament<sup>10<\/sup><\/li>\n<li>Marker de diagnostic, prognostic \u0219i de evaluare a r\u0103spunsului terapeutic \u00een osteoartrita activ\u0103<sup>8<\/sup><\/li>\n<li>Indicator de afectare articular\u0103 la pacien\u021bii cu scleroz\u0103 sistemic\u0103<sup>9<\/sup>.<\/li>\n<\/ul>\n<p><strong><em>Preg\u0103tire pacient <\/em><\/strong><em>- <\/em>nu este necesar\u0103<sup>3<\/sup>.<\/p>\n<p><strong><em>Specimen recoltat <\/em><\/strong><em>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c<sup>3<\/sup>.<\/p>\n<p><strong><em>Recipient de recoltare <\/em><\/strong><em>- <\/em>vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator<sup>3<\/sup>.<\/p>\n<p><strong><em>Volum prob\u0103<\/em><\/strong> \u2013 minim 1 mL ser<sup>3<\/sup>.<\/p>\n<p><strong><em>Cauze de respingere<\/em><\/strong> <strong><em>a probei <\/em><\/strong>\u2013 specimen hemolizat, icteric, lipemic sau contaminat bacterian<sup>3<\/sup>.<\/p>\n<p><strong><em>Stabilitate prob\u0103 <\/em><\/strong><em>- <\/em>serul separat este stabil <em>7 zile <\/em>la 4\u00b0C; <em>timp mai \u00eendelungat<\/em> la -20\u00b0C. Nu decongela\u0163i\/recongela\u0163i<sup>3<\/sup>.<\/p>\n<p><strong><em>Metod\u0103 <\/em><\/strong>- <u>ELISA<\/u><sup>3<\/sup>.<\/p>\n<p><strong><em>Valori de referin\u0163\u0103 <\/em><\/strong>\u2013 &lt;15.1 U\/L<sup>3<\/sup>.<\/p>\n<p><em><strong>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/strong><\/em><\/p>\n<ol>\n<li>Magda Negru. Articula\u0163iile. \u00cen <em>Esen\u0163ialul \u00een Reumatologie<\/em>. Editura Amaltea, Ed.2, 2007,\u00a0 68-72.<\/li>\n<li>Happonen KE, Saxne T, Aspberg A, M\u00f6rgelin M, Heineg\u00e5rd D, Blom AM. Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis. Arthritis Rheum. 2010 Dec;62(12):3574-83<\/li>\n<li>Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2017. Ref Type: Catalog.<\/li>\n<li>Carlsen S, Nandakumar KS, Backlund J, Holmberg J, Hultqvist M, Vestberg M, et al. Cartilage oligomeric matrix protein induction of chronic arthritis in mice. Arthritis Rheum. 2008;58(7):2000\u20132011.<\/li>\n<li>Andersson ML, Svensson B, Petersson IF, Hafstr\u00f6m I, Albertsson K, Forslind K, Heineg\u00e5rd D, <strong>Saxne<\/strong> T. Early increase in serum-COMP is associated with joint damage progression over the first five years in patients with rheumatoid arthritis. BMC Muskuloskelet Disord 2013 Aug 2;14:229.<\/li>\n<li>Kawashiri SY, Kawakami A, Ueki Y, Imazato T, Iwamoto N, Fujikawa K, Aramaki T, Tamai M, Nakamura H, Origuchi T, Ida H, Eguchi Decrement of serum cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis (RA) patients achieving remission after 6 months of etanercept treatment: comparison with CRP, IgM-RF, MMP-3 and anti-CCP Ab.<\/li>\n<li>Verma P, Dalal K. Serum cartilage oligomeric matrix protein (COMP) in knee osteoarthritis: a novel diagnostic and prognostic biomarker. J Orthop Res. 2013 Jul;31(7):999-1006.<\/li>\n<li>Saviola G, Abdi-Ali L, Povino MR, Campostrini L, Sacco S, Carbonare LD. Intramuscular clodronate in erosive osteoarthritis of the hand is effective on pain and reduces serum COMP: a randomized pilot trial-The ER.O.D.E. study (ERosive Osteoarthritis and Disodium-clodronate Evaluation).<\/li>\n<li>Gheita TA, Hussein H. Cartilage Oligomeric Matrix Protein (COMP) in systemic sclerosis (SSc): role in disease severity and subclinical rheumatoid arthritis overlap. Cartilage Oligomeric Matrix Protein (COMP) in systemic sclerosis (SSc): role in disease severity and subclinical rheumatoid arthritis overlap. Clin Rheumatol. 2017 May 23.<\/li>\n<li>E.William, St.Clair, David S.Pisetsky, Barton F.Haynes. Rheumatoid artritis. Ed.Lippincott Williams,2004.<\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"<p>\u041e\u0431\u043b\u0430\u0441\u0442\u044c \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0442\u0435\u0441\u0442\u0430 \u2013 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u043e\u0441\u0442\u0435\u043e\u0430\u0440\u0442\u0440\u043e\u0437\u0430, \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u0439 \u0441\u0443\u0441\u0442\u0430\u0432\u043d\u043e\u0433\u043e \u0445\u0440\u044f\u0449\u0430.<\/p>\n<p>\u041e\u043b\u0438\u0433\u043e\u043c\u0435\u0440\u043d\u044b\u0439 \u043c\u0430\u0442\u0440\u0438\u043a\u0441\u043d\u044b\u0439 \u0431\u0435\u043b\u043e\u043a \u0445\u0440\u044f\u0449\u0430 (COMP) \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 \u0441\u043e\u0431\u043e\u0439 \u043d\u0435\u043a\u043e\u043b\u043b\u0430\u0433\u0435\u043d\u043e\u0432\u044b\u0439 \u0431\u0435\u043b\u043e\u043a \u0441 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