{"id":10025,"date":"2020-04-23T03:54:18","date_gmt":"2020-04-23T00:54:18","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/anticorpi-anti-histone-igg\/"},"modified":"2025-02-05T14:47:30","modified_gmt":"2025-02-05T12:47:30","slug":"anticorpi-anti-histone-igg","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/anticorpi-anti-histone-igg\/","title":{"rendered":"\u0410\u043d\u0442\u0438\u043d\u0443\u043a\u043b\u0435\u043e\u0441\u043e\u043c\u043d\u044b\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 IgG"},"content":{"rendered":"

Informa\u0163<\/em><\/strong>ii generale \u015fi recomand\u0103ri pentru determinarea anticorpilor anti-histone<\/em><\/strong><\/p>\n

Histonele sunt \u00eempreun\u0103 cu\u00a0ADN-ul componentele esen\u0163iale ale cromatinei nucleare. Acestea sunt constituite din proteine bogate\u00a0\u00een aminoacizii arginin\u0103<\/em> \u0438 lizin\u0103<\/em>, iar una din func\u0163iile lor importante este implicarea \u00een organizarea structural\u0103 a cromatinei \u00een nucleozomi3<\/sup>.<\/p>\n

Toate cele cinci clase de histone (H1, H2A, H2B, H3, H4) ca \u015fi complexele ADN-histone pot fi \u0163int\u0103 pentru producerea de autoanticorpi.<\/p>\n

Anticorpii antihistone apar la aproximativ 95% dintre pacien\u0163ii cu lupus eritematos indus medicamentos \u015fi reprezint\u0103 cel mai important criteriu de diagnostic. Lupusul indus medicamentos este clinic similar cu lupusul eritematos sistemic, except\u00e2nd afectarea \u0163esutului renal\u00a0\u015fi nervos \u015fi asocierea cu anticorpii anti-ADN dublu catenar (care apar la un procent redus de pacien\u0163i sau pot fi absen\u0163i)2<\/sup>.<\/p>\n

Cele mai frecvente medicamente implicate\u00a0\u00een apari\u0163ia lupusului medicamentos sunt: procainamida, hidralazina, isoniazida, carbamazepina, penicilamina, clorpromazina, alfa metildopa, chinidina, salazosulfapiridina, minociclina.<\/p>\n

Anticorpii anti-histone prezen\u0163i \u00een lupusul indus de procainamid\u0103 sunt \u00eendrepta\u0163i \u00eempotriva complexului H2A-H2B, \u00een timp ce \u00een lupusul indus de hidralazina, anticorpii au drept \u0163int\u0103 histonele H2A \u015fi H3.<\/p>\n

Anticorpii antihistone sunt detecta\u0163i \u015fi la 30-60% dintre pacien\u0163ii cu lupus eritematos sistemic, deseori asocia\u0163i cu anticorpii anti-ADN dublu catenar. In LES idiopatic, anticorpii au drept \u0163int\u0103 histonele H1, H2B \u015fi complexul H2A-H2B. Diferen\u0163ierea \u00eentre lupusul eritematos sistemic \u015fi lupusul indus medicamentos pe baza determin\u0103rii de anticorpi antihistone nu este \u00eentotdeauna posibil\u0103. Totu\u015fi, \u00een lupusul indus medicamentos anticorpii antihistone sunt \u00een general prezen\u0163i f\u0103r\u0103 asocierea anticorpilor anti-ADN dublu catenar3;5<\/sup>.<\/p>\n

Preg\u0103tire pacient <\/em><\/strong>- <\/em>\u00e0 jeun (pe nem\u00e2ncate) sau postprandial (dup\u0103 mese)1<\/sup>.<\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c1<\/sup>.<\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator1<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare<\/em><\/strong> \u2013 se separ\u0103 serul prin centrifugare1<\/sup>.<\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 minim 1 mL ser1<\/sup>.<\/p>\n

Cauze de respingere<\/em><\/strong> a probei<\/em><\/strong><\/p>\n

\u2022 specimen hemolizat<\/div>\n
\u2022 specimen icteric, lipemic<\/div>\n
\u2022 specimen contaminat bacterian1<\/sup><\/div>\n

Stabilitate prob\u0103 <\/em><\/strong>- <\/em>serul separat este stabil 7 zile<\/em> la 2-8\u00b0C \u015fi\u00a0timp \u00eendelungat <\/em>\u00a0la -20\u00b0C sau la -70\u00b0C. Nu decongela\u0163i\/recongela\u0163i1<\/sup>.<\/p>\n

Metod\u0103 <\/em><\/strong>- ELISA<\/span>1<\/sup>.<\/p>\n

Valori de referin\u0163\u0103 <\/em><\/strong>\u2013 < 20E\/mL1<\/sup>.<\/p>\n

Interpretarea rezultatelor<\/em><\/strong><\/p>\n

Un rezultat pozitiv pentru anticorpii anti-histone asociat cu un rezultat negativ pentru anticorpii anti-ADN dublu catenar este sugestiv pentru lupusul indus medicamentos.<\/div>\n
Un rezultat pozitiv pentru anticorpii anti-histone asociat cu un rezultat pozitiv pentru anticorpii anti-ADN dublu catenar este sugestiv pentru lupusul eritematos sistemic4<\/sup>.<\/div>\n

Anticorpii antihistone pot s\u0103 apar\u0103 \u015fi \u00een alte afec\u0163iuni, cum ar fi:<\/p>\n

    \n
  • Artrita reumatoid\u0103: titrul anticorpilor antihistone tinde s\u0103 fie sc\u0103zut; \u0163inta antigenic\u0103 este reprezentat\u0103 de histona H1; \u00een prezen\u0163a manifest\u0103rilor extraarticulare (de exemplu, sindromul Felty) titrul anticorpilor antihistone este mai crescut<\/li>\n
  • Scleroza sistemic\u0103<\/li>\n
  • Artrita cronic\u0103 juvenil\u0103<\/li>\n
  • Boli autoimune hepatice: ciroza biliar\u0103 primitiv\u0103 \u015fi hepatita autoimun\u01033<\/sup>.<\/li>\n<\/ul>\n

    Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n

    Titrul anticorpilor anti-histone nu are valoare prognostic\u0103 la pacien\u0163ii cu LES sau lupus indus medicamentos.<\/div>\n
    Rezultate pozitive pot fi \u00eent\u00e2lnite la unii pacien\u0163i expu\u015fi la medicamentele men\u0163ionate mai sus care \u00eens\u0103 nu prezint\u0103 semne sau simptome de lupus4<\/sup>.<\/div>\n

    \u00a0<\/span><\/p>\n

    \u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

    1. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate. 2010. Ref Type: Catalog<\/span><\/span><\/div>\n
    2. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Antihistone antibodies Serum. www.labcorp.com 2010. Ref Type: Internet Communication.<\/span><\/div>\n
    3. Lothar Thomas. Autoantibodies in Systemic Rheumatic Diseases. In Clinical Laboratory Diagnostics-Use and Laboratory Results. TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany, 1 Ed., 1998; 810-811.<\/span><\/div>\n
    4. Mayo Clinic\/Mayo Medical Laboratories. Test Catalog. Histone Autoantibodies, Serum. www.mayomedicallaboratories.com. Ref Type: Internet Communication.<\/span><\/div>\n
    5. Ruxandra Ionescu. Lupusul eritematos sistemic. \u00cen Esen\u0163ialul \u00een Reumatologie. Editura Amaltea, Ed.2, 2007, 364.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

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    \u0421\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u043d\u043e, \u043e\u0434\u043d\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0435 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0430\u043d\u0442\u0438-dsDNA \u0438 \u0410\u0422 \u043a \u0433\u0438\u0441\u0442\u043e\u043d\u0430\u043c \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0435\u0442 \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u044c \u0434\u0438\u0444\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u0443\u044e \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0443 \u0421\u041a\u0412 \u0438 \u041b\u041a\u0412. \u041e\u0442\u043c\u0435\u043d\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u043f\u0440\u0438\u0432\u043e\u0434\u0438\u0442 \u043a \u043f\u043e\u0441\u0442\u0435\u043f\u0435\u043d\u043d\u043e\u043c\u0443 \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u044e \u0442\u0438\u0442\u0440\u043e\u0432 \u0430\u0443\u0442\u043e\u0410\u0422 \u0438 \u0438\u0445 \u0438\u0441\u0447\u0435\u0437\u043d\u043e\u0432\u0435\u043d\u0438\u044e \u0438\u0437 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0438 \u043a\u0440\u043e\u0432\u0438 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 6 \u043c\u0435\u0441. \u041a\u0440\u043e\u043c\u0435 \u0442\u043e\u0433\u043e, \u0410\u0422 \u043a \u0433\u0438\u0441\u0442\u043e\u043d\u0430\u043c \u043c\u043e\u0436\u043d\u043e \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u0442\u044c \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u043f\u0435\u0440\u0432\u0438\u0447\u043d\u044b\u043c \u0431\u0438\u043b\u0438\u0430\u0440\u043d\u044b\u043c \u0446\u0438\u0440\u0440\u043e\u0437\u043e\u043c, \u0420\u0410, \u0441\u043a\u043b\u0435\u0440\u043e\u0434\u0435\u0440\u043c\u0438\u0435\u0439, \u0410\u0418 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u043c. \u0414\u0430\u043d\u043d\u044b\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u0432\u0441\u0435\u0433\u0434\u0430 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u044e\u0442\u0441\u044f \u043f\u0440\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e-\u0438\u043d\u0434\u0443\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0439 \u0432\u043e\u043b\u0447\u0430\u043d\u043a\u0435 (\u043d\u043e\u0432\u043e\u043a\u0430\u0438\u043d\u0430\u043c\u0438\u0434, \u0433\u0438\u0434\u0440\u0430\u043b\u0430\u0437\u0438\u043d, \u0445\u0438\u043d\u0438\u0434\u0438\u043d, \u0438\u0437\u043e\u043d\u0438\u0430\u0437\u0438\u0434 \u0438 \u0434\u0440\u0443\u0433\u0438\u0435). \u0420\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u0438\u0435 — 95%. \u041a\u0440\u043e\u043c\u0435 \u0442\u043e\u0433\u043e, \u0434\u0430\u043d\u043d\u044b\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u044e\u0442\u0441\u044f \u0434\u043e 50% \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0421\u041a\u0412, \u0438 \u0432 \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u0441\u043b\u0443\u0447\u0430\u044f\u0445 — \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u043f\u0441\u0435\u0432\u0434\u043e\u0440\u0435\u0432\u043c\u0430\u0442\u0438\u0437\u043c\u043e\u043c.<\/p>\n\n\n\n\n\n\n\n\n\n\n
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    \u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b<\/b><\/td>\n\u0412\u0435\u043d\u043e\u0437\u043d\u0430\u044f\u00a0\u043a\u0440\u043e\u0432\u044c<\/td>\n<\/tr>\n
    \u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438\u00a0\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430<\/b><\/td>\n\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n
    \u0422\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u0430\u044f\u00a0\u0441\u0440\u0435\u0434\u0430,\u00a0\u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0430<\/b><\/td>\n\u0412\u0430\u043a\u0443\u0442\u0430\u0439\u043d\u0435\u0440\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0433\u0435\u043b\u0435\u0432\u043e\u0439\u00a0\u0444\u0430\u0437\u044b<\/td>\n<\/tr>\n
    \u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u0438\u00a0\u0443\u0441\u043b\u043e\u0432\u0438\u044f\u00a0\u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0438\u0440\u043e\u0432\u043a\u0438,\u00a0\u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c\u00a0\u043f\u0440\u043e\u0431\u044b<\/b><\/td>\n\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n
    <\/td>\n<\/td>\n<\/tr>\n
    <\/td>\n<\/td>\n<\/tr>\n
    <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n
    \u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u00a0\u043a\u00a0\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044e<\/b><\/td>\n<\/tr>\n
    \u041c\u0430\u0440\u043a\u0435\u0440\u00a0\u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e-\u0438\u043d\u0434\u0443\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0439\u00a0\u0432\u043e\u043b\u0447\u0430\u043d\u043a\u0438<\/b><\/p>\n

    \u0414\u0438\u0444\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u0430\u044f\u00a0\u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430:<\/p>\n

      \n
    • \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u0430\u044f \u043a\u0440\u0430\u0441\u043d\u0430\u044f \u0432\u043e\u043b\u0447\u0430\u043d\u043a\u0430;<\/li>\n
    • \u0432\u043e\u043b\u0447\u0430\u043d\u043e\u0447\u043d\u044b\u0439 \u0433\u043b\u043e\u043c\u0435\u0440\u0443\u043b\u043e\u043d\u0435\u0444\u0440\u0438\u0442;<\/li>\n
    • \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u0430\u044f \u0432\u043e\u043b\u0447\u0430\u043d\u043a\u0430<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
    \u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f\u00a0\u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/b><\/td>\n<\/tr>\n
    \u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435\u00a0\u0443\u0440\u043e\u0432\u043d\u044f<\/b><\/td>\n<\/tr>\n
    \n
      \n
    • \u0421\u041a\u0412;<\/li>\n
    • \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u0430\u044f \u0432\u043e\u043b\u0447\u0430\u043d\u043a\u0430;<\/li>\n
    • \u0441\u0438\u043d\u0434\u0440\u043e\u043c \u0428\u0435\u0433\u0440\u0435\u043d\u0430;<\/li>\n
    • \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u044b\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u0441\u043e\u0435\u0434\u0438\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0442\u043a\u0430\u043d\u0438;<\/li>\n
    • \u0410\u0418 \u0433\u0435\u043f\u0430\u0442\u0438\u0442;<\/li>\n
    • \u0420\u0410;<\/li>\n
    • \u0441\u043a\u043b\u0435\u0440\u043e\u0434\u0435\u0440\u043c\u0438\u044f;<\/li>\n
    • \u043f\u0435\u0440\u0432\u0438\u0447\u043d\u044b\u0439 \u0431\u0438\u043b\u0438\u0430\u0440\u043d\u044b\u0439 \u0446\u0438\u0440\u0440\u043e\u0437<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[928,929],"product_tag":[],"class_list":{"0":"post-10025","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-boli-autoimune","6":"product_cat-markeri-pentru-afectiuni-reumatismale-si-vasculite","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10025","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10025"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10025"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10025"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10025"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10025"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}