{"id":10019,"date":"2020-04-23T03:54:08","date_gmt":"2020-04-23T01:54:08","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/factorul-xii\/"},"modified":"2025-07-11T14:26:56","modified_gmt":"2025-07-11T11:26:56","slug":"factorul-xii-al-coagularii","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/factorul-xii-al-coagularii\/","title":{"rendered":"Factorul XII al coagularii"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/span><\/p>\n

Factorul XII sau factorul Hageman<\/strong>, o glicoprotein\u0103 sintetizat\u0103 la nivel hepatic, formeaz\u0103 \u00eempreun\u0103 cu prekalicreina \u015fi kininogenul cu greutate molecular\u0103 mare sistemul activ\u0103rii de contact. Ace\u015fti factori sunt necesari pentru formarea cheagului in vitro<\/em> la determinarea timpului de tromboplastin\u0103 par\u0163ial\u0103 activat (APTT). In tubul de testare factorul XII este activat prin contactul cu suprafe\u0163ele \u00eenc\u0103rcate negativ. Deficitul acestor factori nu<\/strong> se \u00eenso\u0163e\u015fte de manifest\u0103ri hemoragice deoarece coagularea fiziologic\u0103 este activat\u0103 prin c\u0103i alternative care \u015funteaz\u0103 activarea de contact2<\/sup>. Se consider\u0103 c\u0103 sistemul kalicreina-kinina nu de\u0163ine rol \u00een activarea coagul\u0103rii; acesta este important pentru controlul tensiunii arteriale prin contrabalansarea efectului sistemului renina-angiotensina, precum \u015fi\u00a0\u00een procesul de fibrinoliz\u01034<\/sup>.<\/span><\/p>\n

Deficitul de FXII este o tulburare congenital\u0103 cu transmitere autosomal recesiv\u0103. Statusul heterozigot este relativ frecvent, cu o prevalen\u0163\u0103 \u00een popula\u0163ie de 1.5-3%. De fapt, deficitul de factor XII constituie cauza cea mai frecvent\u0103 de prelungire a APTT la un pacient f\u0103r\u0103 istoric de sindrom hemoragipar,\u00a0\u00een absen\u0163a anticoagulantului lupic. Persoanele homozigote au de obicei o activitate a factorului XII <1% \u015fi pot asocia o alungire APTT de >100 secunde2;3<\/sup>.<\/span><\/p>\n

Factorul XII poate \u00eenregistra modific\u0103ri variate (at\u00e2t\u00a0\u00een sensul cre\u015fterii c\u00e2t \u015fi\u00a0\u00een sensul sc\u0103derii)\u00a0\u00een anumite condi\u0163ii clinice: septicemie, boala coronarian\u0103, tromboliza farmacologic\u0103, boala intestinal\u0103 inflamatorie, sarcin\u0103, acidoza lactic\u0103, dializ\u0103 \u015fi angioedem2<\/sup>.<\/span><\/p>\n

Testul se recomand\u0103 pentru elucidarea cazurilor de prelungire APTT ce nu sunt asociate cu manifest\u0103ri hemoragice2;4<\/sup>.<\/span><\/p>\n

Preg\u0103tire pacient<\/em><\/strong> - <\/em>\u00e0 jeun (pe nem\u00e2ncate)1<\/sup>.<\/span><\/p>\n

Specimen recoltat<\/em><\/strong> - <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c1<\/sup>.<\/span><\/p>\n

Recipient de recoltare<\/em><\/strong> \u2013 vacutainer cu citrat de Na 0.105M (raport citrat de sodiu \u2013 sange=1\/9). Presiunea realizat\u0103 de garou trebuie s\u0103 fie \u00eentre valoarea presiunii sistolice \u015fi cea a presiunii diastolice \u015fi nu trebuie s\u0103 dep\u0103\u015feasc\u0103 1 minut. Dac\u0103 punc\u0163ia venoas\u0103 a e\u015fuat, o nou\u0103 tentativ\u0103 pe aceea\u015fi ven\u0103 nu se poate face dec\u00e2t dup\u0103 10 minute1<\/sup>.<\/span><\/p>\n

Cantitate recoltat\u0103<\/em><\/strong> \u2013 c\u00e2t permite vacuumul; pentru a preveni coagularea par\u0163ial\u0103 a probei se va asigura amestecul corect al s\u00e2ngelui cu anticoagulantul, prin mi\u015fc\u0103ri de inversiune a tubului1<\/sup>.<\/span><\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>\u2013 proba va fi centrifugat\u0103 15 minute la 2500g, urmat\u0103 imediat de separarea plasmei \u015fi congelarea acesteia; probele recoltate \u00een afara laboratorului vor fi transportate\u00a0\u00een recipientul destinat probelor congelate1<\/sup>.<\/span><\/p>\n

Cauze de respingere a probei<\/em><\/strong> - <\/em>vacutainer care nu este plin; proba de s\u00e2nge hemolizat\u0103 sau coagulat\u0103; plasma care nu a ajuns congelat\u0103 la laborator1<\/sup>.<\/span><\/p>\n

Stabilitate prob\u0103<\/em><\/strong> \u2013 plasma separat\u0103 este stabil\u0103 4 ore<\/em> la temperatura camerei; 3 s\u0103pt\u0103m\u00e2ni<\/em> la\u00a0 \u2013 20\u00baC; > 1 an<\/em> la \u2013 70\u00baC1<\/sup>.<\/span><\/p>\n

Metoda <\/strong>- coagulometric\u0103<\/span> (const\u0103 \u00een m\u0103surarea timpului de coagulare a probei de investigat\u00a0\u00een prezen\u0163a cefalinei + activator \u015fi a unei plasme care con\u0163ine\u00a0\u00een exces to\u0163i factorii plasmatici ai coagul\u0103rii cu excep\u0163ia factorului XII)1<\/sup><\/span><\/p>\n

Valori de referin\u0163\u0103\u00a0<\/em><\/strong>\u00a0\u2013 60% -150%1<\/sup>.<\/span><\/p>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/span><\/div>\n
Inhibitorii de trombin\u0103 (hirudin, argatroban) prezen\u0163i \u00een proba de testat\u00a0 pot duce la o subestimare a nivelului\u00a0 factorului XII1<\/sup>.<\/span><\/div>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog<\/span><\/div>\n
2. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Factor XII Activity.www.labcorp.com 2010. Ref Type: Internet Communication.<\/span><\/div>\n
3. Radu P\u0103un. Tratat de medicin\u0103 intern\u0103. Hematologie. Partea II. Ed. Medical\u0103 1999, 779-854.<\/span><\/div>\n
4. Richard A. McPetersen, Matthew R. Pincus. Clinical diagnosis and management by laboratory methods. 2007, 729-743.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u0421\u0438\u0441\u0442\u0435\u043c\u0430 \u0433\u0435\u043c\u043e\u0441\u0442\u0430\u0437\u0430 \u2013 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0441\u0438\u0441\u0442\u0435\u043c\u0430, \u0432\u044b\u043f\u043e\u043b\u043d\u044f\u044e\u0449\u0430\u044f \u0432 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0435 \u0444\u0443\u043d\u043a\u0446\u0438\u0438 \u043f\u043e\u0434\u0434\u0435\u0440\u0436\u0430\u043d\u0438\u044f \u043f\u043e\u0441\u0442\u043e\u044f\u043d\u043d\u043e\u0433\u043e \u0443\u0440\u043e\u0432\u043d\u044f \u0432\u044f\u0437\u043a\u043e\u0441\u0442\u0438 \u043a\u0440\u043e\u0432\u0438, \u043e\u0441\u0442\u0430\u043d\u043e\u0432\u043a\u0438 \u043a\u0440\u043e\u0432\u043e\u0442\u0435\u0447\u0435\u043d\u0438\u0439 \u043f\u0440\u0438 \u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u044f\u0445 \u0441\u0442\u0435\u043d\u043e\u043a \u0441\u043e\u0441\u0443\u0434\u043e\u0432, \u0440\u0430\u0441\u0442\u0432\u043e\u0440\u0435\u043d\u0438\u044f \u0442\u0440\u043e\u043c\u0431\u043e\u0432, \u0432\u044b\u043f\u043e\u043b\u043d\u0438\u0432\u0448\u0438\u0445 \u0441\u0432\u043e\u044e \u0444\u0443\u043d\u043a\u0446\u0438\u044e. \u0424\u0430\u043a\u0442\u043e\u0440\u044b \u0441\u0432\u0435\u0440\u0442\u044b\u0432\u0430\u043d\u0438\u044f \u043a\u0440\u043e\u0432\u0438 \u2013 \u043e\u0434\u043d\u0438 \u0438\u0437 \u0432\u0430\u0436\u043d\u044b\u0445 \u043a\u043e\u043c\u043f\u043e\u043d\u0435\u043d\u0442\u043e\u0432 \u0441\u0438\u0441\u0442\u0435\u043c\u044b \u0433\u0435\u043c\u043e\u0441\u0442\u0430\u0437\u0430.<\/p>\n

\u0424\u0430\u043a\u0442\u043e\u0440 \u0441\u0432\u0435\u0440\u0442\u044b\u0432\u0430\u0435\u043c\u043e\u0441\u0442\u0438 \u043a\u0440\u043e\u0432\u0438 XII (F\u0425II) \u0441\u0438\u043d\u0442\u0435\u0437\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u0432 \u043f\u0435\u0447\u0435\u043d\u0438, \u0430 \u0435\u0433\u043e \u0430\u043a\u0442\u0438\u0432\u043d\u0430\u044f \u0444\u043e\u0440\u043c\u0430 (FXIIa) \u0438\u043d\u0438\u0446\u0438\u0438\u0440\u0443\u0435\u0442 \u0432\u043d\u0443\u0442\u0440\u0435\u043d\u043d\u0438\u0439 \u043f\u0443\u0442\u044c \u0441\u0432\u0435\u0440\u0442\u044b\u0432\u0430\u043d\u0438\u044f \u043a\u0440\u043e\u0432\u0438 \u043f\u043e\u0441\u0440\u0435\u0434\u0441\u0442\u0432\u043e\u043c \u0430\u043a\u0442\u0438\u0432\u0430\u0446\u0438\u0438 \u0444\u0430\u043a\u0442\u043e\u0440\u0430 XI.<\/p>\n

\u0412\u0440\u043e\u0436\u0434\u0435\u043d\u043d\u044b\u0439 \u0434\u0435\u0444\u0438\u0446\u0438\u0442 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 FXII (\u0431\u043e\u043b\u0435\u0437\u043d\u044c \u0425\u0430\u0433\u0435\u043c\u0430\u043d\u0430) \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e \u0440\u0435\u0434\u043a\u0438\u043c \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435\u043c (\u0447\u0430\u0441\u0442\u043e\u0442\u0430 \u0432\u0441\u0442\u0440\u0435\u0447\u0430\u0435\u043c\u043e\u0441\u0442\u0438 \u2013 1 \u0441\u043b\u0443\u0447\u0430\u0439 \u043d\u0430 1 \u043c\u043b\u043d \u043d\u0430\u0441\u0435\u043b\u0435\u043d\u0438\u044f), \u0441 \u0434\u043e\u043c\u0438\u043d\u0430\u043d\u0442\u043d\u044b\u043c \u0438\u043b\u0438 \u0440\u0435\u0446\u0435\u0441\u0441\u0438\u0432\u043d\u044b\u043c \u0442\u0438\u043f\u043e\u043c \u043d\u0430\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/p>\n

\u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u044b\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043d\u0430\u0431\u043b\u044e\u0434\u0435\u043d\u0438\u044f \u043f\u043e\u043a\u0430\u0437\u0430\u043b\u0438, \u0447\u0442\u043e \u0440\u043e\u043b\u044c FXII \u0431\u043e\u043b\u0435\u0435 \u0437\u043d\u0430\u0447\u0438\u043c\u0430 \u0434\u043b\u044f \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u043e\u0432 \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u043b\u0438\u0437\u0430, \u0447\u0435\u043c \u043d\u0435\u043f\u043e\u0441\u0440\u0435\u0434\u0441\u0442\u0432\u0435\u043d\u043d\u043e \u0434\u043b\u044f \u0433\u0435\u043c\u043e\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u0446\u0438\u0438. \u041f\u043e\u044d\u0442\u043e\u043c\u0443 \u043f\u0440\u0438 \u043d\u0430\u043b\u0438\u0447\u0438\u0438 \u0443 \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u0425\u0430\u0433\u0435\u043c\u0430\u043d\u0430 \u043e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u0443\u044e\u0442 \u0433\u0435\u043c\u043e\u0440\u0440\u0430\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043f\u0440\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u044f, \u043d\u043e \u043e\u0442\u043c\u0435\u0447\u0430\u0435\u0442\u0441\u044f \u0432\u044b\u0441\u043e\u043a\u0430\u044f \u043f\u0440\u0435\u0434\u0440\u0430\u0441\u043f\u043e\u043b\u043e\u0436\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u043a \u0442\u0440\u043e\u043c\u0431\u043e\u0437\u0430\u043c.<\/p>\n

\u0427\u0442\u043e \u043c\u043e\u0436\u0435\u0442 \u043f\u043e\u0432\u043b\u0438\u044f\u0442\u044c \u043d\u0430 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f<\/strong>
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\u041f\u0440\u0430\u0432\u0438\u043b\u0430 \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438 \u043a \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044e<\/strong>
\n\u0412\u0437\u044f\u0442\u0438\u0435 \u043a\u0440\u043e\u0432\u0438 \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u044c \u0443\u0442\u0440\u043e\u043c, \u0434\u043e 11 \u0447., \u0434\u043e\u043f\u0443\u0441\u0442\u0438\u043c\u043e \u043f\u043e\u0441\u043b\u0435 \u043b\u0435\u0433\u043a\u043e\u0433\u043e \u043f\u0440\u0438\u0435\u043c\u0430 \u043d\u0435\u0436\u0438\u0440\u043d\u043e\u0439 \u043f\u0438\u0449\u0438. \u0416\u0435\u043d\u0449\u0438\u043d\u0430\u043c \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u044c \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0432\u043e \u0432\u0440\u0435\u043c\u044f \u043c\u0435\u043d\u0441\u0442\u0440\u0443\u0430\u0446\u0438\u0438 \u043d\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0443\u0435\u0442\u0441\u044f. \u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u043d\u0435 \u0441\u043b\u0435\u0434\u0443\u0435\u0442 \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u044c \u043d\u0430 \u0444\u043e\u043d\u0435 \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[951],"product_tag":[],"class_list":{"0":"post-10019","1":"product","2":"type-product","3":"status-publish","5":"product_cat-teste-de-hemostaza","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10019","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10019"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10019"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10019"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10019"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10019"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}